Patents Assigned to Board of Trustees of the University of Illinois
  • Patent number: 12090153
    Abstract: Synergistic drug combinations with the small molecule PAC-1 against uveal or cutaneous melanoma. There are no current targeted drug treatments for the mutations associated with uveal melanoma. Despite primary radiation or surgical therapy, up to 50% of patients eventually develop metastatic disease, for which there is no standard therapy nor treatment shown to improve overall survival. Drug combinations with PAC-1 allow the use of lower dosages of this compound that result in cancer cell death in uveal melanoma. Drug combinations of PAC-1 with the kinase inhibitor entrectinib have shown a synergistic effect against uveal melanoma cell lines. Specifically, PAC-1 and entrectinib are synergistic against wild-type and mutant uveal melanoma cell lines (e.g., GNAQ and GNA11).
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: September 17, 2024
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Paul J. Hergenrother, Matthew Wesley Boudreau
  • Patent number: 12092576
    Abstract: A method is provided for characterizing a biological sample having a plurality of fluorophores, including a red fluorophore and a blue fluorophore, comprises exciting the red fluorophore via absorption of a photon order of n by a single wavelength band of light that has longer wavelengths than a typical wavelength band of light known to excite the red fluorophore would have. The method further comprises exciting the blue fluorophore substantially via absorption of a photon order of n+1 by the single wavelength band of light. The method also comprises simultaneously detecting light emitted by the red fluorophore and the blue fluorophore. The method further comprises creating an image or a temporal series for sensing from the light detected in the plurality of orthogonal colors.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: September 17, 2024
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Stephen A. Boppart, Haohua Tu, Sixian You
  • Patent number: 12084411
    Abstract: Disclosed are analogues of hinokitiol, methods for preparing them, and pharmaceutical compositions thereof. Also disclosed are methods for their use in treating iron-related diseases.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: September 10, 2024
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Martin D. Burke, Anthony S. Grillo, Alexander G. Cioffi, Anna SantaMaria, Daniel Blair, Andrew Blake
  • Patent number: 12084456
    Abstract: Enantioselective total syntheses of the anticancer isocarbostyril alkaloids (+)-7-deoxypancratistatin, (+)-pancratistatin, (+)-lycoricidine, and (+)-narciclasine are described. Our strategy for accessing this unique class of natural products is based on the development of a Ni-catalyzed dearomative trans-1,2-carboamination of benzene. The effectiveness of this dearomatization approach is notable, as only two additional olefin functionalizations are needed to construct the fully decorated aminocyclitol cores of these alkaloids. Installation of the lactam ring has been achieved through several pathways and a direct interconversion between natural products was established via a late-stage C-7 cupration. Using this synthetic blueprint, we were able to produce natural products on a gram scale and provide tailored analogs with improved activity, solubility, and metabolic stability.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: September 10, 2024
    Assignee: The Board of Trustees of the University Of Illinois
    Inventors: David Sarlah, Tanner W. Bingham, Lucas William Hernandez
  • Publication number: 20240295620
    Abstract: The present disclosure provides technologies that allow reduced field of view or fast imaging with reduced image distortion. The first technique capitalizes on the benefit of reduced field of view imaging for full field of view coverage. The second technique allows achieves high resolution 3D images in a focused region. These techniques are expected to have applications for cancer imaging, neuro imaging, and other biomedical imaging areas.
    Type: Application
    Filed: June 27, 2022
    Publication date: September 5, 2024
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Xiaohong Joe Zhou, Kaibao Sun
  • Publication number: 20240296571
    Abstract: A method for learning a representation of a sequence of frames includes encoding, via an encoder network, the sequence of frames to obtain a set of feature maps and extracting, a motion-guided slot learning mechanism, mid-level features from the set of feature maps. The method further includes quantizing the mid-level features via a vector quantization process to obtain a set of tokens, and decoding, via a decoder network, the tokens to obtain a reconstructed sequence of frames. The method still further includes optimizing a combination of a reconstruction loss and a motion loss to train the encoder and decoder networks.
    Type: Application
    Filed: December 22, 2023
    Publication date: September 5, 2024
    Applicants: TOYOTA RESEARCH INSTITUTE, INC., TOYOTA JIDOSHA KABUSHIKI KAISHA, CARNEGIE MELLON UNIVERSITY, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Zhipeng BAO, Pavel TOKMAKOV, Yuxiong WANG, Adrien David GAIDON, Martial HEBERT
  • Publication number: 20240294685
    Abstract: Rare earth elements (REEs) play an essential role in our modern society, being critical resources for the growing electronic devices and renewable energy technologies. For the reversible capture and release of REEs, we designed and synthesized a redox-copolymer poly(ferrocenylpropyl methacrylamide-co-methacrylic acid) (P(FPMAm-co-MAA)) that combines an ion-exchange carboxylic acid group for REE adsorption, and an redox-active ferrocene moiety for electrochemical regeneration. By molecularly tuning the copolymer composition, efficient adsorption uptake could be achieved alongside electrochemically regenerated adsorbent reuse. The copolymer sorbent showed stoichiometric binding for yttrium (Y), cerium (Ce), neodymium (Nd), europium (Eu), gadolinium (Gd), and dysprosium (Dy) based on carboxylic acid active site.
    Type: Application
    Filed: June 9, 2022
    Publication date: September 5, 2024
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Xiao SU, Haley VAPNIK, Johannes ELBERT
  • Patent number: 12080801
    Abstract: A method of controlling oxygen vacancy concentration in a semiconducting metal oxide includes exposing a treated surface of a crystalline metal oxide to water at a temperature and pressure sufficient to maintain the water in a liquid phase. During the exposure, a portion of the water is adsorbed onto the treated surface and dissociates into atomic oxygen and hydrogen. The atomic oxygen is injected into and diffuses through the crystalline metal oxide, forming isolated oxygen interstitials and oxygen defect complexes. The isolated oxygen interstitials replace oxygen vacancies in the crystalline metal oxide.
    Type: Grant
    Filed: January 10, 2022
    Date of Patent: September 3, 2024
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventor: Edmund G. Seebauer
  • Patent number: 12077812
    Abstract: Disclosed herein, are methods of detecting multiple sclerosis in a subject by measuring relative abundances of multiple oral microbiota in sample. Also, disclosed herein are methods of treatment and prophylaxis of MS.
    Type: Grant
    Filed: April 7, 2022
    Date of Patent: September 3, 2024
    Assignees: The United States Government As Represented By The Department Of Veterans Affairs, The Board Of Trustees Of The University Of Illinois
    Inventors: Douglas Feinstein, Anne Boullerne
  • Patent number: 12077792
    Abstract: Compositions and methods are provided for producing 2?fucosyliaciose and L-fucose from recombinant microorganisms.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: September 3, 2024
    Assignees: The Board of Trustees of the University of Illinois, Korea University Research and Business Foundation
    Inventors: Yong-Su Jin, Jingjing Liu, Sora Yu, Eun Ju Yun, Suryang Kwak, Kyoung Heon Kim, Jaewon Lee
  • Patent number: 12072521
    Abstract: A fiber includes a core and cladding, both of which may have temperature dependent indices of refraction. The materials and size of the core and cladding may be selected such that as the temperature of the core and/or cladding is heated above room temperature, the fiber transitions from supporting multimode optical waveguiding to supporting single mode waveguiding.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: August 27, 2024
    Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, CLEMSON UNIVERSITY
    Inventors: Peter D. Dragic, John Ballato, Thomas W. Hawkins
  • Patent number: 12074213
    Abstract: The invention provides methods and devices for fabricating printable semiconductor elements and assembling printable semiconductor elements onto substrate surfaces. Methods, devices and device components of the present invention are capable of generating a wide range of flexible electronic and optoelectronic devices and arrays of devices on substrates comprising polymeric materials. The present invention also provides stretchable semiconductor structures and stretchable electronic devices capable of good performance in stretched configurations.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: August 27, 2024
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Ralph G. Nuzzo, John A. Rogers, Etienne Menard, Keon Jae Lee, Dahl-Young Khang, Yugang Sun, Matthew Meitl, Zhengtao Zhu
  • Publication number: 20240279719
    Abstract: Provided herein are compositions and methods that rapidly detect a target nucleic acid molecule using a CRISPR or a CRISPR Cascade mechanism where binding of a target nucleic acid molecule initiates an amplification cascade by converting high KD guide RNA molecules to low KD guide RNA molecules.
    Type: Application
    Filed: June 17, 2022
    Publication date: August 22, 2024
    Applicant: The Board of Trustees of the University of Illinois
    Inventor: Anurup Ganguli
  • Patent number: 12067712
    Abstract: A system generates a context mask based on quantitative image data. The system obtains the quantitative image data which was captured via a quantitative imaging of a sample. The quantitative image data is compared to previous quantitative image data through application of the quantitative image data to a neural network trained using the previous quantitative image data and corresponding constructed context masks. The comparison generates the context mask for the quantitative image data. The context mask provides context for the quantitative parameter values that facilities characterization of the sample.
    Type: Grant
    Filed: February 18, 2021
    Date of Patent: August 20, 2024
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Gabriel Popescu, Mikhail Eugene Kandel, Yuchen He, Nahil A. Sobh, Matthew Benjamin Wheeler, Marcello Rubessa
  • Publication number: 20240269671
    Abstract: The disclosure provides example devices and methods for virus and bacterium detection and identification. The example device includes (a) a housing having an air inlet and an air outlet, (b) a substrate disposed within the housing, where the at least one substrate has a through-slot, where the substrate has a plurality of wells, (c) an air-handling and precipitation chamber, a reagent and reaction chamber, and a detection chamber arranged in series and each coupled to the top surface of the substrate, (d) a first actuator coupled to the substrate and configured to rotate the substrate, (e) a second actuator coupled to and configured to rotate the air-handling and precipitation chamber, the reagent and reaction chamber, and the detection chamber, and (f) at least one processor electrically coupled to the air-handling and precipitation chamber, the reagent and reaction chamber, the detection chamber, the first actuator, and the second actuator.
    Type: Application
    Filed: June 6, 2022
    Publication date: August 15, 2024
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Igor Paprotny, Michael S. Caffrey, Nitin S. Jayakumar
  • Patent number: 12053533
    Abstract: Cyclooxygenase-2 (COX-2) over-expression is prominent in inflammatory diseases, neurodegenerative disorders, and cancer. Directly monitoring COX-2 activity within its native environment poses an exciting approach to account for and illuminate the effect of the local environments on protein activity. Herein, we report the development of CoxFluor, the first activity-based sensing approach for monitoring COX-2 within live cells with confocal microscopy and flow cytometry. CoxFluor strategically links a natural substrate with a dye precursor to engage both the cyclooxygenase and peroxidase activities of COX-2. This catalyzes the release of resorufin and the natural product, as supported by molecular dynamics and ensemble docking. CoxFluor enabled the detection of oxygen-dependent changes in COX-2 activity that are independent of protein expression within live macrophage cells.
    Type: Grant
    Filed: April 26, 2021
    Date of Patent: August 6, 2024
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Christopher J. Reinhardt, Anuj K. Yadav, Jefferson Chan
  • Patent number: 12054727
    Abstract: Aspects of the present disclosure relate to methods of cultivating genetically altered plants with increased activity of the PsbS protein. These genetically altered plants have increased water use efficiency and substantially similar photosynthetic efficiency as compared to WT plants grown under the same conditions.
    Type: Grant
    Filed: March 4, 2020
    Date of Patent: August 6, 2024
    Assignees: The Regents of the University of California, The Board of Trustees of the University of Illinois
    Inventors: Stephen P. Long, Katarzyna Glowacka, Johannes Kromdijk, Krishna K. Niyogi, Laurie Beth Leonelli
  • Patent number: 12054469
    Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.
    Type: Grant
    Filed: July 26, 2021
    Date of Patent: August 6, 2024
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Gregory R Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
  • Patent number: 12048655
    Abstract: This disclosure describes a low-profile, high-load, and hands-free ball-balancing omnidirectional rolling system with multiple human-robot interfaces for modular and adaptive design configurations and input control interfaces. The disclosed platform uses a self-balancing ball-based robot to allow for a safe, compact, high-load, self-balancing and intuitive mobility device for a person with lower-limb disability. Advanced driving assistance such as obstacle avoidance and semi-autonomous navigation between predefined locations is also disclosed.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: July 30, 2024
    Assignee: The Board of Trustees of The University of Illinois
    Inventors: Adam Wade Bleakney, Jeannette R. Elliott, Elizabeth T. Hsiao-Wecksler, Patricia Barrett Malik, Deana C. McDonagh, Arielle K. Rausin, William Robert Norris, Joao Luiz Almeida de Souza Ramos, Yu Chen, Chenzhang Xiao, Yinan Pei, Seung Yun Song
  • Patent number: 12050810
    Abstract: Systems and methods for hardware-based asynchronous logging include: initiating first and second atomic regions on first and second cores of a central processing unit (CPU); and asynchronously logging data for the first atomic region and the second atomic region using the CPU by: asynchronously performing log persist operations (LPOs) to log an old data value from each atomic region; updating the old data value to a new data value from each atomic region; tracking dependencies between the first atomic region and the second atomic region using a memory controller; asynchronously performing data persist operations (DPOs) to persist the new data value for each atomic region; and committing the first atomic region and the second atomic region based on the dependencies using the memory controller of the CPU.
    Type: Grant
    Filed: September 27, 2022
    Date of Patent: July 30, 2024
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Ahmed Abulila, Nam Sung Kim, Izzat El Hajj