Abstract: Systems and methods are provided for employing informational models trained using the Autoprogressive Algorithm to learn the mechanical behavior and internal structure of biological materials using a sparse sampling of force and displacement measurements. Forces are applied to the biological material and the force and displacement are measured and applied to the AutoP algorithm. Additionally, a coordinate based scaling factor is applied to the measured displacement.

Abstract: A system for charging a battery includes three sub-modules, each receiving a respective phase of a three-phase alternating current (AC) signal. The three sub-modules cooperate to transform the respective phases of the three-phase AC signal to a direct current (DC) signal by passing the respective phases of the three-phase AC signal through a respective semiconductor device configured to discontinuously modulate the respective phase of the three-phase AC signal to convert it to a DC signal provided to the battery to charge the battery.

Abstract: Systems and methods are provided for encoding information as the pattern of the lengths of RNA tails (or other tail biomolecules, e.g., polypeptides) attached to a dsDNA (or other backbone biomolecule) and the relative locations of attachment thereto. This information can be quickly and accurately read out by passing such information-encoding payload biomolecules through a nanopore and detecting the pattern of conductance of the pore (e.g., the ionic conductance through the pore and/or the transverse conductance of the membrane bearing the pore) as the payload passes therethrough. The conductance can be processed by subtracting a time-varying correction factor therefrom that represents the expected conductance for a ‘tail-free’ backbone as it transits through the pore, by applying a time-varying velocity factor that is dependent on the number of tails present in the pore over time to normalize individual tail dwell times, and/or other processing steps.

Abstract: A coated tubular construct for biological and industrial applications includes a plurality of channels, where each channel is radially surrounded by a wall comprising a first polymer, and a conformal coating comprising a second polymer is disposed on an outer and/or an inner surface of each wall. A method of producing a tubular construct includes 3D printing a template structure comprising a sacrificial material and a photoinitiator, and immersing the template structure in a first prepolymer solution comprising a first prepolymer and a co-initiator. During the immersion, the template structure is exposed to light, and the first prepolymer undergoes radical polymerization to conformally coat the template structure with the first polymer, forming a coated template. The sacrificial material is removed from the coated template, and a tubular construct comprising the first polymer is formed.

Abstract: Disclosed herein are compounds that can act as inhibitors of nicotinamide phosphoribosyltransferase (“NAMPT”), and methods for their use in treating or preventing diseases, such as pulmonary arterial hypertension (“PAH”). The compounds described herein can include compounds of Formula (II) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

Abstract: The present disclosure provides compounds represented by Formula I: and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof, wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.

Abstract: A method of making a bonded polymeric assembly by transfer printing comprises contacting a stamp with a solid-phase ink comprising a photoresist to form an inked stamp, where the solid-phase ink is reversibly bound to the stamp. The inked stamp is aligned with an object comprising the photoresist and is stamped onto the object. The stamp is then removed, thereby transferring the solid-phase ink onto the object. The solid-phase ink is thermally joined with the object. Thus, a bonded polymeric assembly comprising a bonded joint between the solid-phase ink and the object is formed.

Abstract: Provided are implantable probes for analyzing biological fluids and related methods of using and making. The probe is formed with an integrated on-chip probe body that provides for collection and storage of analyte from biological fluid and facilitates subsequent analysis, including by a mass spectrometer (MS). The analysis has high spatial accuracy as the probe tip that collects biological fluid sample is small, including less than 100 ?m with an opening less than 10 ?m. Temporal information can be obtained by storing the analyte from the biological fluid as a train of droplets separated by an immiscible fluid. The probe body can be electrically energized to facilitate sample ionization and transfer to a MS analysis device. In this manner, the integrated on-chip probe body facilitates analyte collection, storage and subsequent analysis within a single probe body material, including a doped silicon material.

Abstract: A multi-modal functional OCT imaging methodology and system are provided that enable concurrent intrinsic optical signal (IOS) imaging of stimulus-evoked neural activity and hemodynamic responses at capillary resolution. An OCT angiography (OCTA)-guided IOS analysis is used to separate neural-IOS and hemodynamic-IOS changes in the same retinal image sequence. The OCTA-guided IOS data processing used for this purpose differentiates two functional images, namely, a neural-IOS map and a hemodynamic-IOS map, from the same image dataset.

Abstract: Compositions and methods for eliciting an immune response in a subject against Vibrio cholerae are provided. The compositions include fusion proteins with one or more epitopes from Vibrio cholerae, nucleic acids and vectors encoding the fusion proteins, pharmaceutical compositions, immunogenic compositions, and vaccines. In examples, the methods include administering a disclosed composition to a subject, such as a human.

Abstract: In an example, a method including dispensing a liquid onto a first portion of a surface of a substrate and dispensing a solution comprising colloidal spheres onto a second portion of the surface of the substrate. The method additionally includes agitating the colloidal spheres to disperse the colloidal spheres along the first portion and the second portion of the surface of the substrate and directing air flow above the colloidal spheres inducing rotation of the colloidal spheres. In another example, a method includes positioning a retaining ring on a surface of a liquid above a substrate below the surface of the liquid and dispensing a solution comprising colloidal spheres onto the surface of the liquid within a surface area of the retaining ring. The method further includes agitating the surface of the liquid and the colloidal spheres to disperse the colloidal spheres along the surface area of the retaining ring.

Abstract: An acoustic resonator includes a piezoelectric thin film (PTF) disposed on a carrier substrate. The PTF confines a fundamental shear-horizontal (SH0) surface-acoustic wave (SAW) within the PTF. The acoustic resonator includes an input bus line coupled to an input source and a ground bus line coupled to a ground potential. The acoustic resonator includes a first grating reflector disposed at a first end of the PTF and coupled between the input bus line and the ground bus line. The acoustic resonator includes a second grating reflector disposed at a second end of the PTF and coupled between the input bus line and the ground bus line. The acoustic resonator includes interdigital transducers (IDTs) disposed between the first grating reflector and the second grating reflector. Each IDT includes an input electrode coupled to the input bus line, and a ground electrode coupled to the ground bus line.

Abstract: A FabI inhibitor called fabimycin that has impressive activity against >200 clinical isolates of E. coli, K. pneumoniae, and A. baumannii. Fabimycin has activity in multiple mouse models of infection caused by Gram-negative bacteria, including a model of urinary tract infection. Fabimycin has translational promise, and its discovery provides data indicating that antibiotics whose spectrum of activity is restricted to Gram-positive bacteria can be systematically modified to accumulate in Gram-negative bacteria and be effective against these problematic pathogens.

Abstract: Aspects of the subject disclosure may include, for example, co-registering MRI data with CT data to derive merged data, the MRI data and the CT data being associated with an anatomical part of a patient, the MRI data being obtained prior to implantation of a plurality of electrodes into the anatomical part and the CT data being obtained after the implantation of the plurality of electrodes, performing segmentation on the merged data to identify locations of the plurality of electrodes, resulting in identified locations, localizing a region of interest in the merged data based on the identified locations of the plurality of electrodes and based on activity recordings relating to the anatomical part, and generating a model of the anatomical part by performing multimodal image fusion of the activity recordings and the merged data to derive an output for VR viewing or manipulation. Additional embodiments are disclosed.

Abstract: A densely integrated and chiplet/dielet based networked memory pool with very high intra-pool bandwidth is provided. Chiplets are used to provide a common interface to the network. This means all memories (even those built with different process technologies) look the same from the network's perspective and vice versa: memory can be assembled in many different configurations while only changing the configuration at a high level of abstraction. The memory pool can easily be scaled in capacity and custom configurations that were previously impossible to achieve because of incompatibility of different technologies or level of integration are made possible.

Abstract: A passive thermal management system and methods of using a thermoresponsive hydrogel coating configured to autonomously switch between a heating state and a cooling state based on ambient temperature. At temperature greater than a lower critical solution temperature of the thermoresponsive hydrogel, the thermoresponsive hydrogel coating becomes solar reflective and has enhanced radiative cooling ability to achieve daytime radiative cooling. At temperatures less than the lower critical solution temperature, the thermoresponsive hydrogel coating becomes transparent to facilitate absorption of solar radiation by sun absorber.

Abstract: A system and method for producing a series of time-resolved magnetic resonance (MR) images is set forth. The system can perform method steps of encoding spatial information into an MRI signal by manipulating a phase of the MRI signal within an MRI system, generating and outputting a phase-encoded MRI signal over time by digitizing a plurality of time points in the MRI signal, repeating the generating and outputting step for a plurality of phase-encoded signals, each phase-encoded signal in synchrony with a trigger, producing a plurality of digitized time points, and reconstructing a series of time resolved MR images, each image of the series of MR images at one specific time point selected from the plurality of digitized time points for each phase-encoded step. Each image in the series of time-resolved MR images corresponding to a specific time point in a cyclic event.

Abstract: A method and system for performing single molecule proteomics utilizing a nanopore sensor to measure an electronic signature of protein or peptide being transported through the nanopore from a first chamber to a second chamber. The protein's electronic signature is a function of ionic current over time. The method and system utilizing an agent, such as guanidinium chloride, to bind to the nanopore's interior and provide an electroosmotic force within the nanopore. The electroosmotic force, in some embodiments, enables stretching and unfolding of the protein during transport through the nanopore. The agent may also or alternatively induce the unfolding of the protein before transport through the nanopore and/or provide force moving the protein through the nanopore.

Abstract: Provided herein are biocompatible polymers having a polymer backbone and one or more repeating units, and methods of making and using the same. The repeating units can each be individually selected from a zwitterionic precursor repeating unit of Formula (1). Also provided are systems for nucleic acid delivery including the biocompatible polymers, the systems having a cationic core and a polysaccharide-anionic peptide conjugate adsorbed to the cationic core.

Abstract: A piezoelectric thin film suspended above a carrier substrate is adapted to propagate an acoustic wave in a Lamb mode excited by a component of an electric field that is oriented in a longitudinal direction along a length of the piezoelectric thin film. A first signal electrode is located on the piezoelectric thin film and oriented in a transverse direction perpendicular to the longitudinal direction. A first ground electrode is located on the piezoelectric thin film and oriented in the transverse direction. The first ground electrode is separated from the first signal electrode by a gap in which the acoustic wave resonates. A first release window and a second release window are located at a first end and a second end of the piezoelectric thin film, respectively. Intermittent release windows are located beyond distal ends of the first signal electrode and the first ground electrode.