Abstract: An analog self-interference cancellation technique for In-Band Full-Duplex (IBFD) systems generates an inherent secondary self-interference (SI) signal of a circulator and uses that signal to cancel a primary SI signal leaked from a transmitter port within a communication device. The communication device manipulates the phase and angle of this secondary SI, using an adjustable Impedance Mismatch Terminal (IMT) circuit. The result is an efficient SI cancellation technique in the analog domain, which uses the circulator inherent SI signals.

Abstract: Methods and compositions for specific cleavage of DNA molecules using single-stranded guides and Argonaute (Ago) proteins are described.

Abstract: The present disclosure provides methods for detection and quantification of trimethylamine (TMA) or trimethylamine oxide (TMAO) comprising passing a sample over a sensor comprising a substrate having a plurality of chemically responsive dyes selected from the following classes of chemically responsive dyes: metal-containing dyes, pH indicators, or solvatochromic/vapochromic dyes. The disclosure also provides devices and sensors for the detection and quantification of TMA, and methods of diagnosing a subject having trimethylaminuria (TMAU).

Abstract: The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in immunotherapy, particularly where the disease is accompanied by elevated levels of NQO1. In particular, embodiments where an immunotherapy, such as a heckpoint inhibitor, are combined with a NQO1 bioactivatable drug.

Abstract: Detection of nitroxyl (HNO), the transient one-electron reduced form of nitric oxide, is a significant challenge owing to its high reactivity with biological thiols (rate constants as high as 109M?1 s?1). Reported herein is a new thiol-based HNO-responsive trigger that can compete against reactive thiols for HNO. This process forms an N-hydroxysulfenamide intermediate which cyclizes to release a masked fluorophore leading to fluorescence enhancement. To ensure a rapid cyclization step, the disclosed design capitalizes on two established physical organic phenomena: the alpha-effect and the Thorpe-Ingold effect. Using this new trigger, NitroxylFluor was developed; a selective HNO-responsive fluorescent probe. Treatment of NitroxylFluor with an HNO donor results in a 16-fold turn-on. This probe also exhibits excellent selectivity over various reactive nitrogen, oxygen, and sulfur species and efficacy in the presence of thiols (e.g., glutathione in mM concentrations).

Abstract: The present disclosure provides compounds represented by Formula I: and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof, wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.

Abstract: Aspects of the subject disclosure may include, for example, an apparatus comprising: a membrane having a first side and a second side, wherein the membrane has first and second pores disposed therein, a processing system; and a memory that stores executable instructions that, when executed by the processing system, facilitate performance of operations comprising: setting a first physical characteristic in a vicinity of the first pore to cause a first end of a molecule having the first end and a second end to be moved through the first pore; setting a second physical characteristic in a vicinity of the second pore to cause the second end of the molecule to be moved through the second pore; and adjusting the first physical characteristic to cause the molecule to be tightened, with a first given amount of force, between the first pore and the second pore. Additional embodiments are disclosed.

Abstract: Described herein are pyridinone-based compounds, derivatives thereof, and pharmaceutical formulations thereof. In some aspects, the pyridinone-based compounds, derivatives thereof, and/or pharmaceutical formulations thereof can be administered to a subject in need thereof. In some aspects, pyridinone-based compounds, derivatives thereof, and/or pharmaceutical formulations thereof can modulate an activity and/or a function of a BRD protein and/or BET protein.

Abstract: A segmentation method and segmentation apparatus are provided, where the segmentation method includes receiving image frames comprising a current frame and an adjacent frame to the current frame, determining a feature map to aggregate the image frames based on temporal information between the current frame and the adjacent frame, extracting a feature of a region of interest (ROI) corresponding to instances included in the current frame from the feature map, predicting a class of an object corresponding to the ROI based on the feature of the ROI, and segmenting the instances by correcting an amodal mask predicted corresponding to the class of the object based on the feature of the ROI.

Abstract: Intermittent energy sources, including solar and wind, require scalable, low-cost, multi-hour energy storage solutions to be effectively incorporated into the grid. Redox-flow batteries offer a solution, but suffer from rapid capacity fade and low Coulombic efficiency due to the high permeability of redox-active species across the battery's membrane. Here we show that active-species crossover can be arrested by scaling the membrane's pore size to molecular dimensions and in turn increasing the size of the active material to be above the membrane's pore-size exclusion limit. When oligomeric redox-active organic molecules were paired with microporous polymer membranes, the rate of active-material crossover was either completely blocked or slowed more than 9,000-fold compared to traditional separators at minimal cost to ionic conductivity. In the case of the latter, this corresponds to an absolute rate of ROM crossover of less than 3 ?mol cm?2 day?1 (for a 1.

Abstract: A memory device (or memory sub-system) includes one or more memory components having multiple blocks, the multiple blocks containing pages of data. A processing device is coupled to the one or more memory components. The processing device to execute firmware to: track write timestamps of the pages of data that have been marked as invalid; retain a storage state stored for each page marked as invalid, wherein invalid data of the marked pages remains accessible via the storage states; in response to a write timestamp of a page being beyond a retention time window, mark the page as expired, indicating that the page is an expired page; and reclaim the expired page for storage of new data during a garbage collection operation.

Abstract: Aspects of the subject disclosure may include, for example, an apparatus comprising: a membrane, wherein the membrane has a first side and a second side, wherein the membrane has a first pore disposed therein, wherein the first pore extends through the membrane from the first side of the membrane to the second side of the membrane, wherein the membrane has a second pore disposed therein, and wherein the second pore extends through the membrane from the first side of the membrane to the second side of the membrane; a first channel disposed on the first side of the membrane, wherein the first channel is along a first longitudinal axis; a second channel disposed on the first side of the membrane, wherein the second channel is along a second longitudinal axis, and wherein the first channel and the second channel are disposed side by side adjacent to each other; a third channel disposed on the second side of the membrane, wherein the third channel is along a third longitudinal axis, wherein the third channel is in

Abstract: The present disclosure provides multivalent polymer-peptide conjugate compositions capable of breaking already formed amyloid fibrils. Also provided are methods of treating a subject having or suspected of having Alzheimer's disease by administering a therapeutically effective amount of these multivalent polymer-peptide conjugate compositions.

Abstract: A computer-implemented method is provided for transferring a target text style using Reinforcement Learning (RL). The method includes pre-determining, by a Long Short-Term Memory (LSTM) Neural Network (NN), the target text style of a target-style natural language sentence. The method further includes transforming, by a hardware processor using the LSTM NN, a source-style natural language sentence into the target-style natural language sentence that maintains the target text style of the target-style natural language sentence. The method also includes calculating an accuracy rating of a transformation of the source-style natural language sentence into the target-style natural language sentence based upon rewards relating to at least the target text style of the source-style natural language sentence.

Abstract: Provided are optical devices and systems fabricated, at least in part, via printing-based assembly and integration of device components. In specific embodiments the present invention provides light emitting systems, light collecting systems, light sensing systems and photovoltaic systems comprising printable semiconductor elements, including large area, high performance macroelectronic devices. Optical systems of the present invention comprise semiconductor elements assembled, organized and/or integrated with other device components via printing techniques that exhibit performance characteristics and functionality comparable to single crystalline semiconductor based devices fabricated using conventional high temperature processing methods. Optical systems of the present invention have device geometries and configurations, such as form factors, component densities, and component positions, accessed by printing that provide a range of useful device functionalities.

Abstract: Disclosed are recombinant extracellular vesicles (EVs), compositions including modified EVs encapsulated in a matrix, methods for controlling the release of EVs from an encapsulating matrix, and methods of using the same in the treatment of disease.

Abstract: Disclosed are novel compounds that accumulate in Gram-negative bacteria. Also disclosed are method of antimicrobial treatment using the compounds.

Abstract: A construct composed of a Kinesin-derived Angiogenesis Inhibitor peptide and one or more carrier moieties and/or stabilizing moieties is provided as are methods for inhibiting angiogenesis and treating a disease or condition characterized by excessive vascularity.

Abstract: Disclosed are compounds for the selective labeling of cell-surface sugars in cancer cells. The compounds are activatable by triggers specific to cancer cells, and, when metabolized, label a cancer cell surface sugar with an azide chemical group. Facilitated by a click chemistry reaction, combination of the cell surface-expressed azide with a alkynyl-drug conjugate enables efficient targeted drug delivery to cancer cells with reduced toxicity. Also disclosed are compounds for delivering a drug to an azide-bearing cancer cell, and methods of treating cancer using the compounds.

Abstract: A method includes generating gate-level activity information of a processor design for all possible executions of a target application for any possible inputs to the target application. The method includes performing a constrained timing analysis on the processor design based on the gate-level activity information to determine a minimum operating voltage for executing the target application on the processor.