Patents Assigned to Board of Trustees of the University of Illinois
  • Publication number: 20220064176
    Abstract: Enantioselective total syntheses of the anticancer isocarbostyril alkaloids (+)-7-deoxypancratistatin, (+)-pancratistatin, (+)-lycoricidine, and (+)-narciclasine are described. Our strategy for accessing this unique class of natural products is based on the development of a Ni-catalyzed dearomative trans-1,2-carboamination of benzene. The effectiveness of this dearomatization approach is notable, as only two additional olefin functionalizations are needed to construct the fully decorated aminocyclitol cores of these alkaloids. Installation of the lactam ring has been achieved through several pathways and a direct interconversion between natural products was established via a late-stage C-7 cupration. Using this synthetic blueprint, we were able to produce natural products on a gram scale and provide tailored analogs with improved activity, solubility, and metabolic stability.
    Type: Application
    Filed: December 4, 2019
    Publication date: March 3, 2022
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: David SARLAH, Tanner W. BINGHAM, Lucas William HERNANDEZ
  • Patent number: 11264047
    Abstract: A voice enabled device includes a transducer to capture multiple inaudible signals received from multiple ultrasonic speakers and audio recording electronics to process the multiple inaudible signals to generate digital output samples, which are recorded sound data comprising non-linearities from frequency-shifted versions of the multiple inaudible signals to within an audible frequency range. A processing device is to detect, within the recorded sound data, at least a portion of the non-linearities, e.g., via: comparison of the recorded sound data with expected patterns from an audible audio signal generated by human voice; and detection of non-linear variations within the recorded sound data as compared to the expected patterns. In response to the detection, the processing device is further to suppress an action programmed for response to a voice command corresponding to the recorded sound data.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: March 1, 2022
    Assignee: Board of Trustees of the University of Illinois
    Inventors: Nirupam Roy, Romit Roy Choudhury, Haitham Al Hassanieh
  • Patent number: 11261483
    Abstract: Methods and compositions for specific cleavage of DNA molecules using single-stranded guides and Argonaute (Ago) proteins are described.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: March 1, 2022
    Assignee: BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Huimin Zhao, Behnam Enghiad
  • Patent number: 11260105
    Abstract: Modified peptides based on C-terminal PDZ binding domains of PTEN and PHLPP, or PDK1 interacting fragment of PKN2 are described as are methods of using the modified peptides for blocking the activity of PTEN, PHLPP and PKN2 and treating sudden cardiac arrest. A method for guiding treatment of cardiac arrest based on sorbitol or taurine levels is also provided.
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: March 1, 2022
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Terry Vanden Hoek, Xiangdong Zhu, Jing Li
  • Patent number: 11253846
    Abstract: Provided herein are methods of catalytic hydrosilylation, including triggerable methods, using metal-ligand complexes as catalysts, characterized by formula MLxDy; wherein: M is a metal; x is equal to the oxidation state of M; each D is independently a neutral coordinating ligand; y is zero or an integer selected from the range of 1 to 4; and each L is independently a mono-anionic ligand. L may be a ?1,?2-?,?-disubstituted-?-alkenyl ligand.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: February 22, 2022
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Gregory S. Girolami, Sumeng Liu
  • Patent number: 11256321
    Abstract: A server system including an enhanced Network Interface Controller (NIC) within a client-server architecture is provided. The server system includes a memory for storing data from one or more network packets and one or more processors for processing network requests based on the one or more network packets. The enhanced NIC is configured to receive the one or more network packets and transfer the data from the one or more network packets to the memory. During a latency period defined from the time required to transfer the network packet to memory, the enhanced NIC performs a Network-driven, packet Context Aware Power (NCAP) management process in order to actively transition a power management state of the one or more processors to a predicted level. In this manner, computational and energy efficiency of the server system is improved.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: February 22, 2022
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Nam Sung Kim, Mohammad Alian
  • Publication number: 20220050112
    Abstract: The post-translational modification (PTM) and signaling molecule poly(ADP-ribose) (PAR) has an impact on diverse biological processes. PTM is regulated by a series of ADP-ribosyl glycohydrolases (PARG enzymes) that cleave polymers and/or liberate monomers from their protein targets. Disclosed herein is a substrate for monitoring PARG activity, TFMU-ADPr, which directly reports on total PAR hydrolase activity via release of a fluorophore; this substrate has excellent reactivity, generality, stability, and usability. A second substrate, TFMU-IDPr, selectively reports on PARG activity only from the enzyme ARH3. Use of these probes in whole-cell lysate experiments has revealed a mechanism by which ARH3 is inhibited by cholera toxin. TFMU-ADPr and TFMU-IDPr are versatile tools for assessing small-molecule inhibitors in vitro and probing the regulation of ADP-ribosyl catabolic enzymes.
    Type: Application
    Filed: September 9, 2019
    Publication date: February 17, 2022
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Paul J. Hergenrother, Bryon S. DROWN
  • Publication number: 20220047631
    Abstract: The disclosure provides Tn epitope-specific chimeric antigen receptors and scFvs, including soluble scFvs and multimeric scFvs, as well as methods of identifying cancer subjects and cancer subject sub-populations amenable to anti-Tn immunotherapy and methods of treating cancer.
    Type: Application
    Filed: September 11, 2019
    Publication date: February 17, 2022
    Applicants: The University of Chicago, The Board of Trustees of the University of Illinois
    Inventors: Hans SCHREIBER, David KRANZ, Karin SCHREIBER, Yanran HE, Preeti SHARMA
  • Patent number: 11246522
    Abstract: The provided systems, methods and devices describe lightweight, wireless tissue monitoring devices that are capable of establishing conformal contact due to the flexibility or bendability of the device. The described systems and devices are useful, for example, for skin-mounted intraoperative monitoring of nerve-muscle activity. The present systems and methods are versatile and may be used for a variety of tissues (e.g. skin, organs, muscles, nerves, etc.) to measure a variety of different parameterps (e.g. electric signals, electric potentials, electromyography, movement, vibration, acoustic signals, response to various stimuli, etc.).
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: February 15, 2022
    Assignees: NORTHWESTERN UNIVERSITY, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: John A. Rogers, Michel Kliot, Roozbeh Ghaffari, YuHao Liu
  • Publication number: 20220045967
    Abstract: A system and method remotely allocate bandwidth among content consumers on a computing network based on optimizing an aggregate objective pertaining to a plurality of flows of content. The system and method create a profile for each flow of the plurality of flows from a content provider to a content consumer on the computing network. Information is stored in each profile based on at least a metric associated with the corresponding flow. A target bandwidth for each profile is computed remotely, based on optimizing an aggregate objective pertaining to the plurality of flows of content. The optimizing is also based on the information stored in their respective profiles. The system and method distribute the bandwidth to each flow of the plurality of flows based on the target bandwidth remotely computed for each profile.
    Type: Application
    Filed: July 28, 2021
    Publication date: February 10, 2022
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Yih-Chun Hu, Zhuotao Liu
  • Patent number: 11241163
    Abstract: Aspects of the subject disclosure may include, for example, obtaining first magnetic resonance imaging (MRI) data of a subject, wherein the first MRI data is obtained during a first scan of a subject, wherein the first scan has a first diffusion sampling time, and wherein the first diffusion sampling time is selected in order to facilitate use of the first MRI data to determine a first Intravoxel Incoherent Motion (IVIM) effective diffusion coefficient in a Stationary Random Flow (SRF) regime; obtaining second MRI data of the subject, wherein the second MRI data is obtained during a second scan of the subject, wherein the second scan has a second diffusion sampling time, wherein the second diffusion sampling time is longer than the first diffusion sampling time, and wherein the second diffusion sampling time is selected in order to facilitate use of the second MRI data to determine a second IVIM effective diffusion coefficient in a pseudodiffusion regime; determining a blood velocity value based upon the firs
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: February 8, 2022
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Bradley P. Sutton, Alexander M. Cerjanic, Luisa Ciobanu, Denis LeBihan, Jing-Rebecca Li, Gabrielle Fournet
  • Patent number: 11242326
    Abstract: Abnormally long r(CUG)n repeat expansion is believed to be the major cause of Myotonic dystrophy type 1 (DM1) because it binds to muscleblind-like 1 (MBNL 1) protein which regulates RNA splicing, leading to the mis-splicing of more than 100 pre-mRNAs. The rational design of oligomers with alternating bisamidine and melamine structure resulted in good binding affinity to the RNA target because of a multivalent effect. The oligomers also showed excellent activity in disrupting nuclear foci, reversing the mis-splicing of IR minigene, and sabotaging the toxic RNA biosynthesis. Excellent activity in Drosophila based DM1 models was also observed for the oligomers, rescuing the climbing ability of the flies upon oral treatment.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: February 8, 2022
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Yugang Bai, Steven C. Zimmerman, Auinash Kalsotra
  • Patent number: 11237343
    Abstract: A device includes an optic in an at least partially rigid scaffold. The scaffold is permeated, at least temporarily during a writing process, by writable media. The optic may be written into a writable volume in the scaffold defined by the writable media. The optic may be written by exposing the writable media to incident light to cause a material property change in the writable media within the writable volume.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: February 1, 2022
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Lynford L. Goddard, Kimani C. Toussaint, Paul V. Braun, Jinlong Zhu, Daniel Bacon-Brown, Christian H. Ocier, Qing Ding, Corey Richards
  • Patent number: 11239320
    Abstract: A classifier circuit includes an array of dual gate graphene transistors, each of the transistors having a source, a top gate receiving one of an input voltage to be evaluated or a reference voltage, a bottom or embedded gate receiving the other of the input voltage or reference voltage and a drain, the source and drain contacting a graphene channel One of the source and the drain is connected to a voltage source. A common output combines output current of a plurality of the dual gate graphene transistors, which current varies in response to the difference between the input voltage and the reference voltage. A method for forming a classifier transistor with high remanent polarization forms dielectric with ferroelectric capability on a low resistivity substrate. A non-ferroelectric oxide layer is formed on the dielectric. A window is opened, and a graphene channel is formed in the window.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: February 1, 2022
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Wenjuan Zhu, Jialun Liu, Hojoon Ryu
  • Publication number: 20220023328
    Abstract: Embodiments of compositions and methods for the treatment of blood disorders and malignancies in a subject are described herein. In one embodiment, a composition for the treatment of a blood disorder or a malignancy in a subject comprises decitabine, tetrahydrouridine, and an excipient. In another embodiment, a method for the treatment of a blood disorder or a malignancy in a subject comprises the oral administration of a composition comprising decitabine and tetrahydrouridine. In some examples, the composition may be administered 1-3 times weekly.
    Type: Application
    Filed: July 14, 2021
    Publication date: January 27, 2022
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Joseph Desimone, Yogen Saunthararajah
  • Publication number: 20220018759
    Abstract: Methods and apparatus for obtaining a vibrational circular dichroism (VCD) image using a discrete frequency infrared (DFIR) microscope are disclosed. The method includes generating a pulsed laser beam comprising a spectral frequency, which may be tunable; modulating the laser beam to generate circularly polarized light; illuminating a sample and collecting, and detecting an optical signal transmitted or transflected from the location of the sample. The detected signal is demodulated at, for example, both the pulse frequency and the sum or difference of the pulse frequency and the modulating frequency to obtain an intensity value that correspond to the absorbance, and a polarization-dependent value that corresponds to the VCD. Other configurations of the apparatus may be employed to measure VCB and VLD.
    Type: Application
    Filed: July 15, 2021
    Publication date: January 20, 2022
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Yamuna PHAL, Kevin Lee YEH, Rohit BHARGAVA
  • Patent number: 11226336
    Abstract: The present disclosure provides quantum dots and methods of making the quantum dots comprising a substantially homogeneous population of monomeric nanocrystals, of a very small size, about 7 nm to about 12 nm in diameter. The method comprises mixing a nanocrystal coated with weakly binding ligands or ions with a polymer in a solution and incubating at a temperature greater than about 100° C., thereby forming a quantum dot having a substantially homogenous population of monomeric nanocrystals. The quantum dots can be further conjugated to bioaffinity molecules, enabling broad utilization of compact, biofunctional quantum dots for studying crowded macromolecular environments.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: January 18, 2022
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Andrew M. Smith, Chunlai Tu, Liang Ma
  • Patent number: 11227964
    Abstract: Luminescent solar concentrators in accordance with various embodiments of the invention can be designed to minimize photon thermalization losses and incomplete light trapping using various components and techniques. Cadmium selenide core, cadmium sulfide shell (CdSe/CdS) quantum dot (“QD”) technology can be implemented in such devices to allow for near-unity QDs and sufficiently large Stokes shifts. Many embodiments of the invention include a luminescent solar concentrator that incorporates CdSe/CdS quantum dot luminophores. In further embodiments, anisotropic luminophore emission can be implemented through metasurface/plasmonic antenna coupling. In several embodiments, red-shifted luminophores are implemented. Additionally, top and bottom spectrally-selective filters, such as but not limited to selectively-reflective metasurface mirrors and polymeric stack filters, can be implemented to enhance the photon collection efficiency.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: January 18, 2022
    Assignees: California Institute of Technology, The Regents of the University of California, The Board of Trustees of the University of Illinois
    Inventors: David R. Needell, Noah Bronstein, Armand P. Alivisatos, Harry A. Atwater, Ralph Nuzzo, Haley Bauser, Ognjen Ilic, Junwen He, Lu Xu, Colton Bukowsky, Sunita Darbe, Zach Nett, Brent Koscher
  • Patent number: 11225507
    Abstract: The disclosure provides a class of pH-sensitive, helix/random conformation switchable antimicrobial polypeptide (HRS-AMP) compositions as a single agent to selectively kill bacteria (e.g., H. pylori) under acidic condition in the stomach with diminished bacterial resistance compared to currently used antibiotics. Methods of treating bacterial infections in the stomach are also provided.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: January 18, 2022
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Jianjun Cheng, Lin-Feng Chen, Menghua Xiong, Yan Bao
  • Publication number: 20220009967
    Abstract: Provided herein are compounds having a structure according to formula I, pharmaceutical compositions thereof, and methods of treating a bacterial infection thereof.
    Type: Application
    Filed: July 13, 2021
    Publication date: January 13, 2022
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventor: Scott G. Franzblau