Abstract: A method for forming a flow channel in a MIO structure includes positioning a plurality of sacrificial spheres along a base substrate, heating a region of the plurality of sacrificial spheres above a melting point of the plurality of sacrificial spheres, thereby fusing the plurality of sacrificial spheres together and forming a solid channel, electrodepositing material between the plurality of sacrificial spheres and around the solid channel, removing the plurality of sacrificial spheres to form the MIO structure, and removing the solid channel to form the flow channel extending through the MIO structure.

Abstract: Synergistic drug combinations with the small molecule PAC-1 against uveal or cutaneous melanoma. There are no current targeted drug treatments for the mutations associated with uveal melanoma. Despite primary radiation or surgical therapy, up to 50% of patients eventually develop metastatic disease, for which there is no standard therapy nor treatment shown to improve overall survival. Drug combinations with PAC-1 allow the use of lower dosages of this compound that result in cancer cell death in uveal melanoma. Drug combinations of PAC-1 with the kinase inhibitor entrectinib have shown a synergistic effect against uveal melanoma cell lines. Specifically, PAC-1 and entrectinib are synergistic against wild-type and mutant uveal melanoma cell lines (e.g., GNAQ and GNA11).

Abstract: Aspects of the subject disclosure may include, for example, determining, at a slower time-scale, inner layer weights of an inner layer of a deep neural network; providing periodically to an outer layer of the deep neural network from the inner layer, a feature vector based upon the inner layer weights; and determining, at a faster time-scale, outer layer weights of the outer layer, wherein the outer layer weights are determined in accordance with a Model Reference Adaptive Control (MRAC) update law that is based upon the feature vector from the inner layer, and wherein the outer layer weights are determined more frequently than the inner layer weights. Other embodiments are disclosed.

Abstract: The present disclosure describes one or more embodiment of a method for creating a patterned quantum dot layer. The method includes bringing a patterning stamp in contact with a layer of quantum dots disposed on a substrate, the patterning stamp comprising a patterned photoresist layer disposed on an elastomer layer, such that a portion of the quantum dots in contact with the patterned photoresist layer adheres to the patterning stamp, the portion of the quantum dots being adhered quantum dots. The method also includes peeling the patterning stamp from the substrate with a peeling speed larger than a pre-determined peeling speed to remove the adhered quantum dots from the substrate. A remaining portion of the quantum dots forms a patterned quantum dot layer on the substrate.

Abstract: A method includes receiving a processor design of a processor, receiving an application to be executed by the processor, and receiving a security policy. The method includes simulating the execution of the application on the processor to identify information flow violations generated by the application based on the security policy.

Abstract: A method for analyzing a processor design includes receiving a design for a processor and receiving an application to be executed by the processor. The method includes simulating the execution of the application on the processor based on the design to identify unexercisable gates of the processor.

Abstract: An inductive wireless power transfer apparatus includes a source coil coupled to a power source such that current flows through the source coil when the source coil is excited by the power source. The apparatus further includes a first capacitor coupled in series to the source coil. The apparatus further includes an intermediate coil surrounding the source coil and positioned within an identical plane as the source coil, and a second capacitor coupled in series to the intermediate coil. The capacitances of the first capacitor and the second capacitor are set to tune out self-inductances of the source coil and the intermediate coil. In embodiments, the source coil is to inductively power the intermediate coil, which is to inductively power a load coil positioned a distance away from the intermediate coil.

Abstract: A saliva-based testing method that bypasses the need for RNA isolation/purification is described herein. In experiments with inactivated SARS-CoV-2 virus spiked into saliva, this method has a limit of detection of 500-1000 viral particles per mL, rivalling the standard NP swab method. Initial studies showed excellent performance with 100 clinical samples. This saliva-based process is operationally simple, utilizes readily available materials, and can be easily implemented by existing testing sites thus allowing for high-throughput, rapid, and repeat testing of large populations.

Abstract: Skin-mounted or epidermal devices and methods for monitoring biofluids are disclosed. The devices comprise a functional substrate that is mechanically and/or thermally matched to skin to provide durable adhesion for long-term wear. The functional substrates allow for the microfluidic transport of biofluids from the skin to one or more sensors that measure and/or detect biological parameters, such as rate of biofluid production, biofluid volume, and biomarker concentration. Sensors within the devices may be mechanical, electrical or chemical, with colorimetric indicators being observable by the naked eye or with a portable electronic device (e.g., a smartphone). By monitoring changes in an individual's health state over time, the disclosed devices may provide early indications of abnormal conditions.

Abstract: An air fed mycoplasma device includes an array of elongate microchannels formed in a plastic or ceramic having tolerance to ozone and other radicals formed when plasma is generated from air in the microchannels. The microchannels include inlets configured to accept an air feed, and outlets configured to direct plasma jets toward a surface (which may be flat or internal to a pipe, for example) or object. An array of electrodes within the plastic/ceramic housing is configured to ignite and maintain plasma in the microchannels and is isolated by the dielectric from the microchannels. A supply intake for is configured to providing a plasma medium into the microchannels.

Abstract: The present disclosure provides a system for monitoring unstructured environments. A predetermined path can be determined according to an assignment of geolocations to one or more agronomically anomalous target areas, where the one or more agronomically anomalous target areas are determined according to an analysis of a plurality of first images that automatically identifies a target area that deviates from a determination of an average of the plurality of first images that represents an anomalous place within a predetermined area, where the plurality of first images of the predetermined area are captured by a camera during a flight over the predetermined area. A camera of an unmanned vehicle can capture at least one second image of the one or more agronomically anomalous target areas as the unmanned vehicle travels along the predetermined path.

Abstract: Disclosed are derivatives of amphotericin B (AmB) characterized by improved clinical efficacy with reduced toxicity compared to AmB. Also disclosed are pharmaceutical compositions comprising the AmB derivatives, therapeutic methods of using the AmB derivatives and methods of making the AmB derivatives.

Abstract: Conformationally-constrained helicases having improved activity and strength are provided. Methods of making conformationally-constrained helicases having improved activity and strength are provided. Methods of using conformationally-constrained helicases having improved activity and strength are provided. The present invention is based on the discovery of novel modified helicases that show dramatically enhanced helicase activity and increased strength as compared to unmodified helicases. As described further herein, it has been surprisingly discovered that, by controlling the conformation of certain subdomains such that the helicase remains in a closed form (e.g., by covalently crosslinking the 2B domain to the 1A domain or the 1B domain in a Rep helicase), a highly active and strong form of the helicase is achieved.

Abstract: A method for the synthesis of siliceous or heteroatom-substituted MFI zeolites (M-MFI; M=Si, Ti, Nb, or Ta) with tunable densities of SiOH that depend simply on the ratio of hydrofluoric acid (HF) to structure-directing agent (SDA; tetrapropylammonium hydroxide) used within the synthesis gel. The equilibrated ion exchange between OH? and F? ions forms tetrapropylammonium fluoride in situ, which does not lead to the formation of SiOH defects within M-MFI. Comparisons of infrared spectra from 15 distinct M-MFI materials show that the densities of SiOH groups within M-MFI decrease linearly with the ratio of HF:SDA, independent of the identity of the heteroatom within the framework.

Abstract: A lithium-air flow battery has minimal cathodic product precipitation, thus extending capacity. The lithium-air flow battery includes a flow electrolyte, flowing proximal to the air cathode, the flow electrolyte having little to no intrinsic lithium ion content. Operation of the lithium-air flow battery generates a lithium-ion concentration gradient across the flow electrolyte, with the lowest lithium-ion concentration adjacent to the air cathode. The extremely low lithium-ion concentration at the cathode, combined with the flow condition at the cathode, results in a minimum of solid product accumulation at the cathode, enabling the cathode to catalyze oxygen reduction for an extended duration.

Abstract: This disclosure relates AC-to-DC rectification and power flow control of electrical power generators. An integrated rectifier-generator AC-DC conversion circuit and system are disclosed for providing a regulated DC output. The integrated rectifier-generator AC-DC conversion circuit and system may include serially stacked passive and active rectifiers connected to multiple AC ports of an electrical power generator driven by mechanical energy captured by an energy harvester. The integrated rectifier-generator AC-DC conversion circuit and system may be configured to perform active ripple control and a maximum power tracking from the energy harvester by controlling a fraction of an overall power that flow through the active rectifier.

Abstract: The present disclosure describes the design, fabrication, and demonstration of a compact spectroscopic analysis system that utilizes a linear variable filter chip attached directly over an image sensor array, and an integrated broadband LED illuminator that supplies light from the edge of the system to provide a low vertical dimension. The instrument is capable of accurately measuring the optical absorption spectra of colored liquids or the scattered spectra from solid objects that are placed in the illumination pathway. Due to the small vertical thickness of the system, the low cost of its components, and the accuracy with which it renders spectra in comparison to conventional spectrometers, we envision potential incorporation of the system into mobile communication devices, such as smartphones and tablets, as a means for providing a dedicated sensor for health diagnostic, environmental monitoring, and general-purpose color sensing applications.

Abstract: The present disclosure provides polynucleotides and vectors for the genomic engineering and editing of non-conventional yeasts such as Issatchenkia orientalis. The polynucleotides and vectors can be used as tools that are efficient to alter the expression of one or more gene products in the yeast, and specifically to induce the production of organic acids or other bioproducts of interest in the yeast.

Abstract: A C—C chemokine receptor 3 (CCR3) peptide analog that exhibits biased antagonism by binding to and inhibiting ligand-mediated signaling and chemotaxis while promoting the internalization and degradation of CCR3 is provided as is a method of using the peptide analog to treat, prevent, or ameliorate one or more symptoms of an eosinophil- or CCR3-mediated disease or condition.

Abstract: The corrosion of unprotected steel substrates causes damage that is costly to repair or replace. Current protective coatings predominately rely on environmentally harmful anticorrosive agents and toxic solvents to protect the underlying substrate. The use of lawsone (2-hydroxy-1,4-napthoquinone) together with a environmentally benign epoxy coating provides an environmentally-friendly alternative for common protective coatings. Microencapsulated lawsone embedded coatings allows the anticorrosive agent to remain dormant until released by damage and is then deposited directly onto the steel substrate. Both visual and electrochemical analysis shows that this self-protective scheme leads to 60% corrosion inhibition in a neutral salt water solution.