Abstract: The invention provides biomarkers and biomarker profiles that discriminate between a subject with breast cancer that has metastasized to the bone and a subject with breast cancer that has not metastasized to the bone. In particular, the biomarker and biomarker profile include polypeptides present or present at higher levels in the circulatory system of subjects having breast cancer bone metastasis compared to subjects having breast cancer without bone metastasis.

Abstract: A method, wireless device and computer program product for expanding the coverage of a cellular network. A wireless device (e.g., cellular telephone) is able to communicate with a base station in a cell of the cellular network over a non-cellular interface via another wireless device in a cell through the use of multi-hopping. A wireless device may request permission to communicate with the base station over a non-cellular interface via hopping off another wireless device when its signal strength is below a threshold. Alternatively, a wireless device may receive a request to communicate with the base station over a non-cellular interface via hopping off the wireless device that sent the request when that wireless device has excess capacity in its bandwidth with the base station. By enabling wireless devices to communicate with a base station in such a manner, the effective capacity of the cellular network is expanded and the effective capacity of the cellular network is improved.

Abstract: A method of making a doped metal oxide comprises heating a first doped metal oxide with a laser, to form a crystallized doped metal oxide. The crystallized doped metal oxide has a different crystal structure than the first doped metal oxide.

Abstract: A variety of applications, systems, methods and constructs are implemented for use in connection with screening of ion-channel modulators. Consistent with one such system, drug candidates are screened to identify their effects on cell membrane ion channels and pumps. The system includes screening cells having light responsive membrane ion switches, voltage-gated ion switches and fluorescence producing voltage sensors. A chemical delivery device introduces the drug candidates to be screened. An optical delivery device activates the light responsive ion switches. An optical sensor monitors fluorescence produced by the voltage sensors. A processor processes data received from the optical sensor. A memory stores the data received from the optical sensor.

Abstract: Devices, methods, and systems for facilitating heat transfer around an electronic component during thermal-cycle testing are presented. A system may include a core, a plurality of solid state heating/cooling devices, and a plurality of heat sinks. The core defines one or more cavities for receiving an electronic component. The system may include an air mover and a duct. In operation, the system may cool an electronic component to sub-ambient temperatures and heat it to above the boiling point of water. A method of thermal-cycle testing may include a core defining a cavity for receiving an electronic component, selectively inducing said heating/cooling devices to operate in a heating mode or a cooling mode, and measuring and recording conditions during the test.

Abstract: Aspects of the present disclosure are directed to electrodes and implementations such as batteries. As may be implemented in accordance with one or more embodiments, an apparatus includes a nanocarbon substrate having at least one of graphene and carbon nanotubes, and a hybrid electrode including a cobalt oxide/carbon nanotube (CoO/CNT) catalyst and a Ni—Fe-layered double hydride (LDH) catalyst. The catalysts and substrate facilitate transfer of charge carriers. Various aspects are directed to a battery type device having an anode and a single or split cathode with the respective catalysts on the cathode to facilitate oxygen reduction and oxygen evolution reactions for discharging and charging the battery type device.

Abstract: This invention provides methods for preparing novel mammalian multipotent stem cells (MSCs), compositions thereof, and methods of preparing and administering the cells.

Abstract: The invention provides polynucleotides and methods for expressing light-activated proteins in animal cells and altering an action potential of the cells by optical stimulation. The invention also provides animal cells and non-human animals comprising cells expressing the light-activated proteins.

Abstract: A volume holographic imaging system, apparatus and/or method enables the projection of a two-dimensional (2D) slice of a four-dimensional (4D) probing object A 4D probing source object is illuminated to emit or scatter an optical field. A holographic element having one or more recorded holograms receives and diffracts the optical field into a diffracted plane beam having spectral information. A 4-ftelecentric relay system includes a pupil filter on the relayed conjugate plane of the volume hologram and images the pupil of the volume hologram onto the front focal plane of the collector lens. A collector lens focuses the diffracted plane beam to a 2D slice of the 4D probing source object. The focused 2D slice is projected onto a 2D imaging plane. The holographic element may have multiple multiplexed holograms that are arranged to diffract light from the corresponding slice of the 4D probing source object.

Abstract: A topological insulator is grown on an IC wafer in a vacuum chamber as a thin film interconnect between two circuits in the IC communicating with each other. As the TI is being grown, magnetic doping of the various TI sub-layers is varied to create different edge states in the stack of sub-layers. The sub-edges conduct in parallel with virtually zero power dissipation. Conventional metal electrodes are formed on the IC wafer that electrically contact the four corners of the TI layer (including the side edges) to electrically connect a first circuit to a second circuit via the TI interconnect. The TI interconnect thus forms two independent conducting paths between the two circuits, with each path being formed of a plurality of sub-edges. This allows bi-direction communications without collisions. Since each electrode contacts many sub-edges in parallel, the overall contact resistance is extremely low.

Abstract: Synbodies specific for Norovirus and coupled with a substrate provide Norovirus binding and detection platforms (FIG. 1). A Norovirus capturing platform, comprising one or more synbodies selected from the group consisting of synbodies 6-6, 92-92, 93-93, and 94-94 coupled to a substrate, has been found to found to bind with either GII.4 Minerva or both GII.4 Minerva and GII.4 Sydney# strains of norovirus.

Abstract: In accordance with the present invention, taught is a high purity germanium crystal growth method utilizing a quartz shield inside a steel furnace. The quartz shield is adapted for not only guiding the flow of an inert gas but also preventing the germanium melt from contamination by insulation materials, graphite crucible, induction coil and stainless steel chamber. A load cell provides automatic control of crystal diameter and helps to ensure exhaustion of the germanium melt. The method is both convenient and effective at producing high purity germanium crystals by relatively low skilled operators.

Abstract: The present invention relates generally to novel allosteric regulators of proteasome activity, methods for preparation and use, and pharmaceutical compositions thereof. Specifically piperidine-2-carboxylic acid derivatives containing 1-oxo-aroyl group and a lipophilic ester side chain are disclosed as allosteric inhibitors of proteasome 2S activity, and as therapeutic agents for the treatment of proteasome-associated disorders in a subject.

Abstract: The invention is drawn to a method of using nanoparticle aggregates to form sensors and optical filters. Properly sized (60 and 200 nm) nanoparticle aggregates with cores having a sulfur-oxygen molecular species and a shell with a surface in contact with the core are obtained. Those nanoparticle aggregates have a first resonance profile to wavelengths between 350 nm and 1075 nm. A modified resonance profile for those nanoparticle aggregates is determined. The nanoparticle aggregates are then selectively sized by irradiating them with electromagnetic energy at sufficient intensity and spectral content to modify the first resonance profile towards the modified resonance profile. The resulting nanoparticle aggregates can be used as sensors or optical filters at a selected wavelength.

Abstract: Robust low-level image features have been proven to be effective representations for a variety of visual recognition tasks such as object recognition and scene classification; but pixels, or even local image patches, carry little semantic meanings. For high-level visual tasks, such low-level image representations are potentially not enough. The present invention provides a high-level image representation where an image is represented as a scale-invariant response map of a large number of pre-trained generic object detectors, blind to the testing dataset or visual task. Leveraging on this representation, superior performances on high-level visual recognition tasks are achieved with relatively classifiers such as logistic regression and linear SVM classifiers.

Abstract: Methods and systems include generating one or more mid-infrared frequencies based at least upon electron transitions in one or more quantum cascade heterostructures. The quantum cascade heterostructures are concurrently configured with a significant second-order nonlinear susceptibility, a significant third-order nonlinear susceptibility, and an insignificant group velocity dispersion. A set of mid-infrared frequencies (that may include a frequency comb) is generated in the quantum cascade heterostructures based at least upon a four-wave mixing of the one or more mid-infrared frequencies. The four-wave mixing arises at least from the significant third-order nonlinear susceptibility and the insignificant group velocity dispersion. A set of terahertz frequencies (that may include a frequency comb) is generated in the quantum cascade heterostructures based at least upon a difference frequency generation from mid-infrared frequency pairs selected from the set of mid-infrared frequencies.

Abstract: Techniques for enhanced isotachophoresis assays using additives with spatial gradients include forming a concentration gradient of an additive along a channel from an input port to an output port. The channel is used for isotachophoresis with ions of a leading electrolyte having a first mobility greater than a mobility of an analyte, and ions of a trailing electrolyte having a second mobility less than the mobility of the analyte. The additive is different from both the leading electrolyte and the trailing electrolyte; and the additive has a third mobility that assures the analyte will encounter the additive. The method further comprises introducing a mixture of the trailing electrolyte and a sample including the analyte. The method further comprises applying an electric field to the channel; and, measuring the analyte.

Abstract: The present invention is directed to an insertion tool for a spinal cord stimulation electrode. The insertion tool comprises a first leg and a second leg coupled to the first leg. The first and second legs are separable for placement around the electrode and resiliently return to a clamped position. Each of the first and second legs generally defines a respective longitudinal axis. Each of the first and second legs defines a blade portion offset from the respective longitudinal axis for clamping the electrode.

Abstract: The present invention provides polyphenolic compositions derived from a plant that inhibit the formation of a biofilm. Also provided are combinations that comprise at least one phenolic phytochemical and at least one antimicrobial agent that inhibit the growth of an established biofilm. Further, the present invention provides methods for inhibiting the formation and growth of biofilms.

Abstract: The disclosure herein is directed toward systems and methods for supporting a person and enabling motion of a person across a surface of snow while satisfying the countervailing requirements of increasing surface area for weight-carrying capacity on soft snow and reducing the opposing forces, like for example drag and friction, in hard snow. More specifically, a snowboard described herein includes an inner edge and an outer edge, and allows the rider to control the amount of board-to-snow contact. This snowboard is configured to improve rider support, increase speed and enhance safety performance.