Abstract: A system for predicting medical events and conditions that are reflected in gait may include a data capture subsystem configured to capture data pertaining to a position and/or motion of a patient, a data analysis and outcome generation subsystem configured to analyze the captured data and to generate output pertaining to a likelihood of the patient experiencing a medical event or medical condition, and a user interface subsystem configured to provide the output to a user, e.g., healthcare provider, and to receive feedback from the user. Methods for predicting medical events and conditions reflected in gait are also provided.

Abstract: The present invention provides a DNA-functionalized conjugate comprising single-stranded DNA (ssDNA) strands conjugated to a semi-conductor nanoparticle, wherein the nanoparticle provides fluorescent emissions.

Abstract: The present disclosure involves compositions and methods for treating brain cancers having mutations in the retinoblastoma (Rb) pathway using an oncolytic adenovirus comprising an alteration in the Rb binding site of E1A, and a targeting motif inserted in the Ad fiber protein. The adenovirus is able to kill the tumor cells without harming cells with a wild-type retinoblastoma pathway.

Abstract: The present invention provides a system and a method for eliciting information to sensitive questions and reliably detecting whether one is being deceptive, concealing information, or experiencing a heightened emotional response to the question. In particular, the system and the method of the invention are based on analyzing the user behavioral biometric of using one or more input device(s).

Abstract: Provided are methods and compositions for the treatment of diseases such as cancer. In certain aspects, compounds which can inhibit Skp2 are provided. Specifically chromenone derivatives are disclosed that have the capability toward reducing differentiation of pluripotent, multipotent or totipotent cells and thus have therapeutic utility in the treatment of a proliferative disease such as cancer.

Abstract: The present disclosure provides compounds that are useful for inhibiting the STAT6 pathway. Also provided are related pharmaceutical compositions and methods of using the compounds. In some embodiments, the compounds may be used to treat a disease such as, e.g., an allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease, or a cancer.

Abstract: To address the inefficiency and unfairness issues in channel bonding, a dynamic channel bonding protocol is presented in which a node is allowed to start a transmission as long as a narrow channel is available and gradually increase channel width during transmission whenever a new narrow channel becomes available. The protocol aggregates all available narrow channels as one wide channel, removing the need of setting guard bands between contiguous narrow channels. A challenge in dynamic channel bonding is the communication over uncertain channels. To enable fast spectrum agreement between transmitter and receiver, a partial spectrum correlation method is introduced. When new channels become available, multiple nodes may contend for them. A compound preamble is designed to make collisions detectable in the frequency domain and a parallel bitwise arbitration mechanism is used to quickly resolve the collisions in the time domain.

Abstract: A method and an apparatus are disclosed for extending the service life of a battery source by fully utilizing the energy in batteries and/or providing higher energy reserve using multiple batteries. An universal battery bank consists of an ensemble of possibly heterogenous batteries all connected in series to provide a usable operational energy source. For a universal battery bank consists on N batteries, the minimum operational voltage for the individual batteries (Vmin) can be lowered to Vmin/N on average, thereby extending the time interval between battery replacements and draining the individual batteries more efficiently. To exploit this power supply that may vary over a wide voltage range, electronics are designed to monitor the individual batteries, guard against excessive voltage and current, and provide constant current sources and/or constant voltage sources for various appliances.

Abstract: The present invention provides compounds that function as modulators of aldehyde dehydrogenase activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition.

Abstract: An electric-pulse-induced-resistance change device (EPIR device) is provided which is a resistance switching device. It has a buffer layer inserted between a first active resistance switching layer and a second active resistance switching layer, with both active switching layers connected to electrode layers directly or through additional buffer layers between the active resistance switching layers and the electrodes. This device in its simplest form has the structure: electrode-active layer-buffer layer-active layer-electrode. The second active resistance switching layer may, in the alternative, be an ion donating layer, such that the structure becomes: electrode-active layer-buffer layer-ion donating layer-electrode. The EPIR device is constructed to mitigate the retention challenge.

Abstract: Compositions and methods are provided for achieving persistent, high level expression of transgenes in vitro and in vivo. Aspects of the invention include vectors comprising an intronic cassette that comprises plasmid elements, and methods that rely on the use of vectors comprising an intronic cassette that comprises plasmid elements. These compositions and methods find use in many applications, including therapeutic applications such as in gene therapy; synthesis applications such as in the synthesis of peptides, proteins, and RNAs, e.g. for research or therapeutic purposes; and research applications, such as in the production of transgenic cells and animals. In addition, reagents, devices and kits thereof that find use in making the subject compositions and practicing the subject methods are provided.

Abstract: Compounds which specifically inhibit legumain, also known as asparaginyl endopeptidase are provided. The compounds have an epoxide or N-Michael acceptor warhead, and have an asparagine side chain attached to a nitrogen atom in the backbone adjacent the warhead. The compounds also preferably comprise a proline residue adjacent the asparagine, and the compound may also contain a third residue and/or a label for cellular or in vivo imaging of active legumain.

Abstract: Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training. Stimulations of nerves such as the vagus nerve that affect subcortical regions such as the nucleus basalis, locus coeruleus or amygdala induce plasticity in the brain, enhancing the effects of a variety of therapies, such as those used to treat tinnitus, stroke, traumatic brain injury and post-traumatic stress disorder.

Abstract: Provided are methods for making a device or device component by providing a multi layer structure having a plurality of functional layers and a plurality of release layers and releasing the functional layers from the multilayer structure by separating one or more of the release layers to generate a plurality of transferable structures. The transferable structures are printed onto a device substrate or device component supported by a device substrate. The methods and systems provide means for making high-quality and low-cost photovoltaic devices, transferable semiconductor structures, (opto-)electronic devices and device components.

Abstract: A nanostructured particulates formed from a redox active, luminescent phenyl substituted polycyclic aromatic hydrocarbon are provided herein. The nanostructured particulates may be used for determining the presence of an analyte of interest in a sample by detecting the emitted electromagnetic radiation generated by exposing a reagent mixture, which includes the nanostructured particulates and the sample, to electrochemical energy.

Abstract: The invention provides a control interface configured to cooperate with a vehicle, such as a wheelchair or mobile robot, said interface comprising at least one sensor is adapted to detect the presence of at least one finger of a user and to act as a switching mechanism between manual and autonomous control of the vehicle. The invention provides a highly intuitive and effective means of switching between automatic and manual vehicle control-no user training required. The control interface allows for user to be comfortable in an autonomous vehicle—users can instantly gain full control when needed.

Abstract: Systems and methods for determining the stiffness of a structure based on vertical track modulus. Vertical deflection data is collected along a particular section of a structure, such as a railroad track. A first set of vertical modulus is determined, based in part, on the collected vertical deflection data. At a second time, vertical deflection data is again collected along the particular section of the structure to be used in determining a second set of vertical modulus. At least the first and second sets of vertical modulus are analyzed to determine a mathematical algorithm that facilitates developing a trend in the vertical track modulus of the structure and evaluating the stiffness of the structure.

Abstract: The present invention describes a device and method for measuring flow rate from air flow using acoustic resonance. It is shown that the device can be used to measure breath flow rate and biomarker concentration within human breath.

Abstract: While methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols (i.e., R—SH). The present invention relates to a method for resolving stereoisomeric mixtures of thiols. In particular, the present invention relates to purely organocatalytic mediated resolution of enantiomeric mixtures of thiols without the need for enzymes. Also disclosed are some novel catalysts. Such catalysts may comprise a cinchona alkaloid-derived moiety.

Abstract: Described herein are modifications and adaptations of iron storage proteins for a novel photo-initiated approach to cancer therapy whereby cells are killed via production of iron-generated hydroxyl radicals. The iron is photo-released from a protein scaffold that includes tumor-targeting peptides and/or proteins fused to the exterior surface of the protein scaffold. One or more photosensitizers are coupled to the protein shell. The multiple tumor-targeting peptides and/or proteins will bind to specific hyperexpressed receptors on the cancer cells. After binding of the photosensitizer-iron-loaded protein to the cancer cells, photochemical excitation of the photosensitizers with tissue-penetrating near-infrared light triggers release of “free” ferrous iron, which in oxic or mildly hypoxic intracellular environments generates toxic hydroxyl radicals via Fenton chemistry. This light-triggered release of “free” iron overwhelms the cancer cells' defenses against free radicals.