Patents Assigned to Boehringer Ingelheim KG
  • Aerosol inhaler
    Patent number: 6390088
    Abstract: In an aerosol inhaler it is proposed that a thermal sensor 5 be arranged in the region of the atomization nozzle 4, which sensor, following the actuation of an actuating element and the triggering of an inhalation process, undergoes cooling as a result of the expansion of the propellant which then occurs. The actuation and cooling are electronically detected in an electronic module 3. Technical and therapeutic data can be derived from the signal, which data are communicated to the user via the display unit and/or alarm devices and influence the therapy in the desired manner. See FIG. 1.
    Type: Grant
    Filed: January 20, 2000
    Date of Patent: May 21, 2002
    Assignee: Boehringer Ingelheim KG
    Inventors: Klaus Nöhl, Harald Sprenger
  • Arylgycinamide derivatives, methods of producing these substances and pharmaceutical compositions containing such compounds
    Patent number: 6303601
    Abstract: The invention relates to new arylglycinamide derivatives of general formula I and the pharmaceutically acceptable salts thereof, wherein R1 and R2 together with the N to which they are bound form a ring of the formula  wherein is 2 or 3 and X denotes oxygen, N(CH2)nR6 or CR7R8, and R34 R5 R6 R7, R8, Ar and n have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin)-antagonists.
    Type: Grant
    Filed: January 3, 2001
    Date of Patent: October 16, 2001
    Assignee: Boehringer Ingelheim KG
    Inventors: Gerd Schnorrenberg, Horst Dollinger, Franz Esser, Hans Briem, Birgit Jung, Georg Speck
  • Ipratropium bromide enantiomer with prolonged duration of effect
    Patent number: 6299861
    Abstract: On account of the surprisingly powerful and long-lasting effect thereof, the salts of the L-(−)-enantiomer of (endo, syn)-(−)-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(methylethyl)-8-azoniabicyclo [3,2,1]octane are suitable as active substances for drugs administered by inhalation for respiratory tract therapy.
    Type: Grant
    Filed: August 6, 1999
    Date of Patent: October 9, 2001
    Assignee: Boehringer Ingelheim KG
    Inventors: Rolf Banholzer, Richard Reichl, Bernd Disse, Georg Speck
  • Arylglycinamide derivatives, methods of producing these substances and pharmaceutical compositions containing such compounds
    Patent number: 6294556
    Abstract: The invention relates to new arylglycinamide derivatives of general formula I and the pharmaceutically acceptable salts thereof, wherein R1 and R2 together with the N to which they are bound form a ring of the formula  wherein p is 2 or 3 and X denotes oxygen, N(CH2)nR6 or CR7R8, and R3, R4, R5, R6, R7, R8, Ar and n have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin)-antagonists.
    Type: Grant
    Filed: February 18, 2000
    Date of Patent: September 25, 2001
    Assignee: Boehringer Ingelheim KG
    Inventors: Gerd Schnorrenberg, Horst Dollinger, Franz Esser, Hans Briem, Birgit Jung, Georg Speck
  • Oxadiazoles, processes for their preparation and their use as medicaments
    Patent number: 6277872
    Abstract: The invention relates to oxadiazole derivatives of general formula (I) wherein X, Y, Z and R1 are defined as described in the specification and claims, processes for preparing them and their use as pharmaceutical compositions.
    Type: Grant
    Filed: July 26, 1999
    Date of Patent: August 21, 2001
    Assignee: Boehringer Ingelheim KG
    Inventors: Michael Brenner, Roland Maier, Marion Wienrich, Thomas Weiser, Rainer Palluk, Wolf-Dietrich Bechtel, Angelo Sagrada, Helmut Ensinger, Uwe Pschorn, Raffaele Cesana
  • Treatment of urinary incontinence by administration of &agr;1L-adrenoceptor agonists
    Patent number: 6268389
    Abstract: The present invention relates to the use of &agr;lL-agonists for treating urinary incontinence.
    Type: Grant
    Filed: January 11, 1999
    Date of Patent: July 31, 2001
    Assignee: Boehringer Ingelheim KG
    Inventors: Franz Esser, Helmut Staehle, Sven Luettke, Ikunobu Muramatsu, Hisato Kitagawa, Shuji Uchida
  • Arylglycinamide derivatives, methods of producing these substances and pharmaceutical compositions containing such compounds
    Patent number: 6251909
    Abstract: The invention relates to new arylglycinamide derivatives of general formula I and the pharmaceutically acceptable salts thereof, wherein R1 and R2 together with the N to which they are bound form a ring of the formula  wherein p is 2 or 3 and X denotes oxygen, N(CH2)nR6 or CR7R8, and R3, R4, R5, R6, R7, R8, Ar and n have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin)-antagonists.
    Type: Grant
    Filed: February 18, 2000
    Date of Patent: June 26, 2001
    Assignee: Boehringer Ingelheim KG
    Inventors: Gerd Schnorrenberg, Horst Dollinger, Franz Esser, Hans Briem, Birgit Jung, Georg Speck
  • Neurokinin antagonists
    Patent number: 6235732
    Abstract: The invention relates to new compounds of general formula I and the pharmaceutically acceptable salts thereof, wherein A, B, Z, R1, R2, R3 and m are defined as in the specification, processes for preparing them and pharmaceutical compositions containing these compounds. The compounds are valuable neurokinin (tachykinin) antagonists.
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: May 22, 2001
    Assignee: Boehringer Ingelheim KG
    Inventors: Horst Dollinger, Gerd Schnorrenberg, Hans Briem, Birgit Jung, Georg Speck
  • Dipeptides with neurokinin-antagonistic activity
    Patent number: 6232468
    Abstract: Disclosed are compounds which are neurokinin (tachykinin)-antagonists, useful for the treatment or prevention of inflammatory and allergic disease.
    Type: Grant
    Filed: December 1, 1999
    Date of Patent: May 15, 2001
    Assignee: Boehringer Ingelheim KG
    Inventors: Franz Esser, Gerd Schnorrenberg, Hans-Peter Ignatow, Günther Giesler, Birgit Jung, Georg Speck
  • Pyranoside derivatives
    Patent number: 6197753
    Abstract: Pyranoside derivatives of the formula I wherein 1, m and n independently of one another denote an integer chosen from 0, 1, 2, 3 and 4 and 1+m+n≦4. These are are LTB4-antagonists. Also disclosed are processes for making these compounds.
    Type: Grant
    Filed: March 8, 1999
    Date of Patent: March 6, 2001
    Assignee: Boehringer Ingelheim KG
    Inventors: Ralf Anderskewitz, Kurt Schromm, Ernst-Otto Renth, Franz Birke, Hans M. Jennewein, Christopher J. M. Meade, Andreas Ding
  • Neurokinin antagonists
    Patent number: 6191135
    Abstract: The invention relates to new compounds of general formula and the pharmaceutically acceptable salts thereof, wherein A, B, Z, R1, R2, R3 and m are defined as in the specification, processes for preparing them and pharmaceutical compositions containing these compounds. The compounds are valuable neurokinin (tachykinin) antagonists.
    Type: Grant
    Filed: February 8, 2000
    Date of Patent: February 20, 2001
    Assignee: Boehringer Ingelheim KG
    Inventors: Horst Dollinger, Gerd Schnorrenberg, Hans Briem, Birgit Jung, Georg Speck
  • Use of 2-amino-6-n-propyl-amino-4,5,6,7-tetrahydrobenzothiazole as a pharmaceutical composition having an antidepressant activity
    Patent number: 6191153
    Abstract: The invention relates to the use of pramipexol as a pharmaceutical composition having an antidepressant activity.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: February 20, 2001
    Assignee: Boehringer Ingelheim KG
    Inventors: Rudolf Hammer, Joachim Mierau, Erich Lehr, Franco Borsini
  • Amino acid derivatives, processes for the manufacture thereof and pharmaceutical compositions containing these compounds
    Patent number: 6147212
    Abstract: The invention relates to new amino acid derivatives of general formula I and the pharmaceutically acceptable salts thereof, wherein group B is --A.sup.2 --NR.sup.2 R.sup.3 or R.sup.5, wherein group R.sup.5 is ##STR1## and R.sup.1, A.sup.1, A.sup.2, R.sup.2, R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.9, X, Y, Z, t and u have the meanings described in the specification, as well as the preparation and use thereof. The novel compounds are valuable neurokinin (tachykinin) antagonists.
    Type: Grant
    Filed: July 8, 1998
    Date of Patent: November 14, 2000
    Assignee: Boehringer Ingelheim KG
    Inventors: Franz Esser, Gerd Schnorrenberg, Horst Dollinger, Birgit Jung, Erich Burger
  • Heat-based process for the re-racemisation of a (-)-2-phenylmethyl-3,3-dimethyl-piperidin-4-on derivative
    Patent number: 6140502
    Abstract: A process for the re-racemisation of a (-)-2-phenylmethyl-3,3-dimethyl-piperidin-4-on derivative wherein a (-)-2-phenylmethyl-3,3-dimethyl-piperidin-4-on derivative of the formula 8.sub.BwhereinR.sub.2 denotes hydrogen C.sub.1 -C.sub.6 -alkyl, halogen, C.sub.1 -C.sub.8 -alkoxy, a benzoyl group bound via an oxygen or an alkylcarboxyl group having a straight chained or branched C.sub.1 -C.sub.6 -lower alkyl group--wherein the alkyl group may optionally be substituted by one or more halogen atoms which may be identical or different;is heated to yield a racemic mixture of compounds of the formulae 8.sub.A and 8.sub.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: October 31, 2000
    Assignee: Boehringer Ingelheim KG
    Inventors: Matthias Grauert, Herbert Merz, Hanfried Baltes
  • Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane
    Patent number: 6136980
    Abstract: The present invention relates to new processes for preparing norbenzomorphan, the central intermediate step in the preparation of pharmaceutically useful benzomorphan derivatives of general formula 1 ##STR1## especially (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzomo rphan or [(-)-(2R, 6S,2'R)-3-(2-methoxypropyl)-6,11,11-trimethyl-1,2,3,4,5,6-hexahydro-2,6-me thano-benzo[.alpha.]oxacin-9-ol] (BIII 277).
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: October 24, 2000
    Assignee: Boehringer Ingelheim KG
    Inventors: Matthias Grauert, Herbert Merz, Hanfried Baltes
  • Transcorneal drug-release system
    Patent number: 6132755
    Abstract: The invention refers to a transcorneal system for the actively controlled transcorneal delivery of a medicament into a subject comprising an active substance reservoir and a device provided with a plurality of micro-pins or micro-blades adapted in use to penetrate the stratum corneum of the subject and connected with reservoir via a liquid conveying connection and thereby allow active substance to pass from the reservoir through capillary openings of the micro-pins or along the micro-blades into the subject.
    Type: Grant
    Filed: June 16, 1998
    Date of Patent: October 17, 2000
    Assignee: Boehringer Ingelheim KG
    Inventors: Joachim Eicher, Bernd Zierenberg
  • Phenylamidine derivatives, a process for preparing the same and their use as medicaments
    Patent number: 6127423
    Abstract: The invention relates to new phenylamidine derivatives, processes for preparing them and their use as pharmaceutical compositions.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: October 3, 2000
    Assignee: Boehringer Ingelheim KG
    Inventors: Ralf Anderskewitz, Kurt Schromm, Ernst-Otto Renth, Franz Birke, Hans Michael Jennewein, Christopher John Montague Meade, Andreas Ding
  • Process for preparing pharmaceutically useful norbenzomorphane derivative
    Patent number: 6124459
    Abstract: The present invention relates to a new process for preparing norbenzomorphane derivatives of general formula 1 ##STR1##
    Type: Grant
    Filed: May 17, 1999
    Date of Patent: September 26, 2000
    Assignee: Boehringer Ingelheim KG
    Inventors: Matthias Grauert, Hanfried Baltes, Juergen Schnaubelt
  • Arylglycinamide derivatives, methods of producing these substances and pharmaceutical compositions containing such compounds
    Patent number: 6124296
    Abstract: The invention relates to new arylglycinamide derivatives of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sup.1 and R.sup.2 together with the N to which they are bound form a ring of the formula ##STR2## wherein p is 2 or 3 andX denotes oxygen, N(CH.sub.2).sub.n R.sup.6 or CR.sup.7 R.sup.8,and R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, Ar and n have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin)-antagonists.
    Type: Grant
    Filed: October 29, 1997
    Date of Patent: September 26, 2000
    Assignee: Boehringer Ingelheim KG
    Inventors: Gerd Schnorrenberg, Horst Dollinger, Franz Esser, Hans Briem, Birgit Jung, Georg Speck
  • Phenylacetic acid benzylamides
    Patent number: RE37035
    Abstract: Phenylacetic acid benzylamides having the following general structure wherein the substituents are defined herein, are disclosed, which compounds are hypoglcemic agents.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: January 30, 2001
    Assignee: Boehringer Ingelheim KG
    Inventors: Wolfgang Grell, Rudolf Hurnaus, Gerhart Griss, Robert Sauter, Manfred Reiffen, Eckhard Rupprecht