Abstract: In an aerosol inhaler it is proposed that a thermal sensor 5 be arranged in the region of the atomization nozzle 4, which sensor, following the actuation of an actuating element and the triggering of an inhalation process, undergoes cooling as a result of the expansion of the propellant which then occurs. The actuation and cooling are electronically detected in an electronic module 3. Technical and therapeutic data can be derived from the signal, which data are communicated to the user via the display unit and/or alarm devices and influence the therapy in the desired manner.
Abstract: Novel disubstituted bicyclic heterocycles, of which the following are exemplary:(a) 1-methyl-2-[(4-amidinophenyl)-oxymethyl]-5-[N-(hydroxycarbonylmethyl)-quin oline-8-sulphonylamino]-benzimidazole,(b) 1-methyl-2-[2-(4-amidinophenyl)-ethyl]-5-[N-(N-(hydroxycarbonylmethyl)-ami nocarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole,(c) 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-5-[N-(hydroxycarbonylmethyl)- quinoline-8-sulphonylamino]-benzimidazole and(d) 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-5-[N-(hydroxycarbonylmethyl)- quinoline-8-sulphonylamino]-indole.These are useful for the treatment of thrombotic disease.
Type:
Grant
Filed:
July 22, 1999
Date of Patent:
September 19, 2000
Assignee:
Boehringer Ingelheim KG
Inventors:
Norbert Hauel, Uwe Ries, Henning Priepke, Gerhard Mihm, Wolfgang Wienen, Jean Marie Stassen, Klaus Binder, Rainer Zimmermann
Abstract: The invention relates to new arylglycinamide derivatives of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and Ar have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokin (tachykinin) antagonists.
Type:
Grant
Filed:
January 12, 1999
Date of Patent:
September 19, 2000
Assignee:
Boehringer Ingelheim KG
Inventors:
Gerd Schnorrenberg, Horst Dollinger, Franz Esser, Hans Briem, Birgit Jung, Georg Speck
Abstract: The present invention relates to novel benzoylguanidine derivatives, processes for preparing them and their use in the preparation of pharmaceutical compositions.The novel benzoylguanidine derivatives correspond to general formula (I) ##STR1## which benzoylguanidine derivatives are useful in the treatment of ischemia.
Type:
Grant
Filed:
September 25, 1998
Date of Patent:
September 5, 2000
Assignee:
Boehringer Ingelheim KG
Inventors:
Erich Buerger, Christian Eickmeier, Otto Roos
Abstract: The present invention relates to new processes for preparing norbenzomorphan, the central intermediate step in the preparation of pharmaceutically useful benzomorphan derivatives of general formula 1 ##STR1## especially (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzomo rphan or [(-)-(2R,6S,2'R)-3-(2-methoxypropyl)-6,11,11-trimethyl-1,2,3,4,5,6-hexahyd ro-2,6-methano-benzo[.alpha.]oxacin-9-ol] (BIII 277).
Type:
Grant
Filed:
February 24, 1999
Date of Patent:
April 25, 2000
Assignee:
Boehringer Ingelheim KG
Inventors:
Matthias Grauert, Herbert Merz, Hanfried Baltes
Abstract: Compounds of the formula ##STR1## which is explained more fully in the specification, may be prepared by conventional methods and used therapeutically in conventional galenic preparations.
Type:
Grant
Filed:
June 5, 1995
Date of Patent:
March 14, 2000
Assignee:
Boehringer Ingelheim KG
Inventors:
Ralf Anderskewitz, Kurt Schromm, Ernst-Otto Renth, Frank Himmelsbach, Franz Birke, Armin Fugner
Abstract: The invention relates to the use of carbocyclically and heterocycally fused dihydroyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for inhabiting blood clotting, and also relates to new compounds of formula Ie ##STR1##
Type:
Grant
Filed:
June 1, 1995
Date of Patent:
March 7, 2000
Assignee:
Boehringer Ingelheim KG
Inventors:
Walter Losel, Otto Roos, Dietrich Arndts, Franz Josef Kuhn, Ilse Strelle
Abstract: The invention relates to new compounds of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein A, B, Z, R.sup.1, R.sup.2, R.sup.3 and m are defined as in the specification, processes for preparing them and pharmaceutical compositions containing these compounds. The compounds are valuable neurokinin (tachykinin) antagonists.
Type:
Grant
Filed:
August 2, 1997
Date of Patent:
November 16, 1999
Assignee:
Boehringer Ingelheim KG
Inventors:
Horst Dollinger, Gerd Schnorrenberg, Hans Briem, Birgit Jung, Georg Speck
Abstract: Precursors of anticholinergically active quaternary compounds can be synthesized from optically active tropic acid by acetylation, conversion into the acid chloride, reaction with amino alcohols of formula (I) ##STR1## (as the methanesulphonate; Q and R are explained in the specification), deacetylation and isolation of the reaction product.
Abstract: A capsule holder for the insertion and fixing of pharmaceutical capsules consists of a plate (2) with a recess (1) in which there are at least three ribs (3) arranged parallel to the central axis and at unequal spacings from one another, between which the capsules can be clamped both by their upper part and by their lower part in such a way that they do not fall out during normal handling but can readily be removed.
Abstract: The present invention relates to a new process for preparing norbenzomorphan, the central intermediate step in the preparation of pharmaceutically useful benzomorphan derivatives of general formula 1 ##STR1## especially (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzomo rphan or ?(-)-(2R,6S,2'R)-3-(2-methoxypropyl)-6,11,11-trimethyl-1,2,3,4,5,6 -hexahydro-2,6-methano-benzo?.alpha.!oxacin-9-ol! (BIII 277).
Type:
Grant
Filed:
May 1, 1998
Date of Patent:
August 31, 1999
Assignee:
Boehringer Ingelheim KG
Inventors:
Matthias Grauert, Herbert Merz, Hanfried Baltes
Abstract: A compound of formula I ##STR1## wherein A denotes a benzo, indolo or thieno group;R.sup.1 denotes thienyl or the group ##STR2## wherein R.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, whilst not more than 2 of the substituents can simultaneously represent phenyl or benzyl;R.sup.2, m, R.sup.3 and R.sup.4 are defined as in the specification, as well as pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
Type:
Grant
Filed:
December 18, 1997
Date of Patent:
July 20, 1999
Assignee:
Boehringer Ingelheim KG
Inventors:
Walter Losel, Otto Roos, Dietrich Arndts
Abstract: An apparatus for cleaning the outside of a container to remove any adhering liquid, particularly in the region of a fill opening thereof. Adhering liquid is blown off of the container by mean of compressed air.
Type:
Grant
Filed:
July 14, 1997
Date of Patent:
June 29, 1999
Assignee:
Boehringer Ingelheim KG
Inventors:
Arun R. Gupte, Heinrich Kladders, Stefan Kruger
Abstract: A device for assisting the manual actuation of aerosol dispensers, especially dispensers of the sort used to dispense metered doses of phamaceuticals. Dispensers to be used with the device of the invention are of known per se design and comprise a container, a nozzle and a valve with an axially movable valve stem which releases material from the container when the valve stem is urged toward the container. Such dispensers are normally actuated by exerting compressive force along the axis of the dispenser, by squeezing the nozzle and one end of the container between the thumb and forefinger. The device of the invention works with such dispensers so that they may instead be actuated by exerting compressive force in a direction that is orthogonal to the axis of the dispenser, by squeezing the device between the fingers and the palm, a motion that is easier for certain individuals.
Abstract: The invention relates to new arylglycinamide derivatives of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and Ar have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokin (tachykinin) antagonists.
Type:
Grant
Filed:
October 9, 1997
Date of Patent:
January 19, 1999
Assignee:
Boehringer Ingelheim KG
Inventors:
Gerd Schnorrenberg, Horst Dollinger, Franz Esser, Hans Briem, Birgit Jung, Georg Speck
Abstract: Compound of general formula I ##STR1## wherein A is a benzo or thieno group;R.sub.1 is (C.sub.4-6)cycloalkyl, (C.sub.4-6)cycloalkyl-(C.sub.1-5)alkyl or ##STR2## R.sup.2, m, R.sup.3, R.sup.4, R and u are defined as in the specification, and pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
Type:
Grant
Filed:
June 10, 1997
Date of Patent:
January 19, 1999
Assignee:
Boehringer Ingelheim KG
Inventors:
Dietrich Arndts, Walter Losel, Otto Roos
Abstract: The invention relates to new amino acid derivatives of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein group B is --A.sup.2 --NR.sup.2 R.sup.3 or R.sup.5, wherein group R.sup.5 is ##STR2## and R.sup.1, A.sup.1, A.sup.2, R.sup.2, R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.9, X, Y, Z, t and u have the meanings described in the specification, as well as the preparation and use thereof. The novel compounds are valuable neurokinin (tachykinin) antagonists.
Type:
Grant
Filed:
June 5, 1995
Date of Patent:
December 15, 1998
Assignee:
Boehringer Ingelheim KG
Inventors:
Franz Esser, Gerd Schnorrenberg, Horst Dollinger, Birgit Jung, Erich Burger
Abstract: A compound of formula I ##STR1## wherein A denotes a benzo, indolo or thieno group;R.sup.1 denotes thienyl or the group ##STR2## wherein R.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, while not more than 2 of the substituents can simultaneously represent phenyl or benzyl;R.sup.2, m, R.sup.3 and R.sup.4 are defined as in the specification, as well as pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
Type:
Grant
Filed:
June 5, 1995
Date of Patent:
November 17, 1998
Assignee:
Boehringer Ingelheim KG
Inventors:
Walter Losel, Otto Roos, Dietrich Arndts
Abstract: A closure cap for sealing containers without gas bubbles displaces some of the contents of the container when fitted onto the neck of the container and at the same time allows any trapped gas to escape through one or more vents before the closure cap engages in the closure position.
Type:
Grant
Filed:
July 14, 1997
Date of Patent:
November 10, 1998
Assignee:
Boehringer Ingelheim KG
Inventors:
Heinrich Kladders, Bernhard Freund, Wulf Bachtler, Joachim Jaeger, Joachim Eicher