Patents Assigned to Boehringer Ingelheim KG
  • Benzoyl guanidine derivatives, the preparation thereof and their use in pharmaceutical compositions
    Patent number: 5783576
    Abstract: New compounds of general formula (I) are provided: ##STR1## which are explained in the specification can be prepared by a variety of methods. The compounds may be used in pharmaceutical compositions.
    Type: Grant
    Filed: August 9, 1996
    Date of Patent: July 21, 1998
    Assignee: Boehringer Ingelheim KG
    Inventors: Otto Roos, Georg Speck, Walter Losel, Dietrich Arndts, Wolf-Dietrich Bechtel
  • Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions
    Patent number: 5770738
    Abstract: The new compounds of formulaA--O--CO--Z (I)(wherein A and Z are defined as explained in the specification) can be prepared by conventional methods; they are suitable as active substances for pharmaceutical compositions.
    Type: Grant
    Filed: March 28, 1995
    Date of Patent: June 23, 1998
    Assignee: Boehringer Ingelheim KG
    Inventors: Rolf Banholzer, Rudolf Bauer, Richard Reichl
  • Halohydrocarbon-free delayed release lacquer solution for pharmaceutical preparation
    Patent number: 5760093
    Abstract: The invention relates to a delayed-release lacquer solution for pharmaceutical preparations which is characterised in that it is free from halogenated hydrocarbons.
    Type: Grant
    Filed: May 2, 1994
    Date of Patent: June 2, 1998
    Assignee: Boehringer Ingelheim KG
    Inventor: Michael Walz
  • Acylamino-substituted hetrazepines
    Patent number: 5753647
    Abstract: A hetrazepine of the formula given below and a pharmaceutical composition comprising a therapeutically effective amount of the hetrazepine and a pharmaceutically acceptable inert carrier are disclosed and are useful in treating disease in a warm-blooded animal induced by endogenously formed PAF; ##STR1## wherein the substituents are defined herein.
    Type: Grant
    Filed: December 5, 1994
    Date of Patent: May 19, 1998
    Assignee: Boehringer Ingelheim KG
    Inventors: Karl-Heinz Weber, Werner Stransky, Ulrike Kufner-Muhl, Hubert Heuer, Franz Birke
  • Substituted benzamidine compounds which have useful pharmaceutical activity
    Patent number: 5731332
    Abstract: Compounds of formula ##STR1## and their therapeutic use, inter alia, as LTB.sub.4 -antagonists. Exemplary compounds are:(Methoxycarbonyl-imino-{4'-?2-(2-propylphenoxy)-ethoxy!-biphenyl-4-yl}-meth yl)-amine;(Benzyloxycarbonyl-imino-{4'-?2-(2-propylphenoxy)-ethoxy!-biphenyl-4-yl}-me thyl-amine;?Hydroxy-imino-(4-{3-?4-(1-methyl-1-phenylethyl)-phenoxymethyl!-benzoyloxy} phenyl)-methyl!-amine;?Ethoxycarbonyl-imino-(4-{3-?4-(1-methyl-1-phenylethyl)-phenoxymethyl!-benz oyloxy}phenyl)-methyl!-amine; and,?3'-Pyridylcarbonyl-imino-(4-{3-?4-(1-methyl-1-phenylethyl)-phenoxymethyl!- benzyloxy}phenyl)-methyl!-amine.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: March 24, 1998
    Assignee: Boehringer Ingelheim KG
    Inventors: Ralf Anderskewitz, Kurt Schromm, Ernst-Otto Renth, Franz Birke, Armin Fugner, Hubert Heuer, Christopher Meade
  • Benzomorphan derivatives
    Patent number: 5731318
    Abstract: Novel benzomorphan derivatives of the formula ##STR1## wherein R.sup.1 -R.sup.8 are as defined herein. The benzomorphan derivatives are useful for treating cerebral ischaemia of various origins, epilepsy and neurodegenerative diseases.
    Type: Grant
    Filed: August 1, 1996
    Date of Patent: March 24, 1998
    Assignee: Boehringer Ingelheim KG
    Inventors: Adrian Carter, Helmut Ensinger, Matthias Grauert, Franz Josef Kuhn, Herbert Merz, Enzio Mueller, Werner Stransky, Ilse Streller
  • Semisolid mixtures of amorphous oligomers and crystalline polymers based on lactic acid
    Patent number: 5725881
    Abstract: The present invention relates to semisolid mixtures of oligomers and/or polymers based on lactic acid, the preparation thereof and the use thereof as absorbable implants.
    Type: Grant
    Filed: October 26, 1994
    Date of Patent: March 10, 1998
    Assignee: Boehringer Ingelheim KG
    Inventors: Berthold Buchholz, Gunther Entenmann
  • Asymmetrically substituted xanthines
    Patent number: 5719279
    Abstract: Xanthine derivatives of formula ##STR1## wherein R.sub.1 is hydrogen, alkyl or alkynyl,R.sub.2 is different and is alkyl, alkynyl, phenyl-alkylene, phenyl alkenylene, cycloalkyl, inter alia,R.sub.3 is cycloalkyl, phenyl, norbornane, inter alia andR.sub.4 is hydrogen, methyl, benzyl, inter alia.
    Type: Grant
    Filed: June 11, 1996
    Date of Patent: February 17, 1998
    Assignee: Boehringer Ingelheim KG
    Inventors: Ulrike Kufner-Muhl, Helmut Ensinger, Joachim Mierau, Franz Josef Kuhn, Erich Lehr, Enzio Muller
  • Arylglycinamide derivatives, processes for the manufacture thereof and pharmaceutical compositions containing these compounds
    Patent number: 5710155
    Abstract: The invention relates to new arylglycinamide derivatives of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and Ar have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokin (tachykinin) antagonists.
    Type: Grant
    Filed: July 30, 1996
    Date of Patent: January 20, 1998
    Assignee: Boehringer Ingelheim KG
    Inventors: Gerd Schnorrenberg, Horst Dollinger, Franz Esser, Hans Briem, Birgit Jung, Georg Speck
  • Neurokinin antagonists
    Patent number: 5708006
    Abstract: The invention relates to new compounds of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein A, B, Z, R.sup.1, R.sup.2, R.sup.3 and m are defined as in the specification, processes for preparing them and pharmaceutical compositions containing these compounds. The compounds are valuable neurokinin (tachykinin) antagonists.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 13, 1998
    Assignee: Boehringer Ingelheim KG
    Inventors: Horst Dollinger, Gerd Schnorrenberg, Hans Briem, Birgit Jung, Georg Speck
  • Resorbable mouldings and process for producing them
    Patent number: 5700901
    Abstract: The invention relates to resorbable mouldings and processes for producing them.
    Type: Grant
    Filed: January 11, 1995
    Date of Patent: December 23, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Achim Hurst, Wladis Winkler-Gwienek, Berthold Buchholz, Dieter Bendix, Gunther Entenmann
  • Hetrazepinoid amides
    Patent number: 5698552
    Abstract: The present invention relates to thienodiazepines of formula Ib: ##STR1## wherein U, V, R.sub.5, R.sub.6 and R.sub.7 are as defined herein. This invention also relates to processes for preparing these thienodiazepines and their use in pharmaceutical compositions with PAF-antagonistic activity.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: December 16, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Karl-Heinz Weber, Werner Stransky, Ulrike Kufner-Muhl, Hubert Heuer, Franz Birke, Wolf-Dietrich Bechtel
  • Neurokinin antagonists
    Patent number: 5696123
    Abstract: The invention relates to new compounds of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein A, B, Z, R.sup.1, R.sup.2, R.sup.3 and m are defined as in the specification, processes for preparing them and pharmaceutical compositions containing these compounds. The compounds are valuable neurokinin (tachykinin) antagonists.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 9, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Horst Dollinger, Gerd Schorrenberg, Hans Briem, Birgit Jung, Georg Speck
  • Xanthine derivatives with adenosine-antagonistic activity
    Patent number: 5696124
    Abstract: The invention relates to new xanthine derivatives of general formula I, processes for preparing them and their use as pharmaceutical compositions.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: December 9, 1997
    Assignee: Boehringer Ingelheim Kg
    Inventors: Ulrike Kufner-Muhl, Karl-Heinz Weber, Gerhard Waither, Werner Stransky, Helmut Ensinger, Gunter Schingnitz, Franz Josef Kuhn, Erich Lehr
  • Bornyl xanthine derivatives with adenosine-antagonistic activity
    Patent number: 5688802
    Abstract: The invention relates to new xanthine derivatives of general formula I, processes for preparing them and their use as pharmaceutical compositions.
    Type: Grant
    Filed: June 14, 1996
    Date of Patent: November 18, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Ulrike Kufner-Muhl, Karl-Heinz Weber, Gerhard Walther, Werner Stransky, Helmut Ensinger, Gunter Schingnitz, Franz Josef Kuhn, Erich Lehr
  • Powder inhaler having magazine storage and a hinged mouthpiece
    Patent number: 5685294
    Abstract: The invention relates to an inhaler for the inhalation of powdered, more particularly micronised drug preparations from capsules, the housing 10 of the inhaler containing tubular chambers 15 for receiving and holding the capsules, in a revolver magazine with an air inlet at the bottom and an air outlet 25 at the opposite end of the chamber opening into a mouthpiece 11, and a cutting device 19 with two blades 21 which are movable into the interior of the chamber in order to open the capsules near the top and bottom ends thereof.
    Type: Grant
    Filed: October 24, 1994
    Date of Patent: November 11, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Rajaram Arun Gupte, Erich Hertl
  • Method for preparing 3-amino-2-chloro-4-alkylpyridine or-4-arylpyridine
    Patent number: 5686618
    Abstract: The present invention relates to a new process for preparing 3-amino-2-chloro-4-alkyl- or -4-aryl-pyridines on an industrial scale.
    Type: Grant
    Filed: September 11, 1995
    Date of Patent: November 11, 1997
    Assignee: Boehringer Ingelheim KG
    Inventor: Heinrich Schneider
  • Anti-inflammatory method
    Patent number: 5686462
    Abstract: The invention relates to the use of carbocyclically and heterocyclically fused dihydropyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for inhibiting blood clotting, and also relates to new compounds of formula Ie ##STR1##
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: November 11, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts, Franz Josef Kuhn, Ilse Strelle
  • Chemical compound, the preparation thereof and its use in pharmaceutical compositions
    Patent number: 5686496
    Abstract: The new compound of formula ##STR1## may be prepared by conventional methods and used therapeutically as an LTB.sub.4 -receptor antagonist.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: November 11, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Ralf Anderskewitz, Kurt Schromm, Ernst-Otto Renth, Franz Birke, Armin Fugner, Hubert Heuer, Christopher Meade
  • Combined inhaler and cover
    Patent number: D395147
    Type: Grant
    Filed: February 18, 1997
    Date of Patent: June 16, 1998
    Assignees: Orion-Yhtyma OY, Boehringer Ingelheim KG
    Inventors: Mika Vidgren, Harald Sprenger, Carman-Ilona Flasch