Patents Assigned to Boehringer Ingelheim Pharma GmbH & Co. KG
  • Process for preparing N-substituted 3-beta-aminonortropanes
    Publication number: 20050096346
    Abstract: The invention relates to a process for preparing N-substituted 3?-aminonortropanes of formula I wherein R1 has the meaning given in the claims, from the corresponding 3-oxonortropane or the corresponding 3 ?-aminonortropane, in which the latter is converted with an arylmethylamine or an arylaldehyde into the corresponding imines which are then tautomerised or isomerised and then hydrolysed. The invention also relates to the new compounds of formula V wherein R1 and Ar have the meanings given in the claims.
    Type: Application
    Filed: October 4, 2004
    Publication date: May 5, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rainer Sobotta, Hans-Peter Ignatow
  • Bilayer pharmaceutical tablet comprising telmisartan and a diuretic and preparation thereof
    Publication number: 20050089575
    Abstract: The present invention relates to a bilayer pharmaceutical tablet comprising a first layer formulated for immediate release of the angiotensin II receptor antagonist telmisartan from a dissolving tablet matrix which contains telmisartan in substantially amorphous form, and a second layer formulated for immediate release of a diuretic like hydrochlorothiazide from a fast disintegrating tablet matrix. A method of producing the bilayer tablet is also disclosed.
    Type: Application
    Filed: July 15, 2004
    Publication date: April 28, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Thomas Friedl, Gottfried Schepky
  • Powder formulations containing tiotropium suitable for inhalation
    Patent number: 6881422
    Abstract: A method of making a physically stable and homogenous powdered pharmaceutical composition comprising a tiotropium salt and a physiologically acceptable excipient, the method comprising: (a) suspending the tiotropium salt and the physiologically acceptable excipient in a suspending agent in which the tiotropium salt and the physiologically acceptable excipient are essentially insoluble to obtain a suspension; and (b) removing the suspending agent from the suspension of step (a) to obtain the pharmaceutical composition, the pharmaceutical composition itself, and method of treating respiratory diseases, especially chronic obstructive pulmonary disease and asthma, in a patient in need thereof by administering an effective amount of the pharmaceutical composition to the patient.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: April 19, 2005
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rolf Banholzer, Manfred Graulich, Christian Kulinna, Andreas Mathes, Helmut Meissner, Peter Seiger, Peter Specht, Michael Josef Friedrich Trunk
  • Ambroxol for the treatment of inflammation in the pharynx
    Publication number: 20050075403
    Abstract: The invention relates to the use of ambroxol (trans-4-(2-amino-3,5-dibromobenzylamino)-cyclohexanole) and the pharmacologically acceptable salts thereof for preparing a pharmaceutical composition for the treatment of inflammation in the pharynx.
    Type: Application
    Filed: October 2, 2003
    Publication date: April 7, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Anke Esperester, Jean-Michel Vix
  • Method for preparing homogenous liposomes and lipoplexes
    Publication number: 20050064026
    Abstract: The present invention relates to a continuous low pressure extrusion process for preparing liposomes, processes for preparing complexes consisting of correspondingly prepared liposomes and nucleic acid molecules (lipoplexes), processes for the stable storage of corresponding lipoplexes, and correspondingly prepared liposomes and lipoplexes.
    Type: Application
    Filed: August 24, 2004
    Publication date: March 24, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Patrick Garidel, Hans Hoermann, Nicole Denkinger, Regine Peschka-Suess, Rolf Schubert
  • Method for recloning production cells
    Publication number: 20050059146
    Abstract: A new method for selecting clones and recloning mammalian cells which are of importance for the production of biopharmaceuticals, preferably hamster or mouse myeloma cells, with a high degree of automation and throughput. The invention relates to methods of depositing and replicating single cell clones of the cells in question. The invention also relates to methods of preparing proteins using cells which have been obtained and replicated by single cell deposition as well as compositions which allow the replication of single cells.
    Type: Application
    Filed: August 19, 2004
    Publication date: March 17, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Ralf Otto, Barbara Enenkel, Juergen Fieder, Thomas Krieg
  • Tiotropium containing HFC solution formulations
    Publication number: 20050058606
    Abstract: This invention relates to tiotropium containing stable pharmaceutical solution formulations suitable for aerosol administration. More particularly, this invention relates to tiotropium containing stable pharmaceutical solution formulations suitable for aerosol administration wherein either an inorganic acid or an organic acid is added to the aerosol solution formulation which contains a tiotropium salt, preferably tiotropium bromide in solution with an environmentally safe hydrofluorocarbon (HFC) as a propellant, together with an organic compound as a cosolvent. The acid provides stability against degradation or decomposition of the medicament resulting largely from interaction of the medicament with the cosolvent and/or water present in the solution formulation.
    Type: Application
    Filed: December 9, 2003
    Publication date: March 17, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Sabine Six, Christel Schmelzer, Friedrich Schmidt
  • Method for regeneration of adsorbent matrices
    Publication number: 20050056592
    Abstract: The present invention relates to the regeneration of adsorbent matrices that are used for the purification of substances from aqueous liquid samples derived from biological material. The method is adapted to adsorbent matrices that are sensitive to hydrolysis either because of a sensitive base matrix or a sensitive ligand including also a sensitive spacer a n d is characterized in contacting at least one regeneration solution with the adsorbent matrix which comprises an organic solvent which is water-miscible and has a pH value ?4, preferably ?3 (acid solution) or ?10 but <13 (alkaline solution).
    Type: Application
    Filed: August 11, 2004
    Publication date: March 17, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH Co., KG
    Inventors: Gabriele Braunger, Jan Feuser, Joachim Walter
  • Capsule containing active substance pellets
    Publication number: 20050058704
    Abstract: The invention relates to a capsule containing different active substance pellets with at least two different active substances which differ in their release profile in the gastro-intestinal tract, these active substances being selected from among the vitamins, minerals, trace elements, unsaturated fatty acids, amino acids and/or plant extracts and substances. The different release profiles represent rapid, moderate and/or slow dissolving of the active substance pellets. This controlled release leads to a targeted absorption of the active substances in the different absorption areas of the gastro-intestinal tract. Using the preparation provided according to the invention it is also possible to improve bioavailability to a high degree even when a large number of active substances are present.
    Type: Application
    Filed: September 2, 2004
    Publication date: March 17, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Roland Schneider, Sergej Anschuetz
  • Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments
    Publication number: 20050054710
    Abstract: The present invention relates to heterocyclically substituted indolinones of general formula wherein R1 to R5 and X are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases and cyclin/CDK complexes and on the proliferation of endothelial cells and various tumour cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Application
    Filed: September 5, 2003
    Publication date: March 10, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Joerg Kley, Frank Hilberg, Armin Heckel, Gerald Roth, Thorsten Lehmann-Lintz, Ralf Lotz, Ulrike Tontsch-Grunt, Jacobus Van Meel
  • Anticholinergics, processes for preparing them and pharmaceutical composition containing them
    Publication number: 20050054664
    Abstract: A compound of formula 1 wherein: A is a group selected from X? is an anion with a single negative charge; R1 and R2 are each independently a C1-C4-alkyl optionally substituted with hydroxy or halogen; and R3, R4, R5, R6, R7, and R8 are each independently hydrogen, C1-C4-alkyl, C1-C4-alkyloxy, hydroxy, CF3, CN, NO2, or halogen, with the proviso that at least one of the groups R3, R4, R5, R6, R7, and R8 is not hydrogen, processes for preparing these compounds, pharmaceutical compositions containing these compounds, and their use as pharmaceutical compositions.
    Type: Application
    Filed: October 21, 2004
    Publication date: March 10, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Helmut Meissner, Gerd Morschhaeuser, Michael Pieper, Gerald Pohl, Richard Reichl, Georg Speck
  • Pramipexole for the treatment ADHD
    Publication number: 20050049289
    Abstract: A method for prevention and/or treatment of ADHD in a patient in need thereof, the method comprising administering to the patient an effective amount of 2-amino-4,5,6,7-tetrahydro-6-n-propylaminobenzothiazole or a pharmacologically acceptable acid addition salt, hydrate, or solvate thereof
    Type: Application
    Filed: October 4, 2004
    Publication date: March 3, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Juergen Reess, Franco Borsini
  • Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
    Patent number: 6861422
    Abstract: The present invention relates to new dihydropteridinones of general formula (I): wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
    Type: Grant
    Filed: February 26, 2003
    Date of Patent: March 1, 2005
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Matthias Hoffmann, Matthias Grauert, Trixi Brandl, Steffen Breitfelder, Christian Eickmeier, Martin Steegmaier, Gisela Schnapp, Anke Baum, Jens Juergen Quant, Flavio Solca, Florian Colbatzky
  • Indoline derivatives substituted in the 6 position, their preparation and their use as medicaments
    Publication number: 20050043389
    Abstract: The present invention relates to indolinone derivatives, substituted in the 6-position, of the formula in which R1 to R6 and X are as defined in claim 1, to their tautomers, enantiomers, diastereomers, to their mixtures and to their salts, in particular their physiologically acceptable salts, which have useful pharmacological properties, in particular in inhibiting action on various receptor tyrosine kinases and on the proliferation of endothelial cells and various tumour cells, to medicaments comprising these compounds, to their use and to processes for their preparation.
    Type: Application
    Filed: July 22, 2003
    Publication date: February 24, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Gerald Roth, Armin Heckel, Thorsten Lehmann-Lintz, Joerg Kley, Frank Hilberg, Jacobus Van Meel, Ulrike Tontsch-Grunt
  • Benzoylguanidine salt and hydrates thereof
    Publication number: 20050043320
    Abstract: 4-[4-(2-pyrrolylcarbonyl)-1-piperazinyl]-3-trifluoromethylbenzoylguanidine hydrochloride and its hydrates, processes for preparing this benzoylguanidine salt and its hydrates, pharmaceutical compositions containing this benzoylguanidine salt and its hydrates, and its use in treating diseases, particularly those in which inhibition of the cellular Na+/H+ exchange is of therapeutic benefit.
    Type: Application
    Filed: September 23, 2004
    Publication date: February 24, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Christian Eickmeier, Peter Sieger, Werner Rall, Volkmar Koerner, Rolf Herter
  • Compounds and methods for treating urinary incontinence
    Patent number: 6858594
    Abstract: The present invention relates to the use of ?1L-agonists for treating urinary incontinence.
    Type: Grant
    Filed: November 15, 2002
    Date of Patent: February 22, 2005
    Assignee: Boehringer Ingelheim Pharma GmbH & Co KG.
    Inventors: Franz Esser, Helmut Staehle, Sven Luettke, Ikunobu Muramatsu, Hisato Kitagawa, Shuji Uchida
  • New difurylglycolic acid esters processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
    Publication number: 20050038252
    Abstract: Difurylglycolic acid esters of the formula 1 wherein X? and the groups A, R, R1, R2, R3 and R3? may have the meanings given in the claims and in the specification, processes for preparing them and their use for treating asthma, COPD, vagally induced sinus bradycardia, heart rhythm disorders, spasms in the gastrointestinal tract, spasms in the urinary tract or menstrual pain.
    Type: Application
    Filed: September 23, 2004
    Publication date: February 17, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Gerd Morschhaeuser, Michael Pieper, Georg Speck
  • Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them
    Patent number: 6852728
    Abstract: A compound of formula 1 wherein: A is a group selected from X? is an anion with a single negative charge; R1 and R2 are each independently a C1-C4-alkyl optionally substituted with hydroxy or halogen; and R3, R4, R5, R6, R7, and R8 are each independently hydrogen, C1-C4-alkyl, C1-C4-alkyloxy, hydroxy, CF3, CN, NO2, or halogen, with the proviso that at least one of the groups R3, R4, R5, R6, R7, and R8 is not hydrogen, processes for preparing these compounds, pharmaceutical compositions containing these compounds, and their use as pharmaceutical compositions.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: February 8, 2005
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Helmut Meissner, Gerd Morschhaeuser, Michael Paul Pieper, Gerald Pohl, Richard Reichl, Georg Speck
  • Process for label-free measurement of modified substrate
    Publication number: 20050026219
    Abstract: Process for measuring a substance in solutions without first having to selectively label the molecule which is to be measured. The process makes it possible to determine the quantity of the substance, and to measure catalysed reactions which lead to the modification of the substance. The process makes it possible to test whether a substance modulates a catalysed reaction or not. The process can be used in High Throughput Screening.
    Type: Application
    Filed: September 1, 2004
    Publication date: February 3, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Steffen Hadamovsky, Gerald Birk
  • New substituted imidazo-pyridinones and imidazo-pyridazinones, the preparation thereof and their use as pharmaceutical compositions
    Publication number: 20050020574
    Abstract: The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula wherein R1 to R4 are defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
    Type: Application
    Filed: December 2, 2003
    Publication date: January 27, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH Co. KG
    Inventors: Norbert Hauel, Frank Himmelsbach, Elke Langkopf, Matthias Eckhardt, Roland Maier, Michael Mark, Mohammad Tadayyon, Iris Kauffmann-Hefner