Patents Assigned to Boehringer Ingelheim Pharma GmbH & Co. KG
  • Substituted indolinones, their manufacture and their use as medicaments
    Patent number: 6794395
    Abstract: The present invention relates to substituted indolinones of general formula wherein R1 to R6 and X are defined as in claim 1, the isomers and the salts thereof, in particular the physiologically acceptable salts thereof which have valuable pharmacological properties, especially an inhibitory effect on various receptor-tyrosine kinases, and cycline/CDK complexes as well as on the proliferation of endothelial cells and various tumor cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: September 21, 2004
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Gerald Juergen Roth, Armin Heckel, Rainer Walter, Ulrike Tontsch-Grunt, Walter Spevak, Jacobus C. A. Van Meel
  • 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate and the use thereof as a pharmaceutical composition
    Publication number: 20040176392
    Abstract: The present invention relates to the compound 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate of formula I and the use thereof as a pharmaceutical composition.
    Type: Application
    Filed: July 21, 2003
    Publication date: September 9, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Gerald J. Roth, Guenter Linz, Peter Sieger, Werner Rall, Frank Hilberg, Thomas Bock
  • New dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
    Publication number: 20040176380
    Abstract: The present invention relates to new dihydropteridinones of general formula (I) 1
    Type: Application
    Filed: February 26, 2003
    Publication date: September 9, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH Co. KG
    Inventors: Matthias Hoffmann, Matthias Grauert, Trixi Brandl, Steffen Breitfelder, Christian Eickmeier, Martin Steegmaier, Gisela Schnapp, Anke Baum, Jens Juergen Quant, Flavio Solca, Florian Colbatzky
  • Substituted nitrogen-containing heterobicycles, the preparation thereof and their use as pharmaceutical compositions
    Publication number: 20040176603
    Abstract: The present invention relates to new substituted nitrogen-containing heterobicyclic compounds of general formula 1
    Type: Application
    Filed: December 18, 2003
    Publication date: September 9, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Henning Priepke, Roland Pfau, Kai Gerlach, Uwe Ries, Wolfgang Wienen, Eckhart Bauer, Herbert Nar
  • Crystalline acetic acid solvate of meloxicam
    Publication number: 20040171611
    Abstract: The present invention relates to a new crystalline modification of the compound 4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazin-3-carboxamide-1,1-dioxide in the form of an acetic acid solvate of formula I as well as the use thereof as a pharmaceutical composition.
    Type: Application
    Filed: September 22, 2003
    Publication date: September 2, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Guenter Trummlitz, Rainer Soyka, Peter Sieger, Ulrike Werthmann, Peter Luger
  • Xanthine derivatives, their preparation and their use in pharmaceutical compositions
    Publication number: 20040166125
    Abstract: Compounds of formula (I) 1
    Type: Application
    Filed: August 7, 2003
    Publication date: August 26, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Frank Himmelsbach, Elke Langkopf, Matthias Eckhardt, Michael Mark, Roland Maier, Ralf R. H. Lotz
  • Nebulizer for applying liquids on the surface of the eye or the ocular connective tissue
    Publication number: 20040164099
    Abstract: The present invention relates to atomizers for administering preservative-free liquids to the cornea or conjunctiva of the eye, with special eye adapters for atomizers and the use of atomizers for ophthalmological administration. The atomizers according to the invention are free from propellant gas.
    Type: Application
    Filed: December 18, 2003
    Publication date: August 26, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co., KG
    Inventors: Michael Diestelhorst, Isolde Martin, Bernd Zierenberg, Dieter Hochrainer
  • Aerosol formulation for inhalation comprising an anticholinergic
    Publication number: 20040166065
    Abstract: The present invention relates to a propellant-free, aqueous aerosol formulation for anticholinergics of formula 1 1
    Type: Application
    Filed: August 8, 2003
    Publication date: August 26, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventor: Friedrich Schmidt
  • Bis-basic compounds with tryptase-inhibitory activity
    Patent number: 6780863
    Abstract: Compounds of which the following are exemplary: These have tryptase-inhibiting activity and are useful for the treatment of inflammatory and allergic disease conditions.
    Type: Grant
    Filed: October 30, 2000
    Date of Patent: August 24, 2004
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Ralf Anderskewitz, Christine Braun, Rainer Hamm, Bernd Disse, Hans Michael Jennewein, Georg Speck
  • Industrial process for preparing tropenol
    Publication number: 20040158069
    Abstract: The invention relates to a new industrially useable process for preparing tropenol, optionally in the form of the acid addition salts thereof.
    Type: Application
    Filed: January 26, 2004
    Publication date: August 12, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rolf Banholzer, Gisela Bodenbach, Andreas Mathes, Helmut Meissner, Peter Specht
  • Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds
    Publication number: 20040152742
    Abstract: The present invention relates to amide compounds of general formula I 1
    Type: Application
    Filed: October 31, 2003
    Publication date: August 5, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Dirk Stenkamp, Stephan Georg Mueller, Gerald Juergen Roth, Philipp Lustenberger, Klaus Rudolf, Thorsten Lehmann-Lintz, Kirsten Arndt, Ralf Lotz, Martin Lenter, Heike-Andrea Wieland
  • Powder inhaler comprising a chamber for a capsule for taking up a non-returnable capsule being filled with an active ingredient
    Publication number: 20040149283
    Abstract: The invention relates to a powder inhaler operating on the Bernoulli principle with replaceable cylindrical disposable capsules as the active substance reservoir. The powder inhaler consists essentially of a preferably cylindrical capsule chamber provided with means for laterally opening the capsule, an air inlet opening in the capsule chamber and an air outlet opening and a mouthpiece mounted downstream of the air outlet opening. The capsule chamber is constructed so that after insertion the reservoir capsule can essentially only move in the longitudinal direction when a sufficiently powerful air stream passes through the capsule chamber, guided substantially parallel to the longitudinal axis of the capsule. According to the invention, the inner wall of the capsule chamber is uneven in order to achieve a better emptying of the capsule than is obtained with a smooth inner surface.
    Type: Application
    Filed: December 4, 2003
    Publication date: August 5, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventor: Dieter Hochrainer
  • Powdered medicaments containing a tiotropium salt and salmeterol xinafoate
    Publication number: 20040152720
    Abstract: The invention relates to powdered preparations for inhalation containing a tiotropium salt and salmeterol xinafoate, processes for preparing them and their use in the preparation of a pharmaceutical composition for treating respiratory diseases, particularly for treating COPD (chronic obstructive pulmonary disease) and asthma.
    Type: Application
    Filed: December 15, 2003
    Publication date: August 5, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Mareke Hartig, Michael Trunk, Rainer Soyka, Peter Sieger, Hagen Graebner, Michael Walz
  • Process for preparing and purifying 1,7?-dimethyl-2?-propyl-2,5?-bi-1H-benzimidazole
    Patent number: 6770762
    Abstract: Disclosed is a process which can be used on an industrial scale for preparing and purifying 1,7′-dimethyl-2′-propyl-2,5′-bi-1H-benzimidazole in which the crude product is subjected to charcoal treatment.
    Type: Grant
    Filed: January 16, 2003
    Date of Patent: August 3, 2004
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Werner Belzer, Rolf Dach, Volker Fachinger, Markus Heitzmann, Hartmut Schmidt
  • New medicaments for the treatment of chronic obstructive pulmonary disease
    Publication number: 20040147513
    Abstract: A pharmaceutical composition comprising a compound of formula 1 1
    Type: Application
    Filed: November 10, 2003
    Publication date: July 29, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Ingo Konetzki, Kurt Schromm, Hermann Schollenberger, Sabine Pestel, Andreas Schnapp, Thierry Bouyssou, Frank Buettner, Claudia Heine, Philipp Lustenberger, Christoph Hoenke, Klaus Rudolf
  • Methods of using dihydropteridinones
    Publication number: 20040147524
    Abstract: Disclosed are dihydropteridinones of the formula (I): 1
    Type: Application
    Filed: January 13, 2004
    Publication date: July 29, 2004
    Applicant: Boehringer Ingelheim Pharma Gmbh & Co. KG
    Inventors: Eckhart Bauer, Steffen Breitfelder, Christian Eickmeier, Matthias Grauert, Matthias Hoffmann, Thorsten Lehmann-Lintz, Gerald Phol, Jens Quant, Norbert Redemann, Gisela Schnapp, Martin Steegmaier
  • Expression vector, methods for the production of heterologous gene products and for the selection of recombinant cells producing high levels of such products
    Publication number: 20040148647
    Abstract: An expression vector for eukaryotic cells comprising a gene which codes for a protein of interest, functionally linked to a hamster-ubiquitin/S27a-promoter and a gene which codes for a fluorescent protein. Preferably the expression vector also contains an amplifiable selectable marker gene.
    Type: Application
    Filed: November 26, 2003
    Publication date: July 29, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Barbara Enenkel, Juergen Fieder, Ralf Otto, Stefanos Grammatikos
  • Process for the preparation of an essentially pure polymorph of an n-pyrazolyl-n'-naphthyl-urea
    Publication number: 20040138216
    Abstract: Disclosed are improved processes for the preparation of a polymorph of 1-[tert-butyl-1-p-tolyl-1H-pyrazol-5-yl]-3-[4-(2-morpolinin-4-yl-ethoxy)naphthalen-1-yl]-urea (1) by crystallization from an alcohol, wherein the improvement is that crude (1) is treated with ethanol.
    Type: Application
    Filed: December 3, 2003
    Publication date: July 15, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Wendelin Samstag, Gunter Koch
  • Potent inhibitor of HCV serine protease
    Publication number: 20040138109
    Abstract: Disclosed are oral pharmaceutical compositions, kits and methods of treating and preventing Hepatitis C Viral (HCV) infections wherein the following Compound (1), a potent inhibitor of HCV serine protease, or a pharmaceutically acceptable salt thereof, is administered in a selected dosage range: 1
    Type: Application
    Filed: September 16, 2003
    Publication date: July 15, 2004
    Applicants: Boehringer Ingelheim Pharmaceuticals, Inc., Boehringer Ingelheim Pharma GmbH & CO. KG
    Inventors: Shirlynn Chen, Jens Oliver Croenlein, Gerhard Nehmiz, Gerhard Steinmann, Jocelyn Abella Gunn, Phuong Do Costa
  • Tiotropium containing powder formulation for inhalation
    Publication number: 20040136919
    Abstract: The invention relates to powdered preparations containing tiotropium for inhalation, processes for preparing them as well as their use in preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.
    Type: Application
    Filed: November 20, 2003
    Publication date: July 15, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Mareke Hartig, Michael Trunk, Michael Walz