Abstract: Reagents for the determination of hydrolase comprises compounds of the formula ##STR1## wherein Z is an organic or inorganic acid residue or a sugar residue, A is an organic or inorganic acid residue, and B is an organic acid residue. Each of R.sup.2 and R.sup.5, is hydrogen, halogen or lower alkyl. Each of R.sup.1, R.sup.3, R.sup.4 and R.sup.6, is hydrogen, halogen, cyano, lower alkyl, lower alkoxy, carboxyl, lower alkoxycarbonyl, carboxy lower alkyl or lower alkoxycarbonyl lower alkyl, or carboxamido groups optical substituted once or twice, or a radical of the formula--COO--(CH.sub.2 CH.sub.2 O).sub.n --R.sup.7in which R.sup.7 is hydrogen or lower alkyl and n is a number from 1 to 4. Additionally, R.sup.6 can be sulpho or nitro.

Abstract: A prosthetic glenoid component is provided for attachment to a glenoid surface of a scapula to replace a natural socket of a shoulder. The glenoid component includes a molded plastic body having an outer concave bearing surface for engagement by a corresponding humeral head and an inner convex surface for abutting the glenoid surface. A plurality of attachment pegs are integrally molded on the inner surface of the glenoid component for penetrating the glenoid surface to secure the plastic body to the glenoid surface.

Abstract: The present invention provides a hapten-protein conjugate, wherein a hapten is bound to the reducing end of a sugar which consists of up to 10 monosaccharide units and on a free CH.sub.2 OH group on the other end of the sugar, which is in the .alpha.-position to a hydroxyl group, is bound a protein.

Abstract: The present invention provides anti-angina pharmaceutical compositions containing at least one compound of the formula: ##STR1## wherein n is 1 or 2, R is a hydrogen atom or an H-(C.sub.1 -C.sub.8)-alkylene, hydroxy-(C.sub.1 -C.sub.8)-alkylene, R.sup.1 R.sup.2 N-(C.sub.1 -C.sub.8)-alkylene, R.sup.1 R.sup.2 N-(C.sub.1 -C.sub.8)-alkylene-CO--, R.sup.1 R.sup.2 N-CO-NR.sup.3 -(C.sub.1 -C.sub.8)-alkylene or R.sup.1 R.sup.2 N-CO-- radical, A is a valency bond or an --NR.sup.4 --CO-- or --CO--NR.sup.4 -- radical, R.sup.4 is a hydrogen atom or a straight-chained or branched, saturated or unsaturated of cyclic alkyl radical containing up to 6 carbon atoms and B is a valency bond or a straight-chained or branched alkylene chain containing up to 8 carbon atoms, in which a --CH.sub.2 -- group can be replaced by a cycloalkylene radical containing 3 to 7 carbon atoms.

Abstract: The present invention relates to instruments for preparing a glenoid surface of a scapula to receive a prosthetic glenoid component to replace the natural socket of a shoulder. More particularly, the present invention relates to a drill guide assembly for aligning and guiding a drill bit to form holes in the glenoid surface at predetermined locations to secure the glenoid component to the glenoid surface. A reamer assembly including a ratchet drive mechanism is also included to facilitate preparation of the glenoid surface prior to installation of the glenoid component.

Abstract: The invention relates to a non-serum based control reagent for glucose determination. Rather than using modified serum, the control reagent contains water, glucose, and the viscosity agent polystyrene sulphonate. The control reagent may also contain a buffer, preservatives, surfactants or surface active agents. A method of making the control reagent is also disclosed.

Abstract: A surgical retractor is disclosed for use when surgery is performed adjacent a bone and remains in place for an appropriate duration without requiring manual assistance. A barrier member includes a plurality of cannulated fixation posts for its temporary placement on, and attached to, the bone and a soft tissue engaging surface which extends transverse of a surface of the bone. Guides, including the cannulated fixation posts, slidably receive mounting pins which supplement the fixation posts for temporarily attaching the barrier member to the bone. The barrier member is also provided with bottom and top flanges which extend transversely of the soft tissue engaging surface and cooperate therewith to prevent entry of the soft tissue into an adjacent surgical site.

Abstract: Naftopidil,1-(2-methoxyphenyl)-4-[3-(naphth-1-yloxy)-2-hydroxypropyl)]-pipe razine, or of a salt thereof, is effective in the treatment of dysuria, particularly in causes of prostatic hypertrophy.

Abstract: The present invention provides compounds of the general formula: ##STR1## wherein Ar is a phenyl radical optionally substituted by alkyl, alkenyl, alkoxy, alkylthio, alkanoyl, hydroxyl, hydroxyalkyl, carboxyl, alkoxycarbonyl, carbamoyl, nitro, amino or halogen, A is a straight-chained or branched, saturated or unsaturated C.sub.1 -C.sub.8 aliphatic hydrocarbon radical which is optionally substituted by a hydroxyl group, n is 0, 1 or 2, B is a straight-chained or branched, saturated or unsaturated C.sub.1 -C.sub.8 -aliphatic hydrocarbon radical and R is 5-(1H)-tetrazolyl, --CO--NH-tetrazolyl, ##STR2## Cn, SCN, OH, halogen, 5-(1H)-tetrazolylthio, ##STR3## or CO--O--NH--R.sub.1, wherein R.sub.

Abstract: A method of joining a polymeric part and a metallic or ceramic part. The result is a bearing for an orthopedic prosthesis comprising a rigid backing component presenting a mating surface having interstices, a polymeric bearing component having a corresponding mating surface, the bearing component and backing components being joined together by heating the backing component to a temperature sufficient to reduce the viscosity of the bearing component at its mating surface and by forcing the components together with sufficient pressure to cause the bearing component mating surface to flow into the interstices of the backing component mating surface.

Abstract: The present invention provides a process for obtaining sarcosine oxidase from micro-organisms by culturing thereof and obtaining the enzyme from the biomass or from the culture broth, wherein a Pseudomonas strain is cultured.

Abstract: Compounds of formula I ##STR1## wherein R.sub.1 is an alkoxycarbonyl group, acetyl, benzoyl, cyano, nitro or aminocarbonyl;R.sub.2 is an optionally substituted aryl or hetaryl group;R.sub.3 is an alkoxycarbonyl group;.phi. is a thio residue such as alkylthio, cycloalkylthio, arylthio, heteroarylthio, aminoalkylthio,are described.Compounds I are useful in human therapy as antihypertensive, antiulcer, antithrombotic, antiischaemic agents.

Abstract: A modular prosthetic system for mounting a variety of styles of wedges to a tibial tray in order to correct for bone deficiencies, alternatively, in the anterior/posterior direction and in the medial/lateral direction. The wedge is mounted on the tibial tray before the system is implanted. The tibial tray has a pair of spaced transverse smooth bores and coaxial counterbores and the wedge has a pair of spaced transverse threaded bores which are aligned, respectively, with the smooth bores and counterbores when the wedge is mounted on the tibial tray. Cannulated screws having a head, threaded shank, and longitudinal bore are attached so as to extend through an associated bore and counterbore, then are threadedly engaged with the wedge. A bone screw is then received through the bore of the cannulated screw for implanting the system on the proximal end of the tibia. Mating spherical surfaces, respectively, on the cannulated screw and on the bone screw enable the bone screw to attain an optimal orientation.

Abstract: The present invention provides compounds of the general formula (I) which inhibit the aggregation of erythrocytes or thrombocytes ##STR1## wherein A is hydrogen or C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -alkynyl, benzyl or C.sub.3 -C.sub.7 -cycloalkyl radical, B is hydrogen, R.sub.1 is a C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl or C.sub.3 -C.sub.7 -cycloalkyl radical, R.sub.2 is a C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.3 -C.sub.7 -cycloalkyl, C.sub.1 -C.sub.6 -alkylcarbonyl, C.sub.1 -C.sub.6 -alkoxycarbonyl, aminocarbonyl or hydrazinocarbonyl radical, or R.sub.1 and R.sub.2, together with the carbon atom to which they are attached, form a C.sub.3 -C.sub.7 -cycloalkyl ring, n is 0, X is a valency bond or a C.sub.1 -C.sub.6 -alkylene radical, R.sub.3 is a carbocyclic aromatic ring, which may be substituted; and the tautomers, optically-active forms and physiologically acceptable salts thereof with organic and inorganic acids.

Abstract: Carrier-bound multicomponent detection system for the colorimetric determination of esterolytically- and/or proteolytically-active ingredients of body fluids, wherein the components of the detection system are present in different reagent layers, and where a liquid exchange between the layers is possible.

Abstract: A process for the determination of substrate or enzyme activities by the use of a redox reaction as a measurement reaction is carried out in the presence of one or more additionally added tetrazolium salts to remove disturbing substances. The tetrazolium salts have the formula ##STR1## in which R.sup.1 is a hydrogen atom, a carboxyl group or an alkyl, phenyl, nitrophenyl, dinitrophenyl, carboxyl-substituted phenyl or trialkylammoniumphenyl radical, R.sup.2 is a phenyl, nitrophenyl, biphenylyl or naphthyl radical, R.sup.3 is a phenyl, carboxyl-substituted phenyl, carboxyl-substituted hydroxyphenyl or dimethylthiazolyl radical, and A.sup..crclbar. is a monovalent anion. The formazanes formed by reaction with reducing substances do not absorb light at all, or absorb light only to a negligible extent, at the measurement wavelength of the redox reaction. New compounds included within the formula are those in which R.sup.

Abstract: An improved acetabular cup for use in cement fixation has at least one flat area on its generally hemispherical outer surface. The flat area resists rotation of the cup in the cement mantle after implantation while avoiding concentrations of stress in the mantle.

Abstract: A personal exhaust system for individual use by the members of a surgical team in an operating room. It may be employed in conjunction with a disposable hood or combination hood and gown worn by each such person. Each system includes a d.c. powdered motor and blower unit adapted to be connected, via a light weight power cord to an a.c.-to-d.c. converter and transformer, or switching mode power supply. A filter is utilized to remove contaminants from the air before it exhausts to the atmosphere. Each unit is provided with its own on-off switch and the flow of air for each unit is individually controlled. A battery back-up allows for short excursions away from the power supply. In another embodiment, fresh filtered air may be directed into the hood simultaneously with removal of stale air from the hood and its subsequent filtered exhaustion to the atmosphere.

Abstract: An artificial implant includes an elongated stem member which is intended for cementless fixation in the medullary canal of a long bone. The stem member is provided with one or more longitudinally extending channels. A porous medium for enabling and encouraging bone ingrowth fixation is bonded to the bottom surface of each channel but is free of the sidewalls of the channel. It has a first outer surface lying in a plane generally parallel to that of the external surface of the stem member and second and third surfaces lying generally, respectively, in angularly spaced radial planes containing the longitudinal axis of the stem member. The resulting implant has a flexibility which can be tailored to that of the bone. Also, the porous medium enables an initial interference fit with the medullary canal of the long bone as well as bone ingrowth fixation over a substantially enlarged surface area than previously possible.