Patents Assigned to Bracco Imaging S.p.A.
  • Publication number: 20220370646
    Abstract: The present invention relates to pharmaceutical compositions comprising an gadolinium-complex and a saturated macrocyclic tetraamine that find application in diagnostic imaging as diagnostic agents, in particular as contrast agents having improved tolerability, specifically in Magnetic Resonance Imaging (MRI), and to their preparation.
    Type: Application
    Filed: October 20, 2020
    Publication date: November 24, 2022
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Zsolt BARANYAI, Mariangela BOCCALON, Federica BUONSANTI, Federico CRIVELLIN, Alessandro MAIOCCHI, Roberta MAZZON, Fabio TEDOLDI, Fulvio UGGERI
  • Publication number: 20220348923
    Abstract: The present invention provides nucleic acid aptamers binding to the Carbonic Anhydrase IX (CA-IX) enzyme, derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing CA-IX, or as therapeutic agents for prevention or treatment of CA-IX related diseases.
    Type: Application
    Filed: September 16, 2020
    Publication date: November 3, 2022
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Vittorio DE FRANCISCIS, Carla Lucia ESPOSITO, Silvia CATUOGNO, Silvia NUZZO, Alessandro MAIOCCHI, Margherita IABONI, Aldo DI VITO, Erika REITANO, Luisa POGGI
  • Publication number: 20220242853
    Abstract: The present invention relates to the field of optical imaging More particularly, it relates to compounds of the cyanine family characterized by improved physico-chemical and biological properties and to their conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.
    Type: Application
    Filed: May 12, 2020
    Publication date: August 4, 2022
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Francesco BLASI, Chiara BRIOSCHI, Federica BUONSANTI, Luigi MIRAGOLI, Roberta NAPOLITANO, Laura ORIO, Lorena PIZZUTO, Giovanni VALBUSA
  • Patent number: 11401262
    Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: August 2, 2022
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Valeria Boi, Roberta Napolitano, Luciano Lattuada
  • Patent number: 11274308
    Abstract: The present invention provides nucleic acid aptamers binding to the Intercellular Adhesion Molecule-1 (ICAM-1), derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing ICAM-1, or as therapeutic agents for prevention or treatment of ICAM-1-related diseases.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: March 15, 2022
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Vittorio De Franciscis, Silvia Catuogno, Carla Lucia Esposito, Alessandro Maiocchi, Margherita Iaboni, Luisa Poggi, Erika Reitano
  • Publication number: 20220062444
    Abstract: The present invention refers to pharmaceutical compositions comprising a macrocyclic gadolinium complex and a water-soluble polyarylene additive useful in diagnostic imaging as diagnostic agents, in particular as contrast agents, specifically in Magnetic Resonance Imaging (MRI).
    Type: Application
    Filed: December 17, 2019
    Publication date: March 3, 2022
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio AIME, Giuseppe FERRAUTO, Eliana GIANOLIO, Luciano LATTUADA, Alessandro MAIOCCHI
  • Publication number: 20220016275
    Abstract: A chelating compound of formula (I) or a pharmaceutically acceptable salt thereof and its complexes with metals or radioisotopes thereof. The invention further relates to the preparation of such ligand and complexes as well as to their use as diagnostic or therapeutic agents.
    Type: Application
    Filed: November 12, 2019
    Publication date: January 20, 2022
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Zsolt BARANYAI, Simona GHIANI, Alessandro MAIOCCHI, Ivan HAWALA
  • Publication number: 20210395832
    Abstract: Disclosed are gene signatures and methods for predicting the recurrence of prostate cancer in prostatectomized subjects. Other objectives of the invention are assay devices and kits for determining the expression levels of specific gene sets correlated to prostate cancer recurrence.
    Type: Application
    Filed: November 8, 2019
    Publication date: December 23, 2021
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Andrea FERRARIS, Erika REITANO, Alessandro MAIOCCHI
  • Publication number: 20210292762
    Abstract: The present invention provides nucleic acid aptamers binding to the Intercellular Adhesion Molecule-1 (ICAM-1), derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing ICAM-1, or as therapeutic agents for prevention or treatment of ICAM-1-related diseases.
    Type: Application
    Filed: July 24, 2019
    Publication date: September 23, 2021
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Vittorio DE FRANCISCIS, Silvia CATUOGNO, Carla Lucia ESPOSITO, Alessandro MAIOCCHI, Margherita IABONI, Luisa POGGI, Erika REITANO
  • Publication number: 20210263122
    Abstract: The present invention relates to on the use of exogenous agents having a pool of mobile proton(s) in CEST-MR imaging to generate Chemical Exchange Rotation Transfer-based CEST contrast, and to a ratiometric-based CEST-MR procedure that comprises using these exogenous agents to set-up CERT-based concentration-independent CEST MR imaging, and as responsive agents to set-up CERT-based concentration independent responsiveness.
    Type: Application
    Filed: April 30, 2021
    Publication date: August 26, 2021
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio AIME, Dario Livio LONGO, Sonia COLOMBO SERRA, Lorena CONSOLINO, Francesca ARENA
  • Publication number: 20210196840
    Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutamic glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.
    Type: Application
    Filed: March 11, 2021
    Publication date: July 1, 2021
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Roberta NAPOLITANO, Luciano LATTUADA, Zsolt BARANYAI, Nicole GUIDOLIN, Giuseppe MARAZZI
  • Patent number: 11021451
    Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: June 1, 2021
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
  • Patent number: 11014942
    Abstract: The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: May 25, 2021
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Roberta Mazzon, Roberta Fretta, Pier Lucio Anelli
  • Patent number: 11007283
    Abstract: The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: May 18, 2021
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
  • Patent number: 10973934
    Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: April 13, 2021
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Roberta Napolitano, Luciano Lattuada, Zsolt Baranyai, Nicole Guidolin, Giuseppe Marazzi
  • Publication number: 20210024500
    Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Application
    Filed: October 1, 2020
    Publication date: January 28, 2021
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Valeria BOI, Roberta NAPOLITANO, Luciano LATTUADA
  • Patent number: 10882849
    Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: January 5, 2021
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Valeria Boi, Roberta Napolitano, Luciano Lattuada
  • Publication number: 20200379070
    Abstract: The present invention relates to on the use of exogenous agents having a pool of mobile proton(s) in CEST-MR imaging to generate Chemical Exchange Rotation Transfer/based CEST contrast, and to a ratiometric-based CEST-MR procedure that comprises using these exogenous agents to set-up CERT-based concentration-independent CEST MR imaging, and as responsive agents to set-up CERT-based concentration independent responsiveness.
    Type: Application
    Filed: December 22, 2016
    Publication date: December 3, 2020
    Applicant: Bracco Imaging S.p.A.
    Inventors: Silvio AIME, Dario Livio LONGO, Sonia COLOMBO SERRA, Lorena CONSOLINO, Francesca ARENA
  • Publication number: 20200376145
    Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutamic acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.
    Type: Application
    Filed: August 6, 2019
    Publication date: December 3, 2020
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Roberta NAPOLITANO, Luciano LATTUADA, Zsolt BARANYAI, Nicole GUIDOLIN, Giuseppe MARAZZI
  • Patent number: 10822371
    Abstract: The present invention discloses a solid-phase process for the preparation of a Near Infra-Red (NIR) fluorescent probe characterized by an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety and used in the guided surgery of tumors and pathologic regions.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: November 3, 2020
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Raphael Campanella, Anthony Clouet, Luciano Lattuada