Patents Assigned to Bracco Imaging S.p.A.
  • Patent number: 12290576
    Abstract: The invention relates to a process for the preparation of dimeric contrast agents for use in Magnetic resonance Imaging (MRI), in particular [?-[1-[bis[2-(hydroxy-?O)-3-[4,7,10-tris[(carboxy-?O)methyl]-1,4,7,10-tetraazacyclododec-1-yl-?N1,?N4,?N7,?N10]propyl]amino]-1-deoxy-D-glucitolate(6-)]]di-gadolinium complex, which includes preparation steps carried out one-pot (without isolation of the obtained intermediate) and precipitation of at least part of free gadolinium metal ions in excess.
    Type: Grant
    Filed: July 26, 2022
    Date of Patent: May 6, 2025
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Andrea Banin, Andrea Barale, Valeria Boi, Sonia Gazzetto, Federica Buonsanti
  • Patent number: 12269790
    Abstract: The invention relates to a process for the preparation of a 2,4,6-triiodo-phenol derivative of formula (II), which is useful as an intermediate for the synthesis of conventional X-ray contrast agents, said process comprising the tri-iodination of the correspondent phenol derivative of said 2,4,6-triiodo-phenol derivative by means of an iodinating system comprising I2 and an oxide or a salt of an element of group 11 of the periodic table.
    Type: Grant
    Filed: April 28, 2023
    Date of Patent: April 8, 2025
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Zsolt Baranyai, Nicol Guidolin, Federica Lazzari, Fulvio Uggeri
  • Publication number: 20250109094
    Abstract: The invention relates to a process for the preparation of a 2,4,6-triiodo-phenol derivative of formula (II), which is useful as an intermediate for the synthesis of conventional X-ray contrast agents, said process comprising the tri-iodination of the correspondent phenol derivative of said 2,4,6-triiodo-phenol derivative by means of an iodinating system comprising I2 and an oxide or a salt of an element of group 11 of the periodic table.
    Type: Application
    Filed: April 28, 2023
    Publication date: April 3, 2025
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Zsolt BARANYAI, Nicol GUIDOLIN, Federica LAZZARI, Fulvio UGGERI
  • Publication number: 20250084066
    Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.
    Type: Application
    Filed: November 25, 2024
    Publication date: March 13, 2025
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Francesco BLASI, Federica BUONSANTI, Federico CRIVELLIN, Andrea FERRARIS, Laura ORIO, Lorena PIZZUTO, Roberta NAPOLITANO, Giovanni VALBUSA
  • Patent number: 12226494
    Abstract: The present invention refers to pharmaceutical compositions comprising a macrocyclic gadolinium complex and a water-soluble polyarylene additive useful in diagnostic imaging as diagnostic agents, in particular as contrast agents, specifically in Magnetic Resonance Imaging (MRI).
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: February 18, 2025
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Giuseppe Ferrauto, Eliana Gianolio, Luciano Lattuada, Alessandro Maiocchi
  • Publication number: 20250051292
    Abstract: The present invention relates to a process for the manufacturing of a mixture comprising the intermediate 1-[bis[2-hydroxy-3-[4,7,10-tris[2-(1,1-dimethylethoxy)-2-oxoethyl]-1,4,7,10-tetraazacyclododec-1-yl]propyl]amino]-1-deoxy-D-glucitol. Such intermediate is useful for the synthesis of the dimeric gadolinium complex [?-[1-[bis[2-(hydroxy-?O)-3-[4,7,10-tris[(carboxy-?O)methyl]-1,4,7,10-tetraazacyclododec-1-yl-?N1,?N4,?N7,?N10]propyl]amino]-1-deoxy-D-glucitolate(6-)]]digadolinium complex, which can be employed as a contrast agent in the field of diagnostic imaging, and in particular of Magnetic Resonance Imaging (MRI).
    Type: Application
    Filed: December 13, 2022
    Publication date: February 13, 2025
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Sonia GAZZETTO, Valeria BOI, Andrea BANIN, Andrea BARALE
  • Publication number: 20250051267
    Abstract: The present invention relates to a novel process for the preparation of 2,4,6-triiodoisophthalic bisamide derivatives, which are useful intermediates in the preparation of non-ionic X-ray contrast agents, starting from the corresponding acyl chloride intermediates which are amidated in a mixture of specific hydrotropic solvents in the presence of a low amount of water. In addition, the invention relates to the use of such hydrotropic solvents in the preparation of said 2,4,6-triiodoisophthalic bisamide intermediates to produce non-ionic X-ray contrast agents.
    Type: Application
    Filed: December 15, 2022
    Publication date: February 13, 2025
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Luciano LATTUADA, Luca BEVERINA, Mauro SASSI, Sara MATTIELLO, Antonio PAPAGNI, Anita ZUCCHI
  • Patent number: 12187708
    Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.
    Type: Grant
    Filed: November 10, 2023
    Date of Patent: January 7, 2025
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Francesco Blasi, Federica Buonsanti, Federico Crivellin, Andrea Ferraris, Laura Orio, Lorena Pizzuto, Roberta Napolitano, Giovanni Valbusa
  • Patent number: 12180550
    Abstract: Disclosed are gene signatures and methods for predicting the recurrence of prostate cancer in prostatectomized subjects. Other objectives of the invention are assay devices and kits for determining the expression levels of specific gene sets correlated to prostate cancer recurrence.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: December 31, 2024
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Andrea Ferraris, Erika Reitano, Alessandro Maiocchi
  • Publication number: 20240425527
    Abstract: The invention relates to a process for the preparation of the gadolinium dimeric contrast agent [p-[1-[bis[2-(hydroxy-KO)-3-[4,7,10-tris[(carboxy-KO)methyl]-1,4,7,10-tetraazacyclododec-1-yl-K/V1,K/V4,K/V7,K/V10]propyl]amino]-1-deoxy-D-glucitolato(6-)]]di-gadolinium complex. Such process includes preparation steps carried out one-pot and without isolation of the obtained intermediates. The gadolinium dimeric contrast agent can be for use in diagnostic imaging, in particular in Magnetic resonance Imaging (MRI).
    Type: Application
    Filed: December 13, 2022
    Publication date: December 26, 2024
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Sonia GAZZETTO, Valeria BOI, Andrea BANIN, Andrea BARALE
  • Publication number: 20240366802
    Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutamic acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.
    Type: Application
    Filed: June 5, 2024
    Publication date: November 7, 2024
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Roberta NAPOLITANO, Luciano LATTUADA, Zsolt BARANYAI, Nicole GUIDOLIN, Giuseppe MARAZZI
  • Patent number: 12129563
    Abstract: The invention is related to a process for preparing a iodinating X-rays contrast agent. More specifically, it relates to a process for the preparation of N,N?-bis-(2,3-dihydroxypropyl)-5-hydroxy-2,4,6-triiodo-1,3-benzenedicarboxaniide (I) by electrochemical iodination of N,N?-(2,3-dihydroxypropyl)-5-hydroxy-1,3-benzenedicarboxamide (II) with molecular iodine (I2) which is in situ electrochemically generated from a source of iodide ions (I?). The iodide ions (I?) are obtained by the dissolution of hydrogen iodide (HI) or an alkali metal iodide in the reaction medium or produced during the reaction of N,N?-(2,3-dihydroxypropyl)-5-hydroxy-1,3-benzenedicarboxamide with I2. The invention also relates to the use of the intermediate compound of formula (I), obtained through the above electrochemical iodination of compound (II), in the preparation of N,N?-bis[2,3-dihydroxypropyl]-5(hydroxyacetyl)methylamino]-2,4,6-triiodo-1,3-benzenedicarboxamide (iomeprol).
    Type: Grant
    Filed: September 22, 2022
    Date of Patent: October 29, 2024
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Luciano Lattuada, Camilla Cavallotti, Giovanni Battista Giovenzana, Fulvio Uggeri, Alessandro Minguzzi, Alberto Vertova, Letizia Sorti, Carlo Morelli
  • Publication number: 20240299594
    Abstract: The invention relates to a process for the manufacturing of a solution of a dimeric C gadolinium complex, such as [?-[1-[bis[2-(hydroxy-xO)-3-[4,7,10-tris[(carboxy-xO)methyl]-1,4,7,10-tetraazacyclododec-1-yl-?N1,?N4, ?N7,?N10]propyl]amino]-1-deoxy-D-glucitolate(6-)]]digadoliniumcomplex, which is useful in the field of diagnostic imaging and of contrast agents in Magnetic Resonance Imaging (MRI), comprising the steps of precipitating a portion of free gadolinium metal ions by means of a precipitating agent. The invention further relates to a process for isolating the dimeric gadolinium complex from said solution, and to the solution and the isolated dimeric gadolinium complex obtainable by such processes.
    Type: Application
    Filed: July 26, 2022
    Publication date: September 12, 2024
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Andrea BANIN, Andrea BARALE, Valeria BOI, Sonia GAZZETTO, Federica BUONSANTI
  • Publication number: 20240269330
    Abstract: The invention relates to a process for the preparation of dimeric contrast agents for use in Magnetic resonance Imaging (MRI), in particular [?-[1-[bis[2-(hydroxy-?O)-3-[4,7,10-tris[(carboxy-?O)methyl]-1,4,7,10-tetraazacyclododec-1-yl-?N1,?N4,?N7,?N10]propyl]amino]-1-deoxy-D-glucitolate(6-)]]di-gadolinium complex, which includes preparation steps carried out one-pot (without isolation of the obtained intermediate) and precipitation of at least part of free gadolinium metal ions in excess.
    Type: Application
    Filed: July 26, 2022
    Publication date: August 15, 2024
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Andrea BANIN, Andrea BARALE, Valeria BOI, Sonia GAZZETTO, Federica BUONSANTI
  • Publication number: 20240271295
    Abstract: The invention is related to a process for preparing a iodinating X-rays contrast agent. More specifically, it relates to a process for the preparation of N,N?-bis-(2,3-dihydroxypropyl)-5-hydroxy-2,4,6-triiodo-1,3-benzenedicarboxaniide (I) by electrochemical iodination of N,N?-(2,3-dihydroxypropyl)-5-hydroxy-1,3-benzenedicarboxamide (II) with molecular iodine (I2) which is in situ electrochemically generated from a source of iodide ions (I?). The iodide ions (I?) are obtained by the dissolution of hydrogen iodide (HI) or an alkali metal iodide in the reaction medium or produced during the reaction of N,N?-(2,3-dihydroxypropyl)-5-hydroxy-1,3-benzenedicarboxamide with I2. The invention also relates to the use of the intermediate compound of formula (I), obtained through the above electrochemical iodination of compound (II), in the preparation of N,N?-bis[2,3-dihydroxypropyl]-5(hydroxyacetyl)methylamino]-2,4,6-triiodo-1,3-benzenedicarboxamide (iomeprol).
    Type: Application
    Filed: September 22, 2022
    Publication date: August 15, 2024
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Luciano LATTUADA, Camilla CAVALLOTTI, Giovanni Battista GIOVENZANA, Fulvio UGGERI, Alessandro MINGUZZI, Alberto VERTOVA, Letizia SORTI, Carlo MORELLI
  • Patent number: 12036289
    Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: July 16, 2024
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Roberta Napolitano, Luciano Lattuada, Zsolt Baranyai, Nicole Guidolin, Giuseppe Marazzi
  • Publication number: 20240199530
    Abstract: The present invention is related to the synthesis of 4-hydroxymethyl-2-oxazolidinone (serinol carbamate, SC), which can be subsequently hydrolyzed to 2-amino-1,3-propanediol (serinol), by reacting glycerol and urea: (I) In general, glycerol is heated with urea and a catalyst, with or without a solvent, to give mainly 4-hydroxymethyl-2-oxazolidinone (serinol carbamate, SC), which is hydrolyzed in the next step to 2-amino-1,3-propanediol (serinol). Alternatively, glycerol 1,2-carbonate can be used instead of glycerol. Serinol obtained by the process of the invention may be used in the synthesis of Iopamidol.
    Type: Application
    Filed: March 21, 2022
    Publication date: June 20, 2024
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Luciano LATTUADA, Giovanni Battista GIOVENZANA, Camilla CAVALLOTTI, Ivan MENEGOTTO
  • Publication number: 20240083880
    Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.
    Type: Application
    Filed: November 10, 2023
    Publication date: March 14, 2024
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Francesco BLASI, Federica BUONSANTI, Federico CRIVELLIN, Andrea FERRARIS, Laura ORIO, Lorena PIZZUTO, Roberta NAPOLITANO, Giovanni VALBUSA
  • Patent number: 11905257
    Abstract: The invention relates to a process for preparing Gadoteridol of formula (I). In particular, the process comprises the use of propylene oxide in the alkylation step of the compound of formula (II), wherein propylene oxide is directly reacted with the compound of formula (II) without being isolated, and wherein propylene oxide is obtained on demand by decomposition of propylene carbonate in the presence of an alkaline or alkaline earth metal halide as catalyst.
    Type: Grant
    Filed: December 1, 2021
    Date of Patent: February 20, 2024
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Roberta Fretta, Luciano Lattuada, Gabriele Meli
  • Patent number: 11851421
    Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.
    Type: Grant
    Filed: June 22, 2021
    Date of Patent: December 26, 2023
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Francesco Blasi, Federica Buonsanti, Federico Crivellin, Andrea Ferraris, Laura Orio, Lorena Pizzuto, Roberta Napolitano, Giovanni Valbusa