Patents Assigned to Bracco Imaging S.p.A.
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Publication number: 20230078638Abstract: The present invention relates to an iron complex having the general formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to a pharmaceutical composition formulated for oral and/or parenteral administration, preferably intravenous, said pharmaceutical composition preferably being formulated as an aqueous solution comprising said complex or salt. The present invention further relates to said complex or a salt thereof or said pharmaceutical composition for use as a contrast agent for magnetic resonance imaging (MRI), as well as a method and a kit for in situ preparation of said complex or salt and said pharmaceutical composition.Type: ApplicationFiled: January 19, 2021Publication date: March 16, 2023Applicant: BRACCO IMAGING S.P.A.Inventor: Camilla CAVALLOTTI
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Publication number: 20230046541Abstract: The present invention relates to the calcium complex of (4RS)(4-carboxy-5,8,11-tris(carboxymethyl)-1-phenyl oxa-5,8,11-triazatridecan-13-oato(5-))pentahydrogen (BOPTA) in the form of a salt, to the process for its preparation and to a formulation comprising said salt.Type: ApplicationFiled: December 17, 2020Publication date: February 16, 2023Applicant: BRACCO IMAGING S.P.A.Inventors: Andrea BANIN, Laura GALIMBERTI, Roberta NAPOLITANO, Roberta FRETTA
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Publication number: 20230040008Abstract: The present invention provides new polypeptide derivatives binding to Human Epidermal Growth Factor Receptor 2 (HER2) and their conjugates thereof, and to their use as a diagnostic agent, particularly for early detection, patient stratification and treatment monitoring of forms of cancer characterized by over-expression of HER2.Type: ApplicationFiled: December 16, 2020Publication date: February 9, 2023Applicant: BRACCO IMAGING S.P.A.Inventors: Erika REITANO, Alessandro MAIOCCHI, Luisa POGGI, Federico CRIVELLIN, Simon HUET, Mathieu CINIER, Olivier KITTEN
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Publication number: 20230040042Abstract: The invention relates to a process for the one-step preparation and isolation of a protected DO3A such as DO3A-tri-tert-butyl ester as a solid salt.Type: ApplicationFiled: December 9, 2020Publication date: February 9, 2023Applicant: BRACCO IMAGING S.P.A.Inventors: Aurelia FERRIGATO, Sonia GAZZETTO
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Publication number: 20220370646Abstract: The present invention relates to pharmaceutical compositions comprising an gadolinium-complex and a saturated macrocyclic tetraamine that find application in diagnostic imaging as diagnostic agents, in particular as contrast agents having improved tolerability, specifically in Magnetic Resonance Imaging (MRI), and to their preparation.Type: ApplicationFiled: October 20, 2020Publication date: November 24, 2022Applicant: BRACCO IMAGING S.P.A.Inventors: Zsolt BARANYAI, Mariangela BOCCALON, Federica BUONSANTI, Federico CRIVELLIN, Alessandro MAIOCCHI, Roberta MAZZON, Fabio TEDOLDI, Fulvio UGGERI
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Publication number: 20220348923Abstract: The present invention provides nucleic acid aptamers binding to the Carbonic Anhydrase IX (CA-IX) enzyme, derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing CA-IX, or as therapeutic agents for prevention or treatment of CA-IX related diseases.Type: ApplicationFiled: September 16, 2020Publication date: November 3, 2022Applicant: BRACCO IMAGING S.P.A.Inventors: Vittorio DE FRANCISCIS, Carla Lucia ESPOSITO, Silvia CATUOGNO, Silvia NUZZO, Alessandro MAIOCCHI, Margherita IABONI, Aldo DI VITO, Erika REITANO, Luisa POGGI
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Publication number: 20220242853Abstract: The present invention relates to the field of optical imaging More particularly, it relates to compounds of the cyanine family characterized by improved physico-chemical and biological properties and to their conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.Type: ApplicationFiled: May 12, 2020Publication date: August 4, 2022Applicant: BRACCO IMAGING S.P.A.Inventors: Francesco BLASI, Chiara BRIOSCHI, Federica BUONSANTI, Luigi MIRAGOLI, Roberta NAPOLITANO, Laura ORIO, Lorena PIZZUTO, Giovanni VALBUSA
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Patent number: 11401262Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: GrantFiled: October 1, 2020Date of Patent: August 2, 2022Assignee: BRACCO IMAGING S.P.A.Inventors: Valeria Boi, Roberta Napolitano, Luciano Lattuada
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Patent number: 11274308Abstract: The present invention provides nucleic acid aptamers binding to the Intercellular Adhesion Molecule-1 (ICAM-1), derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing ICAM-1, or as therapeutic agents for prevention or treatment of ICAM-1-related diseases.Type: GrantFiled: July 24, 2019Date of Patent: March 15, 2022Assignee: BRACCO IMAGING S.P.A.Inventors: Vittorio De Franciscis, Silvia Catuogno, Carla Lucia Esposito, Alessandro Maiocchi, Margherita Iaboni, Luisa Poggi, Erika Reitano
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Publication number: 20220062444Abstract: The present invention refers to pharmaceutical compositions comprising a macrocyclic gadolinium complex and a water-soluble polyarylene additive useful in diagnostic imaging as diagnostic agents, in particular as contrast agents, specifically in Magnetic Resonance Imaging (MRI).Type: ApplicationFiled: December 17, 2019Publication date: March 3, 2022Applicant: BRACCO IMAGING S.P.A.Inventors: Silvio AIME, Giuseppe FERRAUTO, Eliana GIANOLIO, Luciano LATTUADA, Alessandro MAIOCCHI
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Publication number: 20220016275Abstract: A chelating compound of formula (I) or a pharmaceutically acceptable salt thereof and its complexes with metals or radioisotopes thereof. The invention further relates to the preparation of such ligand and complexes as well as to their use as diagnostic or therapeutic agents.Type: ApplicationFiled: November 12, 2019Publication date: January 20, 2022Applicant: BRACCO IMAGING S.P.A.Inventors: Zsolt BARANYAI, Simona GHIANI, Alessandro MAIOCCHI, Ivan HAWALA
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Publication number: 20210395832Abstract: Disclosed are gene signatures and methods for predicting the recurrence of prostate cancer in prostatectomized subjects. Other objectives of the invention are assay devices and kits for determining the expression levels of specific gene sets correlated to prostate cancer recurrence.Type: ApplicationFiled: November 8, 2019Publication date: December 23, 2021Applicant: BRACCO IMAGING S.P.A.Inventors: Andrea FERRARIS, Erika REITANO, Alessandro MAIOCCHI
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Publication number: 20210292762Abstract: The present invention provides nucleic acid aptamers binding to the Intercellular Adhesion Molecule-1 (ICAM-1), derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing ICAM-1, or as therapeutic agents for prevention or treatment of ICAM-1-related diseases.Type: ApplicationFiled: July 24, 2019Publication date: September 23, 2021Applicant: BRACCO IMAGING S.P.A.Inventors: Vittorio DE FRANCISCIS, Silvia CATUOGNO, Carla Lucia ESPOSITO, Alessandro MAIOCCHI, Margherita IABONI, Luisa POGGI, Erika REITANO
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Publication number: 20210263122Abstract: The present invention relates to on the use of exogenous agents having a pool of mobile proton(s) in CEST-MR imaging to generate Chemical Exchange Rotation Transfer-based CEST contrast, and to a ratiometric-based CEST-MR procedure that comprises using these exogenous agents to set-up CERT-based concentration-independent CEST MR imaging, and as responsive agents to set-up CERT-based concentration independent responsiveness.Type: ApplicationFiled: April 30, 2021Publication date: August 26, 2021Applicant: BRACCO IMAGING S.P.A.Inventors: Silvio AIME, Dario Livio LONGO, Sonia COLOMBO SERRA, Lorena CONSOLINO, Francesca ARENA
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Publication number: 20210196840Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutamic glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.Type: ApplicationFiled: March 11, 2021Publication date: July 1, 2021Applicant: BRACCO IMAGING S.P.A.Inventors: Roberta NAPOLITANO, Luciano LATTUADA, Zsolt BARANYAI, Nicole GUIDOLIN, Giuseppe MARAZZI
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Patent number: 11021451Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: GrantFiled: June 30, 2020Date of Patent: June 1, 2021Assignee: BRACCO IMAGING S.P.A.Inventors: Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
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Patent number: 11014942Abstract: The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.Type: GrantFiled: November 8, 2019Date of Patent: May 25, 2021Assignee: BRACCO IMAGING S.P.A.Inventors: Roberta Mazzon, Roberta Fretta, Pier Lucio Anelli
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Patent number: 11007283Abstract: The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: GrantFiled: April 5, 2017Date of Patent: May 18, 2021Assignee: BRACCO IMAGING S.P.A.Inventors: Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
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Patent number: 10973934Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.Type: GrantFiled: August 6, 2019Date of Patent: April 13, 2021Assignee: BRACCO IMAGING S.P.A.Inventors: Roberta Napolitano, Luciano Lattuada, Zsolt Baranyai, Nicole Guidolin, Giuseppe Marazzi
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Publication number: 20210024500Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: ApplicationFiled: October 1, 2020Publication date: January 28, 2021Applicant: BRACCO IMAGING S.P.A.Inventors: Valeria BOI, Roberta NAPOLITANO, Luciano LATTUADA