Abstract: The present invention relates to the use of a NIR fluorescent probe comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety in the fluorescence-guided surgery of pathologic regions and to an optical imaging method that comprises using this fluorescent probe for the identification and demarcation of tumor margins during the surgical resection.
Type:
Grant
Filed:
December 18, 2015
Date of Patent:
June 16, 2020
Assignee:
BRACCO IMAGING S.P.A.
Inventors:
Alessandro Maiocchi, Chiara Brioschi, Fulvio Uggeri, Giovanni Valbusa
Abstract: 1-13C-1,1-Bis(acetoxy(methyl))-2,2?-cyclopropane of formula (I): The compound can be hyperpolarized and used as a contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MR) for the diagnosis of tumor.
Type:
Grant
Filed:
March 25, 2019
Date of Patent:
March 10, 2020
Assignee:
BRACCO IMAGING S.P.A.
Inventors:
Mathilde H. Lerche, Pernille Rose Jensen, Magnus Karlsson, Roberta Napolitano, Claudia Cabella, Luigi Miragoli, Sonia Colombo Serra, Fabio Tedoldi
Abstract: The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.
Type:
Application
Filed:
November 8, 2019
Publication date:
March 5, 2020
Applicant:
BRACCO IMAGING S.P.A.
Inventors:
Roberta MAZZON, Roberta FRETTA, Pier Lucio ANELLI
Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with the paramagnetic metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
Type:
Application
Filed:
December 11, 2017
Publication date:
January 16, 2020
Applicant:
BRACCO IMAGING S.P.A.
Inventors:
Valeria BOI, Roberta NAPOLITANO, Luciano LATTUADA, Giovanni Battista GIOVENZANA
Abstract: The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.
Type:
Grant
Filed:
July 20, 2015
Date of Patent:
December 31, 2019
Assignee:
BRACCO IMAGING S.P.A.
Inventors:
Roberta Mazzon, Roberta Fretta, Pier Lucio Anelli
Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
Type:
Application
Filed:
July 25, 2019
Publication date:
November 14, 2019
Applicant:
BRACCO IMAGING S.P.A.
Inventors:
Valeria BOI, Roberta NAPOLITANO, Luciano LATTUADA
Abstract: The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.
Type:
Grant
Filed:
December 22, 2017
Date of Patent:
October 29, 2019
Assignee:
BRACCO IMAGING S.p.A.
Inventors:
Pier Lucio Anelli, Maria Argese, Valeria Boi, Livio Cavalieri, Laura Galimberti, Sonia Gazzetto, Luciano Lattuada, Federico Maisano, Giovanni Rivolta, Fulvia Vella
Abstract: The present invention relates to a process for the preparation of aqueous solutions of [1-13C]-hyperpolarized carboxylate containing molecules of diagnostic interest that comprises parahydrogenating with molecular para-hydrogen unsaturated alkenyl or alkynyl esters of the concerned 13C-carboxylate molecules.
Abstract: 1-13C-1,1-Bis(acetoxy(methyl))-2,2?-cyclopropane of formula (I): The compound can be hyperpolarized and used as a contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MR) for the diagnosis of tumor.
Type:
Application
Filed:
March 25, 2019
Publication date:
September 12, 2019
Applicant:
BRACCO IMAGING S.P.A.
Inventors:
Mathilde H. LERCHE, Pernille Rose JENSEN, Magnus KARLSSON, Roberta NAPOLITANO, Claudia CABELLA, Luigi MIRAGOLI, Sonia COLOMBO SERRA, Fabio TEDOLDI
Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
Type:
Grant
Filed:
December 12, 2016
Date of Patent:
September 10, 2019
Assignee:
BRACCO IMAGING S.P.A.
Inventors:
Valeria Boi, Roberta Napolitano, Luciano Lattuada
Abstract: The present invention discloses a process for recovery of a boronic acid of formula R3—B(OH)2, wherein R3 is selected from the group consisting of C1-C6 linear or branched alkyl, C3-C6 cycloalkyl, and C6 aryl, optionally substituted with a group selected from the group consisting of methyl, ethyl, n-propyl, i-propyl, n-butyl, sec-butyl, t-butyl, and phenyl, comprising admixing the boronic acid with a water-immiscible organic solvent in a weight ratio between the boronic acid and the water-immiscible organic solvent from 1:10 to 1:20, adding an aqueous solution to a final pH of neutral, and partitioning the boronic acid into an organic water-immiscible phase and recovery of the organic water-immiscible phase.
Abstract: The present invention relates to a process for the preparation of aqueous solutions of [1-13C]-hyperpolarized carboxylate containing molecules of diagnostic interest that comprises parahydrogenating with molecular parahydrogen unsaturated alkenyl or alkynyl esters of the concerned 13C-carboxylate molecules.
Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
Type:
Application
Filed:
February 14, 2019
Publication date:
July 25, 2019
Applicant:
BRACCO IMAGING S.P.A.
Inventors:
Roberta FRETTA, Pietro DELOGU, Fernanda DI GIORGIO, Alfonso NARDELLI, Stefano SGUASSERO, Carlo Felice VISCARDI
Abstract: The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.
Abstract: The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.
Abstract: The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty add; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindele derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.
Type:
Application
Filed:
January 31, 2019
Publication date:
June 6, 2019
Applicant:
BRACCO IMAGING S.P.A.
Inventors:
Simona GHIANI, Alessandro MAIOCCHI, Lara CAMINITI, Luigi MIRAGOLI
Abstract: The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
Type:
Application
Filed:
April 5, 2017
Publication date:
June 6, 2019
Applicant:
BRACCO IMAGING S.P.A.
Inventors:
Luciano LATTUADA, Roberta NAPOLITANO, Valeria BOI, Massimo VISIGALLI, Silvio AIME, Giovanni Battista GIOVENZANA, Alberto FRINGUELLO MINGO
Abstract: The present invention relates to novel substituted ethylenediaminetetraacetic acid bisamide derivatives, their complexes with Mn(II) ion and the use thereof as contrast agents for Magnetic Resonance Imaging (MRI) analysis.
Type:
Grant
Filed:
February 25, 2016
Date of Patent:
April 23, 2019
Assignee:
Bracco Imaging S.P.A.
Inventors:
Zsolt Baranyai, Zoltán Garda, Simona Ghiani, Ferenc Krisztián Kálmán, László Krusper, Alessandro Maiocchi, Gyula Tircsó, Imre Toth
Abstract: The invention relates to a method of Magnetic Resonance (MR) detection, in particular 13C-MR detection, by using a diagnostic medium comprising a hyperpolarized ester, in particular ethyl acetoacetate. The method comprises the detection of the MR signal of a hyperpolarized 13C carboxylic ester and of its respective hyperpolarized metabolite.
Type:
Grant
Filed:
January 30, 2014
Date of Patent:
April 23, 2019
Assignee:
BRACCO IMAGING S.P.A.
Inventors:
Pernille Rose Jensen, Lerche H. Mathilde, Magnus Karlsson, Claudia Cabella, Sonia Colombo Serra, Luigi Miragoli, Luca Venturi, Fabio Tedoldi
Abstract: The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.
Type:
Grant
Filed:
May 28, 2014
Date of Patent:
April 9, 2019
Assignee:
BRACCO IMAGING S.P.A.
Inventors:
Simona Ghiani, Alessandro Maiocchi, Lara Caminiti, Luigi Miragoli