Patents Assigned to Bracco Imaging S.p.A.
  • Process for the iodination of phenolic derivatives
    Patent number: 8766003
    Abstract: The present invention relates to a process for the preparation of iodinated phenols; in particular; it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted phenol compounds to the corresponding 3,5-disubstituted-2,4,6-triiodophenols, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves.
    Type: Grant
    Filed: June 9, 2011
    Date of Patent: July 1, 2014
    Assignee: Bracco Imaging S.p.A.
    Inventors: Attilio Citterio, Elisa Battistini, Davide Belnome, Federica Buonsanti, Luciano Lattuada, Gabriella Leonardi, Fulvio Uggeri, Evelin Vignale, Massimo Visigalli
  • INTEGRIN TARGETED SYNTHETIC LIGANDS FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
    Publication number: 20140178302
    Abstract: The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.
    Type: Application
    Filed: January 13, 2014
    Publication date: June 26, 2014
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Luciano LATTUADA, Pierfrancesco Morosini, Fulvio Uggeri, Silvio Aime, Enzo Terreno, Daniela Delli Castelli, Carlo Scolastico, Leonardo Manzoni, Daniela Arosio
  • Process for the preparation of thyroid hormones and salts thereof
    Patent number: 8759572
    Abstract: The present invention generally refers to a process for the preparation of L-thyroxine derivatives. More in particular, the present invention relates to a iodination reaction of an aromatic derivative with an appropriate iodinating agent, so to afford the related iodinated compound as disodium salt, which may represent a useful intermediate for the synthesis of the L-thyroxine mono-sodium salt, and the free form thereof.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: June 24, 2014
    Assignee: Bracco Imaging S.p.A.
    Inventors: Carlo Felice Viscardi, Enrico Cappelletti, Laura Galimberti, Sonia Gazzetto, Loredana Sini
  • NEW USE OF L-HISTIDINE AND DERIVATIVES THEREOF
    Publication number: 20140155449
    Abstract: The present invention discloses the use of L-Histidine to reduce Gadolinium accumulation into target organs, preventing its toxic effects, after administration of gadolinium based contrast agents. The invention thus, also disclose the use of L-Histidine to prevent the NSF syndrome in patients with renal functionality impairment. A kit of part is also disclosed by the use of which toxicity associated to free Gd3+, deriving from GDBCA, is prevented by oral administration of L-histidine before administration of the contrast agent. A method for the prevention of toxic metal accumulation which consists in the administration, preferably by the oral route, of L-Histidine is also disclosed. L-Histidine is preferably administered a s a single oral dose comprised from 0.2-20 g.
    Type: Application
    Filed: July 24, 2012
    Publication date: June 5, 2014
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Baranyai Zsolt, Ernö Brücher, Simona Bussi, Alessandro Maiocchi, Fulvio Uggeri
  • VALIDATION TECHNIQUES FOR FLUID DELIVERY SYSTEMS
    Publication number: 20140154670
    Abstract: A fluid delivery system may include a container that houses a medical fluid, a fluid pressurizing unit, and a fluid transfer set that transfers the medical fluid from the container to the fluid pressurizing unit. To validate the integrity and sterility of the fluid delivery system, the system may undergo testing protocols to evaluate the susceptibility of the system to pathogenic ingress, chemical degradation, and/or fluid cross-contamination between patient fluid delivery procedures. The testing protocols may help ensure that delivery system components used during multiple different fluid delivery procedures perform as well as if the components were replaced after each fluid delivery procedure.
    Type: Application
    Filed: December 5, 2013
    Publication date: June 5, 2014
    Applicant: Bracco Imaging S.p.A
    Inventors: Robert C. Williams, JR., Patrice Marchildon
  • VALIDATION TECHNIQUES FOR FLUID DELIVERY SYSTEMS
    Publication number: 20140154671
    Abstract: A fluid delivery system may include a container that houses a medical fluid, a fluid pressurizing unit, and a fluid transfer set that transfers the medical fluid from the container to the fluid pressurizing unit. To validate the integrity and sterility of the fluid delivery system, the system may undergo testing protocols to evaluate the susceptibility of the system to pathogenic ingress, chemical degradation, and/or fluid cross-contamination between patient fluid delivery procedures. The testing protocols may help ensure that delivery system components used during multiple different fluid delivery procedures perform as well as if the components were replaced after each fluid delivery procedure.
    Type: Application
    Filed: December 5, 2013
    Publication date: June 5, 2014
    Applicant: Bracco Imaging S.p.A
    Inventors: Robert C. Williams, JR., Patrice Marchildon
  • Integrin targeted synthetic ligands for diagnostic and therapeutic applications
    Patent number: 8636977
    Abstract: The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: January 28, 2014
    Assignee: Bracco Imaging S.p.A.
    Inventors: Luciano Lattuada, Pierfrancesco Morosini, Fulvio Uggeri, Silvio Aime, Enzo Terreno, Daniela Delli Castelli, Carlo Scolastico, Leonardo Manzoni, Daniela Arosio
  • Process For The Preparation Of A Sulfated Derivative Of 3,5-Diiodo-O-[3-Iodophenyl]-L-Tyrosine
    Publication number: 20140024717
    Abstract: The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chloro-sulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.
    Type: Application
    Filed: April 5, 2012
    Publication date: January 23, 2014
    Applicant: BRACCO IMAGING S.p.A.
    Inventors: Pier Lucio Anelli, Maria Argese, Luciano Lattuada, Federico Maisano, Sonia Gazzetto, Laura Galimberti, Valeria Boi, Giovanni Rivolta, Livio Cavalieri, Fulvia Vella
  • Process for the preparation of iodinated contrast agent
    Patent number: 8624061
    Abstract: The present invention relies on a process for the preparation of non ionic iodinated contrast agents and, in more details, it relates to a process for the preparation of Iopamidol in high yields and with a high degree of purity. In more details, the invention discloses a process for the preparation of a compound of formula (III) comprising the condensation reaction a compound of formula (II) with 2-amino-1,3-propandiol, being said reaction carried out in an aprotic dipolar solvent and in the presence of an alkaline or alkaline rare earth metal oxide or hydroxide.
    Type: Grant
    Filed: November 2, 2009
    Date of Patent: January 7, 2014
    Assignee: Bracco Imaging S.p.A.
    Inventors: Silvia Ceragioli, Giovanni Ciarciello, Salvatore Incandela, Pietro Minotti
  • MRI-CEST diagnostic technique based on non-punctual analysis
    Patent number: 8611981
    Abstract: An embodiment in the MRI-CEST field is proposed for analyzing a body-part, which includes a CEST agent providing a magnetization transfer with a bulk substrate of the body-part. A corresponding diagnostic system includes input means for providing an input map including a plurality of input elements each one for a corresponding location of the body-part; each input element is indicative of a spectrum of a magnetic response of the location, which spectrum includes the magnetic response at an agent frequency of resonance of the contrast agent (with the agent frequency that is at an agent offset of frequency from a bulk frequency of resonance of the bulk substance), and at a reference frequency at the opposite of the agent offset from the bulk frequency.
    Type: Grant
    Filed: August 18, 2009
    Date of Patent: December 17, 2013
    Assignee: Bracco Imaging S.p.A.
    Inventors: Silvio Aime, Daniela Delli Castelli, Dario Livio Longo, Joseph Stancanello, Enzo Terreno, Fulvio Uggeri
  • Contrast agents endowed with high relaxivity
    Patent number: 8540966
    Abstract: The present invention relates to a novel class of paramagnetic ion-based contrast agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or more polyhydroxylated chain, that show a pharmacokinetic profile analogous to that of the commonly used T1-general extravascular agents (NSA) but are further characterized by a higher relaxivity.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: September 24, 2013
    Assignee: Bracco Imaging S.p.A.
    Inventors: Silvio Aime, Matteo Galli, Luciano Lattuada, Pierfrancesco Morosini, Fulvio Uggeri, Kondareddiar Ramalingam
  • Method and apparatus for producing stationary intense wave fields of arbitrary shape
    Patent number: 8509928
    Abstract: Method for producing a stationary wave field of arbitrary shape comprising the steps of defining at least one volume being limited in the direction of the axis of propagation of a beam, of the type 0?z?L; defining an intensity pattern within the said region 0?z?L by a function F(z), describing the said localized and stationary intensity pattern, which is approximated by means of a Fourier expansion or by a similar expansion in terms of (trigonometric) orthogonal functions; providing a generic superposition of Bessel or other beams highly transversally confined; calculating the maximum number of superimposed Bessel beams the amplitudes, the phase velocities and the relative phases of each Bessel beam of the superposition, and the transverse and longitudinal wavenumbers of each Bessel beam of the superposition.
    Type: Grant
    Filed: May 23, 2005
    Date of Patent: August 13, 2013
    Assignee: Bracco Imaging S.P.A.
    Inventors: Valerio Abate, Cesar Augusto Dartora, Hugo Enrique Hernàndez Figueroa, Marco Mattiuzzi, Kleber Zuza Nobrega, Michel Zamboni Rached, Erasmo Recami
  • CEST SYSTEMS EXHIBITING A CONCENTRATION INDEPENDENT RESPONSIVENESS
    Publication number: 20130195768
    Abstract: The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.
    Type: Application
    Filed: November 4, 2011
    Publication date: August 1, 2013
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Daniela Delli Castelli, Franco Fedeli, Dario Livio Longo, Enzo Terreno, Fulvio Uggeri
  • Finger-Grip Device For Medical Syringe Or Cartridge
    Publication number: 20130178737
    Abstract: The present invention relates to a finger-grip device designed to be placed on the flange of a cylindrical barrel of a medical syringe or cartridge, increasing the contact surface with the fingers of the operator during the injection or withdrawal of fluids to or from a patient, characterised in that it does not stop or hinder the run of the plunger within the cylindrical barrel.
    Type: Application
    Filed: September 29, 2011
    Publication date: July 11, 2013
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Pier Lucio Anelli, Mauro Citterio, Paolo Morosi
  • GASTRIN RELEASING PEPTIDE COMPOUNDS
    Publication number: 20130136691
    Abstract: Methods and compositions for diagnosing, staging disease, monitoring therapeutic effect of drugs and imaging a patient are provided, including radiopharmaceutical formulations. Compositions comprising Ga-AMBA complexed with a radioactive isotope are provided; as are methods of imaging Gastrin Releasing Peptide receptor (GRP-R) bearing tissue and methods of diagnosing or staging disease in patients suspected of having disease associated with aberrant GRP-R function. Further, methods of monitoring therapeutic effect of a drug targeted to a receptor that crosstalks with GRP-R are provided; as are methods of pre-dosing/co-dosing non-target tissues containing GRP-R.
    Type: Application
    Filed: May 19, 2009
    Publication date: May 30, 2013
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Adrian D. Nunn, Laura Lantry
  • Process For The Preparation Of Contrast Agents
    Publication number: 20130131382
    Abstract: The present invention relates to a process for the preparation of 5-[(2-hydroxyacyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamidic derivatives comprising the Smiles rearrangement of a suitable precursor, by contact of an aqueous solution of this latter with an anion exchanger solid phase.
    Type: Application
    Filed: July 14, 2011
    Publication date: May 23, 2013
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Pier Lucio Anelli, Marino Brocchetta, Enrico Cappelletti, Ornella Gazzotti
  • Gastrin releasing peptide compounds
    Patent number: 8444954
    Abstract: New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are as defined herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: May 21, 2013
    Assignee: Bracco Imaging S.p.A.
    Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Edmund Marinelli, Palaniappa Nanjappan, Adrian Nunn, Natarajan Raju, Kondareddiar Ramalingam, Rolf E. Swenson, Michael Tweedle
  • Process For Preparing Hyperpolarized Substrates And Method For MRI
    Publication number: 20130096420
    Abstract: The present invention generally relates to a process for the preparation of aqueous solutions of hyperpolarized molecules ready for use in in-vivo MR diagnostic imaging, the use thereof as MRI contrast agent in investigation methods for producing diagnostic MR images of a human or non-human animal body organ, region or tissue.
    Type: Application
    Filed: April 8, 2011
    Publication date: April 18, 2013
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Giovanni Battista Giovenzana, Fabio Tedoldi, Alessandro Maiocchi, Fulvio Uggeri, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Massimo Visigalli, Marco Crosetti, Luisa Poggi
  • Gastrin releasing peptide compounds
    Patent number: 8420053
    Abstract: Improved compounds for use in diagnostic imaging or therapy having the formula M-N-O-P-G, wherein M is an optical label or a metal chelator (in the form complexed with a metal radionuclide or not), N-O-P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound are further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.
    Type: Grant
    Filed: August 31, 2009
    Date of Patent: April 16, 2013
    Assignee: Bracco Imaging S.p.A.
    Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Edmund Marinelli, Palaniappa Nanjappan, Natarajan Raju, Kondareddiar Ramalingam, Rolf E. Swenson, Michael Tweedle
  • Gastrin releasing peptide compounds
    Patent number: 8420050
    Abstract: Novel methods of treating prostate tumors or of delaying the progression of prostate tumors are also provided, including, methods of treating bone or soft tissue metastases of prostate cancer methods for treating hormone sensitive and hormone refractory prostate cancer, methods for delaying the progression of hormone sensitive prostate cancer, for facilitating combination therapy in patients with hormone sensitive prostate cancer and for decreasing aberrant vascular permeability in patients with hormone sensitive prostate cancer, said methods comprising the step of administering to a subject a dose comprising an amount of radioactively labeled L70, N-[4-[[[[[4,7,10-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]acetyl]amino]benzoyl]-L-glutaminyl-L-tryptophyl-L-alanyl-L-valyl-glycyl-L-histidyl-L-leucyl-L-methioninamide.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: April 16, 2013
    Assignee: Bracco Imaging S.p.A.
    Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian D. Nunn, Natarajan Raju, Kondareddiar Ramalingam, Rolf E. Swenson, Michael F. Tweedle, Mary Ellen Maddalena