Patents Assigned to Bracco Imaging S.p.A.
  • HYPERPOLARIZED ESTERS AS METABOLIC MARKERS IN MR
    Publication number: 20150374854
    Abstract: The invention relates to a method of Magnetic Resonance (MR) detection, in particular 13C-MR detection, by using a diagnostic medium comprising a hyperpolarized ester, in particular ethyl acetoacetate. The method comprises the detection of the MR signal of a hyperpolarized 13C carboxylic ester and of its respective hyperpolarized metabolite.
    Type: Application
    Filed: January 30, 2014
    Publication date: December 31, 2015
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Pernille Rose JENSEN, LERCHE H. Mathilde, Magnus KARLSSON, Claudia CABELLA, Sonia COLOMBO SERRA, Luigi MIRAGOLI, Luca VENTURI, Fabio TEDOLDI
  • Process for the iodination of aromatic compounds
    Patent number: 9193659
    Abstract: The present invention relates to a process for the preparation of iodinated phenols, —in particular, it relates to a process including the electrochemical iodination of 3,5-disubstituted phenols of formula (1) to the corresponding 3,5-disubstituted-2, 4,6-triiodophenols of formula (2), which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. Furthermore, the present invention includes the electrochemical iodination of 3, 5- disubstituted anilines of formula (6) to the corresponding 3,5-disubstituted-2,4,6-triiodoanilins of formula (7).
    Type: Grant
    Filed: February 16, 2009
    Date of Patent: November 24, 2015
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Giovanni Battista Giovenzana, Camilla Cavallotti, Luciano Lattuada, Fulvio Uggeri
  • CONTINUOUS PROCESS FOR THE PREPARATION OF (S)-2-ACETYLOXYPROPIONIC ACID CHLORIDE
    Publication number: 20150329464
    Abstract: The present invention relates to a continuous method for the preparation of (S)-2-acetyloxypropionic acid from an aqueous solution of lactic acid and acetic anhydride, in acetic acid. (S)-2-acetyloxypropionic acid is used for the preparation of (S)-2-acetyloxypropionic acid chloride, an essential intermediate compound for the preparation of lopamidol and has to be industrially produced with high purity and suitable quality for producing lopamidol according to the Pharmacopoeia requirements. The continuous process according to the invention, comprises therefore also the chlorination steps of (S)-2-acetyloxypropionic acid with thionyl chloride to give the corresponding (S)-2-acetyloxypropionic acid chloride which is further distilled to give the suitable purity characteristics for its use for the preparation of non-ionic iodinated contrast agents as lopamidol.
    Type: Application
    Filed: December 4, 2013
    Publication date: November 19, 2015
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvia CERAGIOLI, Pietro DELOGU, Armando MORTILLARO, Alfonso NARDELLI, Stefano SGUASSERO, Rosario VELARDI, Carlo Felice VISCARDI
  • Process for the preparation of a iodinating agent
    Patent number: 9157156
    Abstract: The present invention describes a process for the synthesis of a iodinating agent, being said iodinating agent iodine chloride (ICI.) In particular, the present invention relates to a process for the electrochemical preparation of ICI, as a useful iodinating agent in the preparation of iodinated organic compounds for use as contrast agents or their precursors in the synthesis of the same.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: October 13, 2015
    Assignee: Bracco Imaging S.P.A.
    Inventors: Pier Lucio Anelli, Carlo Felice Viscardi, Pietro Delogu, Fabrizio Goffredi, Alfonso Nardelli, Giovanni Battista Giovenzana
  • HYPERPOLARIZED 2-OXOGLUTARATE AS METABOLIC AGENT IN MR
    Publication number: 20150273086
    Abstract: Hyperpolarized 1-13C-2-oxoglutarate as contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MRI) for use in the diagnosis of cancer. In particular, upon administration of said 1-13C-2-oxoglutarate, signals of 1-13C-glutamate are detected. More in particular, different MR signals from 13C nuclei are detected and compared, said comparison being useful to determine a difference between tumor and non-tumor tissues, to determine the aggressiveness of a tumor or the efficacy of an anti-tumor therapy.
    Type: Application
    Filed: October 24, 2013
    Publication date: October 1, 2015
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Claudia Cabella, Lara Caminiti, Sonia Colombo Serra, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Luigi Miragoli, Luisa Poggi, Fabio Tedoldi, Luca Venturi
  • Paramagnetic Solid Lipid Nanoparticles (pSLNs) Containing Metal Amphiphilic Complexes For MRI
    Publication number: 20150258221
    Abstract: The present invention relates to paramagnetic solid lipid nanoparticles (pSLNs) comprising an amphiphilic paramagnetic metal chelating moiety selected from: a diazepine derivative of Formula I and a tetraazocyclododecane derivative of Formula (II): being said chelating moiety complexed to a paramagnetic metal ion selected from the group consisting of: Gd(III), Mn(II), Cr(III), Cu(II), Fe(III), Pr(III), Nd(III), Sm(III), Tb(III), Yb(III), Dy(III), Ho(III) and Er(III), or salts thereof. The invention further relates to the process for preparation of said solid lipid nanoparticles comprising amphiphilic complexes of paramagnetic metals (pSLNs) and to the use of pSLNs as MRI contrast agents in the diagnostic field.
    Type: Application
    Filed: September 6, 2013
    Publication date: September 17, 2015
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Chiara Brioschi, Claudia Cabella, Simona Ghiani, Alessandro Maiocchi, Luigi Miragoli, Massimo Visigalli
  • Process for the preparation of triiodinated carboxylic aromatic derivatives
    Patent number: 9096495
    Abstract: The present invention relates to a process for the preparation of given carboxamido compounds, in particular of 2,4,6-triiodoisophthalic acid derivatives, as useful intermediates for the preparation of X-ray contrast media among which is iopamidol. The said process comprises reacting suitable N-sulfinyl intermediate compounds with a commercially available ?-hydroxyacid or a salt thereof.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: August 4, 2015
    Assignee: Bracco Imaging S.P.A.
    Inventors: Pier Lucio Anelli, Marino Brocchetta, Roberta Fretta, Luciano Lattuada, Armando Mortillaro
  • Process For The Preparation Of Chelated Compounds
    Publication number: 20150158887
    Abstract: The present invention generally relies on a process for the preparation of chelated compounds, comprising the selective interaction between a solid matrix and a chelating agent. In more details, the present invention enables the preparation of chelated compounds useful as diagnostic agents, in high yields and in a reliable way.
    Type: Application
    Filed: February 16, 2015
    Publication date: June 11, 2015
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Federico MAISANO, Federico CRIVELLIN
  • TRIARYLMETHYL RADICALS
    Publication number: 20150151009
    Abstract: New radical compounds, useful in the field of MRI imaging of formula (I). The radical compounds are in particular new triarylmethyl (“trityl”) radicals which can be used as polarizing agents for polarizing a molecule in the DNP process.
    Type: Application
    Filed: July 4, 2013
    Publication date: June 4, 2015
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Roberta Napolitano, Fabio Tedoldi, Massimo Visigalli
  • HYPERPOLARIZED AMINO ACIDS
    Publication number: 20150118159
    Abstract: Method for manufacturing a hyperpolarized amino acid, in particular glutamine, which substantially limits the formation of by-products, with respect to conventional aqueous preparations of sodium hydroxide with amino acids. The amino acid is in particular admixed with the hydroxide in the substantial absence of water and the dry mixture is dissolved in an anhydrous solvent in the presence of a polarizing agent. The obtained mixture is then subjected to a DNP process and can be used in metabolic MR imaging.
    Type: Application
    Filed: March 28, 2013
    Publication date: April 30, 2015
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche
  • Use of L-Histidine and derivatives thereof
    Patent number: 9012483
    Abstract: The present invention discloses the use of L-Histidine to reduce Gadolinium accumulation into target organs, preventing its toxic effects, after administration of gadolinium based contrast agents. The invention thus, also disclose the use of L-Histidine to prevent the NSF syndrome in patients with renal functionality impairment. A kit of part is also disclosed by the use of which toxicity associated to free Gd3+, deriving from GDBCA, is prevented by oral administration of L-histidine before administration of the contrast agent. A method for the prevention of toxic metal accumulation which consists in the administration, preferably by the oral route, of L-Histidine is also disclosed. L-Histidine is preferably administered as a single oral dose comprised from 0.2-20 g.
    Type: Grant
    Filed: July 24, 2012
    Date of Patent: April 21, 2015
    Assignee: Bracco Imaging S.p.A.
    Inventors: Baranyai Zsolt, Ernö Brücher, Simona Bussi, Alessandro Maiocchi, Fulvio Uggeri
  • Process for the preparation of chelated compound
    Patent number: 8987508
    Abstract: The present invention generally relies on a process for the preparation of chelated compounds, comprising the selective interaction between a solid matrix and a chelating agent. In more details, the present invention enables the preparation of chelated compounds useful as diagnostic agents, in high yields and in a reliable way.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: March 24, 2015
    Assignee: Bracco Imaging S.p.A.
    Inventors: Federico Maisano, Federico Crivellin
  • Process for the preparation of aqueous solutions of hyperpolarized molecules
    Patent number: 8961933
    Abstract: The invention relates to a one-step process for the preparation of aqueous solutions of hyperpolarized molecules in which, in a single step, the said hyperpolarized molecules are separated from the crude solution by means of a fast phase-transfer extraction and isolated in an impurity-free aqueous solution, ready for use in the MRI diagnostic imaging of organs, region or tissues of the human or animal body.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: February 24, 2015
    Assignee: Bracco Imaging S.p.A.
    Inventors: Francesca Reineri, Alessandra Viale, Giovanni Battista Giovenzana, Daniela Santelia, Walter Dastru′, Roberto Gobetto, Silvio Aime, Fulvio Uggeri
  • Agents for magnetic imaging method
    Patent number: 8961927
    Abstract: The invention provides MRI detectable species of formula (I) Dp-Sn-Nm??(I) wherein D is a MRI detectable moiety S is a spacer N is a molecule of a nutrient or pseudo-nutrient n is 0 or an integer m is an integer and p is an integer. These compounds are useful for internalizing into tumor cells an amount of the MRI detectable moiety that is distinguishably higher than the amount internalized in normal healthy cells thus allowing the diagnosis of tumors. The internalization of the MRI detectable moiety involves the nutrients or pseudo-nutrients transporting system. Preferred compounds of formula (I) are those wherein D is the chelated complex of a paramagnetic metal ion.
    Type: Grant
    Filed: July 2, 2010
    Date of Patent: February 24, 2015
    Assignee: Bracco Imaging S.p.A.
    Inventors: Silvio Aime, Valentina Mainero, Simonetta Chirich Geninatti, Claudia Cabella
  • New Class Of Diazepine Derivative Chelating Agents And Complexes With Paramagnetic Metals Thereof As MRI Contrast Agents
    Publication number: 20150037261
    Abstract: The present invention relates to a new class of diazepine-derivatives as chelating agents for paramagnetic metal ions, the process for their preparation, and use of such paramagnetic complexes as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Application
    Filed: March 13, 2013
    Publication date: February 5, 2015
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Lorena Beltrami, Luciano Lattuada, Alessandro Maiocchi, Massimo Visigalli, Loredana Sini
  • Composition Comprising Acetic Anhydride And A Gadolinium Complex, And Method For The Use In Hyperpolarisation In MRI Analysis
    Publication number: 20140343402
    Abstract: The present invention generally relates to a composition comprising acetic anhydride, a DNP agent and a gadolinium complex and its use for the preparation of hyperpolarised imaging agent for MR diagnostic analysis.
    Type: Application
    Filed: December 3, 2012
    Publication date: November 20, 2014
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Sonia Colombo Serra, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Fabio Tedoldi, Massimo Visigalli
  • Process for the preparation of contrast agents
    Patent number: 8835685
    Abstract: The present invention relates to a process for the preparation of 5-[(2-hydroxyacyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamidic derivatives comprising the Smiles rearrangement of a suitable precursor, by contact of an aqueous solution of this latter with an anion exchanger solid phase.
    Type: Grant
    Filed: July 14, 2011
    Date of Patent: September 16, 2014
    Assignee: Bracco Imaging S.p.A.
    Inventors: Pier Lucio Anelli, Marino Brocchetta, Enrico Cappelletti, Ornella Gazzotti
  • Process For The Preparation Of Hyperpolarized Derivatives For Use In MRI Analysis
    Publication number: 20140257085
    Abstract: The present invention relates to a process for the preparation of aqueous solutions of hyperpolarized carboxylic organic acids ready for use in in-vivo MR diagnostic imaging, and the use of the corresponding anhydrides or esters as glass-forming agents.
    Type: Application
    Filed: October 11, 2012
    Publication date: September 11, 2014
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Sonia Colombo Serra, Giovanni Battista Giovenzana, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Fabio Tedoldi
  • Process For The Preparation Of A Sulfated Derivative Of 3,5-Diiodo-O-[3-Iodophenyl]-L-Tyrosine
    Publication number: 20140221477
    Abstract: The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.
    Type: Application
    Filed: April 10, 2014
    Publication date: August 7, 2014
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Pier Lucio ANELLI, Maria ARGESE, Valeria BOI, Livio CAVALIERI, Laura GALIMBERTI, Sonia GAZZETTO, Luciano LATTUADA, Fulvia VELLA
  • MRI contrast agents endowed with concentration independent responsiveness
    Patent number: 8784778
    Abstract: The present invention relates to a method for the in vivo, ex vivo, or in vitro determination of physical or chemical parameters of diagnostic interest by use of a slow tumbling paramagnetic agent that is responsive to changes of said physical or chemical parameter through changes in the R2p/R1p ratio allowing the determination of the said parameter in a manner that is independent on the actual agent concentration.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: July 22, 2014
    Assignee: Bracco Imaging S.p.A.
    Inventors: Silvio Aime, Enzo Terreno