Patents Assigned to Brigham and Women's Hospital
  • Publication number: 20200288980
    Abstract: An automated system and method is provided for biotype extraction and biomarker discovery from task-based fMRI imaging data. The system and method may include automatically mapping a localizome, such as a task-condition/contrast/population-specific brain functional localizome, based on fMRI data and automatically selecting and sorting brain regions or brain nodes to produce a subset of functional brain regions or brain nodes. A report may then be generated indicating that the subject has a particular brain circuit pattern of activity and connectivity associated with one or more symptoms of the given mental disorder, treatments, or associated with normal brain functions, based upon the extracted biosignatures by searching for the optimal multivariate classifier with least dimensionality in the brain functional localizome.
    Type: Application
    Filed: October 3, 2018
    Publication date: September 17, 2020
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Emily Stern, David Silbersweig, Hong Pan
  • Patent number: 10774124
    Abstract: The present invention is directed stromal cell derived factor-1 peptides that have been mutated to make them resistant to digestion by the proteases dipeptidyl peptidase IV (DPPIV) and matrix metalloproteinase-2 (MMP-2) but which maintain the ability of native SDF-1 to attract T cells. The mutants may be attached to membranes formed by self-assembling peptides and then implanted at sites of tissue damage to help promote repair.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: September 15, 2020
    Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Richard T. Lee, Vincent Segers
  • Patent number: 10765489
    Abstract: Exemplary relates to medical devices and in particular to a tool placement manipulator with multiple rotary guides and rotation bodies, the rotation bodies being free rotationally to the ring shaped rotary guides and rotational axis of the first rotary guide being slanted with respect to the rotational axis of the second rotary guide. The tool placement manipulator has at least one socket and at least one transmission element that transmits torques from the socket to rotation bodies.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: September 8, 2020
    Assignees: Canon U.S.A., Inc., The Brigham and Women's Hospital Inc.
    Inventors: Peter Denes Jakab, Nobuhiko Hata, Takahisa Kato, Peter Tia
  • Patent number: 10768181
    Abstract: Provided herein are methods of detecting an antibody directed against a pathogen and uses thereof. One aspect provided herein relates to a method for detecting an antibody against a pathogen in a subject, the method comprising: (a) contacting a reaction sample comprising a display library with a biological sample comprising antibodies, wherein the display library comprises a plurality of peptides derived from a plurality of pathogens, and (b) detecting a peptide bound to at least one antibody, thereby detecting an antibody capable of binding the peptide.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: September 8, 2020
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Stephen J. Elledge, Harry B. Larman, Tomasz Kula, George Xu
  • Patent number: 10769765
    Abstract: Method and system for lensless, shadow optical imaging. Formation of a hologram shadow image having higher spatial resolution and lower noise level is accomplished by processing image information contained in multiple individual hologram shadow image frames acquired either under conditions of relative shift between point light source and the detector of the system or under stationary conditions, when system remains fixed in space and is devoid of any relative movement during the process of acquisition of individual image frames.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: September 8, 2020
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Antonio C. Sobieranski, Utkan Demirci, Huseyin C. Tekin, Fatih Inci
  • Patent number: 10761173
    Abstract: A system and method for imaging a subject includes a first imaging pulse sequence having gradient blips along an x-direction and a y-direction to acquire calibration image data from multiple slices. The imaging pulse sequence also includes a plurality of Z-shimming gradient blips coincident in time with the gradient blips along the x- and y-directions and varied within each slice. A plurality of calibration images are reconstructed from the calibration image data and a comparison image is formed by selecting an image from the calibration images corresponding to at least one of the varied Z-shimming gradient blips for each slice to determine a desired value of the Z-shimming gradient blips. The desired values are used to perform a second pulse sequence to acquire clinical image data from the subject. The second pulse sequence is used to acquire clinical images having been compensated for magnetic susceptibility variations within the subject.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: September 1, 2020
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Emily Stern, David Silbersweig, Hong Pan, Yihong Yang, Hong Gu
  • Patent number: 10748451
    Abstract: Systems and methods for generating three-dimensional fluid flow simulations from two-dimensional (2D) image data are provided. Data is segmented from 2D images of a sample having a biological structure with fluid flow therethrough. Three-dimensional (3D) geometries are generated from the segmented data, and then a 3D reconstruction of the biological structure is generated from the 3D geometries. This 3D geometric computational analysis tool can be used to evaluate fluid dynamics and hemodynamics in the context of the structure anatomy and geometry.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: August 18, 2020
    Assignees: DUKE UNIVERSITY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Amanda Randles, Jane Leopold
  • Patent number: 10736848
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.
    Type: Grant
    Filed: October 12, 2008
    Date of Patent: August 11, 2020
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., President and Fellows of Harvard College, The Children's Medical Center Corporation
    Inventors: Ulrich H. Von Andrian, Omid C. Farokhzad, Robert S. Langer, Tobias Junt, Elliott Ashley Moseman, Liangfang Zhang, Pamela Basto, Matteo Iannacone, Frank Alexis
  • Patent number: 10736968
    Abstract: The present disclosure relates generally to Cellular Signalling inhibitors of compound of Formula I, compositions and formulations comprising the same, methods, processes, and uses thereof. In particular, the present disclosure provides CSF-1R inhibitors demonstrating sustained inhibition of CSF/CSF1R signalling pathway with decreased toxicity. The present disclosure also provides supramolecular combinatorial therapeutics, wherein a CSF-1R inhibitor is combined with one or more of a chemotherapeutic agent, a kinase inhibitor, and an immunoregulator, each of which is optionally conjugated with a lipid. The present disclosure also provides a method for treating cancer, allergy, Systemic lupus erythematosus, nephritis, Chronic Obstructive Pulmonary Disease, and abnormal macrophage functions or any combinations thereof.
    Type: Grant
    Filed: February 11, 2017
    Date of Patent: August 11, 2020
    Assignees: INVICTUS ONCOLOGY PVT. LTD., THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Monideepa Roy, Goutam Biswas, Hemant Suryavanshi, Anubhab Mukherjee, Ashish Kulkarni, Shiladitya Sengupta
  • Publication number: 20200246545
    Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject) such as a liquid pharmaceutical agent.
    Type: Application
    Filed: January 31, 2020
    Publication date: August 6, 2020
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital Inc., Novo Nordisk A/S
    Inventors: Robert S. Langer, Carlo Giovanni Traverso, Alex G. Abramson, Morten Revsgaard Frederiksen, Mikkel Oliver Jespersen, Brian Mouridsen, Jesper Windum, Mette Poulsen, Brian Jensen, Jorrit Jeroen Water, Mikkel Wennemoes Hvitfeld Ley, Xiaoya Lu
  • Publication number: 20200246398
    Abstract: Disclosed are methods and compositions for the prevention and treatment of food allergy. In particular, described herein are microbial consortia, including minimal microbial consortia, that can prevent and/or cure food allergy. In certain embodiments, the consortia comprise certain members of the taxa Clostridiales and/or Bacteroidetes.
    Type: Application
    Filed: September 12, 2019
    Publication date: August 6, 2020
    Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Talal A. Chatila, Lynn Bry, Georg Gerber, Azza Abdel-Gadir, Rima Rachid
  • Publication number: 20200248147
    Abstract: Described are methods of enhancing development of renal organoids, methods of using the same, and kits.
    Type: Application
    Filed: June 8, 2018
    Publication date: August 6, 2020
    Applicants: President and Fellows of Harvard College, The Brigham And Women's Hospital, Inc.
    Inventors: Kimberly A. Homan, Navin R. Gupta, Katharina T. Kroll, David B. Kolesky, Mark Skylar-Scott, Michael T. Valerius, Joseph Bonventre, Ryuji Morizane, Jennifer Lewis
  • Publication number: 20200241001
    Abstract: Described herein are methods, assays and systems for selecting subjects with immune-mediated diseases who would optimally respond to anti-FcRn therapies and administering effective amounts of compositions comprising anti-FcRn agents for treating, inhibiting and/or reducing the symptoms of immune-mediated diseases in subjects.
    Type: Application
    Filed: August 27, 2019
    Publication date: July 30, 2020
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Richard S. BLUMBERG, Kristi BAKER, Timo RATH
  • Publication number: 20200237800
    Abstract: Described herein are methods and compositions related to the treatment or prevention of an inflammatory disease via administration of an agent that inhibits a long noncoding RNA (Inc-RNA) expressed in a macrophage to a subject in need thereof. In one embodiment, the Inc-RNA is lnc-FAM164A1. Another aspect herein provides a method of treating or preventing an inflammatory disease via administration of an agent that inhibits a protein bound to a Inc-RNA, e.g., ACLY, to a subject in need thereof.
    Type: Application
    Filed: October 9, 2018
    Publication date: July 30, 2020
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Masanori AIKAWA, Jian-Guo WANG, Sasha A. SINGH
  • Patent number: 10723783
    Abstract: Disclosed herein are polypeptides comprising an amino acid sequence of {[VPGVG]4IPGVG}n, wherein n is an integer greater than 1. The polypeptides can be crosslinked to from biocompatible hydrogels with tunable and desirable mechanical properties. The polypeptides and hydrogels can be used in a variety of biomedical applications including treatment of bleeding, treatment of soft tissue injury, injectable filler, and tissue adhesives.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: July 28, 2020
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Nasim Annabi, Ali Khademhosseini
  • Patent number: 10722266
    Abstract: A uterine manipulator operable to detach the uterus and cervix from the vagina. The uterine manipulator includes a shaft, a handle, a tip assembly, and a cutting assembly. The shaft includes a first end and a second end, and the handle is coupled to the first end and pivotable relative to the first end about a first axis. The tip assembly is coupled to the second end and pivotable relative to the second end along a second axis parallel to the first axis, and is adapted for insertion into the uterus. The cutting assembly is coupled around the shaft and adapted to receive the cervix when the tip assembly is inserted into the uterus.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: July 28, 2020
    Assignee: The Brigham and Women's Hospital
    Inventor: Jon Einarsson
  • Publication number: 20200229952
    Abstract: A stent apparatus, system, and method that senses wall shear stress by measuring fluid flow at localized areas within the stent, that processes measured information through an integrated circuit, and selectively sends power to mechanically controllable stent surfaces which results in localized geometric changes. In various embodiments the stent apparatus, system, and method sends data to outside the body in real time.
    Type: Application
    Filed: January 18, 2019
    Publication date: July 23, 2020
    Applicants: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC, The Brigham and Women's Hospital, Inc., Duke University
    Inventors: Erik V. Mukerjee, Jane A. Leopold, Amanda Randles
  • Publication number: 20200230244
    Abstract: Triggerable hydrogel compositions and related methods are generally disclosed. In some embodiments, the compositions and related methods may be used for medical-related or other applications. For example, the compositions and methods described herein may be useful, for example, in biomedical applications such as articles for (e.g., gastric) retention. In some embodiments, methods for deploying and/or removing an article comprising the composition, such as an article for gastric retention, are provided. The article and/or composition may be removed internally from a subject by, for example, introducing at least one reagent (e.g., one reagent, two reagents) such that at least a portion of the composition disassociates. In certain embodiments, the composition comprises a polymer network comprising two or more interpenetrating polymers. In some cases, a first polymer comprises a first cross-link moiety configured to dissociate upon interaction with a reagent.
    Type: Application
    Filed: November 9, 2017
    Publication date: July 23, 2020
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Carlo Giovanni Traverso, Jinyao Liu, Robert S. Langer
  • Patent number: 10716752
    Abstract: Certain embodiments involve gastric residence structures which can be administered to a subject (e.g., a patient) in a configuration constrained by a retaining element, and configured to mediate a change in shape when unconstrained by the retaining element to assume a configuration in the stomach in which is retained and unable to pass through the gastric pyloric orifice of the subject under gastrointestinal physiological conditions. The residence structures can be loaded with an agent for release in the stomach.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: July 21, 2020
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Lowell L. Wood, Jr., Philip A. Eckhoff
  • Patent number: 10716751
    Abstract: Certain embodiments involve administering a residence structure to a subject (e.g., a patient) in a constrained configuration, then unconstraining the structure such that it is retained at a location internally of the subject for a period of time. The structure includes a loadable component that can carry an active substance for release internally of the subject.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: July 21, 2020
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Lowell L. Wood, Jr., Philip A. Eckhoff