Patents Assigned to Brigham and Women's Hospital
  • Patent number: 11123416
    Abstract: The invention relates to the compositions of synthetic oligo-?-(1?6)-2-amino-2-deoxy-D-glu-copyranosides conjugated to carriers, and methods for making and use same.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: September 21, 2021
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Gerald B. Pier, Nikolay Nifantiev, Yury Tsvetkov, Marina Gening
  • Patent number: 11123304
    Abstract: This disclosure relates to nanoparticles comprising a core comprising a poly(ester amide) polymer comprising a repeating unit of Formula (Ia): and a repeating unit of Formula (Ib): wherein W1, W2, X1, A1, X2, A2, and X3 are as described herein, a payload molecule within the core, and a surface layer comprising a targeting ligand that binds or reacts selectively with a receptor on the outside surface of a cell. Methods of making such nanoparticles, and methods of using such nanoparticles as drug delivery vehicles, are also provided.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: September 21, 2021
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Omid C. Farokhzad, Jun Wu, Xi Zhu, Jinjun Shi
  • Patent number: 11123313
    Abstract: Methods and compositions for the treatment of conditions associated with pharyngeal airway muscle collapse while the subject is in a non-fully conscious state, e.g., sleep apnea and snoring, comprising administration of a norepinephrine reuptake inhibitor (NRI) and a muscarinic receptor antagonist.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: September 21, 2021
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: D. Andrew Wellman, Luigi Taranto-Montemurro
  • Patent number: 11117977
    Abstract: Embodiments described herein provide anti-fibulin-3 antibodies, recombinant proteins that bind specifically to fibulin-3, compositions and the treatment methods comprising these antibodies and recombinant proteins.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: September 14, 2021
    Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Mariano S. Viapiano, Nandhu Mohan Sobhana, Ennio Antonio Chiocca
  • Patent number: 11103274
    Abstract: Embodiments of the invention provide a laparoscopic morcellating device and method for removing tissue from a body cavity. The morcellating device includes a containment mechanism having an aperture, a cutting mechanism designed to fit into an interior space of the containment mechanism and a retractor mechanism that is coupled to the cutting mechanism. The containment mechanism and cutting mechanism combination surrounds the tissue and the aperture of the containment mechanism is closed around the tissue. The morcellating device further includes a motor for actuating the retractor such that the cutting mechanism constricts and morcellates the tissue. The laparoscopic morcellating device further allows for torque balancing of the retractor mechanism, gas flow regulation of the body cavity, and safety feedback mechanisms that can alert the surgeon.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: August 31, 2021
    Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Alexander Isakov, Kimberly Murdaugh, William Burke, Jon Einarsson, Conor Walsh
  • Patent number: 11097005
    Abstract: Provided herein are methods and pharmaceutical compositions for the treatment of obesity-associated conditions using cadherin-11 antagonists.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: August 24, 2021
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Michael B. Brenner, Sook Kyung Chang, Lydia Lynch
  • Patent number: 11096552
    Abstract: The present invention provides a method and an apparatus for controlling a flexible manipulator including a plurality of bendable mechanisms via a control apparatus. The control apparatus includes a drive-mode selecting unit allows for the selection of a movement mode which may provide a bending movement, an angled view movement, or a remote center movement.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: August 24, 2021
    Assignees: Canon U.S.A., Inc., The Brigham and Women's Hospital Inc.
    Inventors: Nobuhiko Hata, Takahisa Kato, Kiyoshi Takagi, Hidekazu Kose
  • Patent number: 11092602
    Abstract: In some aspects, the disclosure provides methods of modulating the level of proteasome inhibitor resistance of a cell, the methods comprising manipulating the level of expression or activity of a subunit of the 19S proteasome in the cell. In some aspects, cells in which the level of a 19S subunit is modulated, e.g., reduced, are provided. In some aspects, methods of identifying agents that reduce proteasome inhibitor resistance are provided. In some aspects, methods of classifying cancers according to predicted proteasome inhibitor resistance are provided. In some aspects, methods of killing or inhibiting proliferation of cancer cells, e.g., proteasome inhibitor resistant cancer cells, are provided. In some aspects, methods of treating cancer, e.g., proteasome inhibitor resistant cancer, are provided.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: August 17, 2021
    Assignees: Whitehead Institute for Biomedical Research, The Brigham and Women's Hospital, Inc.
    Inventors: Peter Tsvetkov, Sandro Santagata, Susan Lindquist
  • Patent number: 11090367
    Abstract: Compositions and methods for treating cancer that include administering a therapeutically effective amount of a tumor suppressor mRNA complexed with a delivery vehicle as described herein, e.g., a nanoparticle.
    Type: Grant
    Filed: February 3, 2020
    Date of Patent: August 17, 2021
    Assignees: The Brigham and Women's Hospital, Inc., Children's Medical Center Corporation
    Inventors: Jinjun Shi, Mohammad Ariful Islam, Yingjie Xu, Omid C. Farokhzad, Bruce Zetter
  • Publication number: 20210246182
    Abstract: The present invention is directed stromal cell derived factor-1 peptides that have been mutated to make them resistant to digestion by the proteases dipeptidyl peptidase IV (DPPIV) and matrix metalloproteinase-2 (MMP-2) but which maintain the ability of native SDF-I to attract T cells. The mutants may be attached to membranes formed by self-assembling peptides and then implanted at sites of tissue damage to help promote repair.
    Type: Application
    Filed: September 14, 2020
    Publication date: August 12, 2021
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Richard T. LEE, Vincent SEGERS
  • Patent number: 11083604
    Abstract: A stent apparatus, system, and method that senses wall shear stress by measuring fluid flow at localized areas within the stent, that processes measured information through an integrated circuit, and selectively sends power to mechanically controllable stent surfaces which results in localized geometric changes. In various embodiments the stent apparatus, system, and method sends data to outside the body in real time.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: August 10, 2021
    Assignees: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC, THE BRIGHAM AND WOMEN'S HOSPITAL, INC., DUKE UNIVERSITY
    Inventors: Erik V. Mukerjee, Jane A. Leopold, Amanda Randles
  • Patent number: 11083690
    Abstract: Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: August 10, 2021
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Tokitae LLC
    Inventors: Shiyi Zhang, Andrew Bellinger, Carlo Giovanni Traverso, Robert S. Langer, Dean Liang Glettig, Lowell L. Wood, Jr., Philip A. Eckhoff
  • Patent number: 11083780
    Abstract: This disclosure relates to methods of using shear-thinning compositions in the treatment of a vascular disorders, cancers, infections, abscesses, and fistulas.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: August 10, 2021
    Assignees: The Brigham and Women's Hospital, Inc., The General Hospital Corporation
    Inventors: Ali Khademosseini, Rahmi Oklu
  • Publication number: 20210239615
    Abstract: The invention provides novel non-invasive in vitro methods for assessing the metabolic condition of oocytes and/or embryos with fluorescence lifetime imaging microscope, that can be used, for example, in assessment of oocytes and embryos in assisted reproductive technologies.
    Type: Application
    Filed: March 31, 2021
    Publication date: August 5, 2021
    Applicants: President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.
    Inventors: Catherine Racowsky, Manqi Deng, Daniel Needleman
  • Patent number: 11077056
    Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: August 3, 2021
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Lowell L. Wood, Jr., Philip A. Eckhoff
  • Patent number: 11076875
    Abstract: In accordance with an aspect of the present disclosure, a tissue extraction device may include a bag having an interior and a plurality of cutting elements extending through the interior of the bag. The cutting elements can have a common end.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: August 3, 2021
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Frank Bonadio, Jon I. Einarsson, Jordan Smith, Alexander Isakov, Debasish Pradhan, Athar Anwar Solkar, Mangesh Ratnakar Patankar, Nikhil Katre, Tejas Chavan
  • Patent number: 11058494
    Abstract: Embodiments of the invention provide a system and method for resecting a tissue mass. The system for resecting a tissue mass includes a surgical instrument and a first sensor for measuring a signal corresponding to the position and orientation of the tissue mass. The first sensor is dimensioned to fit insider or next to the tissue mass. The system also includes a second sensor attached to the surgical instrument configured to measure the position and orientation of the surgical instrument. The second sensor is configured to receive the signal from the first sensor. A controller is in communication with the first sensor and/or the second sensor, and the controller executes a stored program to calculate a distance between the first sensor and the second sensor. Accordingly, visual, auditory, haptic or other feedback is provided to the clinician to guide the surgical instrument to the surgical margin.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: July 13, 2021
    Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Raphael Bueno, Jayender Jagadeesan, Ferenc A. Jolesz
  • Patent number: 11058800
    Abstract: The present invention provides compositions and methods for repair and reconstruction of defects and injuries to the cornea.
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: July 13, 2021
    Assignees: Massachusetts Eye and Ear Infirmary, The Brigham and Women's Hospital, Inc.
    Inventors: Ali Khademhosseini, Nasim Annabi, Reza Dana, Ahmad Kheirkhah
  • Publication number: 20210205492
    Abstract: An implantable, autonomously growing medical device is disclosed. The device may have an outer, braided outer element that holds an inner core. Degradation and/or softening of the inner core permits the outer element to elongate, allowing the device to grow with surrounding tissue. The growth profile of the medical device can be controlled by altering the shape/material/cure conditions of the inner core, as well as the geometry of the out element.
    Type: Application
    Filed: January 11, 2021
    Publication date: July 8, 2021
    Applicants: Children's Medical Center Corporation, The Brigham and Women's Hospital, Inc.
    Inventors: Eric N. Feins, Pedro J. del Nido, Nikolay V. Vasilyev, Haruo Yamauchi, Douglas P. Perrin, Peter E. Hammer, Veaceslav Arabagi, Jeffrey M. Karp, Yuhan Lee, Eoin D. O'Cearbhaill
  • Patent number: 11051892
    Abstract: An apparatus including a tendon-driven device such as an endoscope comprising a bendable body, a tendon attached to and extending a length of said body, and an actuator that will actuate said tendon based on a control signal from a controller. The controller is configured to send said control signal to said actuator and comprises a forward-kinematic-mapping unit that estimates an angular displacement, wherein the kinematic-mapping unit is configured for: providing a tension value of the tendon to obtain a desired angular displacement wherein the tension has a nonlinear relationship with the desired angular displacement based on information of friction where the tension is greater that would be calculated without including the effect of friction. The friction coefficient may be determined as it changes over time.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: July 6, 2021
    Assignees: Canon U.S.A., Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Nobuhiko Hata, Takahisa Kato, Ichiro Okumura, Kiyoshi Takagi, Hidekazu Kose