Patents Assigned to Brigham and Women's Hospital
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Publication number: 20230149469Abstract: The present invention is directed to wound healing scaffolds cografted with a population of stem cells, wherein the population of stem cells are ABCB5+ stem cells. The scaffolds are, for instance, collagen glycosaminoglycan scaffolds.Type: ApplicationFiled: September 19, 2022Publication date: May 18, 2023Applicants: The United States Government as represented by The Department of Veterans Affairs, The Brigham and Women's Hospital, Inc., Children's Medical Center CorporationInventors: Markus H. Frank, Natasha Y. Frank, Dennis P. Orgill, George F. Murphy
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Patent number: 11648381Abstract: Residence devices for long term delivery of therapeutic compounds and/or for sensing one or more relevant parameters in vivo are disclosed. In one embodiment, a residence device may include a plurality of links interconnected by a corresponding plurality of flexible hinges to permit the residence device to be deformed into a contracted configuration and subsequently permitted to return to an expanded configuration once positioned in a desired location, such as the stomach, of a subject. In some instances, at least a portion of the interconnected links may include a first link segment, a second link segment, and a coupling that selectively connects the first link segment to the second link segment. The coupling may be configured to weaken or decouple a connection between the first link segment and the second link segment when exposed to a temperature greater than a threshold temperature to selectively weaken and/or disassemble the residence device.Type: GrantFiled: November 15, 2019Date of Patent: May 16, 2023Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Robert S. Langer, Carlo Giovanni Traverso, Sahab I Babaee, Simo Pajovic, Jiuyun | Shi
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Patent number: 11627949Abstract: An insertable catheter device includes a shaft including a proximal end and a distal end, an expandable balloon, and an actuator configured to expand and retract the expandable balloon. The actuator includes a fluid conduit that extends through the shaft and is coupled with the expandable balloon to enable inflation and retraction of the expandable balloon via injection or withdrawal of a fluid to or from the expandable balloon via the fluid conduit. The expandable balloon is displaceably retractable into the shaft and extendable from the shaft. A fluid pump is coupled with the fluid conduit to pump the fluid through the fluid conduit. A patch is positioned to be displaced by the expandable balloon when the expandable balloon is inflated, and the expandable balloon is displaceably retractable into the shaft and displaceably extendable from the shaft.Type: GrantFiled: February 4, 2020Date of Patent: April 18, 2023Assignees: President and Fellows of Harvard College, The Brigham and Women's Hospital, Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: Conor J. Walsh, Ellen T. Roche, Panagiotis Polygerinos, Lucia R. Schuster, Jeffrey Michael Karp, Yuhan Lee, Pedro J. del Nido, Assunta Fabozzo, Ingeborg Friehs, Steven Charles Wasserman
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Patent number: 11629139Abstract: Disclosed herein are compounds having a structure of formula (I), compositions and methods useful for the treatment of a disease or infection, such as a viral infection (e.g.Type: GrantFiled: September 10, 2018Date of Patent: April 18, 2023Assignees: President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.Inventors: James Morgan Cunningham, Hu Liu, Ye Tian, Katie Kyungae Lee
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Patent number: 11630176Abstract: A system and method is provided for controlling physiological-noise in functional magnetic resonance imaging using raw k-space data to extract physiological noise effects. The method can identify these effects when they are separable and directly reflects the artefactual effects on fMRI data, without the need for external monitoring or recording devices and to be compensated for via rigorous statistical analysis modeling of such noise sources. The physiological fluctuations may be treated as global perturbations presented around the origin point in a k-space 2D slice. Each k-space 2D slice may be acquired at a very short repetition time with an effective sampling rate to sample cardiac and respiratory rhythms through proper reordering and phase-unwarping techniques applied to the raw k-space data.Type: GrantFiled: December 23, 2020Date of Patent: April 18, 2023Assignee: The Brigham and Women's Hospital, Inc.Inventors: David Silbersweig, Emily Stern, Hong Pan, Qiang Chen
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Publication number: 20230115483Abstract: Provided herein are compounds that interrupt the function of SALL4. Also described are pharmaceutical compositions and medical uses of these compounds.Type: ApplicationFiled: November 1, 2022Publication date: April 13, 2023Applicants: DANA-FARBER CANCER INSTITUTE, INC., THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Jun Qi, Anthony Varca, Li Chai
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Patent number: 11622973Abstract: Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile.Type: GrantFiled: October 4, 2018Date of Patent: April 11, 2023Assignees: California Institute of Technology, Brigham and Women's HospitalInventors: Sarkis K. Mazmanian, June L. Round, Ryan Michael O'Connell, Dennis L. Kasper
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Patent number: 11624054Abstract: The present invention is directed to purified preparations of dermal mesenchymal stem cells that are characterized by the cell surface expression of the ABCB5 P-glycoprotein. The cells may be used for any purpose that mesenchymal stem cells from other course are used. For instance they may be administered to treat an organ transplant recipient to improve allograft survival or as a treatment to patients with autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.Type: GrantFiled: July 9, 2018Date of Patent: April 11, 2023Assignees: The Brigham and Women's Hospital, Inc., Children's Medical Center CorporationInventor: Markus H. Frank
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Publication number: 20230098646Abstract: Articles and systems configured for treating GI motility disorders are generally provided. In some embodiments, an article comprising one or more electrodes (with both sensing and stimulating capabilities) may be configured to stimulate one or more tissues in the GI tract, electrically and/or chemically, to modulate peristalsis and/or allow neuromodulation. In some embodiments, a system comprises a controller that allows for close-loop operation of the article, e.g., such that the article may stimulate (e.g., via a feedback loop) the one or more organs in the GI tract upon receiving sensed parameters in the GI tract. In some embodiments, an implantation tool comprising a sensor may allow for submucosal or intramuscular implantation of an article. The implantation tool and the article may be useful for, for example, as a general platform for delivery of treating GI motility disorders and/or neuromodulation of the GI tract.Type: ApplicationFiled: September 29, 2022Publication date: March 30, 2023Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Robert S. Langer, Polina Anikeeva, Carlo Giovanni Traverso, Shriya Srinivasan, Marc-Joseph Antonini
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Patent number: 11612639Abstract: Methods and compositions for rejuvenating skeletal muscle stem cells are disclosed.Type: GrantFiled: October 8, 2018Date of Patent: March 28, 2023Assignees: President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.Inventors: Amy J. Wagers, Richard T. Lee
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Patent number: 11612322Abstract: An automated system and method is provided for biotype extraction and biomarker discovery from task-based fMRI imaging data. The system and method may include automatically mapping a localizome, such as a task-condition/contrast/population-specific brain functional localizome, based on fMRI data and automatically selecting and sorting brain regions or brain nodes to produce a subset of functional brain regions or brain nodes. A report may then be generated indicating that the subject has a particular brain circuit pattern of activity and connectivity associated with one or more symptoms of the given mental disorder, treatments, or associated with normal brain functions, based upon the extracted biosignatures by searching for the optimal multivariate classifier with least dimensionality in the brain functional localizome.Type: GrantFiled: October 3, 2018Date of Patent: March 28, 2023Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Emily Stern, David Silbersweig, Hong Pan
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Patent number: 11607390Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface. The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage with a surface. In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components.Type: GrantFiled: November 21, 2019Date of Patent: March 21, 2023Assignees: Massachusetts Institute of Technology, Novo Nordisk A/S, The Brigham and Women's Hospital, Inc.Inventors: Alex G. Abramson, Morten Revsgaard Frederiksen, Brian Jensen, Mikkel Oliver Jespersen, Carlo Giovanni Traverso
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Patent number: 11597913Abstract: In some aspects and embodiments, the invention provides methods for making hematopoietic stem cells, including for HSCT. The method comprises providing a cell population comprising hemogenic endothelial (HE) or endothelial cells, and increasing activity or expression of DNA (cytosine-5-)-methyltransferase 3 beta (Dnmt3b) and/or GTPase IMAP Family Member 6 (Gimap6) in the HE and/or endothelial cells under conditions sufficient for stimulating formation of HSCs.Type: GrantFiled: May 31, 2022Date of Patent: March 7, 2023Assignee: The Brigham and Women's Hospital, Inc.Inventor: Dhvanit I. Shah
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Patent number: 11596605Abstract: The present application provides a method of making a particle comprising (i) obtaining a first solution comprising a negatively charged polysaccharide; (ii) obtaining a second solution comprising a positively charged polysaccharide; and (iii) mixing the first solution and the second solution to obtain a suspension comprising the particle. The present application also provides a method of making a therapeutic particle, comprising: (i) obtaining a solution comprising a therapeutic protein; (ii) obtaining a first suspension comprising the particle comprising a negatively charged polysaccharide and a positively charged polysaccharide, and (iii) mixing the solution of the therapeutic protein and the first suspension to obtain a second suspension comprising the therapeutic particle. The present application also provides particles (e.g.Type: GrantFiled: August 1, 2017Date of Patent: March 7, 2023Assignee: The Brigham and Women's Hospital, Inc.Inventors: Joseph Loscalzo, Ying-Yi Zhang
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Patent number: 11592453Abstract: Disclosed herein is a method of providing a metabololipidomic profile and SPM signature on the progress of the innate host defense response following blood clotting. The method can include the step of taking one or more measurements in a patient's blood sample, wherein the sample is obtained during the time-course of clotting or coagulation or following clotting or coagulation, of pro-thrombotic and pro-inflammatory mediators (eicosanoids) and specialized pro-resolving mediators SPMs. From these measurements, a personalized metabololipidomic profile can be obtained. By comparing the measurement to that taken from normal or reference blood, a comparison profile can be developed. The profile comparison profile can then be used to make a medical or therapeutic decision.Type: GrantFiled: November 22, 2017Date of Patent: February 28, 2023Assignee: The Brigham and Women's Hospital, Inc.Inventors: Charles N. Serhan, Nan Chiang, Paul Norris
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Patent number: 11590225Abstract: Provided herein are nanoparticle compositions (e.g., nanoparticle compositions comprising high atomic number ions) that are useful for imaging diseases in a subject as well as radiosensitizing a disease in a subject (e.g., radiosensitizing a cancer in the subject). Methods of imaging a subject, methods of treating cancer, and processes of preparing the nanoparticle compositions are also provided.Type: GrantFiled: December 8, 2017Date of Patent: February 28, 2023Assignees: The Brigham and Women's Hospital, Inc., NH TherAguix, Université Claude Bernard Lyon 1, Centre National de la Recherche ScientifiqueInventors: Ross Berbeco, Eloise Thomas, Francois Lux, Olivier Tillement, Alexandre Detappe, Geraldine Le Duc
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Patent number: 11591300Abstract: Provided herein are methods and compositions related to a method of stimulating the immune system in a subject in need thereof by administering an agent that increases the level or activity of indoleamine 2,3-dioxygenase (IDO1) and/or aryl hydrocarbon receptor (Ahr).Type: GrantFiled: December 21, 2018Date of Patent: February 28, 2023Assignee: The Brigham and Women's Hospital, Inc.Inventors: Richard S. Blumberg, Shankar S. Iyer, Amit Ghandi, Amadeu Llebaria
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Publication number: 20230050912Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject).Type: ApplicationFiled: May 27, 2022Publication date: February 16, 2023Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Novo Nordisk A/SInventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, Robert S. Langer, Jorrit Jeroen Water, Morten Revsgaard Frederiksen, Bo Uldall Kristiansen, Mikkel Oliver Jespersen, Mette Poulsen, Peter Herskind, Brian Jensen
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Patent number: 11579084Abstract: The invention provides novel non-invasive in vitro methods for assessing the metabolic condition of oocytes and/or embryos with fluorescence lifetime imaging microscope, that can be used, for example, in assessment of oocytes and embryos in assisted reproductive technologies.Type: GrantFiled: March 31, 2021Date of Patent: February 14, 2023Assignees: President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.Inventors: Catherine Racowsky, Manqi Deng, Daniel Needleman
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Patent number: 11576860Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the article includes dimensions configured for transesophageal retrieval. In some cases, the articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).Type: GrantFiled: May 31, 2019Date of Patent: February 14, 2023Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Carlo Giovanni Traverso, Robert S. Langer, Malvika Verma, Niclas Roxhed, Feyisope Eweje, Macy Castaneda