Patents Assigned to Brookhaven Science Associates
  • Patent number: 11912927
    Abstract: A well cement composite and a method for making a well cement composite includes a mixture of calcium aluminate cement (CAC) and fly ash cenospheres (CS) in a weight ratio of from 30:70 to 80:20 CAC to CS; sodium metasilicate (SMS) in an amount of from 1 to 10% of the total weight of the mixture of CAC and CS; polymethylhydrosiloxane (PMHS) in an amount of from 0.5 to 6.0% of the total weight of the mixture of CAC and CS; and water in a weight ratio of from 0.5:1.0 to 1.2:1.0 of water to CAC and CS.
    Type: Grant
    Filed: October 5, 2021
    Date of Patent: February 27, 2024
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Tatiana Pyatina, Toshifumi Sugama
  • Patent number: 11881391
    Abstract: Methods and systems for fabricating a film, such as, for example, a photocathode, having a tailored band structure and thin-film components that can be tailored for specific applications, such as, for example photocathode having a high quantum efficiency, and simple components fabricated by those methods.
    Type: Grant
    Filed: August 13, 2021
    Date of Patent: January 23, 2024
    Assignees: Radiation Monitoring Devices, Inc., University of Chicago, Brookhaven Science Associates, LLP
    Inventors: Harish B. Bhandari, Vivek V. Nagarkar, Olena E. Ovechkina, Henry J. Frisch, Klaus Attenkofer, John M. Smedley
  • Patent number: 11866775
    Abstract: The present method of detection involves increasing an amount of analyte molecules by an isothermal molecular amplification approach. In the present approach a starting molecule of interest may be amplified through a reaction it induces with specifically engineered and functionalized particles, namely protected particles A and storage particles B. This reaction may result in a set of output DNA molecules that is larger in number than the input DNA molecules. Thus the reaction between nanoparticles for amplification of a certain DNA sequence (input DNA molecules) may occur when there is a match with a targeted molecule (stored molecules on storage particles B) and if the DNA sequence of the input DNA molecules does not match (partially or completely) the targeted molecule the reaction may not occur. Without a certain molecular input of the input DNA molecule the reaction may not occur.
    Type: Grant
    Filed: October 7, 2020
    Date of Patent: January 9, 2024
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Oleg Gang, Suchetan Pal
  • Patent number: 11860815
    Abstract: A reconfigurable computing platform includes a reconfigurable computing device, electro-optical transceiver, and first voltage converter disposed on a multilayer board. The electro-optical transceiver converts an optical signal at least one of to and from an electrical signal, and the electrical signal is operatively coupled to the reconfigurable computing device. The electro-optical transceiver is disposed in proximity to the reconfigurable computing device, and the first voltage converter is operatively coupled to a common voltage distributed around a periphery of the multilayer board. The first voltage converter converts the common voltage to a first operating voltage, and the first voltage converter is disposed in proximity to the reconfigurable computing device. The first operating voltage is provided to the reconfigurable computing device as a first power source.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: January 2, 2024
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Shaochun Tang, Michael Begel, Hucheng Chen, Helio Takai, Francesco Lanni
  • Patent number: 11816053
    Abstract: A reconfigurable data acquisition card including at least one field programmable gate array (FPGA) and a configurable bus switch coupled with the FPGA. The bus switch forms at least first and second ports used by the FPGA, the bus switch being adaptable for insertion into a connection having a number of lanes at least equal to a combined number of lanes in the first and second ports. The data acquisition card further includes multiple optical transmitters and optical receivers. Each optical transmitter and optical receiver is coupled with a corresponding transceiver in the FPGA via at least one optical fiber having multiple communication links. Timing circuitry in the data acquisition card is coupled with clock generation and distribution circuitry in the FPGA and is configured to distribute clock and timing signals to detector front-ends with fixed latency and to synchronize input/output links with a system clock generated by the FPGA.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: November 14, 2023
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Kai Chen, Michael Begel, Hucheng Chen, Francesco Lanni
  • Patent number: 11795567
    Abstract: Technologies are described for methods and systems effective for flex plates. The flex plates may comprise a base plate. The base plate may include walls that define an insert location opening in the base plate. The insert location opening in the base plate may be in communication with a securement area. The flex plates may comprise an insert. The insert may include a reservoir region and a crystallization region separated by a wall including channels. The reservoir region and the crystallization region may include a backing. The insert may further include securement tabs. The securement tabs may be configured to secure the insert to the base plate at the securement area.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: October 24, 2023
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Alexei S. Soares, Karan Joshi, Grace C. Shea-McCarthy, Lauren E. Zipper, Ella Teplitsky
  • Patent number: 11739162
    Abstract: The current invention pertains compositions and methods to generate compositions providing stability to biomolecules, including providing physiologically stable and functional DNA origami-based drug/gene delivery carriers by surface coating with the oligo-ethylene glycol conjugated peptoids of Formulas (I), (II), and (III).
    Type: Grant
    Filed: September 9, 2020
    Date of Patent: August 29, 2023
    Assignees: Brookhaven Science Associates LLC, The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of California, The Trustees of Columbia University in the City of New York
    Inventors: Shih-Ting Wang, Oleg Gang, Ronald N. Zuckermann, Carolyn R. Bertozzi
  • Patent number: 11618899
    Abstract: Vectors for cloning, maintaining and expressing a wide range of coding sequences in inducible T7 expression systems in Escherichia coli expression hosts are disclosed herein. Target genes that can be stably maintained and expressed include those that specify proteins that are highly toxic to the host cell. Different configurations of vectors and expression hosts provide different rates of transcription and translation of target genes and therefore different rates of accumulation of target proteins. Methods for cloning by asymmetric ligation and co-expression of more than one target protein in a single vector are also disclosed, as are variants of BL21(DE3) having lower basal transcription by T7 RNA polymerase.
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: April 4, 2023
    Assignee: Brookhaven Science Associates, LLC
    Inventor: F. William Studier
  • Patent number: 11390518
    Abstract: Technologies are described for methods and systems effective for etching nanostructures in a substrate. The methods may comprise depositing a patterned block copolymer on the substrate. The patterned block copolymer may include first and second polymer block domains. The methods may comprise applying a precursor to the patterned block copolymer to generate an infiltrated block copolymer. The precursor may infiltrate into the first polymer block domain and generate a material in the first polymer block domain. The methods may comprise applying a removal agent to the infiltrated block copolymer to generate a patterned material. The removal agent may be effective to remove the first and second polymer block domains from the substrate. The methods may comprise etching the substrate. The patterned material on the substrate may mask the substrate to pattern the etching. The etching may be performed under conditions to produce nanostructures in the substrate.
    Type: Grant
    Filed: December 8, 2020
    Date of Patent: July 19, 2022
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Charles T. Black, Atikur Rahman, Matthew Eisaman, Ahsan Ashraf
  • Patent number: 11355690
    Abstract: A qubit device for use in a quantum computing environment includes a semiconductor substrate, an insulating layer disposed on at least a portion of an upper surface of the substrate, and a transition metal silicide (TMSi) heterojunction disposed on at least a portion of an upper surface of the insulating layer. The TMSi heterojunction includes a link layer and at least first and second TMSi regions coupled with the link layer. The link layer may include a normal conductor, thereby forming a superconductor-normal conductor-superconductor (SNS) junction, or a geometric constriction, thereby forming a superconductor-geometric constriction-superconductor (ScS) junction. The link layer may form at least a portion of a channel including intrinsic or doped silicon.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: June 7, 2022
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Charles T. Black, Mingzhao Liu
  • Patent number: 11336244
    Abstract: A fully differential rail-to-rail-output amplifier includes a differential input inverter pair, folded cascode pair, class AB control pair, and class AB output rail-to-rail pair. A drain associated with the folded cascode pair is operatively coupled to the class AB control pair, and the drain associated with the folded cascode pair is unconnected to the current source associated with the class AB control pair. A method of providing fully differential rail-to-rail-output amplification includes coupling a folded cascode pair operatively to a differential input inverter pair, coupling a drain associated with the folded cascode pair operatively to a class AB control pair, and coupling a class AB output rail-to-rail pair operatively to the class AB control pair.
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: May 17, 2022
    Assignee: Brookhaven Science Associates, LLC
    Inventor: Mieczyslaw M. Dabrowski
  • Patent number: 11305000
    Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: April 19, 2022
    Assignees: Brookhaven Science Associates, LLC, The Research Foundation of State University of New York, Baxalta Incorporated, Baxalta GmbH
    Inventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger, John J. Dunn, Benjamin J. Luft
  • Publication number: 20210397580
    Abstract: A reconfigurable computing platform includes a reconfigurable computing device, electro-optical transceiver, and first voltage converter disposed on a multilayer board. The electro-optical transceiver converts an optical signal at least one of to and from an electrical signal, and the electrical signal is operatively coupled to the reconfigurable computing device. The electro-optical transceiver is disposed in proximity to the reconfigurable computing device, and the first voltage converter is operatively coupled to a common voltage distributed around a periphery of the multilayer board. The first voltage converter converts the common voltage to a first operating voltage, and the first voltage converter is disposed in proximity to the reconfigurable computing device. The first operating voltage is provided to the reconfigurable computing device as a first power source.
    Type: Application
    Filed: October 4, 2019
    Publication date: December 23, 2021
    Applicant: Brookhaven Science Associates, LLC
    Inventors: Shaochun Tang, Michael Begel, Hucheng Chen, Helio Takai, Francesco Lanni
  • Patent number: 11201325
    Abstract: A binder-free, self-supporting electrode including an electrochemically active material in the absence of a binder and a current collector is claimed. The electrochemically active material is a self-supporting transition metal oxide. A method of regenerating the electrode to restore capacity of the electrode is also claimed.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: December 14, 2021
    Assignees: BROOKHAVEN SCIENCE ASSOCIATES, LLC, The Research Foundation of The University of New York
    Inventors: Esther Sans Takeuchi, Altug S. Poyraz, Kenneth James Takeuchi, Amy Catherine Marschilok
  • Publication number: 20210347838
    Abstract: A composition comprising a synthetic growth factor analogue comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor and an osteoconductive material where the synthetic growth factor analogue is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction.
    Type: Application
    Filed: July 19, 2021
    Publication date: November 11, 2021
    Applicants: Ferring B.V., Brookhaven Science Associates, LLC
    Inventors: Paul O. ZAMORA, Brent Lee ATKINSON, Xinhua LIN, Louis A. PENA
  • Publication number: 20210280852
    Abstract: An anode configured for fast charging a lithium-ion battery includes an anode substrate and a coating provided on a surface of the anode substrate for increasing an overpotential of Li metal to inhibit Li metal plating during extreme fast charging a lithium-ion battery fabricated with the anode. The anode is fabricated by a process of applying a coating to the anode substrate surface that comprises a nanolayer of Cu, or a nanolayer of Ni or a composite nanolayer of Cu and Ni.
    Type: Application
    Filed: January 18, 2019
    Publication date: September 9, 2021
    Applicants: The Research Foundation For The State University of New York, Brookhaven Science Associates, LLC
    Inventors: Esther S. Takeuchi, Amy C. MARSCHILOK, Kenneth TAKEUCHI, David C. BOCK
  • Patent number: 11078244
    Abstract: A composition comprising a synthetic growth factor analogue comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor and an osteoconductive material where the synthetic growth factor analogue is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: August 3, 2021
    Assignees: Ferring B.V., Brookhaven Science Associates, LLC
    Inventors: Paul Zamora, Brent Lee Atkinson, Xinhua Lin, Louis A. Pena
  • Patent number: 10971635
    Abstract: A photodetector including graphene and poly(3-hexylthiopene) (P3HT) nanowires is claimed. A method of making the hybrid photodetector is also claimed.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: April 6, 2021
    Assignee: BROOKHAVEN SCIENCE ASSOCIATES, LLC
    Inventors: Mircea Cotlet, Mingxing Li
  • Patent number: 10882739
    Abstract: Technologies are described for methods and systems effective for etching nanostructures in a substrate. The methods may comprise depositing a patterned block copolymer on the substrate. The patterned block copolymer may include first and second polymer block domains. The methods may comprise applying a precursor to the patterned block copolymer to generate an infiltrated block copolymer. The precursor may infiltrate into the first polymer block domain and generate a material in the first polymer block domain. The methods may comprise applying a removal agent to the infiltrated block copolymer to generate a patterned material. The removal agent may be effective to remove the first and second polymer block domains from the substrate. The methods may comprise etching the substrate. The patterned material on the substrate may mask the substrate to pattern the etching. The etching may be performed under conditions to produce nanostructures in the substrate.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: January 5, 2021
    Assignee: BROOKHAVEN SCIENCE ASSOCIATES, LLC.
    Inventors: Charles T. Black, Atikur Rahman, Matthew Eisaman, Ahsan Ashraf
  • Patent number: 10883189
    Abstract: Technologies are described for methods and systems effective for flex plates. The flex plates may comprise a base plate. The base plate may include walls that define an insert location opening in the base plate. The insert location opening in the base plate may be in communication with a securement area. The flex plates may comprise an insert. The insert may include a reservoir region and a crystallization region separated by a wall including channels. The reservoir region and the crystallization region may include a backing. The insert may further include securement tabs. The securement tabs may be configured to secure the insert to the base plate at the securement area.
    Type: Grant
    Filed: July 7, 2020
    Date of Patent: January 5, 2021
    Assignee: BROOKHAVEN SCIENCE ASSOCIATES, LLC
    Inventors: Alexei S. Soares, Karan Joshi, Grace C. Shea-McCarthy, Ella Teplitsky