Patents Assigned to Brookhaven Science Associates LLC
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Patent number: 11816053Abstract: A reconfigurable data acquisition card including at least one field programmable gate array (FPGA) and a configurable bus switch coupled with the FPGA. The bus switch forms at least first and second ports used by the FPGA, the bus switch being adaptable for insertion into a connection having a number of lanes at least equal to a combined number of lanes in the first and second ports. The data acquisition card further includes multiple optical transmitters and optical receivers. Each optical transmitter and optical receiver is coupled with a corresponding transceiver in the FPGA via at least one optical fiber having multiple communication links. Timing circuitry in the data acquisition card is coupled with clock generation and distribution circuitry in the FPGA and is configured to distribute clock and timing signals to detector front-ends with fixed latency and to synchronize input/output links with a system clock generated by the FPGA.Type: GrantFiled: September 23, 2019Date of Patent: November 14, 2023Assignee: Brookhaven Science Associates, LLCInventors: Kai Chen, Michael Begel, Hucheng Chen, Francesco Lanni
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Patent number: 11795567Abstract: Technologies are described for methods and systems effective for flex plates. The flex plates may comprise a base plate. The base plate may include walls that define an insert location opening in the base plate. The insert location opening in the base plate may be in communication with a securement area. The flex plates may comprise an insert. The insert may include a reservoir region and a crystallization region separated by a wall including channels. The reservoir region and the crystallization region may include a backing. The insert may further include securement tabs. The securement tabs may be configured to secure the insert to the base plate at the securement area.Type: GrantFiled: November 30, 2020Date of Patent: October 24, 2023Assignee: Brookhaven Science Associates, LLCInventors: Alexei S. Soares, Karan Joshi, Grace C. Shea-McCarthy, Lauren E. Zipper, Ella Teplitsky
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Patent number: 11739162Abstract: The current invention pertains compositions and methods to generate compositions providing stability to biomolecules, including providing physiologically stable and functional DNA origami-based drug/gene delivery carriers by surface coating with the oligo-ethylene glycol conjugated peptoids of Formulas (I), (II), and (III).Type: GrantFiled: September 9, 2020Date of Patent: August 29, 2023Assignees: Brookhaven Science Associates LLC, The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of California, The Trustees of Columbia University in the City of New YorkInventors: Shih-Ting Wang, Oleg Gang, Ronald N. Zuckermann, Carolyn R. Bertozzi
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Patent number: 11618899Abstract: Vectors for cloning, maintaining and expressing a wide range of coding sequences in inducible T7 expression systems in Escherichia coli expression hosts are disclosed herein. Target genes that can be stably maintained and expressed include those that specify proteins that are highly toxic to the host cell. Different configurations of vectors and expression hosts provide different rates of transcription and translation of target genes and therefore different rates of accumulation of target proteins. Methods for cloning by asymmetric ligation and co-expression of more than one target protein in a single vector are also disclosed, as are variants of BL21(DE3) having lower basal transcription by T7 RNA polymerase.Type: GrantFiled: February 8, 2017Date of Patent: April 4, 2023Assignee: Brookhaven Science Associates, LLCInventor: F. William Studier
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Patent number: 11390518Abstract: Technologies are described for methods and systems effective for etching nanostructures in a substrate. The methods may comprise depositing a patterned block copolymer on the substrate. The patterned block copolymer may include first and second polymer block domains. The methods may comprise applying a precursor to the patterned block copolymer to generate an infiltrated block copolymer. The precursor may infiltrate into the first polymer block domain and generate a material in the first polymer block domain. The methods may comprise applying a removal agent to the infiltrated block copolymer to generate a patterned material. The removal agent may be effective to remove the first and second polymer block domains from the substrate. The methods may comprise etching the substrate. The patterned material on the substrate may mask the substrate to pattern the etching. The etching may be performed under conditions to produce nanostructures in the substrate.Type: GrantFiled: December 8, 2020Date of Patent: July 19, 2022Assignee: Brookhaven Science Associates, LLCInventors: Charles T. Black, Atikur Rahman, Matthew Eisaman, Ahsan Ashraf
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Patent number: 11355690Abstract: A qubit device for use in a quantum computing environment includes a semiconductor substrate, an insulating layer disposed on at least a portion of an upper surface of the substrate, and a transition metal silicide (TMSi) heterojunction disposed on at least a portion of an upper surface of the insulating layer. The TMSi heterojunction includes a link layer and at least first and second TMSi regions coupled with the link layer. The link layer may include a normal conductor, thereby forming a superconductor-normal conductor-superconductor (SNS) junction, or a geometric constriction, thereby forming a superconductor-geometric constriction-superconductor (ScS) junction. The link layer may form at least a portion of a channel including intrinsic or doped silicon.Type: GrantFiled: March 6, 2020Date of Patent: June 7, 2022Assignee: Brookhaven Science Associates, LLCInventors: Charles T. Black, Mingzhao Liu
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Patent number: 11336244Abstract: A fully differential rail-to-rail-output amplifier includes a differential input inverter pair, folded cascode pair, class AB control pair, and class AB output rail-to-rail pair. A drain associated with the folded cascode pair is operatively coupled to the class AB control pair, and the drain associated with the folded cascode pair is unconnected to the current source associated with the class AB control pair. A method of providing fully differential rail-to-rail-output amplification includes coupling a folded cascode pair operatively to a differential input inverter pair, coupling a drain associated with the folded cascode pair operatively to a class AB control pair, and coupling a class AB output rail-to-rail pair operatively to the class AB control pair.Type: GrantFiled: July 10, 2020Date of Patent: May 17, 2022Assignee: Brookhaven Science Associates, LLCInventor: Mieczyslaw M. Dabrowski
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Patent number: 11305000Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.Type: GrantFiled: January 19, 2018Date of Patent: April 19, 2022Assignees: Brookhaven Science Associates, LLC, The Research Foundation of State University of New York, Baxalta Incorporated, Baxalta GmbHInventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger, John J. Dunn, Benjamin J. Luft
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Publication number: 20210397580Abstract: A reconfigurable computing platform includes a reconfigurable computing device, electro-optical transceiver, and first voltage converter disposed on a multilayer board. The electro-optical transceiver converts an optical signal at least one of to and from an electrical signal, and the electrical signal is operatively coupled to the reconfigurable computing device. The electro-optical transceiver is disposed in proximity to the reconfigurable computing device, and the first voltage converter is operatively coupled to a common voltage distributed around a periphery of the multilayer board. The first voltage converter converts the common voltage to a first operating voltage, and the first voltage converter is disposed in proximity to the reconfigurable computing device. The first operating voltage is provided to the reconfigurable computing device as a first power source.Type: ApplicationFiled: October 4, 2019Publication date: December 23, 2021Applicant: Brookhaven Science Associates, LLCInventors: Shaochun Tang, Michael Begel, Hucheng Chen, Helio Takai, Francesco Lanni
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Patent number: 11201325Abstract: A binder-free, self-supporting electrode including an electrochemically active material in the absence of a binder and a current collector is claimed. The electrochemically active material is a self-supporting transition metal oxide. A method of regenerating the electrode to restore capacity of the electrode is also claimed.Type: GrantFiled: November 28, 2016Date of Patent: December 14, 2021Assignees: BROOKHAVEN SCIENCE ASSOCIATES, LLC, The Research Foundation of The University of New YorkInventors: Esther Sans Takeuchi, Altug S. Poyraz, Kenneth James Takeuchi, Amy Catherine Marschilok
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Publication number: 20210347838Abstract: A composition comprising a synthetic growth factor analogue comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor and an osteoconductive material where the synthetic growth factor analogue is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction.Type: ApplicationFiled: July 19, 2021Publication date: November 11, 2021Applicants: Ferring B.V., Brookhaven Science Associates, LLCInventors: Paul O. ZAMORA, Brent Lee ATKINSON, Xinhua LIN, Louis A. PENA
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Publication number: 20210280852Abstract: An anode configured for fast charging a lithium-ion battery includes an anode substrate and a coating provided on a surface of the anode substrate for increasing an overpotential of Li metal to inhibit Li metal plating during extreme fast charging a lithium-ion battery fabricated with the anode. The anode is fabricated by a process of applying a coating to the anode substrate surface that comprises a nanolayer of Cu, or a nanolayer of Ni or a composite nanolayer of Cu and Ni.Type: ApplicationFiled: January 18, 2019Publication date: September 9, 2021Applicants: The Research Foundation For The State University of New York, Brookhaven Science Associates, LLCInventors: Esther S. Takeuchi, Amy C. MARSCHILOK, Kenneth TAKEUCHI, David C. BOCK
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Patent number: 11078244Abstract: A composition comprising a synthetic growth factor analogue comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor and an osteoconductive material where the synthetic growth factor analogue is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction.Type: GrantFiled: March 19, 2019Date of Patent: August 3, 2021Assignees: Ferring B.V., Brookhaven Science Associates, LLCInventors: Paul Zamora, Brent Lee Atkinson, Xinhua Lin, Louis A. Pena
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Patent number: 10971635Abstract: A photodetector including graphene and poly(3-hexylthiopene) (P3HT) nanowires is claimed. A method of making the hybrid photodetector is also claimed.Type: GrantFiled: June 17, 2019Date of Patent: April 6, 2021Assignee: BROOKHAVEN SCIENCE ASSOCIATES, LLCInventors: Mircea Cotlet, Mingxing Li
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Patent number: 10882739Abstract: Technologies are described for methods and systems effective for etching nanostructures in a substrate. The methods may comprise depositing a patterned block copolymer on the substrate. The patterned block copolymer may include first and second polymer block domains. The methods may comprise applying a precursor to the patterned block copolymer to generate an infiltrated block copolymer. The precursor may infiltrate into the first polymer block domain and generate a material in the first polymer block domain. The methods may comprise applying a removal agent to the infiltrated block copolymer to generate a patterned material. The removal agent may be effective to remove the first and second polymer block domains from the substrate. The methods may comprise etching the substrate. The patterned material on the substrate may mask the substrate to pattern the etching. The etching may be performed under conditions to produce nanostructures in the substrate.Type: GrantFiled: September 6, 2018Date of Patent: January 5, 2021Assignee: BROOKHAVEN SCIENCE ASSOCIATES, LLC.Inventors: Charles T. Black, Atikur Rahman, Matthew Eisaman, Ahsan Ashraf
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Patent number: 10883189Abstract: Technologies are described for methods and systems effective for flex plates. The flex plates may comprise a base plate. The base plate may include walls that define an insert location opening in the base plate. The insert location opening in the base plate may be in communication with a securement area. The flex plates may comprise an insert. The insert may include a reservoir region and a crystallization region separated by a wall including channels. The reservoir region and the crystallization region may include a backing. The insert may further include securement tabs. The securement tabs may be configured to secure the insert to the base plate at the securement area.Type: GrantFiled: July 7, 2020Date of Patent: January 5, 2021Assignee: BROOKHAVEN SCIENCE ASSOCIATES, LLCInventors: Alexei S. Soares, Karan Joshi, Grace C. Shea-McCarthy, Ella Teplitsky
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Patent number: 10753834Abstract: Technologies are described for methods and systems effective for flex plates. The flex plates may comprise a base plate. The base plate may include walls that define an insert location opening in the base plate. The insert location opening in the base plate may be in communication with a securement area. The flex plates may comprise an insert. The insert may include a reservoir region and a crystallization region separated by a wall including channels. The reservoir region and the crystallization region may include a backing. The insert may further include securement tabs. The securement tabs may be configured to secure the insert to the base plate at the securement area.Type: GrantFiled: January 8, 2016Date of Patent: August 25, 2020Assignee: Brookhaven Science Associates, LLCInventors: Alexei Soares, Karan Joshi, Lauren E. Zipper, Grace Shea-McCarthy
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Patent number: 10680249Abstract: Nitride stabilized metal (M or Pt(M)) nanoparticles and methods for their manufacture are disclosed. In one embodiment the metal nanoparticles have a nonporous noble metal shell with a nitride-stabilized non-noble metal core. The nitride-stabilized core provides a stabilizing effect under high oxidizing conditions suppressing the noble metal dissolution during potential cycling. Introduction of nitrogen into the core by annealing produces metal nitride(s) that are less susceptible to dissolution during potential cycling under high oxidizing conditions.Type: GrantFiled: February 8, 2019Date of Patent: June 9, 2020Assignee: Brookhaven Science Associates, LLCInventors: Kurian Abraham Kuttiyiel, Kotaro Sasaki, Radoslav R. Adzic
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Patent number: 10657456Abstract: An apparatus for performing quantum computing includes multiple qubits, each of at least a subset of the qubits comprising a loop formed of a Dirac or Weyl semimetal and having at least two stable quantum states. The apparatus further includes at least one terahertz cavity coupled with the qubits, the terahertz cavity being configured to detect the quantum states of the qubits. Each of at least the subset of qubits is configured to receive a circularly polarized radiation source. The radiation source is adapted to excite a chiral current in each of at least the subset of qubits, the quantum states of the plurality of qubits being a function of the chiral current.Type: GrantFiled: June 17, 2019Date of Patent: May 19, 2020Assignees: BROOKHAVEN SCIENCE ASSOCIATES, LLC, THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORKInventors: Dmitri Kharzeev, Qiang Li
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Patent number: 10636974Abstract: Embodiments of the present invention provides compounds, compositions, and methods for their preparation that provide efficient intramolecular fission, such that local order and strong nearest neighbor coupling is no longer a design constraint. Inventive materials include organic oligomers and polymers designed to exhibit strong intrachain donor-acceptor interactions and provide intramolecular singlet fission, whereby triplet populations can be generated in very high yields of, e.g., 170% or more.Type: GrantFiled: October 24, 2016Date of Patent: April 28, 2020Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, BROOKHAVEN SCIENCE ASSOCIATES, LLC.Inventors: Luis Miguel Campos, Matthew Y. Sfeir, Jianlong Xia, Erik Michael Allan Busby, Jonathan Zhaozhi Low