Patents Assigned to Brookhaven Science Associates LLC
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Patent number: 10246499Abstract: A composition comprising a synthetic growth factor analogue comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor and an osteoconductive material where the synthetic growth factor analogue is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction.Type: GrantFiled: August 5, 2014Date of Patent: April 2, 2019Assignees: Ferring B.V., Brookhaven Science Associates, LLCInventors: Paul Zamora, Brent Lee Atkinson, Xinhua Lin, Louis A. Pena
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Patent number: 10242770Abstract: A method for producing a long length high temperature superconductor wire, includes providing a substrate, having a surface with a length of at least 50 meters and a width. The surface supports a biaxially textured high temperature superconducting layer and the biaxially textured high temperature superconducting layer has a length and a width corresponding to the length and width of the surface of the substrate. The method includes irradiating the biaxially textured high temperature superconductor layer with an ion beam impinging uniformly along the length and across the width of the biaxially textured high temperature superconductor layer to produce a uniform distribution of pinning microstructures in the biaxially textured high temperature superconductor layer.Type: GrantFiled: August 25, 2016Date of Patent: March 26, 2019Assignees: American Superconductor Corporation, Brookhaven Science Associates, LLCInventors: Martin W. Rupich, Srivatsan Sathyamurthy, Qiang Li, Vyacheslav F. Solovyov
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Patent number: 10189704Abstract: Technologies are described for methods and systems effective for etching nanostructures in a substrate. The methods may comprise depositing a patterned block copolymer on the substrate. The methods may comprise applying a precursor to the patterned block copolymer to generate an infiltrated block copolymer. The precursor may infiltrate into the first polymer block domain and generate a material. The methods may comprise applying a removal agent effective to remove the polymer block domains to the infiltrated block copolymer to generate a pattern of the material. The methods may comprise etching the substrate. The pattern of the material may mask the substrate to pattern the etching. The etching may be performed under conditions to produce nanostructures in the substrate. The methods may comprise removing the pattern of the material and coating the nanostructures and the surface of the substrate with a hydrophobic coating.Type: GrantFiled: June 13, 2014Date of Patent: January 29, 2019Assignee: Brookhaven Science Associates, LLCInventors: Antonio Checco, Charles T. Black, Atikur Rahman, Benjamin M. Ocko
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Patent number: 10132942Abstract: TOF-PET detector systems, and methods for imaging photon-emitting samples using the detector systems, are provided. The TOF-PET detector systems use large-area photodetectors with extremely high time-resolution and an approach to data collection and analysis that allows for the use of inexpensive low-density scintillator materials. The TOF-PET detector systems are characterized by their ability to identify, on a statistical basis, the transverse and depth location of the first of the series of energy deposition events that are generated when a gamma photon enters the low-density scintillator material.Type: GrantFiled: April 8, 2016Date of Patent: November 20, 2018Assignees: The University of Chicago, Brookhaven Science Associates, LLCInventors: Henry J. Frisch, Eric J. Oberla, Hee-Jong Kim, Minfang Yeh
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Patent number: 10126167Abstract: Technologies are described for methods and systems effective to detect photon receiving events. A first comparator may compare a magnitude of a photon signal to a first threshold voltage to produce a first output. A second comparator may compare the magnitude of the photon signal to a second threshold voltage to produce a second output. A counter control circuit may increment a second counter in response to a determination that the magnitude of a first peak of the photon signal exceeds and then falls below the second threshold voltage. The counter control circuit may prevent a third counter from incrementing in response to a second peak of the photon signal. The counter control circuit may increment the first counter in response to the magnitude of the signal exceeding and then falling below the first threshold voltage. The first counter may be associated with a number of photon receiving events detected.Type: GrantFiled: January 18, 2017Date of Patent: November 13, 2018Assignee: Brookhaven Science Associates, LLCInventor: Gianluigi De Geronimo
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Patent number: 10126652Abstract: This disclosure provides embodiments of an approach that enforces coexistence of multiple, aligned block copolymer morphologies within a single patterning layer.Type: GrantFiled: September 19, 2016Date of Patent: November 13, 2018Assignee: Brookhaven Science Associates, LLCInventors: Charles Thomas Black, Aaron Stein, Gwen Wright, Kevin G. Yager
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Publication number: 20180296656Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.Type: ApplicationFiled: January 19, 2018Publication date: October 18, 2018Applicants: BROOKHAVEN SCIENCE ASSOCIATE, LLC, RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORKInventors: Brian A. Crowe, Ian Livey, Maria O'rourke, Michael Schwendinger, John J Dunn, Benjamin J Luft
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Patent number: 10049848Abstract: Technologies are described for methods for fabricating a film component. The methods may comprise sputtering a first film onto a substrate. The first film may include a semiconductor compound material. The semiconductor compound material may include a semi-metal material and one or more alkali material. The methods may further comprise evaporating a second film onto the first film. The second film may include the one or more alkali materials. The one or more alkali materials may catalyze crystallization of the semiconductor compound material in the first film substantially throughout the first film to form the film component in the first layer.Type: GrantFiled: June 10, 2016Date of Patent: August 14, 2018Assignees: Brookhaven Science Associates, LLC, The Regents of the University of CaliforniaInventors: John Smedley, Klaus Attenkofer, Susanne Schubert, Mengjia Gaowei, John Walsh
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Patent number: 9976199Abstract: Embodiments of the disclosure relate to intermetallic nanoparticles. Embodiments include nanoparticles having an intermetallic core including a first metal and a second metal. The first metal may be palladium and the second metal may be at least one of cobalt, iron, nickel, or a combination thereof. The nanoparticles may further have a shell that includes palladium and gold.Type: GrantFiled: April 22, 2015Date of Patent: May 22, 2018Assignee: Brookhaven Science Associates, LLCInventors: Kurian A. Kuttiyiel, Kotaro Sasaki, Radoslav R. Adzic
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Patent number: 9976155Abstract: Compositions and methods include genetically encoding and expressing a novel ?9-18:0-ACP desaturase in plant cells. In some embodiments, nucleic acid molecules encode the novel ?9-18:0-ACP desaturase. In other embodiments, amino acid sequences have ?9-18:0-ACP desaturase activity. Methods can involve expression of ?9-18:0-ACP desaturase in plant cells, plant materials, and whole plants for the purpose of increasing the amount of unusual fatty acids in whole plants, plant seeds, and plant materials, for example, seeds.Type: GrantFiled: April 15, 2016Date of Patent: May 22, 2018Assignees: Dow AgroSciences LLC, Brookhaven Science Associates, LLCInventors: John Shanklin, Tam Huu Nguyen, Terence A. Walsh, Mark S. Pidkowich, Edward J. Whittle
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Patent number: 9957514Abstract: The present disclosure provides methods and compositions for genetic transformation of Lemnaceae species.Type: GrantFiled: August 21, 2014Date of Patent: May 1, 2018Assignees: Cold Spring Harbor Laboratory, Brookhaven Science Associates, LLCInventors: Rob Martienssen, Almudena Molla-Morales, Alex Cantó-Pastor, Evan Ernst, John Shanklin, Yiheng Yan
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Patent number: 9916958Abstract: Methods and systems for fabricating a film, such as, for example, a photocathode, having a tailored band structure and thin-film components that can be tailored for specific applications, such as, for example photocathode having a high quantum efficiency, and simple components fabricated by those methods.Type: GrantFiled: January 29, 2015Date of Patent: March 13, 2018Assignees: RADIATION MONITORING DEVICES, INC., THE UNIVERSITY OF CHICAGO, BROOKHAVEN SCIENCE ASSOCIATES, LLCInventors: Harish B. Bhandari, Vivek V. Nagarkar, Olena E. Ovechkina, Henry J. Frisch, Klaus Attenkofer, John M. Smedley
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Patent number: 9895434Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.Type: GrantFiled: February 22, 2016Date of Patent: February 20, 2018Assignees: Research Foundation of the State University of New York, Brookhaven Science Associates, LLCInventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger, John J. Dunn, Benjamin J. Luft
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Patent number: 9882222Abstract: Nitride stabilized metal nanoparticles and methods for their manufacture are disclosed. In one embodiment the metal nanoparticles have a continuous and nonporous noble metal shell with a nitride-stabilized non-noble metal core. The nitride-stabilized core provides a stabilizing effect under high oxidizing conditions suppressing the noble metal dissolution during potential cycling. The nitride stabilized nanoparticles may be fabricated by a process in which a core is coated with a shell layer that encapsulates the entire core. Introduction of nitrogen into the core by annealing produces metal nitride(s) that are less susceptible to dissolution during potential cycling under high oxidizing conditions.Type: GrantFiled: November 26, 2014Date of Patent: January 30, 2018Assignee: Brookhaven Science Associates, LLCInventors: Kurian Abraham Kuttiyiel, Kotaro Sasaki, Radoslav R. Adzic
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Publication number: 20180024254Abstract: Technologies are described for semiconductor radiation detectors. The semiconductor radiation detectors may comprise a semiconductor material. The semiconductor material may include a first surface and a second surface. The first surface may be opposite from the second surface. The semiconductor material may include at least one metal component. The semiconductor material may be effective to absorb radiation and induce a current pulse in response thereto. The semiconductor radiation detector may comprise an electrode contact. The electrode contact may include a metal doped oxide deposited on the first surface of the semiconductor material. The metal doped oxide may include the metal component element of the semiconductor material.Type: ApplicationFiled: February 12, 2016Publication date: January 25, 2018Applicants: BROOKHAVEN SCIENCE ASSOCIATES, LLC, NORFOLK STATE UNIVERSITYInventors: UTPAL N. ROY, RALPH B. JAMES, ALEKSEY BOLOTNIKOV, GIUSEPPE CAMARDA, YONGGANG CUI, ANWAR HOSSAIN, GE YANG, ASWINI PRADHAN, RAJ EH MUNDLE
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Patent number: 9875821Abstract: Technologies are described for apparatus, methods and systems effective for filtering. The filters may comprise a first plate. The first plate may include an x-ray absorbing material and walls defining first slits. The first slits may include arc shaped openings through the first plate. The walls of the first plate may be configured to absorb at least some of first x-rays when the first x-rays are incident on the x-ray absorbing material, and to output second x-rays. The filters may comprise a second plate spaced from the first plate. The second plate may include the x-ray absorbing material and walls defining second slits. The second slits may include arc shaped openings through the second plate. The walls of the second plate may be configured to absorb at least some of second x-rays and to output third x-rays.Type: GrantFiled: December 1, 2015Date of Patent: January 23, 2018Assignee: Brookhaven Science Associates, LLCInventors: John Jay Sinsheimer, Raymond P. Conley, Nathalie C. D. Bouet, Eric Dooryhee, Sanjit Ghose
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Patent number: 9850291Abstract: The present invention discloses a novel gene encoding a transporter protein trigalactosyldiacylglycerol-5 (TGD5), mutations thereof and their use to enhance TAG production and retention in plant vegetative tissue.Type: GrantFiled: May 22, 2015Date of Patent: December 26, 2017Assignee: Brookhaven Science Associates, LLCInventors: Changcheng Xu, Jilian Fan, Chengshi Yan, John Shanklin
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Patent number: 9853255Abstract: Embodiments of the disclosure relate to membrane electrode assemblies. The membrane electrode assembly may include at least one gas-diffusion layer having a first side and a second side, and particle cores adhered to at least one of the first and second sides of the at least one gas-diffusion layer. The particle cores includes surfaces adhered to the at least one of the first and second sides of the at least one gas-diffusion layer and surfaces not in contact with the at least one gas-diffusion layer. Furthermore, a thin layer of catalytically atoms may be adhered to the surfaces of the particle cores not in contact with the at least one gas-diffusion layer.Type: GrantFiled: June 20, 2017Date of Patent: December 26, 2017Assignee: Brookhaven Science Associates, LLCInventors: Radoslav Adzic, Stoyan Bliznakov, Miomir Vukmirovic
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Patent number: 9842958Abstract: A method of forming electrical contacts on a diamond substrate comprises producing a plasma ball using a microwave plasma source in the presence of a mixture of gases. The mixture of gases include a source of a p-type or an n-type dopant. The plasma ball is disposed at a first distance from the diamond substrate. The diamond substrate is maintained at a first temperature. The plasma ball is maintained at the first distance from the diamond substrate for a first time, and a UNCD film, which is doped with at least one of a p-type dopant and an n-type dopant, is disposed on the diamond substrate. The doped UNCD film is patterned to define UNCD electrical contacts on the diamond substrate.Type: GrantFiled: October 31, 2016Date of Patent: December 12, 2017Assignees: UChicago Argonne, LLC, Brookhaven Science Associates, LLC, The Research Foundation for the State University of New YorkInventors: Anirudha V. Sumant, John Smedley, Erik Muller
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Patent number: 9837814Abstract: A radio frequency-assisted fast superconducting switch is described. A superconductor is closely coupled to a radio frequency (RF) coil. To turn the switch “off,” i.e., to induce a transition to the normal, resistive state in the superconductor, a voltage burst is applied to the RF coil. This voltage burst is sufficient to induce a current in the coupled superconductor. The combination of the induced current with any other direct current flowing through the superconductor is sufficient to exceed the critical current of the superconductor at the operating temperature, inducing a transition to the normal, resistive state. A by-pass MOSFET may be configured in parallel with the superconductor to act as a current shunt, allowing the voltage across the superconductor to drop below a certain value, at which time the superconductor undergoes a transition to the superconducting state and the switch is reset.Type: GrantFiled: April 9, 2013Date of Patent: December 5, 2017Assignee: Brookhaven Science Associates, LLCInventors: Vyacheslav Solovyov, Qiang Li