Abstract: Bacterial multidrug resistance is attenuated in a subject by administering an aminoacyl-tRNA synthetase inhibitor and an antibacterial agent to the subject, wherein the aminoacyl-tRNA synthetase inhibitor is distinct from the antibacterial agent.
Abstract: In one exemplary embodiment of the invention, a method includes: receiving, by an input, input data descriptive of a stochastic scheduling optimization problem; generating, by a processor, at least one solution to the stochastic scheduling optimization problem using a one-step anticipatory algorithm, where the one-step anticipatory algorithm is configured to reduce an anticipatory gap of the stochastic scheduling optimization problem, where the anticipatory gap is a measure of stochasticity of the stochastic scheduling optimization problem, where the one-step anticipatory algorithm operates by determining a set of possible decisions for the stochastic scheduling optimization problem, generating a plurality of scenarios and solving the plurality of scenarios to obtain the at least one solution; and outputting, by an output, the generated at least one solution.
Abstract: The invention involves methods and products related to the micronization of hydrophobic drugs. A method of micronizing hydrophobic drugs using a set of solutions including an aqueous solution is provided. The invention also relates to products of micronized hydrophobic drugs and related methods of use.
Type:
Grant
Filed:
June 17, 2008
Date of Patent:
September 3, 2013
Assignee:
Brown University Research Foundation
Inventors:
Edith Mathiowitz, Christopher Thanos, Zhi Liu
Abstract: In one aspect, a method and apparatus for detecting subject matter of interest in view data obtained by scanning an object including generating a filter adapted to respond to the subject matter of interest, splatting the filter onto a portion of the view data to provide a filter splat, and performing at least one operation on the portion of the view data using the filter splat to facilitate determining whether the subject matter of interest is present in the portion of the view data.
Type:
Grant
Filed:
June 7, 2011
Date of Patent:
August 20, 2013
Assignee:
Brown University
Inventors:
Joseph L. Mundy, Benjamin Kimia, Philip Nathan Klein, Kongbin Kang, Huseyin Can Aras
Abstract: The present invention is directed towards methods for growing diamond nanowires via chemical vapor deposition and apparatuses that incorporate these diamond nanowires.
Abstract: The present invention is a method and material for using a sorbent material to capture and stabilize mercury. The method for using sorbent material to capture and stabilize mercury contains the following steps. First, the sorbent material is provided. The sorbent material, in one embodiment, is nano-particles. In a preferred embodiment, the nano-particles are unstabilized nano-Se. Next, the sorbent material is exposed to mercury in an environment. As a result, the sorbent material captures and stabilizes mercury from the environment. In the preferred embodiment, the environment is an indoor space in which a fluorescent has broken.
Type:
Grant
Filed:
August 27, 2010
Date of Patent:
August 13, 2013
Assignee:
Brown University
Inventors:
Robert H. Hurt, Steven P. Hamburg, Love Sarin, Indrek Kulaots
Abstract: The present invention is directed to methods for inhibiting growth of bacteria and to nanometer scale surfaces having antibacterial properties.
Abstract: Provided are assays and methods for creating proto-tissues from aggregates of cells. The invention concerns assays and methods useful in tissue engineering and reconstruction techniques, specifically in the formation of macrotissues from microtissues using microtissue pre-culture time as a controlling parameter.
Type:
Grant
Filed:
October 1, 2010
Date of Patent:
August 6, 2013
Assignee:
Brown University
Inventors:
Jeffrey R. Morgan, Dylan Dean, Adam Rago
Abstract: Disclosed herein are systems for delivery of one or more molecules (such as a drug, for example, a small molecule, polypeptide, and/or nucleic acid) to a subject, for example to a targeted location in the subject. In some embodiments, the delivery system includes an encapsulated inducing agent or repressing agent and a plurality of cells. In some examples, the inducing agent or repressing agent and the cells are each separately encapsulated. In other examples, the encapsulated inducing agent or repressing agent and the cells are co-encapsulated. The cells include one or more genes which are operably linked to an inducible promoter or a repressible promoter which is inducible or repressible by the encapsulated inducing agent or repressing agent, respectively. Methods of use of the delivery systems, for example to treat or inhibit a disease or disorder in a subject, are also disclosed.
Type:
Application
Filed:
January 24, 2013
Publication date:
July 25, 2013
Applicants:
Brown University, The United States Government as Represented by the Department of Veterans Affairs
Inventors:
The United States Government as Represented by the Department of Veterans Affairs, Brown University
Abstract: mGluR5 antagonists are used for the treatment of autism. The human treated by the methods of the invention can also have fragile X syndrome, epilepsy and anxiety.
Abstract: The present invention is a method and material for using a sorbent material to capture and stabilize mercury. The method for using sorbent material to capture and stabilize mercury contains the following steps. First, the sorbent material is provided. The sorbent material, in one embodiment, is nano-particles. In a preferred embodiment, the nano-particles are unstabilized nano-Se. Next, the sorbent material is exposed to mercury in an environment. As a result, the sorbent material captures and stabilizes mercury from the environment. In the preferred embodiment, the environment is an indoor space in which a fluorescent has broken.
Type:
Grant
Filed:
August 27, 2010
Date of Patent:
July 23, 2013
Assignee:
Brown University
Inventors:
Robert H. Hurt, Steven P. Hamburg, Love Sarin, Indrek Kulaots
Abstract: The invention relates to the use of one or more growth factors in a drug delivery system, optionally with an external mesh housing, to recruit and optionally harvest progenitor cells. These cells include those that normally reside in the bone marrow.
Abstract: An improved device and method for extended repair and regeneration of muscle tissue. An exemplary device comprises (a) a scaffold comprising an ECM component; (b) a combination of growth factors such as VEGF and IGF; and (c) a population of myogenic cells. Implantation of the device leads to muscle regeneration and repair over an extended period of time.
Type:
Application
Filed:
March 7, 2011
Publication date:
July 11, 2013
Applicants:
Brown University, President and Fellows of Harvard College
Inventors:
David J. Mooney, Cristina Borselli, Herman Vandenburgh, Eduardo Silva, Lin Wang, Dmitry Shvartsman, Hannah Storrie, Jeff Lichtman
Abstract: The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds.
Type:
Grant
Filed:
March 7, 2007
Date of Patent:
June 25, 2013
Assignees:
Brown University, Women and Infants' Hospital Rhode Island
Inventors:
Giselle L. Saulnier Sholler, Satyan Kalkunte, Rakesh K. Singh, Laurent Brard, Kyu Kwang Kim, Hena Swamy
Abstract: The evaporator (10) efficiently evaporates solvent and/or introduces gases to multiple samples. The evaporator (10) contains a top plate (20) and a bottom plate (30). The top plate (20) is mated to the bottom plate (30) to define a main chamber (130) for distribution of gas. An input port (80) is defined within the bottom plate (30) of the evaporator (10) is in fluid communication with a gas distribution channel (100). The gas distribution channel (100) has a series of gas distribution ports (110A-C) increasing in diameter, in proportion to a distance from the input port (80), that provide for an even distribution of gas into the main chamber (130). Gas exits the main chamber (130) through exit ports (120A-C) defined within the bottom plate (30). Screws (50) respectively control gas flow to exit ports (120A-C) for delivery to an array of nozzles (90) on the bottom plate (30).
Abstract: Methods, compositions, devices and kits having a novel chromatographic material are provided herein for separating and identifying organic molecules and compounds, for example molecules and compounds containing electron rich functional groups such as carbon-carbon double bonds. The methods, compositions, and kits include a metal-thiolate chromatographic medium (MTCM) with a sulfur-containing functional group or a metal-selenolate chromatographic medium (MSCM) comprising a selenium-containing functional group covalently attached to a support medium, such that the sulfur-containing functional group or selenium-containing functional group is bound to at least one metal atom. The MTCM and/or MSCM has affinity and specificity to compounds having one or more carbon-carbon double bonds, and performs a highly efficient and rapid separation of samples yielding non-overlapping peaks of purified materials compared to traditional media.
Abstract: Molds for making cell aggregation devices include upper and lower surfaces. Methods of aggregating cells include depositing cells on in a seeding chamber, incubating the cells and removing aggregated cells. Devices for encapsulating aggregates of cells include biocompatible, bio-sustainable substrates compartments and a coating of a biocompatible, bio-sustainable polymer that completely surrounds the substrate and cell-encapsulating compartments.
Abstract: Magnetic tracking systems and methods for determining the position and orientation of a remote object. A magnetic tracking system includes a stationary transmitter for establishing a reference coordinate system, and at least one receiver. The remote object is attached to, mounted on, or otherwise coupled to the receiver. The transmitter can include a set of three mutually perpendicular coils having a common center point, or a set of three coplanar coils with separate centers. The receiver can include a set of three orthogonal coils. The position and orientation of the receiver and the remote object coupled thereto is determined by measuring the nine mutual inductances between the three transmitter coils and the three receiver coils. The magnetic tracking system provides reduced power consumption, increased efficiency, digital compensation for component variation, automatic self-calibration, automatic synchronization with no connections between transmitter and receiver, and rapid low-cost implementation.
Abstract: The present invention is directed to implants and the modification of the surface of implants using amino acid or polypeptide functionalized rosette nanotubes.
Type:
Application
Filed:
March 16, 2011
Publication date:
May 23, 2013
Applicants:
NATIONAL RESEARCH COUNCIL OF CANADA, BROWN UNIVERSITY
Inventors:
Thomas J. Webster, Hicham Fenniri, Usha Devi Hemraz
Abstract: The present invention is directed to a redox-active, conducting polymer energy storage system, said system including an electrode and a counter electrode, wherein the electrode comprises a first conducting polymer and the counter electrode comprises a second conducting polymer, wherein the first conducting polymer is doped by at least one or more first redox-active compounds and/or by a polymer and/or a co-polymer of the one or more first redox-active compounds and the second conducting polymer is doped by at least one or more second redox-active compounds and/or by a polymer and/or a co-polymer of the one or more second redox-active compounds, and wherein there is a potential difference between the dopant for the electrode and the dopant for the counter electrode. In one preferred embodiment, the first or the second redox-active compound is 2,2?-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS).
Type:
Grant
Filed:
October 15, 2010
Date of Patent:
May 7, 2013
Assignee:
Brown University
Inventors:
G. Tayhas R. Palmore, Jiangfeng Fei, Hyun-Kon Song