Abstract: A participant, engages in healthcare provider prescribed physical rehabilitation exercises utilizing specifically designed controllers, and these exercises are mapped to one or more video game commands. These commands are coupled with other inputs to control the video game that will be used to ensure adherence to a prescribed rehabilitation regimen. Information is gathered on the participant, in order to aid in rehabilitation.

Abstract: A method that estimates the coordinates of the calibration points in the projector image plane using local homographies obtained from the imaging camera. First, a dense set of correspondences between projector and camera pixels is found by projecting onto the calibration object an identical pattern sequence as the one later projected when scanning the target, reusing most of the software components written for the scanning application. Second, the set of correspondences is used to compute a group of local homographies that allow projection back of any of the points in the calibration object onto the projector image plane with sub-pixel precision. In the end, the data projector is then calibrated as a normal camera.

Abstract: This invention discloses CN2097-like compositions that facilitate the induction of long-term potentiation (LTP). In one embodiment the method comprises inducing long-term potentiation in a subject by the method of administering a therapeutically effective dose of a CN2097-like compound.

Abstract: Nanoparticles, compositions, and methods for the improved uptake of active agents are disclosed herein. The compositions contain a monodisperse population of nanoparticles, preferably including an active agent, where the nanoparticles are formed from a polymeric material possessing specified bioadhesion characteristics. Following enteral administration, preferably oral administration, the nanoparticles exhibit total intestinal uptakes of greater than 20%, preferably greater than 45%, more preferably greater than 65%. When compared to uptake of the same compositon in the absence of the bioadhesive polymeric material, the nanoparticles have significantly increased uptake with intestinal uptake of the increased by more than 100%, preferably even greater than 500%. Further disclosed herein is a method of producing multi-walled nanoparticles, as well as methods of using thereof. Multi-walled particles prepared using the method disclosed herein are useful for controlling the release of active agents.

Abstract: The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Examples of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.

Abstract: Magnetic tracking systems and methods for determining the position and orientation of a remote object. A magnetic tracking system includes a stationary transmitter for establishing a reference coordinate system, and at least one receiver. The remote object is attached to, mounted on, or otherwise coupled to the receiver. The transmitter can include a set of three mutually perpendicular coils having a common center point, or a set of three coplanar coils with separate centers. The receiver can include a set of three orthogonal coils. The position and orientation of the receiver and the remote object coupled thereto is determined by measuring the nine mutual inductances between the three transmitter coils and the three receiver coils. The magnetic tracking system provides reduced power consumption, increased efficiency, digital compensation for component variation, automatic self-calibration, automatic synchronization with no connections between transmitter and receiver, and rapid low-cost implementation.

Abstract: The present disclosure provides methods for predicting a patient's response to biglycan therapy for diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, for example, due to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Examples of such diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders. This application also provides combination therapeutics, such as a biglycan therapeutic and a utrophin therapeutic.

Abstract: The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds.

Abstract: In some aspects, a multi-camera device to facilitate multiple camera video conferencing is provided. The multi-camera device comprises a plurality of input ports, each configured to receive video information when connected to a respective external video camera, an output port configured to output video information, and a selection component coupled to the plurality of input ports and the output port, the selection component configured to provide video information received by at least one of the input ports to the output port for output to an external computer.

Abstract: An opto-acoustic transducer assembly includes a substrate; at least one layer of opto-acoustic material coupled to a surface of the substrate, where the at least one layer of opto-acoustic material generates sound waves when struck by pulses of pump light; and an acoustic lens configured to focus sound waves generated by the at least one layer of opto-acoustic material towards a sample. The acoustic lens is further configured to collect sound waves returning from the sample and to direct the returning sound waves to the at least one layer of opto-acoustic material. In one non-limiting embodiment the at least one layer of opto-acoustic material is interposed between the substrate and the acoustic lens, and the substrate is substantially transparent to light having wavelengths of interest.

Abstract: A system and method for cryptographically checking the correctness of outsourced set operations performed by an untrusted server over a dynamic collection of sets that are owned (and updated) by a trusted source is disclosed. The system and method provides new authentication mechanisms that allow any entity to publicly verify a proof attesting the correctness of primitive set operations such as intersection, union, subset and set difference. Based on a novel extension of the security properties of bilinear-map accumulators as well as on a primitive called accumulation tree, the system and method achieves optimal verification and proof complexity, as well as optimal update complexity, while incurring no extra asymptotic space overhead. The method provides an efficient proof construction, adding a logarithmic overhead to the computation of the answer of a set-operation query. Applications of interest include efficient verification of keyword search and database queries.

Abstract: Methods, compositions, systems, devices and kits are provided for preparing and using a multi-layer polymeric microstructure composition for delivering a therapeutic agent to a subject. In various embodiments, the therapeutic agent includes at least one selected from the group of: a drug, a protein, a sugar, a carbohydrate, and a nucleotide sequence. In related embodiments, the composition is a fiber, a suture, a sphere, an implant, or a scaffold.

Abstract: The present invention is a method and material for using a sorbent material to capture and stabilize mercury. The method for using sorbent material to capture and stabilize mercury contains the following steps. First, the sorbent material is provided. The sorbent material, in one embodiment, is nano-particles. In a preferred embodiment, the nano-particles are unstabilized nano-Se. Next, the sorbent material is exposed to mercury in an environment. As a result, the sorbent material captures and stabilizes mercury from the environment. In the preferred embodiment, the environment is an indoor space in which a fluorescent has broken.

Abstract: A system for harvesting electric energy from illumination by photons by photo- and bioelectrocatalysis includes an electrode coated with conducting polymer matrix containing the oxidoreductase, laccase, and a redox mediator, 2,2?-azino-bis(3-ethylbenzothiaxoline-6-sulfonic acid (ABTS). The photo-anode is based on nanocrystalline TlO2 (Degussa, P25) adhered to a fluorine tin oxide (FTO) electrode. The device operation is based on a continuous photocatalytic oxidation of water to oxygen at a TiO2-photoanode and bioelectrocatalytic reduction of oxygen to water at a biocathode under illumination with light.

Abstract: A method for characterizing a sample is described. The method includes applying a first pulse of electromagnetic radiation to the surface of the sample and thus creating a propagating strain pulse within the sample. A second pulse of second electromagnetic radiation is applied to the surface of the sample so as to intercept the propagating strain pulse. The first and second pulses are applied through a structure, such as a reflector, that is disposed over the surface of the sample at a distance predetermined to form an optical cavity; the cavity having a width related to a wavelength of the second electromagnetic radiation. The method includes detecting at least one optical property of a reflection of the second pulse from the sample. The detected optical property(ies) of the reflection are associated with a characteristic of the sample. An apparatus, computer-readable medium and structure are also described.

Abstract: Methods of detecting a source of a microbial contamination in a suspect sample include detecting at least one member selected from the group consisting of a microbial geosmin synthase, a microbial 2-methylisoborneol synthase and a microbial 2-methylgeranyl diphosphate synthase in the suspect sample. The method can include conducting a nucleic acid amplification assay in the presence of at least one member selected from the group consisting of at least one microbial geosmin primer and at least one microbial 2-methylisoborneol synthase primer on a sample obtained from a suspect source of the microbial contamination.

Abstract: The present invention generally relates to mass spectrometry and related techniques, and in some cases, to determining single species using mass spectrometry. In certain instances, polymers such as DNA or RNA can also be sequenced. Certain embodiments of the invention relate to passing a polymer, such as DNA, RNA, a protein, a polypeptide, a polysaccharide, etc., through a pore and cleaving the polymer in sequence. For instance, the polymer may be cleaved using a laser or an electric field. In some embodiments, a property of at least one subunit of a polymer is determined using mass spectrometry. In some embodiments, a single ion (which may be a subunit of a polymer, or an ion based on another species) can be isolated in a mass spectrometer and a signal generated from the single ion.

Abstract: A new structure-control strategy to optimize nanoparticle catalysis is provided. The presence of Au in FePtAu facilitates FePt structure transformation from chemically disordered face centered cubic (fcc) structure to chemically ordered face centered tetragonal (fct) structure, and further promotes formic acid oxidation reaction (FAOR). The fct-FePtAu nanoparticles show high CO poisoning resistance, achieve mass activity as high as about 2810 mA/mg Pt, and retain greater than 90% activity after a 13 hour stability test.

Abstract: The present invention is directed to methods for inhibiting growth of pathogens and to substrates with selenium nanoparticles or selenium nanoclusters having antipathogenic properties.

Abstract: A system is provided for removing arsenic from water to safe levels at or below the EPA standards. The system is a hybrid spouted vessel/fixed bed filter system that significantly enhances/improves arsenic removal for drinking water using zero-valent iron (ZVI) particles. Movement of the circulating, iron-containing particles in a dense moving bed that forms on the spouted vessel bottom creates an abrasive “self-polishing” action among them that continuously generates colloidal iron corrosion products. This material then circulates with the water in the vessel and is removed and concentrated in a fixed bed filter. The colloidal material captured and immobilized in the filter has been shown to remove arsenic from contaminated water at very rapid rates.