Abstract: The present invention relates to a method of determining conserved ribosomal RNA (rRNA) nucleotide motifs that are specific to one domain of life, Eukarya, Bacteria, or Archaea, and degenerate in at least one other domain of life. The invention also relates to a method of determining conserved ribosomal RNA (rRNA) nucleotide motifs that are specific to one subgroup and degenerate in another subgroup within a domain of life or for a subset group within a domain of life. The invention relates to a method of identifying a compound that is a domain-specific or subgroup-specific ribosomal RNA inhibitor.

Abstract: The present invention generally relates to mass spectrometry and related techniques, and in some cases, to determining single species using mass spectrometry. In certain instances, polymers such as DNA or RNA can also be sequenced. Certain embodiments of the invention relate to passing a polymer, such as DNA, RNA, a protein, a polypeptide, a polysaccharide, etc., through a pore and cleaving the polymer in sequence. For instance, the polymer may be cleaved using a laser or an electric field. In some embodiments, a property of at least one subunit of a polymer is determined using mass spectrometry. In some embodiments, a single ion (which may be a subunit of a polymer, or an ion based on another species) can be isolated in a mass spectrometer and a signal generated from the single ion.

Abstract: The invention provides, among other aspects, compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; diseases or conditions associated with an abnormal level or activity of collagen VI; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); and disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation.

Abstract: In one exemplary embodiment, an apparatus includes a memory storing data and a processor performing operations. The apparatus generates or maintains an accumulation tree for the stored data—an ordered tree structure with a root node, leaf nodes and internal nodes. Each leaf node corresponds to a portion of the data. A depth of the tree remains constant. A bound on a degree of each internal node is a function of a number of leaf nodes of a subtree rooted at the internal node. Each node of the tree has an accumulation value. Accumulation values of the root and internal nodes are determined by hierarchically employing an accumulator over the accumulation values of the nodes lying one level below the node in question. The accumulation value of the root node is a digest for the tree.

Abstract: The present invention is directed to implants and the modification of the surface of implants using amino acid or polypeptide functionalized rosette nanotubes.

Abstract: The present invention provides a system for engaging a fluid flow. The system comprising one or more foil members operationally connected to a feedback control loop system. In one embodiment, the foil member is a hydrofoil member or an airfoil member. The foil members are configured for one or more degrees of freedom of oscillatory movement within the fluid flow. The feedback control loop system comprises a sensor system, actuator system, and a controller system. The feedback control loop system configured for actuating the foil members and thereby optimizing the operation of the foil members to attain one or more optimization objectives. In operation, the foil members are situated in the fluid flow and are manipulated to attain one or more optimization objectives.

Abstract: An effective method for prolonging localization of therapeutics within the rat gastrointestinal tract of at least about 12 hours is provided. Attractive forces between an orally administered magnetic dose and an external magnet were monitored and internal dose motion in real time using biplanar videofluoroscopy was visualized. Tissue elasticity was quantified as a measure of tissue health by combining data streams. The methods address safety, efficacy, and monitoring capacity of magnetically localized doses and show a platform for testing the benefits of localized drug delivery.

Abstract: The present disclosure focuses on Ge nanostructured materials for optoelectronic devices: including high-efficiency quantum dot (QD) photodetectors and Si and Ge heteronanowire solar cells. The common thread among these materials is the use of Ge/Si or Ge/oxide barriers to confine carriers and enhance photoconductive gain in detectors and optical absorption and spectral coverage in solar cells.

Abstract: Methods using DNA Methylation arrays are provided for identifying a cell or mixture of cells and for quantification of alterations in distribution of cells in blood or in tissues, and for diagnosing, prognosing and treating disease conditions, particularly cancer. The methods use fresh and archival samples.

Abstract: A method for the problem of reconstructing a watertight surface defined by an implicit equation from a finite set of oriented points. As in other surface reconstruction approaches disctretizations of this continuous formulation reduce to the solution of sparse least-squares problems. Rather than forcing the implicit function to approximate the indicator function of the volume bounded by the surface, in the present formulation the implicit function is a smooth approximation of the signed distance function to the surface. Then solution thus introduced is a very simple hybrid FE/FD discretization, which together with an octree partitioning of space, and the Dual Marching Cubes algorithm produces accurate and adaptive meshes.

Abstract: The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids.

Abstract: In an embodiment, a single-ended transmission line N-path filter includes one or more filter stages, each stage having a first series inductive element, a shunt N-path filter, and a second series inductive element; an input port; and an output port.

Abstract: In one exemplary embodiment, an apparatus includes a memory storing data and a processor performing operations. The apparatus generates or maintains an accumulation tree for the stored data—an ordered tree structure with a root node, leaf nodes and internal nodes. Each leaf node corresponds to a portion of the data. A depth of the tree remains constant. A bound on a degree of each internal node is a function of a number of leaf nodes of a subtree rooted at the internal node. Each node of the tree has an accumulation value. Accumulation values of the root and internal nodes are determined by hierarchically employing an accumulator over the accumulation values of the nodes lying one level below the node in question. The accumulation value of the root node is a digest for the tree.

Abstract: Magnetic tracking systems and methods for determining the position and orientation of a remote object. A magnetic tracking system includes a stationary transmitter for establishing a reference coordinate system, and at least one receiver. The remote object is attached to, mounted on, or otherwise coupled to the receiver. The transmitter can include a set of three mutually perpendicular coils having a common center point, or a set of three coplanar coils with separate centers. The receiver can include a set of three orthogonal coils. The position and orientation of the receiver and the remote object coupled thereto is determined by measuring the nine mutual inductances between the three transmitter coils and the three receiver coils. The magnetic tracking system provides reduced power consumption, increased efficiency, digital compensation for component variation, automatic self-calibration, automatic synchronization with no connections between transmitter and receiver, and rapid low-cost implementation.

Abstract: A pump light pulse is generating a strain pulse in a sample that includes quantum wells. A signal is measured using a probe light pulse. The probe light pulse is delayed in relation to the pump light pulse. The signal derives from a change in an optical property of the sample, which optical property responds to the generated strain pulse. One may deduce parameters of interest of the sample, including the quantum wells, from the characteristics of the signal. For discerning between various components of the stress in the quantum wells a lead pump pulse, preceding the pump light, pulse my also be used. A system for the application of such methods is also disclosed.

Abstract: Devices and methods are provided for a nanocomposite having a phase change polymer matrix and conductive nanoparticles to provide greatly enhanced responsivity to temperature and/or humidity. A sensing film includes carbon nanotubes (CNTs) and the polymer. Operation near the transition temperature increases the TCR by over an order of magnitude, thus providing a new platform for devices such as IR sensors, bolometers and imaging elements, MEMS devices, compensating or uncompensated circuit elements and other electronic devices. Nanocomposite films may be under about one micron thick, and coatings, constant environment chambers or mounts, and other engineered improvements and variations may be provided to further enhance the response, range, response times or sensitivity of the film-based devices. One embodiment employs a nanocomposite film under one micron in thickness to operate as an uncooled but highly sensitive infrared bolometer under ambient conditions.

Abstract: The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Example of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.

Abstract: Provided herein are inventive enopeptin compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Further provided are methods of preparation, use, and treatment.

Abstract: Systems and methods for providing an electrical interface to a body are provided. In one embodiment, an implantable module is disclosed, comprising: an implantable electrode array, implantable within a body and capable of providing a plurality of communication channels for communicating electrical signals detected in a body; an amplifier circuit for processing electrical signals received from the electrode array; a wireless transceiver for sending and receiving telemetry data between the amplifier circuit and a wireless receiver located outside of the body; and a sealed enclosure that houses the amplifier circuit and the wireless transmitter and is biocompatible with surrounding tissue, the enclosure having a window that is transparent to a wireless medium used by the wireless transceiver.

Abstract: Diuretic bioactivity profiles of phase inversion micronized furosemide and furosemide co-precipitated with Eudragit L100, and mixtures of those formulations with stock furosemide, reduced or eliminated the rapid spike in diuresis associated with immediate release formulations and maintained cumulative urine output. Of the formulations tested, each of a mixture of micronized furosemide with stock furosemide, and Eudragit L100 polymer with stock furosemide demonstrated optimal diuretic bioactivity profiles in subjects.