Patents Assigned to California Institute of Technology
  • Publication number: 20240201563
    Abstract: On-chip generation of coherent radiation, i.e. laser-like radiation, can be tuned over broad and/or hard-to-access wavelength regions in an integrated platform. Target spectral coverage is beyond what could be achieved with existing integrated laser systems.
    Type: Application
    Filed: December 18, 2023
    Publication date: June 20, 2024
    Applicant: California Institute of Technology
    Inventors: Luis M. Ledezma, Alireza Marandi, Robert M. Gray, Benjamin K. Gutierrez
  • Patent number: 12015694
    Abstract: A communication system including a first detector; a first scattering medium; a second detector; an intensity modulator; a second scattering medium; wherein electromagnetic radiation transmitted from a first spot at the first scattering medium, and scattered by and through the first scattering medium and then the second scattering medium, forms a first speckle pattern detected by the second detector. The intensity modulator outputs a second spot of electromagnetic radiation representing the “ones” in a data stream at locations of the bright speckles (or at locations of the dark speckles to represent the “zeros” in the data stream) so that the electromagnetic radiation, transmitted from the second spot and scattered by and through the second scattering medium and then the first scattering medium, forms one or more second bright or dark speckles on the first detector. The data stream can be constructed from the second bright or dark speckles.
    Type: Grant
    Filed: September 28, 2021
    Date of Patent: June 18, 2024
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Jian Xu, Changhuei Yang
  • Patent number: 12015472
    Abstract: Interplanetary networks for space internet and space positioning are presented. The described networks deploy spacecraft swarms along the solar system to form a science and communications platform. The disclosed network nodes are placed around planetary Lagrange points. Creation of optical synthetic apertures using smallsat swarms for inter- and intranet communications is further described. Exemplary subnetworks such as the cislunar network are also presented.
    Type: Grant
    Filed: March 16, 2022
    Date of Patent: June 18, 2024
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventor: Jose E. Velazco
  • Publication number: 20240192776
    Abstract: An apparatus and method for a pre-trained brain machine interface based on brain state data is disclosed. An initial session of determining brain state data during performance of a task by a subject at a first time is conducted. The brain state data correlated with task performance are recorded. A pre-training set of the brain state data is assembled. A decoder module of the brain machine interface system is pre-trained via the pre-training set of the recorded brain state data to decode intentions of the subject correlated with brain state. A current session is conducted at a second time subsequent to the first time. The current session includes the decoder module accepting a brain state data input of the brain of the subject, decoding a brain state output from the brain state data input, and generating a control signal to perform the task based on the determined brain state output.
    Type: Application
    Filed: November 9, 2023
    Publication date: June 13, 2024
    Applicant: California Institute of Technology
    Inventors: Whitney S Griggs, Sumner L Norman, Richard A Andersen, Mikhail G Shapiro
  • Publication number: 20240195077
    Abstract: An integrated photonic platform for a transceiver aperture. New functions that can only be realized in the integrated platform are further described.
    Type: Application
    Filed: December 12, 2023
    Publication date: June 13, 2024
    Applicant: California Institute of Technology
    Inventors: Aroutin Khachaturian, Babak Bahari, Seyed Ali Hajimiri
  • Patent number: 12006404
    Abstract: In an aspect, provided herein are low density materials, including shell-based materials, with three-dimensional architectures formed, in part, via self-assembly processes. Shell-based materials of some embodiments exhibit a combination of ultralow density (e.g., ?100 mg cm?3 and optionally ?10 100 mg cm?3) and non-periodic architectures characterized by low defect densities and geometries avoiding stress concentrations. Low density shell based materials of some embodiments have architectures characterized by small curvatures and lack of straight edges providing enhance mechanical response. In some embodiments, for example, the present low density materials, including shell-based materials, providing a combination target mechanical properties including high stiffness-to-density ratios, mechanical resilience and tolerance for deformation.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: June 11, 2024
    Assignee: California Institute of Technology
    Inventors: Carlos M. Portela, Daryl Wei Liang Yee, Dennis M. Kochmann, Julia R. Greer
  • Patent number: 12004996
    Abstract: A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.
    Type: Grant
    Filed: November 9, 2022
    Date of Patent: June 11, 2024
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Aubrey M. Shapero, Nicholas E. Scianmarello, Mark S. Humayun
  • Patent number: 12005246
    Abstract: A system configured to be at least partially implanted along an aorta includes an inelastic, static member and a pinching member. The pinching member is configured to receive an activation signal at an activation rate and in response to the activation signal, repeatedly compress the aorta at the second location at the activation rate to pump fluid within the aorta in a desired pumping direction. The system is configured to selectively control wave reflections in order to achieve both improved wave dynamics to reduce cardiac load and increased (or at least non-diminished) blood flow to targeted organs within the cardiovascular system.
    Type: Grant
    Filed: January 6, 2021
    Date of Patent: June 11, 2024
    Assignee: California Institute of Technology
    Inventors: Niema M. Pahlevan, Morteza Gharib, Marie Csete
  • Patent number: 12006206
    Abstract: Embodiments described herein include systems and techniques for converting (i.e., transducing) a quantum-level (e.g., single photon) signal between the three wave forms (i.e., optical, acoustic, and microwave). A suspended crystalline structure is used at the nanometer scale to accomplish the desired behavior of the system as described in detail herein. Transducers that use a common acoustic intermediary transform optical signals to acoustic signals and vice versa as well as microwave signals to acoustic signals and vice versa. Other embodiments described herein include systems and techniques for storing a qubit in phonon memory having an extended coherence time. A suspended crystalline structure with specific geometric design is used at the nanometer scale to accomplish the desired behavior of the system.
    Type: Grant
    Filed: July 15, 2022
    Date of Patent: June 11, 2024
    Assignee: California Institute of Technology
    Inventors: Oskar Painter, Jie Luo, Michael T. Fang, Alp Sipahigil, Paul B. Dieterle, Mahmoud Kalaee, Johannes M. Fink, Andrew J. Keller, Gregory MacCabe, Hengjiang Ren, Justin D. Cohen
  • Patent number: 12004876
    Abstract: An auto-powered biosensor capable detecting a target molecule, and a method of powering the same, wherein the biosensor is fabricated with a microfluidics layer, a multimodal sensing layer comprising a biofuel cell and an electrode, and a logic circuit that may include a processor and non-transitory memory with computer executable instructions embedded thereon.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: June 11, 2024
    Assignee: California Institute of Technology
    Inventors: Wei Gao, You Yu
  • Publication number: 20240186653
    Abstract: Separator membranes for ion batteries and methods of producing such separator membranes are disclosed herein. The separator membranes have vertically-aligned pores that have as small as submicron diameters at one or both membrane surfaces. The separator membranes may be fabricated via a novel and innovative bidirectional freeze-casting process that produces a temperature gradient in two directions. The separator membranes disclosed herein and fabricated by this method can be used in ion batteries, such as sodium ion batteries.
    Type: Application
    Filed: September 18, 2023
    Publication date: June 6, 2024
    Applicants: TalosTech LLC, California Institute of Technology
    Inventors: Hansan Liu, Chun-Wei Wu, Xiaoping Lin, Katherine T. Faber
  • Publication number: 20240182340
    Abstract: A dual-pathway system for CO2 capture in both acidified and basified streams is provided. The system may be embodied in an off-shore stand-alone facility to allow for the operation of oceanic CO2 capture to be more efficient and cost effective. Systems maintain high environmental standards by containing all intermediate acidic and alkaline solutions in a closed system so that the effluent discharged back into the ocean is at the similar pH and salinity as the feed oceanwater, with only CO2 removed. Acid and base produced by an electrodialyzer unit is used to achieve oceanwater decarbonization via gaseous CO2 removal and solid CaCO3 precipitates removal. The system is configured to require the processing of a very small fraction of the total oceanwater intake for the acid-base generation process.
    Type: Application
    Filed: December 2, 2022
    Publication date: June 6, 2024
    Applicant: California Institute of Technology
    Inventors: Harry A. Atwater, Chengxiang Xiang, Ibadillah A. Digdaya
  • Patent number: 11998616
    Abstract: The present application discloses nanoparticles carrying therapeutic agents, including chemotherapeutic agents, and targeting ligands suitable for delivering these therapeutic agents through the blood brain barrier and methods of using these patients on those patients in need of such treatment.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: June 4, 2024
    Assignee: California Institute of Technology
    Inventors: Mark E. Davis, Emily A. Wyent
  • Patent number: 11999964
    Abstract: Disclosed herein include circuits, compositions, nucleic acids, populations, systems, and methods enabling cells to sense, control, and/or respond to their own population size. In some embodiments, an orthogonal communication channel allows specific communication between engineered cells. Also described herein, in some embodiments, is an evolutionarily robust ‘paradoxical’ regulatory circuit architecture in which orthogonal signals both stimulate and inhibit net cell growth at different signal concentrations. In some embodiments, engineered cells autonomously reach designed densities and/or activate therapeutic or safety programs at specific density thresholds. Methods of treatment are also provided in some embodiments.
    Type: Grant
    Filed: August 27, 2021
    Date of Patent: June 4, 2024
    Assignee: California Institute of Technology
    Inventors: Yitong Ma, Mark W. Budde, Michaelle N. Mayalu, Michael B. Elowitz
  • Patent number: 11999954
    Abstract: Disclosed herein are programmable, conditionally activated small interfering RNA constructs (Cond-siRNAs) and methods of making and using the same as therapeutic agents. The Cond-siRNA comprises a sensor strand, a core strand, and a guide strand, which crossover to form a sensor duplex and a RNAi duplex attached to each other to form a single structure. Upon binding an input strand to the sensor strand, the Cond-siRNA is activated and releases RNAi targeting a desired gene.
    Type: Grant
    Filed: February 10, 2021
    Date of Patent: June 4, 2024
    Assignees: Clty of Hope, California Institute of Technology
    Inventors: Si-ping Han, William A. Goddard, III, Marwa Ben Haj Salah, Lisa Scherer, John J. Rossi
  • Patent number: 12001115
    Abstract: An optical device. In some embodiments, the device comprises: an input waveguide, configured to receive light; a first electro-absorption modulator, coupled to receive light from the input waveguide, and operable to produce a first output or a second output, wherein the second output has a lower amplitude than the first output; a second electro-absorption modulator, coupled to receive light from the input waveguide, and operable to produce a third output or a fourth output, wherein the fourth output has a lower amplitude than the third output; and an output waveguide, coupled to receive light from the first electro-absorption modulator and the second electro-absorption modulator, and output a combined signal comprising an output of the first electro-absorption modulator and an output of the second electro-absorption modulator.
    Type: Grant
    Filed: April 1, 2022
    Date of Patent: June 4, 2024
    Assignees: Rockley Phonics Limited, California Institute of Technology
    Inventors: Arian Hashemi Talkhooncheh, Azita Emami, Yi Zhang, Aaron Zilkie
  • Patent number: 11998383
    Abstract: An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic sensors, and other sensors to obtain a series of measurements about a subject. The series of measurements may be correlated, such as by machine learning, to extract clinically relevant information. Also described are systems and methods for ultrasonic beamsteering by interference of an audio signal with an ultrasonic signal.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: June 4, 2024
    Assignee: California Institute of Technology
    Inventors: Aditya Rajagopal, Alaina Ann Brinley Rajagopal
  • Patent number: 12000735
    Abstract: A substrate for sensing, a method of manufacturing the substrate, and an analyzing apparatus including the substrate are provided. The substrate for sensing includes: a support layer; a plurality of metal nanoparticle clusters arranged on the support layer; and a plurality of perforations arranged among the plurality of metal nanoparticle clusters. The plurality of metal nanoparticle clusters each comprise a plurality of metal nanoparticles stacked in a three-dimensional structure. Each of the plurality of perforations transmits incident light therethrough.
    Type: Grant
    Filed: August 19, 2021
    Date of Patent: June 4, 2024
    Assignees: SAMSUNG ELECTRONICS CO., LTD., CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Daejong Yang, Hyunjun Cho, Youngzoon Yoon, Hyuck Choo
  • Publication number: 20240175002
    Abstract: This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids.
    Type: Application
    Filed: December 5, 2023
    Publication date: May 30, 2024
    Applicant: California Institute of Technology
    Inventors: David K. Romney, Javier Murciano Calles, Jori E. Wehrmuller
  • Patent number: 11994671
    Abstract: A focusing device includes a substrate and a plurality of scatterers provided at both sides of the substrate. The scatterers on the both sides of the focusing device may correct geometric aberration, and thus, a field of view (FOV) of the focusing device may be widened.
    Type: Grant
    Filed: July 26, 2022
    Date of Patent: May 28, 2024
    Assignees: SAMSUNG ELECTRONICS CO., LTD., CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Amir Arbabi, Seunghoon Han, Andrei Faraon