Patents Assigned to California Institute Technology
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Patent number: 12109440Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.Type: GrantFiled: July 29, 2022Date of Patent: October 8, 2024Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Avinoam D. Bar-Zion, Atousa Nourmahnad, David Maresca, Mikhail Shapiro
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Patent number: 12113259Abstract: Low-loss terahertz switches with nanometer resolution positioning and feedback are disclosed. In one embodiment, the switch uses a U-bend waveguide surrounded by an electromagnetic band gap and is implemented in a fully metal-machined fashion in combination with a piezo-electric motor and an optical linear encoder. In another embodiment, the switch comprises a MEMS device.Type: GrantFiled: June 21, 2022Date of Patent: October 8, 2024Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Goutam Chattopadhyay, Robert H. Lin, Sven L. Van Berkel, Sofia Rahiminejad
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Patent number: 12102477Abstract: An ultrasound measurement device includes: a processing device and multiple ultrasound sensors that capture tomographic information of a physiological structure. The ultrasound sensors include a first ultrasound sensor including a first transducer having a first frequency response with a first resonant frequency, and a second ultrasound sensor including a second transducer having a second frequency response with a second resonant frequency different from the first resonant frequency. The first frequency response partially overlaps with the second frequency response.Type: GrantFiled: March 30, 2023Date of Patent: October 1, 2024Assignee: California Institute of TechnologyInventors: Alaina Ann Brinley Rajagopal, Aditya Rajagopal
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Publication number: 20240315628Abstract: Medical diagnostic devices and related methods of use are described in which one or multiple coils in a sensor, each coil connected with an RLC circuit and frequency counter, are held against a patient's head at predetermined cranial locations. Frequencies of the RLC circuit are measured and compared against those taken from known, control heads, to determine whether there is a medical problem and what type of problem. In some instances, too high of frequencies can reveal pooled blood in the head, a sign of hemorrhagic stroke, while too low of frequencies imply lack of blood supply, a sign of ischemic stroke. A head-mountable frame can assist a first responder in securing and guiding the coils and, along with fiducials, allow for automatic comparison of frequencies with the correct control data.Type: ApplicationFiled: May 30, 2024Publication date: September 26, 2024Applicant: California Institute of TechnologyInventors: Yu-Chong Tai, Shane S. Shahrestani
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Publication number: 20240322226Abstract: Aspects disclosed herein include materials comprising: a lithium thioborate composition characterized by formula FX1: Li3?z[B+Q]1[S+G]3 (FX1); wherein Q is a first dopant being a substitute for B in the composition and being one or more elements each aliovalent with respect to B; wherein G is a second dopant being a substitute for S in the composition and being one or more elements each aliovalent with respect to S; wherein z is a number greater than 0 and less than or equal to 0.40, optionally less than or equal to 0.05; and wherein the composition comprises only the first dopant, only the second dopant, or both the first dopant and the second dopant.Type: ApplicationFiled: May 31, 2024Publication date: September 26, 2024Applicant: California Institute of TechnologyInventors: Forrest A.L. LASKOWSKI, Daniel B. McHAFFIE, Kimberly A. ROBB
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Publication number: 20240317575Abstract: A device includes an opto-acoustic transducer configured to convert between an optical signal and an acoustic signal, an electro-acoustic transducer coupled to a microwave resonant circuit and configured to convert between an acoustic signal and a microwave signal, and an acoustic waveguide coupling the opto-acoustic transducer to the electro-acoustic transducer.Type: ApplicationFiled: April 30, 2024Publication date: September 26, 2024Applicant: California Institute of TechnologyInventors: Oskar Painter, Jie Luo, Michael T. Fang, Alp Sipahigil, Paul B. Dieterle, Mahmoud Kalaee, Johannes M. Fink, Andrew J. Keller, Gregory MacCabe, Hengjiang Ren, Justin D. Cohen
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Patent number: 12097033Abstract: A method includes providing a first electrode and a second electrode, receiving a first plurality of signals from the first electrode during a first period of time, and receiving a second plurality of signals from the second electrode during a second period of time. The method also includes receiving a pooled signal comprising a third plurality of signals from the first electrode and a fourth plurality of signals from the second electrode and isolating, from the pooled signal, one or more of the third plurality of signals and one or more of the fourth plurality of signals.Type: GrantFiled: November 25, 2020Date of Patent: September 24, 2024Assignee: California Institute of TechnologyInventors: Markus Meister, Kyu Hyun Lee, Yu-Li Ni
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Patent number: 12097015Abstract: Energy harvesting devices and methods for converting the mechanical energy of a flowing ionic solution, such as rainwater or seawater, into electric energy are provided. The energy harvesting devices include an electric current generating device that includes a metal layer and an amphoteric metal oxide film disposed over a surface of the metal layer. By moving an electric double layer across the surface of the amphoteric metal oxide film, an electric current is generated in the metal layer.Type: GrantFiled: September 17, 2019Date of Patent: September 24, 2024Assignees: Northwestern University, California Institute of TechnologyInventors: Mavis D. Boamah, Franz M. Geiger, Thomas F. Miller, III, Jeongmin Kim
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Publication number: 20240314006Abstract: Communication systems and methods in accordance with various embodiments of the invention utilize modulation on zeros. Carrier frequency offsets (CFO) can result in an unknown rotation of all zeros of a received signal's z-transform. Therefore, a binary MOCZ scheme (BMOCZ) can be utilized in which the modulated binary data is encoded using a cycling register code (e.g. CPC or ACPC), enabling receivers to determine cyclic shifts in the BMOCZ symbol resulting from a CFO. Receivers in accordance with several embodiments of the invention include decoders capable of decoding information bits from received discrete-time baseband signals by: estimating a timing offset for the received signal; determining a plurality of zeros of a z-transform of the received symbol; identifying zeros from the plurality of zeros that encode received bits by correcting fractional rotations resulting from the CFO; and decoding information bits based upon the received bits using a cycling register code.Type: ApplicationFiled: October 20, 2023Publication date: September 19, 2024Applicants: California Institute of Technology, The Regents of the University of California, Technische Universität BerlinInventors: Philipp Walk, Babak Hassibi, Peter Jung, Hamid Jafarkhani
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Publication number: 20240309487Abstract: Systems and alloying methods for forming metals are described. Waste materials from various industrial processes and botched master alloy production heats result in numerous byproducts that can form constituent components for the formation of bulk alloys with higher value and more diverse applications. Reusing and upcycling industrial byproducts into material with specific structure and properties result in additional commercial and industrial applications and value.Type: ApplicationFiled: March 13, 2024Publication date: September 19, 2024Applicant: California Institute of TechnologyInventors: Douglas C. Hofmann, Punnathat Bordeenithikasem
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Publication number: 20240307026Abstract: A measurement device includes: a processing device and multiple sensors that capture tomographic information of a physiological structure. The sensors include a first sensor including a first transducer having a first frequency response with a first resonant frequency, and a second sensor including a second transducer having a second frequency response with a second resonant frequency different from the first resonant frequency. The first frequency response partially overlaps with the second frequency response. The second transducer transmits a signal that is reflected by the physiological structure to create a reflected signal, the first transducer generates a first received signal from the reflected signal, the second transducer generates a second received signal from the reflected signal, and the processing device normalizes the first received signal with the second received signal or the second received signal with the first received signal.Type: ApplicationFiled: May 28, 2024Publication date: September 19, 2024Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Alaina Ann Brinley RAJAGOPAL, Aditya Rajagopal
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Publication number: 20240306925Abstract: Some implementations of the disclosure describe a blood pressure measurement apparatus and method that enable continuous, non-invasive blood pressure measurement using sound and ultrasound transducers. In one implementation, a blood pressure measurement device includes: a first transducer configured to emit multiple soundwaves having multiple frequencies, the soundwaves configured to cause a blood vessel of a subject to vibrate; a second transducer configured to capture one or more ultrasound images of the blood vessel; and a processing device configured to: determine, based on the one or more ultrasound images, a wall thickness, a radius, and a resonant frequency of the blood vessel; and calculate, based on the wall thickness, the radius, and the resonant frequency, a blood pressure of the subject.Type: ApplicationFiled: January 31, 2024Publication date: September 19, 2024Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Aditya RAJAGOPAL, Dominic Yurk, Yaser Abu-Mostafa, Alaina Ann Brinley Rajagopal
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Patent number: 12094126Abstract: Disclosed herein include systems and methods for biological object tracking and lineage construction. Also disclosed herein include cloud-based systems and methods for allocating computational resources for deep learning-enabled image analysis of biological objects. Also disclosed herein include systems and methods for annotating and curating biological object tracking-specific training datasets.Type: GrantFiled: December 30, 2022Date of Patent: September 17, 2024Assignee: California Institute of TechnologyInventors: Erick K. Moen, Enrico Z. Borba, David A. Van Valen, William H. Graf, Barry D. Bannon
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Patent number: 12091763Abstract: A CO2 reduction system has a cathode in contact with a catholyte. The cathode includes a selectivity-determining layer on an electron conductor. The selectivity-determining layer includes a selectivity-determining component that includes a substituted heterocycle.Type: GrantFiled: June 9, 2022Date of Patent: September 17, 2024Assignee: California Institute Of TechnologyInventors: Zhiji Han, Ruud Kortlever, Hsiang-Yun Chen, Jonas C. Peters, Theodor Agapie, Jorge A. Rosas Hernandez, Arnaud A. Thevenon
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Patent number: 12095508Abstract: Multiple-link optical terabit terminals (MLOTT) allowing high speed data transfer rates in terabit per second range in an omnidirectional fashion are disclosed. The described terminals have multifaceted structure, provide full coverage, implement single laser or laser arrays, and single detector or detector arrays to achieve higher transmission rates. Wavelength division multiplexing schemes can also be used when implementing the disclosed terminals for higher data rates. Steerable mirrors and lenses can be implemented as part of the terminals and based on angle-of-arrival calculations performed in real time.Type: GrantFiled: August 24, 2022Date of Patent: September 17, 2024Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventor: Jose E. Velazco
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Patent number: 12091343Abstract: A water purification electrode composed of a porous carbon material is disclosed. The electrode may be used as a flow-through cathode in an electro-peroxone process providing high H2O2 production activity for electrochemical wastewater treatment. The porous carbon material is a binding agent-free carbon structure that enables H2O2 to be electro-generated in situ at cathode. The porous carbon material may be synthesized from resorcinol and can provide a relatively large reaction surface area of 200-800 m2/g. The porous carbon material also achieves low energy consumption as well as a wide pH working range, making it suitable for treating many types of organic, inorganic, and biological contaminants in water. The electrode may be integrated with an anode, ozone generator, and other components into a compact, integrated water purification system.Type: GrantFiled: February 9, 2018Date of Patent: September 17, 2024Assignee: California Institute of TechnologyInventors: Kai Liu, Michael R Hoffmann
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Publication number: 20240302158Abstract: Interferometric speckle visibility spectroscopy methods, systems, and non-transitory computer readable media for recovering sample speckle field data or a speckle field pattern from an off-axis interferogram recorded by one or more sensors over an exposure time and determining sample dynamics of a sample being analyzed from speckle statistics of the speckle field data or the speckle field pattern.Type: ApplicationFiled: November 13, 2023Publication date: September 12, 2024Applicant: California Institute of TechnologyInventors: Joshua Brake, Jian Xu, Changhuei Yang
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Publication number: 20240302104Abstract: Systems and methods for thermal management using separable heat pipes and methods of manufacture thereof. Various embodiments provide a porous insert that can be used to join or connect heat pipes. Further embodiments provide thermal management systems that are modular, expandable, reparable, by allowing for joining of evaporators, condensers, and adiabatic sections via porous inserts. Various embodiments allow for two-phase thermal management systems, where liquid and gaseous phases can be transported simultaneously. Certain embodiments incorporate heat generating components with embedded evaporators and/or condensers. Many embodiments are additively manufactured, including via 3D printing.Type: ApplicationFiled: May 14, 2024Publication date: September 12, 2024Applicant: California Institute of TechnologyInventors: Weibo Chen, Benjamin I. Furst, Scott N. Roberts
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Patent number: 12083109Abstract: In some embodiments, methods of inhibiting, ameliorating, reducing the severity of, treating, reducing the likelihood of, or preventing social isolation stress or symptoms thereof in a subject in need thereof are described. In some embodiments, methods of determining a risk of social isolation stress in a subject are described.Type: GrantFiled: September 30, 2022Date of Patent: September 10, 2024Assignee: California Institute of TechnologyInventors: David J. Anderson, Moriel Zelikowsky, Andrea Choe
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Patent number: 12084782Abstract: A heterojunction anode for electrolysis is disclosed. The anode has a first conductive metal oxide (FCMO) layer, a second semiconductor layer contacting the FCMO layer, and one or more islands of a third semiconductor contacting the second semiconductor layer. The FCMO layer may be formed on a metallic base, such as titanium. The FCMO layer may include iridium, the second semiconductor layer may include titanium oxide, and the third semiconductor may include tin oxide. The anode may be manufactured using spray pyrolysis to apply each semiconductor material. The anode may be configured such that when placed in an electrolyte at least a portion of the second semiconductor layer and the islands are in direct physical contact with the electrolyte. The second semiconductor interlayer and third semiconductor islands enhance the production of reactive chlorine in chlorinated water. A water treatment system and method using the anode are also disclosed.Type: GrantFiled: August 22, 2017Date of Patent: September 10, 2024Assignee: California Institute of TechnologyInventors: Michael R. Hoffmann, Yang Yang