Abstract: The invention relates to gene therapies using viral vectors. The invention provides, for the first time, packaging cells that comprise enhanced Fc receptor expression (e.g. CD16, CD32, or CD64) to generate gene therapy viruses that evade antibody-dependent inactivation (ADI) or complement-dependent inactivation (CDI). The invention also provides gene therapy viruses with the enhanced Fc receptors displayed on their viral envelope.
Type:
Application
Filed:
March 7, 2022
Publication date:
May 2, 2024
Applicant:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Abstract: Described herein are methods for characterizing the age of an insect fecal pellet, where the method can comprise: (1) obtaining insect fecal pellet material to be tested; (2) exposing the pellet material to an H2O2 solution; and (3) detecting the presence of generated oxygen, where the amount of oxygen generated is inversely proportional to the age of the insect pellet. Also described are kits for carrying out the method.
Type:
Application
Filed:
October 26, 2023
Publication date:
May 2, 2024
Applicant:
The Regents of the University of California
Inventors:
Dong-Hwan Choe, Kathleen Campbell, Michael K. Rust
Abstract: Opsin proteins are GPCRs known for light perception. Here it is shown that these receptors are also expressed in chemosensory cells and function as chemosensory receptors activated by a range of molecules, including tastants such as theobromine, for which a receptor has not previously been known. Provided are novel assay systems for assessing chemosensory opsin activation by chemical ligands. By these assays, novel ligands of chemosensory opsins may be identified, the chemosensory properties of molecules may be evaluated; and the modulation of chemosensory properties by modifications or modulators may be tested.
Type:
Application
Filed:
February 24, 2022
Publication date:
May 2, 2024
Applicant:
The Regents of the University of California
Abstract: Systems and methods for utilizing a small form-factor, wirelessly powered transceiver are disclosed. In one embodiment, a wireless powered transceiver includes a receive antenna configured to receive a receive signal, a transmit antenna configured to transmit a transmit signal, a power harvesting system including a rectifier circuit configured convert radio frequency energy from the receive signal into DC (direct current) voltage, and a power management unit (PMU) configured to set the operating mode and biasing condition of the receive and transmit circuitry blocks and provide DC voltage from the receive circuitry block to the transmit circuitry block to maintain a minimum voltage, a receiver circuitry block configured to provide energy from the receive signal to the power harvesting system, and a transmitter circuitry block including a data modulator circuit, the data modulator circuit configured to generate the transmit signal using DC voltage received from the power management unit.
Type:
Application
Filed:
December 20, 2023
Publication date:
May 2, 2024
Applicant:
The Regents of the University of California
Abstract: A Photonic molecule may include a first ring resonator that is tunable by a first piezoelectric actuator. A Photonic molecule may include a second ring resonator that is tunable by a second piezoelectric actuator, wherein the second ring resonator optically coupled to the first ring resonator. A Photonic molecule may include a third ring resonator that is tunable by a third piezoelectric actuator, wherein the third ring resonator is optically coupled to the first ring resonator and the second ring resonator. A Photonic molecule may include a waveguide optically coupled to the first ring resonator.
Type:
Application
Filed:
November 1, 2023
Publication date:
May 2, 2024
Applicant:
The Regents of the University of California
Abstract: Candidate cancer antigens are identified using transposable elements. Differential expression levels are determined for proteins using baseline expression levels (using measurements of healthy tissue) and tumor expression levels (using measurements of tumor tissue). Protein(s) having a differential expression level greater than a threshold are selected. Cancer vaccine(s) are generated for the selected cancer antigens (s). Particular cancer vaccine(s) are selected for a patient based on differential expression levels for proteins using baseline expression levels of the patient and tumor expression levels of the patient. A vaccine for protein(s) having a differential expression level greater than a threshold can be selected. A microarray can be used for the measurements of the patient. A first array of probes can hybridize to RNA from transposable elements. A second array of probes can hybridize to RNA of different MHC haplotypes. A third array of probes can hybridize to RNA of different APOBEC genotypes.
Type:
Application
Filed:
October 19, 2020
Publication date:
May 2, 2024
Applicant:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Abstract: A multi-phase hybrid power converter architecture which provides high efficiency, high power density and high conversion ratios for non-isolated DC to DC power conversion. Hybrid converters are described in which a switched-capacitor network is interoperably merged with a switched-inductor network having multiple inductors, resulting in a circuit with reduced component count and in which soft-charging of the capacitors is performed. Multi-phase switching is utilized and includes a freewheeling state for output voltage regulation in which inductor current ramps down. The SC converter can be configured to provide various conversion ratios, such as 4-to-1, 6-to-1 and 8-to-1, and optimized for the needs of specific application.
Type:
Application
Filed:
November 6, 2023
Publication date:
May 2, 2024
Applicant:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Abstract: Recombinant proteins comprising a non-canonical amino acid with high yield and high fidelity are made by expressing the protein in an engineered Vibrio natriegens strain containing an orthogonal translation system comprising an orthogonal aminoacyl tRNA synthetase that charges the non-canonical amino acid onto the orthogonal cognate tRNA.
Type:
Application
Filed:
November 30, 2023
Publication date:
May 2, 2024
Applicant:
The Regents of the University of California
Inventors:
Alanna Schepartz Shrader, Sebasthian Santiago González
Abstract: A drug delivery for treating renal cancer, and in particular, clear cell renal carcinoma is provides. The drug delivery system includes a plurality of nanoparticles wherein each nanoparticle includes CD70-targeting peptides conjugated thereto and anti-HIF2? siRNAs conjugated thereto. A method for treating renal cancer is also provided.
Abstract: A smart retail product shelf liner called ‘MOOCA’ to detect product loads on its surface. The liner preferably has an origami like structure whose properties (e.g., angles, unit size, material) are adjusted to make the liner configurable for different sizes, load ranges, and product packaging. The smart liner is well suited for autonomous checkout systems. MOOCA is an origami-inspired low-cost configurable surface structure having conductive threads and copper wires integrated into the origami structure to detect and recognize product loads and thus to detect when products are either picked-up, or put-down, upon the smart MOOCA liner of the shelf.
Type:
Application
Filed:
October 14, 2023
Publication date:
May 2, 2024
Applicant:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors:
Shijia Pan, Shubham Rohal, Yue Zhang, Carlos Ruiz
Abstract: A device including an activated p-type layer comprising a III-Nitride based Mg-doped layer grown by vapor phase deposition or a growth method different from MBE. The p-type layer is activated through a sidewall of the p-type layer after the removal of defects from the sidewall thereby increasing a hole concentration in the p-type layer. In one or more examples, the device includes an active region between a first n-type layer and the p-type layer; a second n-type layer on the p-type layer; and a tunnel junction between the second n-type layer and the p-type layer, and the activated p-type layer has a hole concentration characterized by a current density of at least 100 Amps per centimeter square flowing between the first n-type layer and the second n-type layer in response to a voltage of 4 volts or less applied across the first n-type layer and the second n-type layer.
Type:
Application
Filed:
February 28, 2022
Publication date:
May 2, 2024
Applicant:
The Regents of the University of California
Inventors:
David Hwang, Matthew S. Wong, Shuji Nakamura
Abstract: A method for abnormality detection in an energy unit includes passively detecting an abnormality in an energy unit by detecting electromagnetic radiation generated by the abnormality, the energy unit comprising at least one of an electrical energy unit and an electrochemical energy unit. A method for detecting an abnormality in an energy unit includes (a) applying a signal to the energy unit, (b) performing a plurality of measurements, at a respective plurality of different locations within the energy unit, of a response of the energy unit to the signal, and (c) processing the plurality of measurements to identify the abnormality.
Abstract: The present disclosure relates to the use of recombinant proteins for inducing epigenetic modifications at specific loci, as well as to methods of using these recombinant proteins for modulating the expression of genes in plants.
Type:
Application
Filed:
January 5, 2024
Publication date:
May 2, 2024
Applicant:
The Regents of the University of California
Inventors:
Steve E. JACOBSEN, Javier GALLEGO-BARTOLOMÉ, Ashot PAPIKIAN, Jason GARDINER
Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
Type:
Grant
Filed:
May 17, 2023
Date of Patent:
April 30, 2024
Assignee:
CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventors:
Samson Chen, Axel Scherer, Dvin I. Adalian, Peter Petillo, Muhammad Musab Jilani, Xiomara L. Madero, Deepan Kishore Kumar
Abstract: The technology described in this document can be used to implement beam steering in optical systems and photonic devices, to provide a nonmechanical beam steering system for projecting optical energy and controlling the direction of the optical energy using a collection of devices and components that are fixed in position to selectively direct light from an array of different optical emitters at different locations.
Type:
Grant
Filed:
September 29, 2020
Date of Patent:
April 30, 2024
Assignee:
The Regents of the University of California
Inventors:
Andrew Grieco, Abdelkrim El Amili, Yeshaiahu Fainman, Stephen Pappert
Abstract: Embodiments of the presently disclosed technology provide a synergistic combination of a conjugated open-shell donor-acceptor polymer with a carbon-based compound (e.g., reduced graphene oxide) to produce a composite electrode material which demonstrates state-of-the-art capacitance and potential window, with excellent kinetics and cycle life. The conjugated open-shell donor-acceptor polymer may comprise a plurality of alternating electron-rich monomers (i.e., donors) and electron-deficient monomers (i.e., acceptors) bonded together via a conjugated backbone. The conjugated backbone may comprise a connection of n-orbitals of the plurality of monomers in alternating single and double bonds that facilitates unpaired electron delocalization—thereby stabilizing charge for the polymer. The carbon-based compound of the composite electrode material may provide porous, conductive scaffolds for the composite electrode material, resulting in electrodes scalable to microns-thick films with fast kinetics.
Type:
Grant
Filed:
June 14, 2022
Date of Patent:
April 30, 2024
Assignees:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE UNIVERSITY OF SOUTHERN MISSISSIPPI
Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.
Type:
Grant
Filed:
August 18, 2021
Date of Patent:
April 30, 2024
Assignees:
DOMPÉ FARMACEUTICI S.P.A., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors:
Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Michael Christopher Scaife, Benedikt Vollrath, Sergio G. Duron, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
Abstract: Human interactive texture generation and search systems and methods are described. A deep convolutional generative adversarial network is used for mapping information in a latent space into texture models. An interactive evolutionary computation algorithm for searching a texture through an evolving latent space driven by human preference is also described. Advantages of a generative model and an evolutionary computation are combined to realize a controllable and bounded texture tuning process under the guidance of human preferences. Additionally, a fully haptic user interface is described, which can be used to evaluate the systems and methods in terms of their efficiency and accuracy of searching and generating new virtual textures that are closely representative of given real textures.
Type:
Grant
Filed:
April 21, 2022
Date of Patent:
April 30, 2024
Assignee:
UNIVERSITY OF SOUTHERN CALIFORNIA
Inventors:
Shihan Lu, Heather Culbertson, Matthew Fontaine, Mianlun Zheng
Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
Type:
Grant
Filed:
September 21, 2021
Date of Patent:
April 30, 2024
Assignees:
The Regents of the University of California, University of Vienna
Inventors:
Jennifer A. Doudna, Martin Jinek, Krzysztof Chylinski, Emmanuelle Charpentier
Abstract: Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
Type:
Grant
Filed:
November 13, 2020
Date of Patent:
April 30, 2024
Assignee:
The Regents of the University of California
Inventors:
Mark A. Akeson, David W. Deamer, William B. Dunbar, Roger Jinteh Arrigo Chen, Noah A. Wilson