Abstract: Systems and method for wireless recording system-on-chips for distributed neural interface systems with inductive power delivery and UWB data transmission are described. In an embodiment, the system includes an implantable neural interface including: an electrode array having several electrodes; front end circuitry including: one or more digital components, and at least one amplifier coupled to a first electrode and a second electrode of the electrode array, wherein the amplifier and the first electrode and the second electrode form a sensing channel configured to sense electrical activity; and a transceiver including: several digital components; a power harvesting system that receives RF energy through a wireless power link; and a wireless clock receiver that provides a clock signal to the one or more digital components of the front end circuitry and the several digital components of the transceiver.
Type:
Application
Filed:
December 20, 2021
Publication date:
April 11, 2024
Applicant:
The Regents of the University of California
Abstract: The present disclosure relates generally to methods for preparing a tissue sample for detection of the expression of a transmembrane protein in the tissue sample. The present disclosure also provides antibodies and treatments targeting tumor samples expressing the PLXDC1 or the PLXDC2 proteins.
Type:
Application
Filed:
October 16, 2020
Publication date:
April 11, 2024
Applicant:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Abstract: Trehalose-based nanogels for stabilizing and controlled releasing biomolecules such as glucagons are disclosed. Specifically, trehalose-based nanogels comprise (a) a copolymer comprising first methacrylate units and second methacrylate units, wherein (i) the first methacrylate units comprise trehalose side chains; and (ii) the second methacrylate units comprise disulfide side chains; (b) dithiol cross-linkers; wherein the dithiol cross-linkers cross link the copolymer through the disulfide side chains of the second methacrylate units.
Type:
Grant
Filed:
November 30, 2018
Date of Patent:
April 9, 2024
Assignee:
The Regents of the University of California
Abstract: The present disclosure provides compounds and compositions capable of treating cancer or an autoimmune disease, such as Crohn's disease, and methods of use thereof.
Type:
Grant
Filed:
July 22, 2019
Date of Patent:
April 9, 2024
Assignee:
The Regents of the University of California
Inventors:
Dimitrios Iliopoulos, Michael E. Jung, Jonghoon Kim, Jill M. Hoffman, Iordanes Karagiannides
Abstract: Ferromagnetic materials are disclosed that comprise at least one Dirac half metal material. In addition, Dirac half metal materials are disclosed, wherein the material comprises a plurality of massless Dirac electrons. In addition, ferromagnetic materials are disclosed that includes at least one Dirac half metal material, wherein the material comprises a plurality of massless Dirac electrons, wherein the material exhibits 100% spin polarization, and wherein the plurality of electrons exhibit ultrahigh mobility. Spintronic devices and heterostructures are also disclosed that include a Dirac half metal material.
Type:
Grant
Filed:
November 4, 2022
Date of Patent:
April 9, 2024
Assignee:
The Trustees of the California State University
Abstract: Provided herein, inter alia, are methods and compositions for treating diabetes mellitus comprising co-transplantation of an insulin-producing cell and a cell derived from a parathyroid gland (PTG), a CD34+ cell derived from a parathyroid gland, a CD34+ cell derived from a stem cell, or other progenitor cell-derived CD34+ cell.
Type:
Grant
Filed:
December 12, 2018
Date of Patent:
April 9, 2024
Assignees:
The Regents of the University of California, The United States Government as Represented by the Department of Veterans Affairs
Inventors:
Casey Ward, Qizhi Tang, Peter Stock, Gaetano Faleo, Gopika Nair, Matthias Hebrok, Wenhan Chang, Thuy Vo, Jeffrey A. Bluestone, Eleonora De Klerk
Abstract: A computer vision pipeline is provided for fully automated interpretation of cardiac function, using a combination of machine learning strategies to enable building a scalable analysis pipeline for echocardiogram interpretation. Videos from patients with heart failure can be analyzed and processed as follows: 1) preprocessing of echo studies; 2) convolutional neural networks (CNN) processing for view identification; 3) segmentation of chambers and delineation of cardiac boundaries using CNNs; 4); particle tracking to compute longitudinal strain; and 5) targeted disease detection.
Type:
Grant
Filed:
March 14, 2019
Date of Patent:
April 9, 2024
Assignee:
The Regents of the University of California
Abstract: Some implementations of the disclosure describe a blood pressure measurement apparatus and method that enable continuous, non-invasive blood pressure measurement using sound and ultrasound transducers. In one implementation, a blood pressure measurement device includes: a first transducer configured to emit multiple soundwaves having multiple frequencies, the soundwaves configured to cause a blood vessel of a subject to vibrate; a second transducer configured to capture one or more ultrasound images of the blood vessel; and a processing device configured to: determine, based on the one or more ultrasound images, a wall thickness, a radius, and a resonant frequency of the blood vessel; and calculate, based on the wall thickness, the radius, and the resonant frequency, a blood pressure of the subject.
Abstract: The disclosure provides for pathogenic biomarkers and serum extracellular vesicular biomarkers that are associated with vascular anomalies and malformation of endothelial cells, and uses thereof, including for diagnosis, prognosis and therapy.
Type:
Grant
Filed:
June 3, 2019
Date of Patent:
April 9, 2024
Assignee:
The Regents of the University of California
Inventors:
Wenbin Tan, John Stuart Nelson, Dongbao Chen
Abstract: Systems, device configurations, and processes are provided for navigation and determination of navigation observables based on low Earth orbit (LEO) satellite signals. A method for navigation includes using differential carrier phase measurement of LEO signals including correction of position estimates using integer ambiguity resolution and double difference carrier phase determinations. Frameworks described herein can use a computationally efficient integer ambiguity resolution to reduce the size of the integer least squares (ILS) determination. The framework may include a joint probability density function (pdf) of the megaconstellation LEO satellites' azimuth and elevation angle to characterize a LEO system. Embodiments are also directed to correction of ambiguities of carrier phase differential (CD)-low Earth orbit (LEO) (CD-LEO) measurements that may utilize a base and a rover without requiring prior knowledge of rover position.
Type:
Grant
Filed:
July 2, 2021
Date of Patent:
April 9, 2024
Assignee:
The Regents of the University of
California
Inventors:
Zak Kassas, Joe Khalife, Mohammad Neinavaie
Abstract: A thermoresponsive suspension composition for use in additive manufacturing includes an aqueous suspension of a thermosetting resin, a crosslinking agent configured to react with the thermosetting resin, and a mineral particulate, wherein the thermosetting resin and crosslinking agent react at or above a trigger temperature.
Type:
Grant
Filed:
November 18, 2021
Date of Patent:
April 9, 2024
Assignees:
The Regents of the University of California, Technical University of Munich, Master Builders Solutions Admixtures US, LLC
Inventors:
Gaurav Sant, Sharu Bhagavathi Kandy, Torben Gädt, Iman Mehdipour, Thiyagarajan Ranganathan, Samanvaya Srivastava, Paul Seiler
Abstract: Provided herein are compositions, devices, electrochemical systems, and methods relating to lithium-rich iron sulfide lithium-ion battery cathodes. In one embodiment, a composition may be characterized by formula FX1: Liw-?AlxFezS2. In some embodiments, w may be greater than or equal to 2 and less than or equal to 2.5. In some embodiments, x may be greater than 0 and less than or equal to 0.5. In some embodiments, z may be greater than 0 and less than or equal to 1. In some embodiments, ? may be greater than or equal to 0 and less than w. In some embodiments, the composition may have a net charge of 0.
Abstract: Provided herein are klotho polypeptide compositions and methods for improving cognitive function in an individual comprising treatment of with klotho polypeptides.
Type:
Application
Filed:
June 28, 2023
Publication date:
April 4, 2024
Applicant:
The Regents of the University of California
Abstract: A thin oil film having parylene irregular dendritic-like columns extending from one side to another exhibits hydrophobic properties that can be used as a corrosion resistant coating or water-repellant, biofouling resistant surface. This parylene-in-oil layer can be paired with an adjacent layer of solid parylene that it overlays or underlays. The solid parylene cross polymerizes with the parylene dendrites, keeping them in place as well as the oil film. The parylene dendrites are fabricated by chemical vapor deposition (CVD) of parylene over the oil layer, the dendrites self-forming from the bottom to the top. Continued CVD over the dendrites can produce a top layer of solid parylene. Etching the solid parylene away can result in a water repellant, anti-biofouling surface.
Type:
Application
Filed:
October 2, 2023
Publication date:
April 4, 2024
Applicant:
California Institute of Technology
Inventors:
Yu-Chong Tai, Kuang-Ming Shang, Haixu Shen, Ningxuan Dai, David Q. Kong
Abstract: The disclosure relates to systems and methods for noninvasively performing cardiac auscultation. In some implementations, a method includes: performing, using a BP cuff of a BP cuff system, a blood pressure measurement of a subject to obtain one or more blood pressure values corresponding to the subject; inflating, based on the one or more blood pressure values corresponding to the subject, the BP cuff to a subject specific pressure value; capturing, using the BP cuff system, while the BP cuff is inflated to the subject specific pressure value, a pulse pressure waveform signal associated with an artery of the subject; obtaining a sound waveform signal associated with a heart valve of the subject by filtering the pulse pressure waveform signal to extract sound components associated with the opening or closing of the heart valve; and analyzing the sound waveform signal to identify characteristics of the heart of the subject.
Abstract: A membrane desalination system includes a housing, an electrically conductive membrane disposed within the housing, wherein the electrically conductive membrane includes a porous support and an electrically conductive layer disposed on the porous support, and the electrically conductive layer includes nanostructures, and an alternating current power source connected to the electrically conductive membrane.
Type:
Application
Filed:
December 1, 2021
Publication date:
April 4, 2024
Applicant:
The Regents of the University of California
Inventors:
David Jassby, Unnati Rao, Eric Hoek, Bongyeon Jung
Abstract: Aspects of the subject disclosure may include, for example, receiving, from a machine learning model, information about an event causing a service degradation in a cellular network, wherein the event is external to the cellular network, determining one or more event categories associated with the event causing the service degradation, determining, based on the one or more event categories, likely affected customers, the likely affected customers being likely to experience the service degradation, determining, by the machine learning model, proper resources for resolution of the service degradation, wherein the determining proper resources is based on the one or more event categories, and dispatching the proper resources for resolution of the service degradation. Other embodiments are disclosed.
Type:
Application
Filed:
September 30, 2022
Publication date:
April 4, 2024
Applicants:
AT&T Intellectual Property I, L.P., The Regents of the University of California
Inventors:
Jia Wang, Amit Kumar Sheoran, Xiaofeng Shi, Matthew Osinski, Chen Qian
Abstract: A minimally invasive glucose-responsive colloidal crystal microneedle (GCC-MN) patch is disclosed for naked-eye glucose monitoring. The (GCC-MN) patch is designed with a resin or polymeric core to mechanically support a shell of glucose-responsive colloidal crystal material for glucose sensing and reporting of glucose concentrations or concentration changes. The GCC-MN patch could translate the glucose concentrations into naked-eye distinguishable color changes within about 5 min, and such glucose responsiveness is reversible. Demonstrated in a type 1 diabetic mouse model, the interstitial fluid extraction, glucose sensing, and resulting glucose-relevant color display procedures are simultaneously achieved with this GCC-MN patch.
Type:
Application
Filed:
January 19, 2022
Publication date:
April 4, 2024
Applicant:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Abstract: The invention relates to antiviral compounds, compositions comprising antiviral compounds, and methods of use. In particular, the antiviral compounds are cytidine triphosphate synthetase 1 (CTPS1) inhibitors that are effective in treating and/or preventing viral infection and in particular, SARS-CoV-2 infection and/or COVID-19 disease.
Type:
Application
Filed:
February 1, 2022
Publication date:
April 4, 2024
Applicant:
UNIVERSITY OF SOUTHERN CALIFORNIA
Inventors:
Pinghui FENG, Chao ZHANG, Jun ZHAO, Biancha ESPINOSA, Chao QIN, Ali SAVAS, Youliang RAO, Ting-Yu WANG
Abstract: A new prune cultivar designated ‘UC G2S-8’ has been developed. The fruit of this cultivar are medium, yellow in color and covered with a grayish waxy bloom. The ‘UC G2S-8’ tree is productive and a regular bearer.
Type:
Grant
Filed:
April 12, 2023
Date of Patent:
April 9, 2024
Assignee:
The Regents of the University of California
Inventors:
Theodore M. DeJong, Sarah Castro, James F. Doyle, Carolyn DeBuse