Patents Assigned to Cambridge Enterprise Limited
  • Patent number: 11983875
    Abstract: Embodiments of the present techniques provide apparatus and methods for analysing intracoronary images, for example to predict the likelihood of a disease, disease presentation or event, and/or to track performance of a drug or other treatment. The method may comprise: for each image in the set of images of a coronary artery: classifying the image, using a first neural network, for the presence or absence of diseased tissue; when the image is classified as having diseased tissue present, classifying the image, using a second neural network, for the presence or absence of an artefact; determining whether to analyse the image based on the classifying steps; when the image is to be analysed, analysing the image by identifying, using a third neural network, one or more features of interest in a coronary artery tissue; and measuring each identified feature of interest.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: May 14, 2024
    Assignee: CAMBRIDGE ENTERPRISE LIMITED
    Inventors: Adam Woolf, Martin Bennett
  • Publication number: 20240153578
    Abstract: The invention provides a method of characterising a DNA sample obtained from a tumour, the method including the steps of: determining the value of one or more mutational signature metrics for the sample, wherein the mutational signature metrics are selected from: exposure of one or more mutational signatures of mismatch repair (MMR), similarity between the substitution profile of the sample and that of one or more MMR gene knockouts, the number of repeat mediated indels in the mutational profile of the sample, and the similarity between the repeat mediated deletion profile of the sample and that of one or more MMR gene knockouts; and based on said values of said one or more mutational signature metrics, classifying said sample between a class associated with a high likelihood of being mismatch repair (MMR)-deficient and a class associated with a low likelihood of being MMR-deficient.
    Type: Application
    Filed: March 21, 2022
    Publication date: May 9, 2024
    Applicant: Cambridge Enterprise Limited
    Inventors: Serena Nik-Zainal, Andrea Degasperi, Xueqing Zou
  • Patent number: 11976137
    Abstract: The present invention relates to synthetic polypeptide compounds which bind to a class A G-protein-coupled receptor, the Apelin receptor. These compounds may act as apelin receptor antagonists. These compounds and compositions comprising them may be useful in the treatment of diseases, such as cancer.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: May 7, 2024
    Assignee: Cambridge Enterprise Limited
    Inventors: Anthony Peter Davenport, Robert Charles Glen, Janet Julie Maguire
  • Patent number: 11959923
    Abstract: Flow apparatuses comprising a separation channel, a downstream flow separator, a detection zone, an observation zone, and a waste channel. The separation channel has first and second flows in contact and allows lateral movement of components between contacting first and second flows. The downstream flow separator is in communication with the separation channel and diverts a part of the first fluid flow, the second fluid flow, or both, from the separation channel. The detection zone comprises a detection channel downstream of and in communication with the flow separator and configured to receive a plurality of diverted flows from the flow separator and a label channel configured to label the diverted flows from the flow separator. The observation zone is configured to record an analytical signal indicative of the quantity and the electrical properties of the component. The waste channel is at the downstream end of the observation zone.
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: April 16, 2024
    Assignee: Cambridge Enterprise Limited
    Inventors: Emma Yates, Christopher Dobson, Therese Herling, Tuomas Pertti Jonathan Knowles
  • Patent number: 11936157
    Abstract: A laser device comprises a first optical cavity comprising a first gain medium and a second optical cavity comprising a second gain medium. The first gain medium and the second gain medium generate light at respective different ranges of wavelengths. A synchronizer is optically coupled to both the first optical cavity and the second optical cavity and is configured to synchronize and mode-lock light from the first optical cavity and the second optical cavity. The laser device also includes a first optical filter and a second optical filter to filter the light from the first optical cavity and the second optical cavity respectively to output first filtered light pulses at a first predetermined range of wavelengths and second filtered light pulses at a second predetermined range of wavelengths.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: March 19, 2024
    Assignees: CAMBRIDGE ENTERPRISE LIMITED, POLITECNICO DI MILANO, FONDAZIONE INSTITUTO ITALIANO DI TECNOLOGIA
    Inventors: Daniel Popa, Giulio Cerullo, Tullio Scopigno, Dario Polli, Andrea Ferrari
  • Patent number: 11903346
    Abstract: The invention relates to the grafting of perennial monocots such as bananas and oil palms. Processes for the production of such plants are disclosed herein.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: February 20, 2024
    Assignee: CAMBRIDGE ENTERPRISE LIMITED
    Inventors: Gregory Reeves, Julian Hibberd
  • Publication number: 20240050379
    Abstract: The present application relates to metal-organic framework (MOF) nanoparticles, in particular, coated MOF nanoparticles, methods of manufacturing said coated MOF nanoparticles, and uses of said coated MOF nanoparticles.
    Type: Application
    Filed: December 9, 2021
    Publication date: February 15, 2024
    Applicant: Cambridge Enterprise Limited
    Inventors: David Fairén Jiménez, Xu Chen
  • Publication number: 20240043485
    Abstract: The invention relates to a polypeptide selected from bone morphogenetic protein 10 (BMP10), or a bone morphogenetic protein 9 (BMP9) variant lacking osteogenic activity, for use in the treatment of a vascular disease or a respiratory disease. The invention also relates to novel BMP9 variants and to pharmaceutical compositions comprising said polypeptides.
    Type: Application
    Filed: January 3, 2023
    Publication date: February 8, 2024
    Applicant: CAMBRIDGE ENTERPRISE LIMITED
    Inventors: Nicholas W. MORRELL, Wei LI, Paul D. UPTON
  • Patent number: 11883228
    Abstract: An electronic stethoscope system comprising a device to capture an acoustic heart signal from a patient and a neural network to classify the data into heart sound categories to provide time series sound category data comprising, for each of a succession of time intervals, category probability data representing a probability of the acoustic signal falling into each of the categories. The stethoscope also includes one or more heart state models each having a sequence of heart cardiac cycle states, a system to fit the time series sound category data to the models and determine timing data for the sequence of heart states and a confidence value for the model fit, and an output to output one or both of a model fit indication dependent upon the confidence value and an indication of the timing data.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: January 30, 2024
    Assignee: CAMBRIDGE ENTERPRISE LIMITED
    Inventors: Anurag Agarwal, Edmund Kay, Andrew McDonald
  • Patent number: 11878080
    Abstract: The present invention provides capsules having a shell of material that comprises an assembly of a protein, and the capsule is optionally provided with a network of material within the shell that is an assembly of the protein. The assembly of the protein is obtained or obtainable by the aggregation of the protein, optionally together with another protein. The assembly is a non-covalent assembly of a protein.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: January 23, 2024
    Assignees: CAMBRIDGE ENTERPRISE LIMITED, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Tuomas Knowles, Ulyana Shimanovich, Christopher Dobson, David Weitz
  • Patent number: 11869728
    Abstract: We disclose herein a hetero-structure comprising: a curved material; at least one layer of a first material rolled around the curved material; at least one intermediate layer rolled on the at least one layer of the first material; and at least one layer of a second material rolled around the at least one intermediate layer.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: January 9, 2024
    Assignee: CAMBRIDGE ENTERPRISE LIMITED
    Inventors: Shahab Akhavan, Amin Taheri Najafabadi, Ilya Goykhman, Luigi Occhipinti, Andrea Carlo Ferrari
  • Patent number: 11866436
    Abstract: Provided are a compound of the formula: (5-(2-(4-((3,5-difluoro-4-(trifluoromethoxy)benzyl)amino)butoxy)ethoxy)benzo[c][2,6]naphthyridine-8-carboxylic acid) or a pharmaceutically acceptable salt thereof and a pharmaceutical composition comprising the above compound, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
    Type: Grant
    Filed: April 14, 2023
    Date of Patent: January 9, 2024
    Assignee: Cambridge Enterprise Limited
    Inventors: Marko Juhana Hyvonen, Paul Brear, David Robert Spring, Paul Glossop
  • Publication number: 20230404777
    Abstract: A microfluidic sensor comprising: a first substrate; a second substrate; a cavity formed between the first substrate and the second substrate, the cavity comprising a reservoir portion and a channel portion extending from the reservoir portion; a capacitive element disposed between the first substrate and the second substrate, the capacitive element being at least partially disposed in the channel portion of the cavity; and a dielectric sensing liquid provided in the reservoir portion. Upon application of a force to the first substrate adjacent the reservoir portion, the reservoir portion is configured to deform and displace the sensing liquid along the channel portion, so as to change the capacitance of the capacitive element within the channel portion.
    Type: Application
    Filed: August 27, 2021
    Publication date: December 21, 2023
    Applicant: CAMBRIDGE ENTERPRISE LIMITED
    Inventors: Sohini KAR-NARAYAN, Qingshen JING, Jehangir CAMA, Liam IVES, Vikas KHANDUJA
  • Patent number: 11817315
    Abstract: A method is disclosed of manufacturing a semiconductor structure comprising an (001) oriented zincblende structure group III-nitride layer, such as GaN. The layer is formed on a 3C-SiC layer on a silicon substrate. A nucleation layer is formed, recrystallized and then the zincblende structure group III-nitride layer is formed by MOVPE at temperature T3 in the range 750-1000° C., to a thickness of at least 0.5?. There is also disclosed a corresponding semiconductor structure comprising a zincblende structure group III-nitride layer which, when characterized by XRD, shows that the substantial majority, or all, of the layer is formed of zincblende structure group III-nitride in preference to wurtzite structure group III-nitride.
    Type: Grant
    Filed: February 25, 2022
    Date of Patent: November 14, 2023
    Assignees: Cambridge Enterprise Limited, Anvil Semiconductors Limited
    Inventors: David John Wallis, Martin Frentrup, Menno Johannes Kappers, Suman-Lata Sahonta
  • Publication number: 20230348983
    Abstract: The present invention concerns methods of diagnosing and/or prognostication of non-alcoholic fatty liver disease (NAFLD) or alcohol-related fatty liver disease (ARLD) in a subject, wherein said methods comprise detecting somatic mutations in DNA, RNA and/or protein that confer a selective advantage on one or more liver cells of the subject. The present invention also provides methods for identifying subjects suffering from NAFLD or ARLD who would benefit from treatment with a therapeutic agent and/or identifying subjects suffering from NAFLD or ARLD who would benefit from increased disease monitoring. The present invention also provides therapeutic agents that find utility in the treatment of NAFLD or ARLD.
    Type: Application
    Filed: September 23, 2021
    Publication date: November 2, 2023
    Applicants: Cambridge Enterprise Limited, Genome Research Limited
    Inventors: Matthew Hoare, Peter Campbell, Stanley NG
  • Publication number: 20230338298
    Abstract: The present invention relates to plant-based microcapsules for the efficient encapsulation and retention of water-soluble ingredients, as well as the efficient co-encapsulation of water-soluble and water-insoluble ingredients. The present invention also relates to compositions comprising the microcapsules, a method of making the microcapsules and compositions, and to uses of the microcapsules and compositions.
    Type: Application
    Filed: September 9, 2021
    Publication date: October 26, 2023
    Applicants: XAMPLA LIMITED, CAMBRIDGE ENTERPRISE LIMITED, CAMBRIDGE ENTERPRISE LIMITED
    Inventors: Marc Rodriguez Garcia, Tuomas Pertti Jonathan Knowles, Jack Henry Jeremy Cordrey, Ioana-Alina Dumitru
  • Publication number: 20230288307
    Abstract: A method of characterizing one or more particles in a fluid, e.g. a liquid, using interferometric scattering optical (iSCAT) microscopy. The method involves illuminating a region of a fluid using an objective lens so that light is scattered by one or more particles in the fluid. The scattered light and reference light are captured using the objective lens and interfere at an imaging device. A succession of images of the interference is processed to determine image correlation values which define a gradual decorrelation over time from which a property of the particle(s) is determined.
    Type: Application
    Filed: July 2, 2021
    Publication date: September 14, 2023
    Applicant: Cambridge Enterprise Limited
    Inventors: Quentin Alexis Peter, Raphaël Jacquat, Georg Krainer, Tuomas Pertti Jonathan Knowles
  • Patent number: 11753508
    Abstract: A method for treating polymer particles is disclosed. Polymer particles and a liquid are provided. The method includes the following steps (a) and (b). (a) Mixing said polymer particles with said carrier liquid to form a dispersion of said particles in said carrier liquid at a concentration of at least 0.1 g/L, based on the volume of the dispersion. (b) Subjecting the dispersion to microfluidization treatment thereby causing particle stretching, particle size reduction and increasing the surface area per unit mass of the polymer particles. Also disclosed is a particulate composition comprising polymer particles mixed with nanoplates derived from a layered material, wherein the particulate composition has a BET surface area of at least 10 m2/g. Furthermore, there is disclosed a method for the manufacture of a component formed of a composite of a polymer with a dispersion of nanoplates. The particulate composition is provided as a precursor particulate.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: September 12, 2023
    Assignee: Cambridge Enterprise Limited
    Inventors: Andrea Carlo Ferrari, Stephen Anthony Hodge, Panagiotis Karagiannidis, Yue Lin
  • Patent number: 11752176
    Abstract: Provided herein are methods and compositions comprising cardiomyocytes and epicardial cells for the treatment of cardiac disease.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: September 12, 2023
    Assignees: University of Washington, Cambridge Enterprise Limited
    Inventors: Charles E. Murry, Sanjay Sinha, Johannes Bargehr
  • Patent number: 11724241
    Abstract: Disclosed herein is a constant shear continuous reactor device, comprising: an annular gas delivery tube comprising a gas inlet and a gas outlet; a first annular liquid delivery tube comprising a first liquid inlet and a first liquid outlet arranged concentrically around the annular gas delivery tube along a common axis, where the first liquid outlet is located at a downstream position relative to the gas outlet or is coterminous with the gas outlet; and an annular reactor wall tube comprising a final liquid inlet, a mixing zone section and a reactor outlet, where the annular reactor wall tube is arranged concentrically around the first annular liquid delivery tube along the common axis.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: August 15, 2023
    Assignee: Cambridge Enterprise Limited
    Inventors: Nicholas Jose, Alexei Lapkin