Abstract: A gravimeter or inertial sensor system and method of operating such a system is provided. The system comprises a variable frequency signal source (100, 101, 102) configured to provide first and second signals, a resonant sensor (103) connected to receive the first signal, a phase comparator (111) connected to the output of the resonant sensor and to receive the second signal, and a controller (114) connected to the phase comparator. In a first mode, the controller controls the desired frequency of the signals from the variable frequency signal source based on a value of the phase comparator output signal to lock the frequency of the input signals to a resonant frequency of the resonant sensor. In a second mode, the controller disconnects from the variable frequency signal source and records an open loop output signal indicative of the physical parameter to be measured based on the response of the resonant sensor.

Abstract: Flow apparatuses comprising a separation channel, a downstream flow separator, a detection zone, an observation zone, and a waste channel. The separation channel has first and second flows in contact and allows lateral movement of components between contacting first and second flows. The downstream flow separator is in communication with the separation channel and diverts a part of the first fluid flow, the second fluid flow, or both, from the separation channel. The detection zone comprises a detection channel downstream of and in communication with the flow separator and configured to receive a plurality of diverted flows from the flow separator and a label channel configured to label the diverted flows from the flow separator. The observation zone is configured to record an analytical signal indicative of the quantity and the electrical properties of the component. The waste channel is at the downstream end of the observation zone.

Abstract: The invention relates optical devices, for example pixelated devices such as an optical device having a plurality of coloured pixels, each said pixel comprising a filter structure, the filter structure comprising: a first metallic layer; a dielectric layer over said first metallic layer; and a second metallic layer over said dielectric layer; wherein said second metallic layer comprises a nanostructured metallic layer having a lateral structure with features having at least one characteristic lateral dimension equal to or less than 1 ?m, and wherein said second metallic layer is structured to couple light incident on said second metallic layer into at least two absorption modes of the filter structure, one to either side of a target wavelength, such that said filter structure appears coloured at said target wavelength in reflected or transmitted light.

Abstract: There is provided an inertial sensor comprising a frame, a resonator assembly fixed to the frame comprising a first and second resonator coupled to one another by a mechanical coupling and a drive means coupled to the resonator assembly for driving the first and second resonators to vibrate. The resonator assembly is configured such that energy is transferred between the first and second resonators through the mechanical coupling. An amount of energy transferred through the mechanical coupling is dependent on the value of an input measurand acting on one of the first and second resonators. The inertial sensor also comprises a pumping means coupled to the resonator assembly for applying a pumping signal to the resonator assembly, the pumping means controlled by electrical circuitry, and a sensor assembly configured to detect the amplitude of oscillation of the first resonator at a first resonant frequency and the amplitude of oscillation of the second resonator at a second resonant frequency.

Abstract: The invention provides an amorphous metal-organic framework for use in methods of treatment. The amorphous metal-organic framework may hold a component for delivery. The amorphous metal-organic framework is obtained or is obtainable by amorphization of a crystalline amorphous metal-organic framework holding the component. The amorphous metal-organic framework may be a zirconium-containing or a bismuth-containing metal-organic framework, such as a framework having arylcarboxylate ligands, such as benzenedicarboxylate ligands.

Abstract: This invention relates to the use of AMPK agonists, such as metformin to, restore the responsiveness of aged oligodendrocyte progenitor cells (OPCs) to differentiation factors. This may be useful in promoting oligodendrocyte differentiation and increasing the remyelination of neuronal axons, for example in the treatment of demyelinating diseases, such as multiple sclerosis (MS). Therapeutic combinations comprising AMPK agonist and a differentiation factor and therapeutic uses thereof are provided.

Abstract: The present invention provides a method of assessing whether an individual is at high risk or low risk of inflammatory bowel disease (IBD) progression by determining the expression level of two or more genes in a whole blood sample. Also provided are methods for treating IBD in an individual who is determined to be at high risk or low risk for IBD progression, and kits for assessing whether an individual is at high risk or low risk for IBD progression. Arrays, and methods of providing arrays, of patient-identified selected gene expression products from a whole blood sample of a patient are also provided.

Abstract: A CMOS-based sensing device includes a substrate including an etched portion and a first region located on the substrate. The first region includes a membrane region formed over an area of the etched portion of the substrate, a flow sensor formed within the membrane region and a pressure sensor formed within the membrane region.

Abstract: Flow apparatuses comprising a separation channel, a downstream flow separator, a detection zone, an observation zone, and a waste channel. The separation channel has first and second flows in contact and allows lateral movement of components between contacting first and second flows. The downstream flow separator is in communication with the separation channel and diverts a part of the first fluid flow, the second fluid flow, or both, from the separation channel. The detection zone comprises a detection channel downstream of and in communication with the flow separator and configured to receive a plurality of diverted flows from the flow separator and a label channel configured to label the diverted flows from the flow separator. The observation zone is configured to record an analytical signal indicative of the quantity and the electrical properties of the component. The waste channel is at the downstream end of the observation zone.

Abstract: This invention relates to the efficient generation of cholangiocyte progenitor (CP) cells. Foregut stem cells (FSCs) are cultured in a hepatic induction medium comprising bone morphogenetic protein (BMP) and a TGF? signalling inhibitor to produce a population of hepatoblasts. The hepatoblasts are then cultured in a biliary induction medium comprising fibroblast growth factor (FGF), retinoic acid and a TGF? ligand to produce a population of cholangiocyte progenitors (CPs). The cholangiocyte progenitors (CPs) may be matured into cholangiocyte-like cells (CLCs) that display functional properties of Common Bile Duct (CBD) cholangiocytes. Methods, kits, cell populations and uses of these cell populations are provided.

Abstract: The present invention relates to synthetic polypeptide compounds which bind to a class A G-protein-coupled receptor, the Apelin receptor. These compounds may act as apelin receptor antagonists. These compounds and compositions comprising them may be useful in the treatment of diseases, such as cancer.

Abstract: A method and apparatus for processing data of a neural network. The method includes: obtaining one or more bit representations of data used for processing a neural network; generating a plurality of candidate profiles based on the bit representations; determining a final profile by comparing compression performances for each of the candidate profiles; and determining an optimal configuration for compressing data of the neural network based on the determined final profile.

Abstract: A method is provided of controlling the functionality of a substrate containing at least one nanopore. The method includes the steps of: introducing to the substrate a solution containing a molecular construct having a body formation which defines an aperture and a tail formation extending from the body formation; applying a potential difference across the substrate to thread the tail formation through the nanopore thereby docking the molecular construct to the substrate with the aperture aligned with the nanopore such that the sleeve formation lines the nanopore; and expelling the molecular construct from the substrate by varying the potential difference. A DNA construct for docking to a substrate having a nanopore is also provided, the construct having a body formation which defines an aperture, and a tail formation extending from the body formation for threading through the nanopore to dock the construct to the substrate with the aperture and nanopore in alignment.

Abstract: A heterojunction power device includes a substrate; a III-nitride semiconductor region over the substrate; a source operatively connected to the semiconductor region; a drain operatively connected to the semiconductor region; a gate between the source and drain and over the semiconductor region. The source is in contact with a first portion located between the source and gate and having a two dimensional carrier gas. The drain is in contact with a second portion located between the drain and gate and having a two dimensional carrier gas. At least one of the first and second portions has a trench having vertical sidewalls and formed within the semiconductor region; mesa regions extend away from each sidewall of the trench. The two dimensional carrier gas is located alongside the mesa regions and the trench. At least one of the source and drain is in contact with the respective two dimensional carrier gas.

Abstract: A heart valve is at least partially constructed from a block-copolymer, the block-copolymer having a phase structure formed by its constituent blocks, and wherein the phase structure is arranged so as to produce anisotropic physical properties in the heart valve.

Abstract: The present invention relates to a light emitting device comprising a light source and a luminescent material, which luminescent material comprises one or more matrix materials and two pluralities of nanoparticles, which two pluralities of nanoparticles comprise different perovskite compounds. The invention also relates to a luminescent material.

Abstract: A spatial phase modulator and a method for producing a spatial phase modulator are provided. The spatial phase modulator includes a first substrate and a second substrate that are meshed together, and a liquid crystal layer disposed between the two substrates, where a transparent electrode layer and a first alignment and guiding layer are disposed in a cascading manner on a side that is of the first substrate and that faces the liquid crystal layer; and an electrode layer and an insulation medium glass layer are disposed in a cascading manner on a side that is of the second substrate and that faces the liquid crystal layer, where the insulation medium glass layer has an inclined serration structure on a side facing the liquid crystal layer.

Abstract: Raising the level of Factor I above physiological levels can be used to treat diseases in which the underlying pathology is linked to overactivity of the C3b-feedback cycle and the generation and pro-inflammatory effects of iC3b. Methods, agents, and compositions for treatment of such diseases are described.

Abstract: We describe a luminescent device (120, 130) comprising a substrate (102) and a film comprising perovskite crystals (122, 132) deposited on the substrate, wherein the film comprising perovskite crystals is encapsulated with a layer (124, 134)) or within a matrix (124, 134) of an insulating oxide or an insulating nitride.

Abstract: A method for producing nanoplates derived from a layered material, includes the steps: (a) mixing particles of said layered material with a carrier liquid to form a dispersion of said particles in said carrier liquid; (b) pressurizing the dispersion to a pressure of at least 10 kpsi; and (c) forcing the dispersion along a microfluidic channel under said pressure, to apply a shear rate of at least 105 s?1 to said particles in the dispersion. Exfoliation of nanoplates from said particles is thereby caused. The nanoplates may be graphene nanoplates, for example. Steps (b) and (c) may be repeated for a number of cycles in order to promote exfoliation. The method may be carried out using a microfluidizer.