Abstract: A method is disclosed of manufacturing a semiconductor structure comprising an (001) oriented zincblende structure group III-nitride layer, such as GaN. The layer is formed on a 3C—SiC layer on a silicon substrate. A nucleation layer is formed, recrystallized and then the zincblende structure group III-nitride layer is formed by MOVPE at temperature T3 in the range 750-1000° C., to a thickness of at least 0.5 ?m. There is also disclosed a corresponding semiconductor structure comprising a zincblende structure group III-nitride layer which, when characterized by XRD, shows that the substantial majority, or all, of the layer is formed of zincblende structure group III-nitride in preference to wurtzite structure group III-nitride.

Abstract: A microfluidic device (11) is provided for separation and analysis of microfluidic samples. The device comprises: a separation channel (10); a first electrolyte channel (12) configured to provide a flow of high conductivity electrolyte solution, in use; and provided with a positive electrode (13) at a downstream outlet of the channel; a second electrolyte channel (14) configured to provide a flow of high conductivity electrolyte solution, in use, and provided with a negative electrode (15) at a downstream outlet of the channel; and wherein the flow of electrolyte through the first and second electrolyte channels removes electrophoresis products and gas bubbles from the device; and wherein the presence of the electrolyte provides a substantially homogenous electric field across the separation channel.

Abstract: Method of tracking a plurality of objects comprising: focusing an image of the objects on an imaging element using an optical system; capturing the image of the objects using an imaging element comprising a plurality of pixels; measuring at least one characteristic of the objects from the captured image using an image processor; wherein the field of view is set be the widest field of view for which the image processor is able to measure the at least one characteristic.

Abstract: Disclosed is a method of sensing a target analyte in a liquid sample using a bulk acoustic wave resonator device. The liquid sample is placed on the bulk acoustic wave resonator device which is operated to generate bulk acoustic waves. A shift in the fundamental resonant frequency of the bulk acoustic wave resonator device is measured. The bulk acoustic wave resonator device comprises a resonator structure and an acoustic decoupling layer. The resonator structure comprises: a piezoelectric material layer; electrodes arranged to apply a driving signal to the piezoelectric material layer to generate bulk acoustic waves; and a resonator structure surface. The acoustic decoupling layer is formed over the resonator structure surface. The acoustic decoupling layer acoustic impedance is: up to ? times or not less than 5 times the resonator structure acoustic impedance, and up to ? times or not less than 5 times the liquid sample acoustic impedance.

Abstract: A photon multiplying material containing a luminescent material having organic semiconductor molecules capable of singlet fission attached thereto, wherein the organic semiconductor molecules are chemically attached to the luminescent material by a linking group and wherein the linking group and the band gap of the luminescent material are selected so that exciton triplet states formed by singlet fission in the attached organic semiconductor molecules can be energy transferred into the luminescent material.

Abstract: This invention relates to modular proteins that interact with one or more target molecules. The chimeric proteins comprise two or more repeat domains, such as tetratricopeptide repeat domains; inter-repeat loops linking the repeat domains; and one or more peptide ligands. Each peptide ligand is located in an inter-repeat loop or at the N or C terminus of the chimeric protein. The peptide ligands may include heterologous peptidyl binding motifs, such as short linear motifs (SLiMs). Chimeric proteins with various configurations and methods for their production and use are provided.

Abstract: The disclosure relates to a III-nitride power semiconductor based heterojunction device including a low voltage terminal, a high voltage terminal, a control terminal and an active heterojunction transistor formed on a substrate, and further including the following monolithically integrated components: voltage clamp circuit configured to limit a maximum potential that can be applied to the internal gate terminal, an on-state circuit configured to control the internal gate terminal of the active heterojunction transistor during an on-state operation, a turn-off circuit configured to control the internal gate terminal of the active heterojunction transistor during a turn-off operation and during an off-state.

Abstract: A solid state light-emitting device comprising: a first electrode coupled to a first charge injecting layer; a second electrode coupled to a second charge injecting layer; an emissive layer comprising a perovskite material, wherein the emissive layer is provided between the first and second charge injecting layers; and wherein the bandgaps of the first and second charge injecting layers are larger than the bandgap of the emissive perovskite layer.

Abstract: The present invention provides a display system for displaying image data. The display system comprises a light source; a spatial light modulator including a plurality of controllable reflective elements; a light source controller, configured to control the light source to emit, in each of a plurality of time intervals, light with a different illumination power level, wherein the time intervals have the same length; and a spatial light modulator controller, configured to activate, based on received image data, the plurality of controllable elements for at least one of the time intervals for directing the light from the light source for display the image data. Accordingly, the frame rate and bandwidth of the display system are increased significantly so as to be suitable for the light filed applications.

Abstract: The invention provides methods of diagnosing and treating multiple sclerosis (MS) patients, including methods of identifying and treating multiple sclerosis patients who are at increased risk of developing a secondary autoimmune disease following lymphocyte depletion, caused, e.g., by treatment with an anti-CD52 antibody. The increased risk may be linked to certain single nucleotide polymorphism genotypes that are indicative of elevated IL-21 levels. Also embraced are methods of selecting treatment regimens for MS patients, and reagents useful in the above methods.

Abstract: A device and a method is provided for profiling particles such as proteins. The device comprises: a liquid chromatography column (16) in a mixture separation module (10); a fractionation device (22, 24) and a plurality of microfluidic analysis modules (26, 28) in a microfluidic network (14). The microfluidic analysis modules are configured to provide multi-dimensional analysis of the particles. Furthermore, a fluidic flow adaptor (20) allows for controlled flow between separator (16) and the microfluidic network to provide a continuous fluid flow.

Abstract: Described herein is the use of organic materials in methods of barocaloric cooling. The barocaloric effects may be exhibited where the organic material is near a non-isochoric phase transition, such as a non-isochoric first-order phase transition. The organic material has one or more carbon atoms and may be an organic compound or a salt thereof. In some cases that organic material is a soft matter material, such as a plastic crystal or a liquid crystal. The methods may be adapted for use of the organic material as a heating agent.

Abstract: The invention relates to the production of graft-mediated hybrid monocotyledonous plants. Methods for the production of such plants are disclosed herein.

Abstract: A flow apparatus for detecting a component on a surface is provided. The flow apparatus, comprising an inlet for receiving a solution of the components to be detected; a detection chamber in fluid connection with and downstream from the inlet, and in fluid connection with a downstream outlet, wherein the internal surface of the detection chamber comprises a plurality of detection zones and the detection zones are configured to adhere to the component to be detected such that the component is immobilised in the detection zones; a detector for detecting components immobilised on each of the detection zones; and a director for directing the flow of the solution of the components to each of the detection zones in sequence, wherein the director is provided by flow rates.

Abstract: A method of increasing the interference contrast in interferometric scattering optical microscopy. The method comprises providing a particle detection region comprising a chamber or channel having a boundary defined by one or more interfaces, illuminating a particle in the particle detection region with coherent light using an objective lens such that the light is reflected from the interface and scattered by the particle, capturing the reflected light and the scattered light using the objective lens, and providing the captured reflected and scattered light to an imaging device to image interference between the reflected light and the scattered light. The particle is illuminated by coherent light at an oblique angle to the interface.

Abstract: A method of optically characterizing individual molecules/molecular complexes, or other particles, in solution. The method comprises flowing a solution comprising the molecules/molecular complexes into an imaging region of a microfluidic channel, wherein the imaging region of the microfluidic channel has a first lateral dimension of greater than 1 ?m in an x-direction wherein the x-direction is perpendicular to a direction of the flow; capturing a succession of images of the individual molecules/molecular complexes in the imaging region; tracking movement of the individual molecules/molecular complexes in at least the x-direction in the imaging region using the succession of images; and characterizing the individual molecules/molecular complexes from the tracked movement. In some implementations the characterizing comprises determining a diffusion coefficient of the molecules/molecular complexes from the tracked movement.

Abstract: The invention relates to the grafting of perennial monocots such as bananas and oil palms. Processes for the production of such plants are disclosed herein.

Abstract: The disclosure relates to power semiconductor devices in GaN technology. The disclosure proposes an integrated auxiliary gate terminal (15) and a pulldown network to achieve a normally-off (E-Mode) GaN transistor with threshold voltage higher than 2V, low gate leakage current and enhanced switching performance. The high threshold voltage GaN transistor has a high-voltage active GaN device (205) and a low-voltage auxiliary GaN device (210) wherein the high-voltage GaN device has the gate connected to the source of the integrated auxiliary low-voltage GaN transistor and the drain being the external high-voltage drain terminal and the source being the external source terminal, while the low-voltage auxiliary GaN transistor has the gate (first auxiliary electrode) connected to the drain (second auxiliary electrode) functioning as an external gate terminal.

Abstract: A photon multiplying material includes a first organic semiconductor, a luminescer and a light harvesting material wherein the light harvesting material has a bandgap which provides that exciton states formed in the light harvesting material by absorbance of light can be energy transferred to the first organic semiconductor and the luminescer has a bandgap which provides that triplet exciton states formed in the first organic semiconductor can be energy transferred into the luminescer; and wherein at least one of the first organic semiconductor and the light harvesting material is capable of singlet fission.

Abstract: A closed-loop system for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”).