Abstract: The invention relates to a polypeptide selected from bone morphogenetic protein 10 (BMP10), or a bone morphogenetic protein 9 (BMP9) variant lacking osteogenic activity, for use in the treatment of a vascular disease or a respiratory disease. The invention also relates to novel BMP9 variants and to pharmaceutical compositions comprising said polypeptides.

Abstract: A method for the oxidation of C1-9-alkanes including providing a mixture of a C1-9-alkane in a liquid phase, a boron containing reagent, a free radical initiator, and a drying means, and performing an oxidation reaction at a temperature from 130° C. to 180° C. in the presence of oxygen. The drying means may be a drying agent such as a molecular sieve, or a membrane. Also a composition for oxidation of C1-9-alkanes to sec-C1-9-alcohols.

Abstract: The present invention relates to a light emitting device comprising a light source and a luminescent material, which luminescent material comprises: one or more matrix materials, and, disposed in said one or more matrix materials, a first plurality of nanoparticles comprising a first crystalline compound and a second plurality of nanoparticles comprising a second crystalline compound, which first crystalline compound and second crystalline compounds are different compounds of formula [A]a[M]b[X]c, wherein: [A] is at least one cation; [M] is at least one metal or metalloid cation; [X] is at least one anion; a is an integer from 1 to 6; b is an integer from 1 to 6; and c is an integer from 1 to 18. The invention also relates to the use of said luminescent material as a phosphor in a light emitting device.

Abstract: Fiber optic sensors are used to monitor the integrity of a subsurface concrete structure such as a pile or diaphragm wall. A fiber optic sensor array (48) is attached to a reinforcement or framework assembly (20) for the subsurface concrete structure. Concrete is applied to surround the reinforcement or framework assembly (20) and fiber optic sensor array (48). The fiber optic sensor array (48) is then used to collect temperature data during hydration of the subsurface concrete structure. The temperature data is monitored in real time to determine differentials across the structure, indicative of a problem within the structure.

Abstract: An electronic or optoelectronic device including a semiconductor layer, wherein the semiconductor layer comprises at least a semiconductive organic material, water species, and at least one additive in an amount of at least 0.1% by weight relative to the semiconductive organic material, which additive at least partly negates a charge carrier trapping effect caused by the water species on the semiconductive organic material.

Abstract: Flow apparatuses comprising a separation channel, a downstream flow separator, a detection zone, an observation zone, and a waste channel. The separation channel has first and second flows in contact and allows lateral movement of components between contacting first and second flows. The downstream flow separator is in communication with the separation channel and diverts a part of the first fluid flow, the second fluid flow, or both, from the separation channel. The detection zone comprises a detection channel downstream of and in communication with the flow separator and configured to receive a plurality of diverted flows from the flow separator and a label channel configured to label the diverted flows from the flow separator. The observation zone is configured to record an analytical signal indicative of the quantity and the electrical properties of the component. The waste channel is at the downstream end of the observation zone.

Abstract: A method of producing graphene sheets comprising the steps of, forming a carbonaceous powder by electrochemical erosion of a graphite electrode in a molten salt comprising hydrogen ions, recovering the resulting carbonaceous powder from the molten salt liquid, and thermally treating the carbonaceous powder by heating the carbonaceous powder in a non-oxidising atmosphere to produce a thermally treated powder comprising graphene sheets. The method allows high production rates of high purity graphene sheets.

Abstract: This invention relates to methods for the expansion of T-lymphocytes with a memory-like phenotype in which the intracellular concentration of a memory induction compound, such as 2-hydroxyglutarate (2HG), is increased in order to facilitate the maintenance of a memory-like phenotype. This may be useful for example, in cellular immunotherapy. The memory induction compound may the formula (I) wherein: p is 0 or 1, and when p is 0, Y is —CH2— or —C?, and when p is 1, Y is selected from —CH—, CH2, —NH—, —S, and -0-; —R1 is —H, —(CH2)nCH3, —(CH2)nCH2CO2H, —CH2Ph or —CH2PhOCH2Ph; and when Y is —CH—, CH2, —NH—, —S, or —O—, X is a single bonded group selected from —H, —OH, —NH2, —SH, —(CH2)nCH3 —(CH2)nCH2CO2H, —F, —Cl, —Br, and —I, or a double bonded group selected from ?O and ?S; and when Y is a double bonded —C?, X is —H; and each n is independently 0 to 12.

Abstract: A gravimeter or inertial sensor system and method of operating such a system is provided. The system comprises a variable frequency signal source (100, 101, 102) configured to provide first and second signals, a resonant sensor (103) connected to receive the first signal, a phase comparator (111) connected to the output of the resonant sensor and to receive the second signal, and a controller (114) connected to the phase comparator. In a first mode, the controller controls the desired frequency of the signals from the variable frequency signal source based on a value of the phase comparator output signal to lock the frequency of the input signals to a resonant frequency of the resonant sensor. In a second mode, the controller disconnects from the variable frequency signal source and records an open loop output signal indicative of the physical parameter to be measured based on the response of the resonant sensor.

Abstract: A thermal conductivity sensing device (1) is disclosed, along with a method for operation of the thermal conductivity sensing device and use of the thermal conductivity sensing device in a system for gas chromatography and a method of carrying out gas chromatography. The thermal conductivity sensing device is for use in sensing one or more gaseous components in a flowing gaseous environment. The device has a first sensor (4B) and a second sensor (4A) for exposure to the same flowing gaseous environment (G). The first sensor has an associated flow altering means (20) to affect gas flow at least at part of the surface of the first sensor, to be different to gas flow at the surface of the second sensor. Each sensor provides an output relating to heat transfer between a surface of the sensor and the gaseous environment. The device is operable to compare outputs of the first and second sensors. The sensor is able to reduce the effects of bulk convection of the flowing gas on thermal conductivity measurements.

Abstract: Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described.

Abstract: A method for analyzing a component is provided. The method includes the steps of: (iii) providing the electrophoretic or thermophoretic movement of the component into a second fluid flow; (iv) diverting a part of a first fluid flow, a part of the second fluid flow, or parts of the first fluid flow and the second fluid flow, wherein the diverted part is a third fluid flow which includes, the component; (v) contacting the third fluid flow with a fourth fluid flow, such as to form a laminar flow; (vi) providing the diffusion of the component into the fourth fluid flows.

Abstract: The invention relates to a method of differentially diagnosing schizophrenia, bipolar disorder and major depressive disorder.

Abstract: A holographic display system for generating a super hologram with full parallax in different fields of view in the horizontal and vertical directions. The display system includes assemblies or subsystems each adapted to combine holographic displays and coarse integral displays to produce or display a coarse integral hologram. Briefly, the display system described herein teaches techniques for enhancing operations of coarse integral holographic (CIH) displays. The enhanced CIH displays may utilize ganged scanners, may operate scanners to provide boustrophedon scanning, may be configured to add color information such by view sequential color hologram display and scanning, may replace or supplement X-Y scanning abilities with a resonant scanner, and may replace physical lenslet arrays by generating and displaying a holographic lenslet for each elemental hologram used to create the super hologram.

Abstract: The present disclosure provides methods for increasing meiotic recombination in crop plants, as well as plants and seeds produced by such methods.

Abstract: This invention relates pro-coagulant serpin molecules engineered by modification of the P4, P2, P1 and/or P1? residues within the reactive center loop (RCL) to display increased specificity for anticoagulant proteases. These modified serpin molecules may be useful in therapy, for example as pro-coagulants for the treatment of bleeding.

Abstract: The invention relates to a polypeptide selected from bone morphogenetic protein 10 (BMP10), or a bone morphogenetic protein 9 (BMP9) variant lacking osteogenic activity, for use in the treatment of a vascular disease or a respiratory disease. The invention also relates to novel BMP9 variants and to pharmaceutical compositions comprising said polypeptides.

Abstract: A method is provided of controlling the functionality of a substrate containing at least one nanopore. The method includes the steps of: introducing to the substrate a solution containing a molecular construct having a body formation which defines an aperture and a tail formation extending from the body formation; applying a potential difference across the substrate to thread the tail formation through the nanopore thereby docking the molecular construct to the substrate with the aperture aligned with the nanopore such that the sleeve formation lines the nanopore; and expelling the molecular construct from the substrate by varying the potential difference. A DNA construct for docking to a substrate having a nanopore is also provided, the construct having a body formation which defines an aperture, and a tail formation extending from the body formation for threading through the nanopore to dock the construct to the substrate with the aperture and nanopore in alignment.

Abstract: A device for the processing of a sample comprises a location apparatus, a processing chamber for receiving the sample and a plurality of reagent chambers. The reagent chambers have openings defined in the location apparatus. The processing chamber is movable relative to the reagent chambers to enable sequential communication with each reagent chamber in turn.

Abstract: The present disclosure discloses a display apparatus, a stereoscopic display apparatus, and an application terminal thereof. The display apparatus includes a display panel and a light collimation module. The display panel includes an RGB pixel array. The RGB pixel array includes multiple RGB pixels disposed at intervals. The light collimation module includes a control electrode layer, a first transparent substrate, a liquid crystal layer, and a second transparent substrate. The control electrode layer is disposed within the intervals between the RGB pixels or at positions that are on the display panel and that are corresponding to the intervals between the RGB pixels. The first transparent substrate is disposed on the display panel and covers the control electrode. The liquid crystal layer is disposed on the first transparent substrate. The second transparent substrate is disposed on the liquid crystal layer.