Patents Assigned to Cambridge Polymer Group, Inc.
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Patent number: 10821632Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: GrantFiled: March 7, 2018Date of Patent: November 3, 2020Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Publication number: 20180194042Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: ApplicationFiled: March 7, 2018Publication date: July 12, 2018Applicants: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Patent number: 9968709Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.Type: GrantFiled: June 24, 2016Date of Patent: May 15, 2018Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Edward T. Kopesky, Ebru Oral
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Patent number: 9962463Abstract: The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.Type: GrantFiled: June 16, 2016Date of Patent: May 8, 2018Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Patent number: 9943993Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: GrantFiled: May 16, 2017Date of Patent: April 17, 2018Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Patent number: 9873769Abstract: A method of forming thiolated poly(vinyl alcohol) hydrogels including reacting, in the presence of an acid, compounds containing a thiol functional group and a hydroxyl reactive group with one or more hydroxyl groups of poly(vinyl alcohol) via said hydroxyl reactive group, thereby forming thiolated poly(vinyl alcohol). The method further including reacting the thiol functional group of said compounds with a thiol reactive group of a crosslinker, thereby forming a hydrogel.Type: GrantFiled: July 10, 2014Date of Patent: January 23, 2018Assignee: CAMBRIDGE POLYMER GROUP, INC.Inventors: Gavin Braithwaite, Yuri Svirkin
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Publication number: 20170259467Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: ApplicationFiled: May 16, 2017Publication date: September 14, 2017Applicants: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. MURATOGLU, Stephen H. SPIEGELBERG
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Patent number: 9688004Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: GrantFiled: May 27, 2014Date of Patent: June 27, 2017Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Publication number: 20170049934Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.Type: ApplicationFiled: June 24, 2016Publication date: February 23, 2017Applicants: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. MURATOGLU, Edward T. KOPESKY, Ebru ORAL
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Patent number: 9561306Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.Type: GrantFiled: March 10, 2014Date of Patent: February 7, 2017Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Publication number: 20160296661Abstract: The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.Type: ApplicationFiled: June 16, 2016Publication date: October 13, 2016Applicants: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. MURATOGLU, Stephen H. SPIEGELBERG
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Patent number: 9441081Abstract: The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.Type: GrantFiled: March 3, 2008Date of Patent: September 13, 2016Assignees: The General Hospital Corp., Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Patent number: 9433705Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.Type: GrantFiled: September 25, 2013Date of Patent: September 6, 2016Assignees: The General Hospital Corp., Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Edward T. Kopesky, Ebru Oral
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Patent number: 9370878Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: GrantFiled: March 14, 2013Date of Patent: June 21, 2016Assignees: The General Hospital Corp., Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Patent number: 8968628Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: GrantFiled: January 10, 2011Date of Patent: March 3, 2015Assignees: The General Hospital Corp., Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Patent number: 8888859Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: GrantFiled: April 23, 2012Date of Patent: November 18, 2014Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Patent number: 8865043Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.Type: GrantFiled: September 7, 2012Date of Patent: October 21, 2014Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Publication number: 20140275318Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: ApplicationFiled: May 27, 2014Publication date: September 18, 2014Applicants: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. MURATOGLU, Stephen H. Spiegelberg
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Publication number: 20140183794Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.Type: ApplicationFiled: March 10, 2014Publication date: July 3, 2014Applicants: Cambridge Polymer Group, Inc., The General Hospital CorporationInventors: Orhun K. MURATOGLU, Stephen H. Spiegelberg
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Patent number: 8728379Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: GrantFiled: September 15, 2010Date of Patent: May 20, 2014Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg