Patents Assigned to Cambridge Polymer Group, Inc.
  • Publication number: 20180194042
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Application
    Filed: March 7, 2018
    Publication date: July 12, 2018
    Applicants: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • Patent number: 9968709
    Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: May 15, 2018
    Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Edward T. Kopesky, Ebru Oral
  • Patent number: 9962463
    Abstract: The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: May 8, 2018
    Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • Patent number: 9943993
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: April 17, 2018
    Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • Patent number: 9873769
    Abstract: A method of forming thiolated poly(vinyl alcohol) hydrogels including reacting, in the presence of an acid, compounds containing a thiol functional group and a hydroxyl reactive group with one or more hydroxyl groups of poly(vinyl alcohol) via said hydroxyl reactive group, thereby forming thiolated poly(vinyl alcohol). The method further including reacting the thiol functional group of said compounds with a thiol reactive group of a crosslinker, thereby forming a hydrogel.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: January 23, 2018
    Assignee: CAMBRIDGE POLYMER GROUP, INC.
    Inventors: Gavin Braithwaite, Yuri Svirkin
  • Publication number: 20170259467
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Application
    Filed: May 16, 2017
    Publication date: September 14, 2017
    Applicants: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. MURATOGLU, Stephen H. SPIEGELBERG
  • Patent number: 9688004
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: June 27, 2017
    Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • Publication number: 20170049934
    Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.
    Type: Application
    Filed: June 24, 2016
    Publication date: February 23, 2017
    Applicants: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. MURATOGLU, Edward T. KOPESKY, Ebru ORAL
  • Patent number: 9561306
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: February 7, 2017
    Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • Publication number: 20160296661
    Abstract: The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.
    Type: Application
    Filed: June 16, 2016
    Publication date: October 13, 2016
    Applicants: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. MURATOGLU, Stephen H. SPIEGELBERG
  • Patent number: 9441081
    Abstract: The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.
    Type: Grant
    Filed: March 3, 2008
    Date of Patent: September 13, 2016
    Assignees: The General Hospital Corp., Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • Patent number: 9433705
    Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: September 6, 2016
    Assignees: The General Hospital Corp., Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Edward T. Kopesky, Ebru Oral
  • Patent number: 9370878
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: June 21, 2016
    Assignees: The General Hospital Corp., Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • Patent number: 8968628
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: March 3, 2015
    Assignees: The General Hospital Corp., Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • Patent number: 8888859
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: November 18, 2014
    Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • Patent number: 8865043
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: October 21, 2014
    Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • Publication number: 20140275318
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Application
    Filed: May 27, 2014
    Publication date: September 18, 2014
    Applicants: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. MURATOGLU, Stephen H. Spiegelberg
  • Publication number: 20140183794
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.
    Type: Application
    Filed: March 10, 2014
    Publication date: July 3, 2014
    Applicants: Cambridge Polymer Group, Inc., The General Hospital Corporation
    Inventors: Orhun K. MURATOGLU, Stephen H. Spiegelberg
  • Patent number: 8728379
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Grant
    Filed: September 15, 2010
    Date of Patent: May 20, 2014
    Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • Publication number: 20140097559
    Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.
    Type: Application
    Filed: September 25, 2013
    Publication date: April 10, 2014
    Applicants: Cambridge Polymer Group, Inc., The General Hospital Corporation
    Inventors: Orhun K. MURATOGLU, Edward T. Kopesky, Ebru Oral