Patents Assigned to Cambridge Polymer Group, Inc.
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Patent number: 7790095Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: GrantFiled: November 30, 2007Date of Patent: September 7, 2010Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Patent number: 7776352Abstract: In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex.Type: GrantFiled: August 7, 2006Date of Patent: August 17, 2010Assignee: Cambridge Polymer Group, Inc.Inventors: Jeffrey W. Ruberti, Gavin J. C. Braithwaite
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Publication number: 20100190882Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.Type: ApplicationFiled: January 25, 2008Publication date: July 29, 2010Applicants: The General Hosital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Edward T. Kopesky, Ebru Oral
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Patent number: 7745532Abstract: The preferred embodiments of the present invention provide polymer compositions and methods for controlling a property of a resultant gel. A preferred method includes dissolving a vinyl polymer in a first solvent to form a solution; and contacting the vinyl polymer solution in a suitable volume of at least one immersion solvent comprising a second solvent to cause gelation. In preferred embodiments, the invention provides poly(vinyl alcohol) compositions and methods that produce physically crosslinked hydrogels that have tunable physical properties. Also provided are articles of manufacture such as prosthetic intervertebral disks and contact lenses.Type: GrantFiled: July 31, 2003Date of Patent: June 29, 2010Assignee: Cambridge Polymer Group, Inc.Inventors: Jeffrey W. Ruberti, Gavin J. C. Braithwaite
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Publication number: 20090326659Abstract: The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.Type: ApplicationFiled: June 26, 2009Publication date: December 31, 2009Applicants: Massachusetts General Hospital, Cambridge Polymer Group, Inc.Inventors: Orhun K. MURATOGLU, Stephen H. SPIEGELBERG, Gareth H. MCKINLEY
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Patent number: 7619009Abstract: In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex.Type: GrantFiled: August 7, 2006Date of Patent: November 17, 2009Assignee: Cambridge Polymer Group, Inc.Inventors: Jeffrey W. Ruberti, Gavin J. C. Braithwaite
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Publication number: 20090265001Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: ApplicationFiled: May 12, 2009Publication date: October 22, 2009Applicants: Massachusetts General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Patent number: 7569620Abstract: The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.Type: GrantFiled: October 17, 2007Date of Patent: August 4, 2009Assignees: Massachusetts General Hospital, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg, Gareth H. McKinley
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Patent number: 7507774Abstract: The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.Type: GrantFiled: October 17, 2007Date of Patent: March 24, 2009Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg, Gareth H. McKinley
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Patent number: 7498365Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: GrantFiled: April 13, 2005Date of Patent: March 3, 2009Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Patent number: 7485670Abstract: In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex.Type: GrantFiled: February 4, 2004Date of Patent: February 3, 2009Assignee: Cambridge Polymer Group, Inc.Inventors: Jeffrey W. Ruberti, Gavin J. C. Braithwaite
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Patent number: 7431874Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: GrantFiled: January 15, 2004Date of Patent: October 7, 2008Assignees: Massachusetts General Hospital, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Publication number: 20080215142Abstract: The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.Type: ApplicationFiled: March 3, 2008Publication date: September 4, 2008Applicants: The General Hospital Corporation dba Massachusetts General Hospital, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Publication number: 20080090934Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.Type: ApplicationFiled: November 30, 2007Publication date: April 17, 2008Applicants: The General Hospital Corporation dba Massachusetts General Hospital, Cambridge Polymer Group, Inc.Inventors: Orhun Muratoglu, Stephen Spiegelberg
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Publication number: 20080090933Abstract: The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.Type: ApplicationFiled: October 17, 2007Publication date: April 17, 2008Applicants: Massachusetts General Hospital, Cambridge Polymer Group, Inc.Inventors: Orhun Muratoglu, Stephen Spiegelberg, Gareth McKinley
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Publication number: 20080067724Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: ApplicationFiled: November 30, 2007Publication date: March 20, 2008Applicants: Massachusetts General Hospital, Cambridge Polymer Group, Inc.Inventors: Orhun MURATOGLU, Stephen Spiegelberg
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Publication number: 20080039545Abstract: The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.Type: ApplicationFiled: October 17, 2007Publication date: February 14, 2008Applicants: Massachusetts General Hospital, Cambridge Polymer Group, Inc.Inventors: Orhun MURATOGLU, Stephen Spielgelberg, Gareth McKinley
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Patent number: 7304097Abstract: The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.Type: GrantFiled: August 16, 2006Date of Patent: December 4, 2007Assignees: Massachusetts General Hospital, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg, Gareth H. McKinley
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Publication number: 20070114702Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: ApplicationFiled: November 29, 2006Publication date: May 24, 2007Applicants: The General Hospital Corporation dba Massachusetts General Hospital, Cambridge Polymer Group, Inc.Inventors: Orhun MURATOGLU, Stephen Spiegelberg
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Patent number: 7166650Abstract: The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.Type: GrantFiled: January 7, 2005Date of Patent: January 23, 2007Assignees: Massachusetts General Hospital, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg, Gareth H. McKinley