Abstract: A computer-implemented method can include determining an amplitude for each of a plurality of input channels, corresponding to respective nodes. A measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. The method can also include comparing an amplitude for each node relative to other nodes to determine temporary bad channels. For each of the temporary bad channels, a measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. Channel integrity can then be identified based on the computed measures of similarity.

Abstract: A method can determine one or more origins of focal activation. The method can include computing phase for the electrical signals at a plurality of nodes distributed across a geometric surface based on the electrical data across time. The method can determine whether or not a given candidate node of the plurality of nodes is a focal point based on the analyzing the computed phase and magnitude of the given candidate node. A graphical map can be generated to visualize focal points detected on the geometric surface.

Abstract: This disclosure provides isolation for a medical amplifier by providing a low impedance path for noise across an isolation barrier. The low impedance path can include a capacitive coupling between a patient ground, which is isolated from control circuitry, and a functional ground of an isolation system that is isolated from earth ground. The low impedance path can draw noise current from an input of an amplifier of patient circuitry.

Abstract: Systems and methods can be used to provide an indication of heart function, such as an indication of mechanical function or hemodynamics of the heart, based on electrical data. For example, a method for assessing a function of the heart can include determining a time-based electrical characteristic for a plurality of points distributed across a spatial region of the heart. The plurality of points can be grouped into at least two subsets of points based on at least one of a spatial location for the plurality of points or the time-based electrical characteristics for the plurality of points. An indication of synchrony for the heart can be quantified based on relative analysis of the determined time-based electrical characteristic for each of the at least two subsets of points.

Abstract: A method can include analyzing non-invasive electrical data for a region of interest (ROI) of a patient's anatomical structure to identify one or more zones within the ROI that contain at least one mechanism of distinct arrhythmogenic electrical activity. The method also includes analyzing invasive electrical data for a plurality of signals of interest at different spatial sites within each of the identified zones to determine intracardiac signal characteristics for the plurality of sites within each respective zone. The method also includes generating an output that integrates the at least one mechanism of distinct arrhythmogenic electrical activity for the one or more zones with intracardiac signal characteristics for the plurality of sites within each respective zone.

Abstract: A method can include storing a plurality of data sets including values computed for each of a plurality of points for a given spatial region of tissue, the values in each of the data sets characterizing electrical information for each respective point of the plurality of points for a different time interval. The method can also include combining the values computed for each of a plurality of points in a first interval, corresponding to a first map, with the values for computed for each of the respective plurality of points in another interval and to normalize the combined values relative to a common scale. The method can also include generating a composite map for the given spatial region based on the combined values that are normalized.

Abstract: A method can determine one or more origins of focal activation. The method can include computing phase for the electrical signals at a plurality of nodes distributed across a geometric surface based on the electrical data across time. The method can determine whether or not a given candidate node of the plurality of nodes is a focal point based on the analyzing the computed phase and magnitude of the given candidate node. A graphical map can be generated to visualize focal points detected on the geometric surface.

Abstract: A sensor array system (10, 30) can include a substrate layer (12, 14) that includes a stretchable and conformable material that is configured to allow spaced apart and interconnected portions thereof to stretch and conform commensurate with movement of the substrate layer (12, 14), such as when attached to a patient's body. A plurality of electrodes (16) are disposed on a contact surface of the substrate layer (12, 14). Electrically conductive paths are also disposed on the substrate layer (14) and extending from each of the electrodes to which it is connected and terminating in an end thereof. The substrate layer may itself include more than one layer, such as including a flexible substrate layer (12) that is affixed to a stretchable material layer (14).

Abstract: Systems and methods can be used to determine activation information for points along a surface or selected region of interest. In one example, a computer-readable medium having computer-executable instructions for performing a method that includes computing a local activation vector based on relative timing among electrical signals corresponding to neighboring points of a plurality of points on a surface envelope. An activation time can be computed for each of the plurality of points as a function of corresponding local activation vectors.

Abstract: Systems and methods are disclosed to determine one or more sensing zones on a body surface for electrocardiographic mapping of a region of interest associated with the heart. The sensing zone can be utilized to facilitate acquisition, processing and mapping of electrical activity for the corresponding region of interest. In other examples, an application-specific arrangement of electrodes can also be provided based on the sensing zone that is determined for the region of interest.

Abstract: A method (500) can comprise performing principal component analysis (PCA) on data corresponding to a subset of a plurality of signals and a selected template to generate a virtual lead and an optimized template (530). The method can also comprise calculating a cross correlation on the virtual lead and the optimized template to determine a strength of linear dependence between the virtual lead and the optimized template to determine regions of interest (ROIs) of the virtual lead (540). The method can further comprise detecting peak correlation coefficients in the virtual lead (550). The method can still further comprise comparing the amplitude of each of the ROIs of the virtual lead with the selected template to determine an error between the template and each ROI of the virtual lead (560). The method can yet further comprise averaging the ROIs to generate averaged data (570).

Abstract: A computer-implemented method can include determining an amplitude for each of a plurality of input channels, corresponding to respective nodes. A measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. The method can also include comparing an amplitude for each node relative to other nodes to determine temporary bad channels. For each of the temporary bad channels, a measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. Channel integrity can then be identified based on the computed measures of similarity.

Abstract: An electrical connector has dielectric posts surrounding the contacts and extending outwardly from the root along the contact axis a finite amount. The mating connector (or plug) has a housing that surrounds the posts. A device that includes both the electrical connector and the mating connector provides good electrical isolation between adjacent contacts.

Abstract: A method includes storing baseline data representing at least one local or global electrical characteristics for at least a portion of a region of interest (ROI) of a patient's anatomical structure. The baseline data is determined based on electrical measurement data obtained during at least one first measurement interval. The method also includes storing in memory other data representing the at least one local or global electrical characteristics for the at least a portion of the ROI based on electrical measurement data obtained during at least one subsequent measurement interval. The method also includes evaluating the baseline data relative to the other data to determine a change in the at least one local or global electrical characteristics. The method also includes generating an output based on the evaluating to provide an indication of progress or success associated with the applying the treatment.

Abstract: A method can determine one or more origins of focal activation. The method can include computing phase for the electrical signals at a plurality of nodes distributed across a geometric surface based on the electrical data across time. The method can determine whether or not a given candidate node of the plurality of nodes is a focal point based on the analyzing the computed phase and magnitude of the given candidate node. A graphical map can be generated to visualize focal points detected on the geometric surface.

Abstract: A non-transitory computer-readable medium can have instructions executable by a processor. The instructions can include an electrogram reconstruction method to generate reconstructed electrogram signals for each of a multitude of points residing on or near a predetermined cardiac envelope based on geometry data and non-invasively measured body surface electrical signals. The instructions can include a phase calculator to compute phase signals for the multitude of points based on the reconstructed electrogram signals and a visualization engine to generate an output based on the computed phase signals.

Abstract: A system can include a sensor array comprising a plurality of sensors configured to measure electrical activity across a body surface of a patient and generate electrical data characterizing the measured electrical activity. The plurality of sensors are arranged at predetermined locations for placement over the patient's body to define at least one predetermined zone of the patient's body that maps deterministically to at least one predetermined region of interest of at least one internal anatomical structure of the patient. A control system is configured to analyze the electrical data for the at least one predetermined zone to provide a surrogate estimate of electrical activity at the at least one predetermined region of interest. The control system also is configured to control delivery of a therapy to the patient based on the surrogate estimate of electrical activity at the at least one predetermined region of interest.

Abstract: Systems and methods are provided to detect and analyze arrhythmia drivers. In one example, a system can include a wave front analyzer programmed to compute wave front lines extending over a surface for each of the plurality of time samples based on phase information computed from electrical data at nodes distributed across the surface. A trajectory detector can be programmed to compute wave break points for each of the wave front lines and to determine a trajectory of at least one rotor core across the surface. A stability detector can be programmed to identify at least one stable rotor portion corresponding to subtrajectories of the determined trajectory.

Abstract: A device includes an electrical connector coupled to the end of a flex circuit. The connector includes interior ribs that engage slots in the flex circuit, with the ribs and slots separating adjacent contact pads on the flex circuit. The contact pads are exposed portions of conductive traces on the flex circuit. Other portions of the conductive traces may be covered by a dielectric material, such as a non-conductive ink. The ribs provide an increased isolation path between the contact pads.

Abstract: Uniquely positioned slots are provided in the receptacle and uniquely positioned bosses are provided in the plug of a connector pair. These features are designed to prevent the plug from being inserted midspan and damaging the exposed contacts of the receptacle. The bosses may be located near outside corners of the plug, and may protrude sufficiently from the face of the plug to prevent the corners of the plug from being inserted into the receptacle, except when the bosses are aligned with the boss-receiving slots in the receptacle.