Abstract: The invention relates to mobile computer devices, front-mounted optical systems and computer program products allowing perimetry measurement.

Abstract: Various systems and methods for improved OCT angiography imaging are described. An example method of identifying intraretinal fluid in optical coherence tomography (OCT) image data of an eye includes collecting OCT image data using an OCT system. The data includes at least one cluster scan containing OCT image data collected at approximately same set of locations on the sample. A first motion contrast image is generated by applying a first OCT angiography processing technique to the cluster scan to highlight motion contrast in the sample. A second motion contrast image is generated by applying a second OCT angiography processing technique to the cluster scan to highlight motion contrast in the sample. An image displaying intraretinal fluid in the eye is generated using the first and second motion contrast images and then displayed or stored or a further analysis thereof.

Abstract: Methods for improved acquisition and processing of optical coherence tomography (OCT) angiography data are presented. One embodiment involves improving the acquisition of the data by evaluating the quality of different portions of the data to identify sections having non-uniform acquisition parameters or non-uniformities due to opacities in the eye such as floaters. The identified sections can then be brought to the attention of the user or automatically reacquired. In another embodiment, segmentation of layers in the retina includes both structural and flow information derived from motion contrast processing. In a further embodiment, the health of the eye is evaluating by comparing a metric reflecting the density of vessels at a particular location in the eye determined by OCT angiography to a database of values calculated on normal eyes.

Abstract: Systems and methods for sub-aperture correlation based wavefront measurement in a thick sample and correction as a post processing technique for interferometric imaging to achieve near diffraction limited resolution are described. Theory, simulation and experimental results are presented for the case of full field interference microscopy. The inventive technique can be applied to any coherent interferometric imaging technique and does not require knowledge of any system parameters. In one embodiment of the present application, a fast and simple way to correct for defocus aberration is described. A variety of applications for the method are presented.

Abstract: Techniques are introduced to improve the ability of OCT to determine more accurately the nature of the flow of fluids in the eye, including faster measurements of the flow and a method to reduce geometric uncertainties due to eye movements.

Abstract: Improved scanning ophthalmoscopes for scanning the retina of an eye are discussed in the present disclosure. One example scanning ophthalmoscope includes an uncollimated light source, a first scanning element, a second scanning element, a slit of a first aspherical mirror, and a second aspherical mirror. The uncollimated light source produces a beam of light to illuminate the retina. The beam of light is relayed from the first scanning element onto the second scanning element by the slit of the first aspherical mirror. The second aspherical mirror relays the beam of light from the second scanning element to the pupil of the eye.

Abstract: Methods and systems are presented to analyze a retinal image of an eye and assigns features to known anatomical structures such as retinal layers. One example method includes receiving interferometric image data of an eye. A set of features is identified in the image data. A first subset of identified features is associated with known retinal structures using prior knowledge. A first set of characteristic metrics is determined of the first subset of features. A second set of characteristic metrics is determined of a second subset of features. Using the characteristic metrics of the first and the second sets, the second subset of features is associated with the retinal structures. Another example method includes dividing interferometric image data into patches. The image data in each patch is segmented to identify one or more layer boundaries. The segmentation results from each patch are stitched together into a single segmentation dataset.

Abstract: Systems and methods to improve the detection and classification of inflammation in the eye are presented. The inflammatory markers in image data can be graded by comparing identified and extracted characteristics from the images with characteristics derived from a set of images of eyes from a general population of subjects. The image data can be divided into sub-regions for analysis to better isolate the true inflammatory markers from the impacts of cataracts or other opacities. In another embodiment, the location of an imaging beam can be controlled to minimize the impact of lens opacities from the collected data used to analyze the inflammation state of an eye.

Abstract: Various methods for automatically identifying the Schwalbe's line location in an optical coherence tomography (OCT) image of the anterior chamber of an eye are described. In one example method, the posterior corneal surface in the ROI is segmented by using one or more segmentation approaches to produce a segmented output. A curvature is computed at each segmented point to identify a set of local curvature maxima locations. Features at each local curvature maxima location are evaluated. The Schwalbe's line location is identified using the evaluated features at each maxima location. Other methods for identifying the Schwalbe's line location discussed in the present application are based on identification of a location of maximum curvature in the curvature function and identification of a maximum distance to the convex-hull of a model fit.

Abstract: Improved line-field imaging systems incorporating planar waveguides are presented. In one embodiment the optics of the system are configured such that a line of light on the light scattering object is imaged to the planar waveguide in at least one dimension. Embodiments where the waveguide incorporates a beamsplitter of an interferometer, where the beam divider and waveguide are referenced to one or more common surfaces, and wherein the source and waveguide are optically coupled, are also considered. In another embodiment, the planar waveguide is in contact or close proximity to the light scattering object.

Abstract: Systems and methods for efficiently obtaining optical coherence tomography (OCT) measurement data with reduced effects of motion are presented. One embodiment involves determining the amount of motion present during the collection of an OCT data set based on images of the eye collected at the same time as the OCT data, and recollecting select portions of the OCT data set when the amount of eye motion is determined to exceed a predetermined threshold. Another embodiment includes enabling or disabling a tracking feature based on the quality of the images available for tracking. Another embodiment includes reducing the effect of motion in the axial direction based on a comparison to a model of the eye constructed from OCT data. The method can also be used to reduce the presence of mirror image artifacts in an OCT image.

Abstract: An OCT system comprises an OCT scan module for retinal scanning and an add-on anterior segment scanning module which includes at least one anterior segment scan lens (11) and an add-on fixation target (15) which is used to maintain the viewing direction of the eye (6) under investigation while achieving anterior segment scanning. Because the anterior segment scan module added to the exterior of an existing OCT system for retinal scanning has an add-on fixation target (15), it is possible to maintain the viewing direction of the eye (6) under investigation while carrying out anterior segment scanning without adjusting the internal beam path of the OCT system, and the OCT system of the present invention can be adapted to patients with only one functioning eye.

Abstract: Systems and methods for classifying abnormalities within optical coherence tomography images of the eye are presented. One embodiment of the present invention is the classification of pigment epithelial detachments (PEDs) based on characteristics of their internal reflectivity, size and shape. The classification can be based on selected subsets of the data located within or surrounding the abnormalities. Training data can be used to generate the classification scheme and the classification can be weighted to highlight specific classes of particular clinical interest.

Abstract: Various systems and methods for improved OCT angiography imaging are described. An example method of identifying intraretinal fluid in optical coherence tomography (OCT) image data of an eye includes collecting OCT image data using an OCT system. The data includes at least one cluster scan containing OCT image data collected at approximately same set of locations on the sample. A first motion contrast image is generated by applying a first OCT angiography processing technique to the cluster scan to highlight motion contrast in the sample. A second motion contrast image is generated by applying a second OCT angiography processing technique to the cluster scan to highlight motion contrast in the sample. An image displaying intraretinal fluid in the eye is generated using the first and second motion contrast images and then displayed or stored or a further analysis thereof.

Abstract: Systems and methods for performing a visual field test of a patient are described. One example method for performing the visual field test of the patient using a visual field testing device having a refractive correction element, a patient support, and a motor operably attached to one of the refractive correction element or the patient support includes positioning the patient's head relative to the device using the patient support. An image showing the position of the eye relative to the refractive correction element is collected. The relative displacement of the eye with respect to the refractive correction element is determined based on the collected image. The motor is actuated in a manner to reduce the determined displacement. A series of test stimuli is displayed to the patient's eye and responses to the test stimuli are received from the patient. The responses are analyzed to make an assessment of the patient's visual field.

Abstract: Systems and methods that use interference signal from a sample tissue (e.g. retina) obtained in a self-referenced manner to obtain one or more characteristics about the sample tissue, such as thickness and intensity information, are discussed in the present disclosure. One example method of analyzing the sample tissue using an interferometry system includes illuminating the sample tissue with a beam of light using a spectrally broadband source. Scattered light signal is collected from the sample tissue at a detector. The signal results from optical interference between light scattered from multiple scatterers located at different depths in the tissue. The light signal is dominated by light scattered from a scatterer located within the bulk of the tissue. One or more characteristics of the sample tissue are determined based on the collected signal.

Abstract: Various methods of displaying combined structural and functional disease progression information of a patient's eye are described. In one exemplary method, a set of structural measurements of the patient's eye is received. The set of structural measurements are taken at a plurality of testing dates. A set of functional measurements of the patient's eye is received. The set of functional measurements are taken at a plurality of testing dates. A single viewport comprising a side by side display of structural and functional measurements over a common time scale is generated, which is then displayed or the results of the generated viewport are stored. The structural and functional measurements are arranged in a chronological order of testing dates over the common time scale. Further, a structural and a functional measurement that have testing dates falling within a certain time period are placed in close proximity to each other for comparison purposes.

Abstract: Systems and methods for improving ophthalmic imaging by correlating the location of a measurement on the pupil of the eye with a quality of the measurement and further controlling subsequent measurements based on the quality are presented. Aspects of the invention include obtaining optical coherence tomography (OCT) measurements through cataracts or other media opacities, obtaining B-scans with minimized tilt, and automated OCT data acquisition of select structures in the eye. Embodiments of the invention directed towards imaging tissues with angle dependent layer contrast and mapping the size and location of cataracts in the eye are also described.

Abstract: The present invention relates to structural analysis of the optic nerve head (ONH). In one approach, a 3D volume of intensity data which includes the optic nerve head is acquired using an optical coherence tomography (OCT) system. The vitreoretinal interface (VRI) and the optic disc margin are identified from the 3D data. The minimum area of a surface from the optic disc margin to the VRI is determined. This minimum area can be displayed as an image or in the alternative, a value corresponding to this minimum area can be displayed. The minimum area measurement provides relevant clinical information to determine the health of the eye.