Patents Assigned to Carl Zeiss Microimaging GmbH
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Patent number: 8097865Abstract: An illumination device includes at least four semiconductor radiation sources (18) for emitting optical radiation in respectively different emission wavelength ranges. At least one color splitter (22.1, 22.2, 22.3), which is reflective for optical radiation of the respective semiconductor radiation source (18), is assigned to each of at least three of the semiconductor radiation sources (18). The semiconductor radiation sources (18) and the color splitters (22.1, 22.2, 22.3) are arranged such that the optical radiation, which is emitted in each case from each of the semiconductor radiation sources (18), is coupled into a common illumination beam path section (24). In each case, one collimating unit (20.1, 20.2, 20.3, 20.4), which collimates the optical radiation emitted by the respective semiconductor radiation source (18), is arranged in the beam path sections from the semiconductor radiation sources (18) to the color splitters (22.1, 22.2, 22.3).Type: GrantFiled: November 9, 2006Date of Patent: January 17, 2012Assignee: Carl Zeiss MicroImaging GmbHInventors: Peter Westphal, Daniel Bublitz
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Patent number: 8077413Abstract: An adjustable pinhole, in particular for a beam path for illumination and/or detection in a laser-scanning microscope. The pinhole consists of at least two planar basic modules, which have frame-like joints, on which at least one blade is arranged in a displaceable manner in one direction, whereby the basic component advantageously contains at least one integrated, preferably optical or electromagnetic actuator. A device is provided at the blade, or connected with it, for preferably optical or electromagnetic detection of the position, and is provided, advantageously, with two asymmetric apertures, with mutually opposite orientation, for optical detection of the position, whereby in front of or behind the apertures, a slit is provided, oriented preferably at a right angle to the direction of displacement, and the quantity of light passing through the slit is detected separately for each aperture.Type: GrantFiled: April 28, 2004Date of Patent: December 13, 2011Assignee: Carl Zeiss MicroImaging GmbHInventors: Theo Lasser, Antonio Lopez, Thomas Sidler, Sebastian Favre, Ronald Gianotti
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Patent number: 8040598Abstract: A microscope for observing an object selectably using the bright-field transmitted light contrast procedure or the incident-light fluorescence contrast procedure. During the bright-field transmitted light contrast procedure, an illumination beam path is directed from a bright-field light source to the object and an imaging beam path is directed from the object through the microscope objective into the microscope tube, which includes a fluorescence unit that includes a fluorescence excitation light source, an illumination optical system, a filter set having at least one excitation filter and at least one emission filter, as well as a beamsplitter. The fluorescence unit is mounted movably, so that in a first end position of movement the beamsplitter and the emission filter are out of the imaging beam path of the microscope and in a second end position of movement they are in the imaging beam path between the microscope objective and the microscope tube.Type: GrantFiled: June 12, 2008Date of Patent: October 18, 2011Assignee: Carl Zeiss MicroImaging GmbHInventors: Andreas Nolte, Thomas Bocher, Ingo Fahlbusch
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Patent number: 8036868Abstract: A method for creating a virtual slide is provided. A virtual slide is a digital representation of an area of interest of a microscopic slide. One method is to use a motorized microscope that can move a specimen with respect to a microscopic objective. With such a system, one can capture one or more images through a microscopic objective, such that a region of interest is imaged. Each image is then joined together to form a composite or “virtual image.” In one embodiment, after a virtual slide is created, a user may fully utilize the full capabilities of the remote microscope. Among these capabilities is a set of “optical objectives” and “virtual objectives.” Optical objectives are images created by digitizing an image through a microscopic objective in real time. Virtual objectives are digitally created magnifications created by utilizing the existing virtual slide data to digitally create a field of view.Type: GrantFiled: September 11, 2009Date of Patent: October 11, 2011Assignee: Carl Zeiss MicroImaging GmbHInventors: Jack A. Zeineh, Usman Rashid, Rui-Tao Dong
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Patent number: 8013288Abstract: In a method for correcting a control of an optical scanner (14) which has a beam deflecting element (31) for deflecting a beam of optical radiation and a drive unit (30, 30?) for moving the beam deflecting element (31), said drive unit deflecting a beam of optical radiation directed at the beam deflecting element (31) according to a predetermined target movement using at least one parameter and/or a transfer function, preferably optical, said parameter or transfer function being used to control or regulate the system. In a determination step at least one current value of a drive unit transfer function that reproduces the response of the drive unit (30, 30?) to a predetermined target movement or a change in a target movement is ascertained for at least one frequency, and in a correction step at least one parameter and/or the transfer function is corrected as a function of the current value of the drive unit transfer function.Type: GrantFiled: June 25, 2010Date of Patent: September 6, 2011Assignee: Carl Zeiss MicroImaging GmbHInventors: Joerg Steinert, Joerg Engel
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Patent number: 8004757Abstract: A laser radiation-guiding device including: a laser including a control unit; ports for connection of one module each, it being possible that laser radiation may exit at the ports. The device further can include joining part sensors respectively assigned to a port and whose electrical condition depends on whether a predetermined joining part is spaced apart from the respective port by less than a maximum distance in a predetermined orientation relative to the respective port, and an evaluating unit connected to the joining part sensors via a signal link that detects the electrical conditions of the joining part sensors and, depending on the detected conditions, emits a control signal to the control unit of the laser or to a laser radiation-blocking unit, by which emission of eye-damaging laser radiation to the ports of the device can be prevented inhibited.Type: GrantFiled: September 14, 2005Date of Patent: August 23, 2011Assignee: Carl Zeiss Microimaging GmbHInventors: Andreas Nolte, Hubert Wahl, Klaus Becker
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Patent number: 8000511Abstract: The present disclosure includes systems and techniques relating to focusing in automated microscope systems. In general, in one implementation, the technique includes obtaining an image of at least a portion of a scan region, analyzing the image to find an area in the image representing a sample, determining a nature of the sample at a selected focus point location in the area in the image, selecting an automated focusing process for use at the selected focus point location based on the determined nature of the sample at the selected focus point location, and focusing the selected automated focusing process. The selecting can include selecting different automated focusing processes for different focus point locations based on different tissue characteristics at the locations.Type: GrantFiled: April 20, 2010Date of Patent: August 16, 2011Assignee: Carl Zeiss Microimaging GmbHInventor: Cynthia B. Perz
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Patent number: 7999238Abstract: An arrangement for signal processing at the output of a multichannel detector in the spectrally resolved acquisition of time-variable fluorescence phenomena in a microscope, particularly lifetime measurements, is characterized in that an FPGA (free programmable gate array) is arranged downstream of the output of the multichannel detector.Type: GrantFiled: July 16, 2007Date of Patent: August 16, 2011Assignee: Carl Zeiss MicroImaging GmbHInventors: Ralf Wolleschensky, Mirko Liedtke
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Publication number: 20110187846Abstract: A method for creating a virtual slide is provided. A virtual slide is a digital representation of an area of interest of a microscope slide. One method is to use a motorized microscope that can move a specimen with respect to a microscope objective. With such a system, one can capture one or more images through a microscope objective, such that a region of interest is imaged. Each image is then joined together to form a composite or “virtual image.” In one embodiment, after a virtual slide is created, a user may fully utilize the full capabilities of the remote microscope. Among these capabilities is a set of “optical objectives” and “virtual objectives.” Optical objectives are images created by digitizing an image through a microscope objective in real time. Virtual objectives are digitally created magnifications created by utilizing the existing virtual slide data to digitally create a field of view.Type: ApplicationFiled: December 2, 2010Publication date: August 4, 2011Applicant: Carl Zeiss MicroImaging GmbHInventors: Jack A. Zeineh, Usman Rashid, Rui-Tao Dong
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Patent number: 7933083Abstract: A diaphragm device with which individual wavelengths or ranges of wavelengths in the path of a beam of spectrally dispersed light can be suppressed. Such a diaphragm device comprises at least one array of diaphragms, wherein the individual diaphragms of the array are arranged in a definite relation to each other and may be coupled in the path of the beam and each diaphragm of the array in the coupled state is arranged in a given relation to an individual wavelength or a range of wavelengths.Type: GrantFiled: April 27, 2010Date of Patent: April 26, 2011Assignee: Carl Zeiss MicroImaging GmbHInventors: Jörg Steinert, Thomas Mehner, Volker Gerstner
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Patent number: 7929824Abstract: An optical image recordation and image evaluation system has an imaging beam path and at least two digital cameras and a beam splitter. The beam splitter splits the light of the imaging beam path and conducts the same to respective digital cameras. The start time points for image recordation by the digital cameras are synchronized with respect to each other and the beam splitter is a dichroic beam splitter. The synchronization of the start time points preferably has an accuracy which is equal to or less than 1/1000th of the shortest exposure time of the digital cameras so that simultaneous images are recorded in different spectral ranges.Type: GrantFiled: September 13, 2004Date of Patent: April 19, 2011Assignee: Carl Zeiss MicroImaging GmbHInventor: Dan Davidovici
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Patent number: 7923672Abstract: A device for optically sensing a specimen with a large depth of field has a lighting module which illuminates a zone of the specimen during a predetermined measurement period with a pattern whose phase is modified in time during the measurement period, generating a specimen light to which a corresponding time-variable phase is imparted. The device also includes a detection module having a space-resolving detection zone which records the specimen zone and has multiple recording pixels, two analysis channels which can be connected to the recording pixels, and an analysis unit is connected to both analysis channels.Type: GrantFiled: September 14, 2006Date of Patent: April 12, 2011Assignee: Carl Zeiss Microimaging GmbHInventor: Ralf Wolleschensky
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Patent number: 7923679Abstract: In relation with a laser-induced transport process of an object from a carrier to a collecting device, the invention provides a collecting medium in the collecting device in a liquid state. Prior to the laser-induced transport process, the object is separated from a mass on the carrier by laser irradiation. After the laser-induced transport process, the object, thus selected and separated, is transferred together with the collecting medium to a destination, for example, a container, for further treatment. To this end, a manipulation system for liquids is provided, the system permitting manipulation of the collecting medium with the object contained therein with a high degree of reliability and a high throughput.Type: GrantFiled: June 1, 2006Date of Patent: April 12, 2011Assignee: Carl Zeiss MicroImaging GmbHInventors: Bernd Sägmüller, Yilmaz Niyaz, Thomas Staltmeier
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Patent number: 7916916Abstract: A method of providing remote navigation of a specimen includes receiving a command to remotely control a microscope and a camera coupled with the microscope to view a portion of a specimen disposed on the microscope, capturing a digital image of the portion with the camera in response to the command, representing the digital image as a plurality of digital image components, each of the digital image components providing a different level of detail of the image, and transmitting the components in sequential order of increasing level of detail from least detailed to most detailed.Type: GrantFiled: September 3, 2009Date of Patent: March 29, 2011Assignee: Carl Zeiss MicroImaging GmbHInventor: Jack A. Zeineh
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Patent number: 7916913Abstract: A system and method for reconstructing a diagnostic trajectory.Type: GrantFiled: June 26, 2009Date of Patent: March 29, 2011Assignee: Carl Zeiss MicroImaging GmbHInventor: Jack A. Zeineh
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Patent number: 7907348Abstract: The invention relates to a microscope objective with preferably anti-symmetric lenses or lens groups with an optical magnification of ?100 and a visual field factor of 20. According to the invention the microscope objective consists of 9 lenses with 3 cemented elements, starting from the object side (left), a lens which is almost a hemisphere L1 with positive refractive power, a meniscus lens L2 with positive refractive power, a two-part cemented element G1 with positive refractive power, another two-art cemented element G2 with positive refractive power, a two-part cemented element G3 with negative refractive power, and finally a meniscus lens L9 with negative refractive power. By using cemented elements and lens pairings of the same construction, production costs can be reduced compared with methods of the prior art while image contrast is improved.Type: GrantFiled: April 26, 2007Date of Patent: March 15, 2011Assignee: Carl Zeiss MicroImaging GmbHInventors: Renhu Shi, Werner Kleinschmidt, Thomas Bocher
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Patent number: 7907259Abstract: A microdissection method for separating and taking a target zone of a biological preparation, disposed on a carrier device with a laser light-absorbent incisable layer and a carrier means, comprises cutting the preparation and the incisable layer along an edge segment of the target zone and removing of a non-excised segment of the incisable layer from the carrier means.Type: GrantFiled: June 23, 2008Date of Patent: March 15, 2011Assignee: Carl Zeiss MicroImaging GmbHInventors: Bernd Sägmüller, Renate Burgemeister, Yilmaz Niyaz
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Patent number: 7888628Abstract: For a confocal scanning microscope (1) an optical zoom system (41) with linear scanning is provided, which not only makes a zoom function possible, in that a variable magnification of an image is possible, but rather which additionally produces a pupil image in the illuminating beam path (IB) [BS] and thereby makes a variable image length possible (distance between the original pupil (En.P) [EP] and the imaged/reproduced pupil (Ex.P) [AP]) so that axially varying objective pupil positions can thereby be compensated.Type: GrantFiled: January 22, 2009Date of Patent: February 15, 2011Assignee: Carl Zeiss MicroImaging GmbHInventors: Ralf Wolleschensky, Joerg Steinert, Michael Goelles, Kristina Uhlendorf
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Patent number: 7876948Abstract: An imaging apparatus. The imaging apparatus may find an area in which a specimen is present, then focus on the specimen and capture images of the specimen during continuous stage motion.Type: GrantFiled: July 24, 2009Date of Patent: January 25, 2011Assignee: Carl Zeiss MicroImaging GmbHInventors: Arthur W. Wetzel, John R. Gilbertson, II, Jeffrey A. Beckstead, Patricia A. Feineigle, Christopher R. Hauser, Frank A. Palmieri, Jr.
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Patent number: D639324Type: GrantFiled: June 21, 2010Date of Patent: June 7, 2011Assignee: Carl Zeiss MicroImaging GmbHInventors: Martin Stohr, Michael Winterot, Ilka Schlesiger