Patents Assigned to Carlo Erba S.p.A.
  • .omega.-Nor-cycloalkyl-13,14-dehydro-prostaglandins
    Patent number: 4169145
    Abstract: .omega.-NOR-CYCLOALKYL-13,14-DEHYDRO-PROSTAGLANDIN COMPOUNDS, SPECIFICALLY 13,14-DEHYDRO-17-CYCLOHEXYL-20,19,18-TRINOR-PGF.sub.2.alpha. having antiulcer and luteolytic activity, are disclosed.
    Type: Grant
    Filed: September 21, 1977
    Date of Patent: September 25, 1979
    Assignee: Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Renato Pellegata, Roberto Ceserani, Maria M. Usardi
  • Pyridazinyl-ergoline compounds having neuroleptic activity
    Patent number: 4166911
    Abstract: Pyridazinyl-ergoline compounds having neuroleptic activity are obtained by reacting an 8.beta.-tosylmethyl ergoline with the sodium derivative of an amino-pyridazine or a mercaptopyridazine in a dipolar aprotic solvent.
    Type: Grant
    Filed: January 17, 1978
    Date of Patent: September 4, 1979
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Luigi Bernardi, Carlo Elli, Giovanni Falconi, Alberto Bonsignori
  • Substituted 2-cyclopropyl-chromones and pharmaceutical compositions and use thereof
    Patent number: 4160028
    Abstract: Substituted 2-cyclopropylchromones, process of preparation, pharmaceutical compositions and method of treating allergies are disclosed.
    Type: Grant
    Filed: July 3, 1978
    Date of Patent: July 3, 1979
    Assignee: Carlo Erba S.p.A.
    Inventors: Gianfederico Doria, Ciriaco Romeo, Maria L. Corno, Francesco Lauria, Piero Sberze, Marcellino Tibolla
  • 2-Disubstituted phenyl-3,4-dihydro-4-oxo-quinazoline derivatives and process for their preparation
    Patent number: 4159330
    Abstract: 3,4-Dihydro-4-oxo-quinazoline derivatives substituted in the 2-position by a substituted phenyl group are disclosed. The derivatives possess anti-allergy properties and can be used for the treatment of allergic conditions.
    Type: Grant
    Filed: December 2, 1977
    Date of Patent: June 26, 1979
    Assignee: Carlo Erba S.p.A.
    Inventors: Gianfederico Doria, Ciriaco Romeo, Piernicola Giraldi, Francesco Lauria, Maria L. Corno, Piero Sberze, Marcello Tibolla
  • Apparatus for providing skin cuts to a predetermined measure
    Patent number: 4157086
    Abstract: Improved apparatus for providing skin cuts to a predetermined measure in order to determine blood bleeding time, comprising a casing having a cutting blade accommodated therein and restrained to the casing through a pin coupling within an elongate groove. The blade is moved by a rotating spring member to cause its cutting end to project from a casing slit to a degree and travel that are exactly predetermined and repeatable.
    Type: Grant
    Filed: December 29, 1977
    Date of Patent: June 5, 1979
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Michele Maiorano, Luigi Valentini, Claudio Praga
  • Process for the production of substituted 4-thia-2,6-diaza[3.2.0]-2-heptene-7-one
    Patent number: 4155911
    Abstract: A new process is disclosed for the preparation of compounds of structure: ##STR1## and are as defined herein characterized in that a compound of structure ##STR2## where R and R.sup.1 have the meanings given herein, is reacted in a suitable solvent with a haloamide in the presence of a metal oxide or a haloamide in the presence of a free radical initiator under the influence of light or heat or alternatively with a halogen in the presence of a metal oxide, to give a compound of structure: ##STR3## where R and R.sup.
    Type: Grant
    Filed: August 1, 1977
    Date of Patent: May 22, 1979
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Maurizio Foglio, Antonino Suarato, Paolo Masi, Giovanni Franceschi, Giorgio Palamidessi, Luigi Bernardi
  • Unsaturated derivatives of 7-acylamido-3-cephem-4-carboxylic acid
    Patent number: 4154830
    Abstract: Unsaturated derivatives of 7-acylamido-3-cephem-4-carboxylic acid are disclosed which exhibit antibacterial activity against Gram-positive and Gram-negative microorganisms and can be used to treat infections caused by such microorganisms.
    Type: Grant
    Filed: August 8, 1977
    Date of Patent: May 15, 1979
    Assignee: Carlo Erba S.p.A.
    Inventors: Giuliano Nannini, Ettore Perrone, Dino Severino, Giuseppe Meinardi, Gisella Monti, Alberta Bianchi, Angelo Forgione, Carlo Confalonieri
  • 5:6-Benzo-.gamma.-pyrone derivatives and process for their preparation
    Patent number: 4148900
    Abstract: Chromone compounds carrying a pyridyl substituent at the 2-position are disclosed, such as, for instance, 6-carboxy-2-(2'-pyridyl)-chromone. The disclosed compounds are useful in the treatment of allergies.
    Type: Grant
    Filed: September 16, 1977
    Date of Patent: April 10, 1979
    Assignee: Carlo Erba S.p.A.
    Inventors: Gianfederico Doria, Piernicola Giraldi, Francesco Lauria, Maria L. Corno, Piero Sberze, Marcello Tibolla
  • 8,12-Diisoprostanoic acid derivatives
    Patent number: 4133829
    Abstract: 8,12-Diisoprostanoic acid compounds and intermediates useful in the processes of making them have been prepared.
    Type: Grant
    Filed: February 3, 1975
    Date of Patent: January 9, 1979
    Assignee: Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Gianfederico Doria, Pietro Gaio
  • N-tricyclic derivatives of azetidine and process for their preparation
    Patent number: 4123527
    Abstract: Novel N-tricyclic derivatives of azetidine are disclosed of the general formula ##STR1## where A is a C.sub.1 -C.sub.3 alkylene group, a C.sub.2 -C.sub.3 alkenylene group or a cyclopropylene group, the remaining substituents being defined in the specification. Such compounds are useful for their anti-depressant, anti-convulsant and anxiolytic activities. The compound 1-[5-(10, 11-dihydro-5H-dibenzo [a,d]cyclopheptenyl)]-3-methyl-amino-azetidine is illustrative.
    Type: Grant
    Filed: January 9, 1976
    Date of Patent: October 31, 1978
    Assignee: Carlo Erba, S.p.A.
    Inventors: Piero Melloni, Arturo Della Torre, Francesco Lauria, Norina Passerini, Alessandro Rossi, Raffaele Tommasini
  • 8,12-Diisoprostanoic acid derivatives
    Patent number: 4089896
    Abstract: Optically active 8,12-diisoprostanoic acids and derivatives, processes for making same, pharmaceutical compositions containing same, and intermediates for producing same are disclosed. The acids include, for instance, 5c,13t-11.alpha.,15S-dihydroxy-9-oxo-8,12-diisoprostadienoic acid. The compounds of the present invention can be used in the same uses as the natural prostaglandins, including the treatment of asthma, parturition to facilitate child bearing labor and as abortion agents.
    Type: Grant
    Filed: December 15, 1972
    Date of Patent: May 16, 1978
    Assignee: Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Gianfederico Doria, Pietro Gaio
  • Pharmaceutical composition containing 5:6-benzo-alpha-pyrone derivatives and method of use thereof
    Patent number: 4083953
    Abstract: A pharmaceutical composition, and method of treating allergic conditions therewith, is disclosed, wherein said composition contains a 5:6-benzo-.gamma.-pyrone derivative, such as, for instance, 6-carboxy-2'-isopropoxy-flavone.The composition may be used to treat various allergic conditions, including bronchial asthma, allergic rhinitis, hay fever, urticaria and dermatosis.
    Type: Grant
    Filed: October 27, 1976
    Date of Patent: April 11, 1978
    Assignee: Carlo Erba, S.p.A.
    Inventors: Gianfederico Doria, Pier Nicola Giraldi, Francesco Lauria, Maria Luisa Corno, Piero Sberze, Marcello Tibolla
  • N-tricyclic derivatives of azetidine and pharmaceutical compositions and methods containing them
    Patent number: 4078072
    Abstract: Novel N-tricyclic derivatives of azetidine are disclosed of the general formula: ##STR1## WHERE A is a --CH.sub.2 --S-- or --S--CH.sub.2 -- group, the remaining substituents being defined in the specification. Illustrative is the compound 1-[11-(6,11-dihydro-dibenzo [b,e] thiopinyl)]-3-methylamino-azetidine. The compounds are useful for their anti-depressant, anti-convulsant and anxiolytic activities.
    Type: Grant
    Filed: November 2, 1976
    Date of Patent: March 7, 1978
    Assignee: Carlo Erba S.p.A.
    Inventors: Piero Melloni, Arturo Della Torre, Francesco Lauria, Norina Passerini, Alessandro Rossi, Raffaele Tommasini
  • N-tricyclic derivatives of azetidine
    Patent number: 4078073
    Abstract: Novel N-tricyclic derivatives of azetidine of the formula: ##STR1## wherein A is a --CH.sub.2 --O-- or an --O--CH.sub.2 group, and the remaining substituents being defined in the specification are disclosed. An illustrative compound is 1-[11-(6,11-dihydro-dibenzo [b,e] oxepinyl)]-3-methylamino-azetidine. The compounds are useful for their anti-depressant, anti-convulsant and anxiolytic activities.
    Type: Grant
    Filed: November 2, 1976
    Date of Patent: March 7, 1978
    Assignee: Carlo Erba S.p.A.
    Inventors: Piero Melloni, Arturo Della Torre, Francesco Lauria, Norina Passerini, Alessandro Rossi, Raffaele Tommasini
  • Pyrazine 4-oxide derivatives and process for their preparation
    Patent number: 4051245
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 are hydrogen, C.sub.1-6 alkyl or alkoxy, at least one of R.sup.1, R.sup.2 and R.sup.3 is other than hydrogen, R.sup.4 is carboxy, carbalkoxy or a carboxamide group, or a pharmaceutically acceptable salt when R.sup.4 is carboxy are disclosed.
    Type: Grant
    Filed: October 15, 1976
    Date of Patent: September 27, 1977
    Assignee: Carlo Erba, S.p.A.
    Inventors: Vittorio Ambrogi, Willy Logemann, Marc'Antonio Parenti, Raffaele Tommasini
  • 16-Methyl prost-5-en-13-ynoic acid derivatives
    Patent number: 4041064
    Abstract: 16S and 16R methyl 13, 14 dehydro PGE.sub.2 compounds have been prepared.
    Type: Grant
    Filed: July 29, 1975
    Date of Patent: August 9, 1977
    Assignee: Carlo-Erba S.p.A.
    Inventors: Carmelo Gandolfi, Gianfederico Doria, Renato Pellegata, Maria M. Usardi
  • Prostanoic acid intermediate
    Patent number: 4035392
    Abstract: Lactone and laclol intermediates for prosten-ynoic acids have been prepared.
    Type: Grant
    Filed: February 5, 1975
    Date of Patent: July 12, 1977
    Assignee: Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Gianfederico Doria, Pietro Gaio
  • Omega-nor-cycloalkyl-13,14-dehydro-prostaglandins
    Patent number: 4035415
    Abstract: Omega-nor-cycloalkyl-13,14-dehydro-prostaglandin compounds, specifically 13,14-dehydro-17-cyclohexyl-20,19,18-trinor-PGF.sub.2.sub..alpha., having selective luteolytic, abortifacient and labor-inducing activity and extremely low untoward gastrointestinal effects are disclosed.
    Type: Grant
    Filed: August 8, 1975
    Date of Patent: July 12, 1977
    Assignee: Carlo Erba, S.p.A.
    Inventors: Carmelo Gandolfi, Renato Pellegata, Roberto Ceserani, Maria M. Usardi
  • Prostanoic acid derivatives
    Patent number: 4035414
    Abstract: 8,12-DISO-14-CHLORO PGE.sub.2 and PGF.sub.2 and 8,12-diso-prosten-ynoic acids have been prepared.
    Type: Grant
    Filed: November 13, 1975
    Date of Patent: July 12, 1977
    Assignee: Carlo Erba S.P.A.
    Inventors: Carmelo Gandolfi, Gianfederico Doria, Pietro Gaio
  • 14-Chloro prostadienoic acid compounds
    Patent number: 4021477
    Abstract: 14-Chloro PG.sub.2 compounds have been prepared.
    Type: Grant
    Filed: November 13, 1975
    Date of Patent: May 3, 1977
    Assignee: Carlo-Erba S.p.A.
    Inventors: Carmelo Gandolfi, Gianfederico Doria, Pietro Gaio