Abstract: Compounds of the formula (I) ##STR1## are disclosed, wherein at least one of R.sup.1, R.sup.2 and R.sup.3 is C.sub.1.sub.-6 alkyl and the others are hydrogen atoms; R.sup.4 is hydroxy or C.sub.1.sub.-6 alkoxy, or a salt of the compound wherein R.sup.4 is hydroxy with a pharmaceutically acceptable base. A typical compound is, for example, 2-carboxy-5-methylpyrazine 4-oxide.These compounds exhibit hypoglycaomic and hypolipaomic activity.
Type:
Grant
Filed:
May 19, 1975
Date of Patent:
January 11, 1977
Assignee:
Carlo Erba S.p.A.
Inventors:
Vittorio Ambrogi, Willy Logemann, Marc Antonio Parenti, Raffaele Tommasini
Abstract: 1-Oxo-1H-naphtho [ 2,1-b] pyran derivatives, such as, for instance, 1-oxo-3-(N-methyl-N-ethyl) amino-1H-naphtho [2,1-b] pyran, are disclosed, as well as pharmaceutical compositions containing same and the method of treating depression by administering such compositions.These compounds are active on the central nervous system, and therefore function as antidepressive agents.