Patents Assigned to Carlo Erba S.p.A.
  • Certain thiacyclic PGI compounds
    Patent number: 4242508
    Abstract: Bicyclic prostaglandins and pharmaceutical and veterinary compositions containing them having numerous pharmaceutical or veterinary utilities including, for example, hypotensive, vasodilatory, antiaggregating, luteolytic, and cytoprotective activities. Processes for preparing the compounds and compositions are also disclosed.
    Type: Grant
    Filed: April 13, 1979
    Date of Patent: December 30, 1980
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Carlo Passarotti, Alessandro Andreoni, Angelo Fumagalli, Franco Faustini, Roberto Ceserani, Maria M. Usardi
  • Bicyclic prostaglandins
    Patent number: 4230721
    Abstract: New 2-oxa-bicyclic prostaglandin compounds, and pharmaceutical and veterinary compositions containing them, having pharmaceutical utility for example as anti-aggregating, vasodilating, and cytoprotective agents. Processes for preparing the compounds are also disclosed.
    Type: Grant
    Filed: February 26, 1979
    Date of Patent: October 28, 1980
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Carlo Passarotti, Alessandro Andreoni, Angelo Fumagalli, Franco Faustini, Roberto Ceserani, Maria M. Usardi
  • Synthetic routes to azetidinones related to nocardicin
    Patent number: 4230619
    Abstract: There is disclosed a process for the manufacture of azetidinones related to nocardicin having the formula ##STR1## wherein R is a saturated or unsaturated alkyl having from 1 to 6 carbon atoms, .alpha.-aminobenzyl, benzyl, free or substituted phenyl, or a free or substituted heterocyclic;R.sub.1 is hydrogen, alkyl having from 1 to 4 carbon atoms, trimethylsilyl, trichloroethyl, benzhydryl or benzyl; andR.sub.2 is a free or substituted phenyl, or a free or substituted heterocyclic, using the same starting compound, but with the possibility of proceeding to the final compound via two somewhat different routes. A number of novel intermediates are also disclosed.
    Type: Grant
    Filed: June 30, 1978
    Date of Patent: October 28, 1980
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Maurizio Foglio, Giovanni Franceschi, Paolo Lombardi, Cosimo Scarafile, Federico Arcamone
  • Substituted morpholine derivatives and compositions
    Patent number: 4229449
    Abstract: Substituted morpholine derivatives, such as, for instance, the compound 2-[.alpha.-(2-methoxy-phenoxy)-benzyl]-morpholine are disclosed.The claimed compounds are active on the central nervous system, and may be used as antidepressant agents.
    Type: Grant
    Filed: January 8, 1979
    Date of Patent: October 21, 1980
    Assignee: Farmitalia Carlo Erba, S.p.A.
    Inventors: Piero Melloni, Arturo D. Torre, Giovanni C. Carniel, Alessandro Rossi
  • 4,5,6,7-Tetrahydroimidazo-[4,5-c]-pyridine derivatives
    Patent number: 4223146
    Abstract: Compounds are disclosed of the general formula (I): ##STR1## wherein R.sub.1 is a lower alkyl having from 1 to 4 carbon atoms; R.sub.2 is hydrogen or a lower alkyl having from 1 to 4 carbon atoms; and R.sub.3 is a saturated or unsaturated straight or branched alkyl having from 1 to 4 carbon atoms. A process for making such compounds is also disclosed. These compounds are useful as antiulcer agents and as inhibitors of gastric secretion.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: September 16, 1980
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Giuliana Arcari, Luigi Bernardi, Giovanni Falconi, Ugo Scarponi
  • 13,14-Dehydro-11-deoxy-prostaglandins and process for their preparation
    Patent number: 4220759
    Abstract: 14-Halo lactone and lactol prostaglandin intermediates have been prepared.
    Type: Grant
    Filed: July 13, 1979
    Date of Patent: September 2, 1980
    Assignee: Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Renato Pellegata, Franco Faustini, Angelo Fumagalli
  • Antitumordeoxy-anthracyclines and use thereof
    Patent number: 4218440
    Abstract: Compounds having the formula: ##STR1## wherein R is H or OH, and which are useful in treating certain mammalian tumors, are prepared from 9,10-anhydro-N-trifluoroacetyldaunorubicin, a known compound.
    Type: Grant
    Filed: September 13, 1978
    Date of Patent: August 19, 1980
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Sergio Penco, Giuliano Franchi, Federico Arcamone
  • Substituted antitumor anthracyclines
    Patent number: 4216157
    Abstract: Compounds having the formula: ##STR1## wherein (a) when R.sup.1 is --COCH.sub.3 or --COCH.sub.2 OH, R.sup.2 is --OH, R.sup.3 is --OCH.sub.3 and R.sup.4 is --H;(b) when R.sup.2 is --COCH.sub.3 or --COCH.sub.2 OH; R.sup.1 is --OH, R.sup.3 is --H and R.sup.4 is --OCH.sub.3 ;and which are useful in treating certain mammalian tumors, are prepared from 9,10-anhydro-N-trifluoroacetyl daunorubicin, a known compound.
    Type: Grant
    Filed: April 27, 1979
    Date of Patent: August 5, 1980
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Sergio Penco, Fausto Gozzi, Francesco Angelucci, Federico Arcamone
  • Daunorubicin and doxorubicin labelled with .sup.14 C at the 14-position and processes for their preparation
    Patent number: 4211864
    Abstract: [14-.sup.14 C]-daunorubicin and doxorubicin are prepared by reacting 9-desacetyl-9-formyl-N-trifluoroacetyl daunorubicin with [.sup.14 C]-diazomethane to form [14-.sup.14 C]-N-trifluoroacetyl daunorubicin from which the protecting group is removed by mild alkaline hydrolysis to afford [14-.sup.14 C]-daunorubicin which is then, in the form of the hydrochloride, reacted with bromine to form the corresponding labelled 14-bromo derivative, which, upon treatment with sodium formate leads to [14-.sup.14 C]-doxorubicin.
    Type: Grant
    Filed: February 14, 1978
    Date of Patent: July 8, 1980
    Assignee: Societa Farmaceutici Italia (Farmitalia Carlo Erba S.p.A.)
    Inventors: Gian P. Vicario, Sergio Penco, Federico Arcamone
  • Cephalosporins
    Patent number: 4206211
    Abstract: 7.beta.-acylamino-7.alpha.-methoxy-3-pyrazinylthiomethyl-cephalosporins and their intermediates having high resistance toward .beta.-lactamase enzymes, as well as good antibacterial activity and processes for preparation thereof.
    Type: Grant
    Filed: March 10, 1978
    Date of Patent: June 3, 1980
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Giorgio Palamidessi, Maurizio Foglio, Franco Zarini, Giovanni Franceschi, Aurora Sanfilippo, Federico Arcamone
  • 13,14-Dehydro-11-deoxy-prostaglandis
    Patent number: 4198430
    Abstract: Optionally active 13,14-dehydro-11-deoxy prostaglandins useful in inhibiting gastric secretions and as anti-asmthmatic agents are disclosed.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: April 15, 1980
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Renato Pellegate, Franco Faustini, Angelo Fumagalli
  • Novel daunomycin derivatives, their aglycones and the use thereof
    Patent number: 4191755
    Abstract: Daunomycin derivatives of the formula: ##STR1## wherein R.sub.1 is a lower alkyl having from 1 to 4 carbon atoms and R is hydrogen or a trifluoroacetyl group are useful in treating certain mammalian tumors.
    Type: Grant
    Filed: May 1, 1978
    Date of Patent: March 4, 1980
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Paolo Masi, Antonino Suarato, Luigi Bernardi, Federico Arcamone
  • Daunomycin derivatives, their aglycones and the use thereof
    Patent number: 4191756
    Abstract: Daunomycin derivatives of the formula: ##STR1## wherein R.sub.1 is a lower alkyl having from 1 to 4 carbon atoms and R is a hydrogen atom or a trifluoroacetyl group are useful in treating certain mammalian tumors.
    Type: Grant
    Filed: May 1, 1978
    Date of Patent: March 4, 1980
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Paolo Masi, Antonino Suarato, Luigi Bernardi, Federico Arcamone
  • Carminomycin derivatives, their preparation and use
    Patent number: 4188377
    Abstract: N-acyl derivatives of the known antitumor antibiotic carminomycin, particularly N-trifluoroacetyl carminomycin, have a much lower toxicity than carminomycin.
    Type: Grant
    Filed: January 26, 1978
    Date of Patent: February 12, 1980
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Antonino Suarato, Paolo Masi, Luigi Bernardi, Federico Arcamone
  • Antitumor glycosides, process for their preparation including intermediates therefor and their use
    Patent number: 4183919
    Abstract: Disclosed is a new class of antitumor glycoside antibiotics of the formula (IA): ##STR1## wherein R is hydrogen or hydroxy; and X is ##STR2## These compounds are prepared, using novel intermediates, by condensing the appropriate aglycone and amino-deoxy sugar to form the .alpha.-glycosidic linkage.
    Type: Grant
    Filed: December 14, 1977
    Date of Patent: January 15, 1980
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Giuseppe Cassinelli, Federico Arcamone, Aurelio Di Marco
  • Substituted 2-vinyl-chromones and process for their preparation
    Patent number: 4183946
    Abstract: Substituted 2-vinyl chromones are disclosed, wherein the chromone ring has an alkyl or alkenyl substituent at the 3-position, and a styryl substituent at the 2-position. The compounds exhibit anti-allergy activity and can be used to treat allergic conditions.
    Type: Grant
    Filed: July 24, 1978
    Date of Patent: January 15, 1980
    Assignee: Carlo Erba S.p.A.
    Inventors: Gianfederico Doria, Ciriaco Romeo, Francesco Lauria, Maria L. Corno, Piernicola Giraldi, Marcello Tibolla
  • Substituted 2-vinyl-chromones and process for their preparation
    Patent number: 4183945
    Abstract: Substituted 2-vinyl-chromones are disclosed, wherein the chromone ring has an alkyl or alkenyl substituent at the 3-position, and a styryl substituent at the 2-position. The compounds exhibit anti-allergy activity and can be used to treat allergic conditions.
    Type: Grant
    Filed: July 24, 1978
    Date of Patent: January 15, 1980
    Assignee: Carlo Erba S.p.A.
    Inventors: Gianfederico Doria, Ciriaco Romeo, Francesco Lauria, Maria L. Corno, Piernicola Giraldi, Marcello Tibolla
  • Substituted 2-vinyl-chromones and process for their preparation
    Patent number: 4177276
    Abstract: Substituted 2-vinyl chromones are disclosed, wherein the chromone ring has an alkyl or alkenyl substituent at the 3-position, and a pyridyl-vinyl substituent at the 2-position. The compounds exhibit anti-allergy activity and can be used to treat allergic conditions.
    Type: Grant
    Filed: July 24, 1978
    Date of Patent: December 4, 1979
    Assignee: Farmitalia Carlo Erba, S.p.A.
    Inventors: Gianfederico Doria, Ciriaco Romeo, Francesco Lauria, Maria L. Corno, Piernicola Giraldi, Marcello Tibolla
  • Substituted 2-vinyl-chromones and process for their preparation
    Patent number: 4177286
    Abstract: Substituted 2-vinyl chromones are disclosed, wherein the chromone ring has an alkyl or alkenyl substituent at the 3-position, and an unsubstituted furyl substituent at the 2-position. The compounds exhibit anti-allergy activity and can be used to treat allergic conditions.
    Type: Grant
    Filed: July 24, 1978
    Date of Patent: December 4, 1979
    Assignee: Farmitalia Carlo Erba, S.p.A.
    Inventors: Gianfederico Doria, Giriaco Romeo, Francesco Lauria, Maria L. Corno, Piernicola Giraldi, Marcello Tibolla
  • Heteromonocyclic and heterobicyclic derivatives of unsaturated 7-acylamido-3-cephem-4-carboxylic acid
    Patent number: 4172892
    Abstract: Heteromonocyclic and heterobicyclic derivatives of unsaturated 7-acylamido-3-cephem-4-carboxylic acid are disclosed which exhibit antibacterial activity against Gram-positive and Gram-negative microorganisms and can be used to treat infections caused by such microorganisms.
    Type: Grant
    Filed: January 11, 1978
    Date of Patent: October 30, 1979
    Assignee: Carlo Erba S.p.A.
    Inventors: Giuliano Nannini, Ettore Perrone, Dino Severino, Giuseppe Meinardi, Gisella Monti, Alberta Bianchi, Angelo Forgione, Carlo Confalonieri