Abstract: The present invention relates to a process for modifying hydrophilic polymers by mixing with a modifier, characterized in that the pulverulent polymer and the modifier are introduced continuously into a vertical, cylindrical mixer, mixed at a power of from 1,000 to 5,000 Wh/m3 of powder by means of rotating blades at a blade rate of from 100 to 300 s−1 at a residence time of 1-10 seconds, during which the powder is passed through zones having energy dissipation densities of 300-600 W/l of mixer volume.
Type:
Grant
Filed:
April 21, 1994
Date of Patent:
October 9, 2001
Assignee:
Cassella Aktiengesellschaft
Inventors:
Friedrich Engelhardt, Uwe Stüven, Manfred Mayer
Abstract: The present invention relates to pulverulent water-swellable hydrophilic (co)polymers which comprise, for reducing dusting, auxiliaries from the series consisting of silicones and/or other auxiliaries, the latter in a total amount of less than 1% by weight, for example polyglycols or polyglycol ethers, the vapor pressure of the individual auxiliaries being not more than 0.1 mbar at 20.degree. C. and their melting point being not more than 100.degree. C., processes for their preparation and their use for absorption of water and aqueous solutions.
Type:
Grant
Filed:
April 19, 1995
Date of Patent:
October 28, 1997
Assignee:
Cassella Aktiengesellschaft
Inventors:
Helmut Klotzsche, Gustav Remmel, Ulrich Riegel, Uwe Stuven
Abstract: The invention relates to the use of 2-(N-(2-aminoethyl)amino)acetic acid derivatives of the formula I ##STR1## in which R denotes, for example, phenyl or thienyl, and their pharmacologically acceptable acid addition salts as pharmacological active compounds.
Type:
Grant
Filed:
October 16, 1995
Date of Patent:
October 21, 1997
Assignee:
Cassella Aktiengesellschaft
Inventors:
Karl Schonafinger, Ursula Schindler, Eckhard Schraven
Abstract: The present invention relates to a hydrophilic highly swellable hydrogel based on (co)polymerized hydrophilic monomers or based on graft (co)polymers, characterized in that it is post-crosslinked with a polyamidoamine in an aqueous medium.
Type:
Grant
Filed:
April 29, 1996
Date of Patent:
September 16, 1997
Assignee:
Cassella Aktiengesellschaft
Inventors:
Fritz Engelhardt, Ulrich Riegel, Uwe Stuven, Helmut Klotzsche, Gustav Remmel
Abstract: Water-swellable hydrophilic polymers which contain polymers prepared by free radical (co)polymerization of one or more hydrophilic monomers of the formula I ##STR1## wherein R.sup.1 is hydrogen, methyl or ethyl,R.sup.2 is the group --COOR.sup.4, the sulphonyl group, the phosphonyl group, the phosphonyl group esterified by (C.sub.1 -C.sub.4)-alkanol or a group of the formula ##STR2## R.sup.3 is hydrogen, methyl, ethyl or the carboxyl group, R.sup.4 is hydrogen, amino or hydroxy-(C.sub.1 -C.sub.4)-alkyl andR.sup.5 is the sulphonyl group, the phosphonyl group or the carboxyl group, or grafting (co)polymerization of one or more hydrophilic monomers of the formula I onto a grafting base, using a free radical initiator which forms three or more free radical sites per molecule.
Type:
Grant
Filed:
March 22, 1995
Date of Patent:
January 14, 1997
Assignee:
Cassella Aktiengesellschaft
Inventors:
R udiger Funk, Fritz Engelhardt, Ulrich Riegel, Michael Wessling
Abstract: The present invention relates to absorbents for water and aqueous solutions, in particular for blood, which contain a product from the tuber of a plant from the family of the Araceae.
Type:
Grant
Filed:
January 16, 1996
Date of Patent:
November 5, 1996
Assignee:
Cassella Aktiengesellschaft
Inventors:
Rainer Greve, Gerlinde Ebert, Ulrich Riegel, Fritz Engelhardt
Abstract: The present invention consequently relates to the use of coumarins of the general formula I ##STR1## in which R.sup.1 and R.sup.6 are defined as indicated in the claims, for controlling and preventing disorders which arise as a result of an elevated NO level.
Type:
Grant
Filed:
November 8, 1994
Date of Patent:
September 10, 1996
Assignee:
Cassella Aktiengesellschaft
Inventors:
Karl Sch onafinger, Peter Klemm, J org Ostrowski, deceased
Abstract: The present invention relates to improved processes for the preparation of 1-amino-2,6-dimethylpiperidine whereby the yield is more than 90%. The processes involve the hydrogenation of 1-nitroso-2,6-dimethylpiperidine in the presence of a palladium catalyst partly poisoned with iron ions but in the substantial absence of water or other solubilizing agents added to the reaction vessel.
Abstract: The present invention relates to improved processes for the preparation of 1-amino-2,6-dimethylpiperidine whereby the yield is more than 90%. The processes involve the hydrogenation of 1-nitroso-2,6-dimethylpiperidine in the presence of a palladium catalyst which is partly poisoned with iron ions, in an aqueous solvent, and are characterized by the inclusion of at least one surfactant. The surfactant preferably is anionic or nonionic.
Type:
Grant
Filed:
May 17, 1994
Date of Patent:
April 23, 1996
Assignee:
Cassella Aktiengesellschaft
Inventors:
Wolfgang Rybczynski, Wolfgang Bauer, Eckard Kujath, Manfred Schrod
Abstract: The present invention relates to a process for the preparation of compounds of the general formula I ##STR1## by reaction of compounds of the general formula II ##STR2## with compounds of the general formula III ##STR3## in inert aprotic solvents in the presence of a base and subsequent rearrangement of the resulting intermediate compound with an alkali metal hydroxide, characterized in that the intermediate compound is not isolated.
Type:
Grant
Filed:
August 22, 1994
Date of Patent:
April 16, 1996
Assignee:
Cassella Aktiengesellschaft
Inventors:
Wolfgang Bauer, Klaus Delpy, Andreas Bittner
Abstract: The present invention relates to a process for the preparation of compounds of the general formula I ##STR1## in which R.sup.1 and R.sup.2 are defined as stated in claim 1, characterized in that a 1,1,1-tris(hydroxymethyl)-(C.sub.2 -C.sub.5)-alkane or 2,2-bis(hydroxymethyl)-1,3-propanediol is reacted with vinylphosphonic anhydride.
Type:
Grant
Filed:
February 21, 1995
Date of Patent:
March 26, 1996
Assignee:
Cassella Aktiengesellschaft
Inventors:
Fritz Engelhardt, Ulrich Riegel, Hans-Jerg Kleiner
Abstract: The invention relates to the use of 2-(N-(2-aminoethyl)amino)acetic acid derivatives of the formula I ##STR1## in which R denotes, for example, phenyl or thienyl, and their pharmacologically acceptable acid addition salts as pharmacological active compounds.
Type:
Grant
Filed:
November 10, 1994
Date of Patent:
March 19, 1996
Assignee:
Cassella Aktiengesellschaft
Inventors:
Karl Schonafinger, Ursula Schindler, Eckhard Schraven
Abstract: The present invention relates to hydrophilic, swellable graft polymers which comprise, in a random distribution, from 0.5 to 50% by weight of radicals of the general formula I ##STR1## and radicals of the general formula II ##STR2## from 49 to 99% by weight of radicals of the general formula III ##STR3## containing an acid group, and from 0.1 to 2% by weight of radicals of a crosslinking agent which are derived from monomers containing at least two olefinically unsaturated double bonds, where the radicals R.sup.1 to R.sup.4, X and Y and n and m are where X and Y, independently of one another are COCH.sub.3, CH.sub.2 COOR.sup.2, COCH.sub.2 CH.sub.2 COOH ##STR4## n and m, independently of one another, are 2 to 300, R.sup.1 is hydrogen or methyl, R.sup.2, independently of one another, are hydrogen, methyl or ethyl, R.sup.
Abstract: The present invention relates to hydroxymethylfurazancarboxylic acid derivatives of the general formula I ##STR1## in which one of the radicals R.sup.1 and R.sup.2 represents hydroxymethyl and the other represents ##STR2## where X represents NR.sup.3 R.sup.4, OH or OR.sup.7, and R.sup.3, R.sup.4 and R.sup.7 are defined as indicated in claim 1, to processes for their preparation and to their use.
Abstract: The present invention relates to valuable monoazo dyes of the general formula I ##STR1## in which R is methyl or ethyl,R.sup.1 is methyl, ethyl, methoxyethyl or ethoxyethyl,R.sup.2 is methyl or ethyl, if n is equal to 0, and hydrogen, if n is equal to 1,R.sup.3 is methyl, ethyl, n-propyl or i-propyl andn is 0 or 1,to mixtures of dyes of the general formula I and to the preparation of these dyes and their mixtures and to their use for the dyeing of hydrophobic fiber materials.
Abstract: The present invention relates to phenyl-1,2,5-oxadiazolecarboxamide-2-oxides of the general formula I ##STR1## in which one of the radicals R.sup.1 and R.sup.2 represents ##STR2## and the other represents ##STR3## and R.sup.3 and R.sup.4 are defined as indicated in claim 1, to processes for their preparation and to their use for the treatment of disorders of the cardiovascular system, including angina pectoris and erectile dysfunctions.
Abstract: Aspartic acid derivatives of the formula ##STR1## in which X denotes, for example, ##STR2## and R denotes, for example, cyclohexylamino, have useful pharmacological properties.
Type:
Grant
Filed:
March 25, 1993
Date of Patent:
March 21, 1995
Assignee:
Cassella Aktiengesellschaft
Inventors:
Otmar Klingler, Gerhard Zoller, Melitta Just, Bernd Jablonka
Abstract: The present invention relates to a process for the preparation of N-ethylcarbazole by reaction of carbazole or N-ethoxycarbonylcarbazole with diethyl carbonate.
Abstract: The present invention relates to compounds of the general formula I ##STR1## wherein R.sup.1 denotes formyl or (C.sub.1 -C.sub.3)-alkylcarbonyl,R.sup.2 denotes the group CH.sub.2 --CH(A)--B, wherein A represents hydroxyl and B represents hydrogen or methyl, or A represents hydrogen and B represents hydroxymethyl, or the group COO--CH(X)--CH.sub.2 --D, wherein X represents hydrogen or methyl and D represents chlorine or bromine, or X represents hydrogen and D represents chloromethyl or bromomethyl, andR.sup.3 denotes (C.sub.1 -C.sub.4)-alkyl,processes for their preparation and their use.