Patents Assigned to Cassella Aktiengesellschaft
  • Patent number: 6300423
    Abstract: The present invention relates to a process for modifying hydrophilic polymers by mixing with a modifier, characterized in that the pulverulent polymer and the modifier are introduced continuously into a vertical, cylindrical mixer, mixed at a power of from 1,000 to 5,000 Wh/m3 of powder by means of rotating blades at a blade rate of from 100 to 300 s−1 at a residence time of 1-10 seconds, during which the powder is passed through zones having energy dissipation densities of 300-600 W/l of mixer volume.
    Type: Grant
    Filed: April 21, 1994
    Date of Patent: October 9, 2001
    Assignee: Cassella Aktiengesellschaft
    Inventors: Friedrich Engelhardt, Uwe Stüven, Manfred Mayer
  • Patent number: 5681878
    Abstract: The present invention relates to pulverulent water-swellable hydrophilic (co)polymers which comprise, for reducing dusting, auxiliaries from the series consisting of silicones and/or other auxiliaries, the latter in a total amount of less than 1% by weight, for example polyglycols or polyglycol ethers, the vapor pressure of the individual auxiliaries being not more than 0.1 mbar at 20.degree. C. and their melting point being not more than 100.degree. C., processes for their preparation and their use for absorption of water and aqueous solutions.
    Type: Grant
    Filed: April 19, 1995
    Date of Patent: October 28, 1997
    Assignee: Cassella Aktiengesellschaft
    Inventors: Helmut Klotzsche, Gustav Remmel, Ulrich Riegel, Uwe Stuven
  • Patent number: 5679704
    Abstract: The invention relates to the use of 2-(N-(2-aminoethyl)amino)acetic acid derivatives of the formula I ##STR1## in which R denotes, for example, phenyl or thienyl, and their pharmacologically acceptable acid addition salts as pharmacological active compounds.
    Type: Grant
    Filed: October 16, 1995
    Date of Patent: October 21, 1997
    Assignee: Cassella Aktiengesellschaft
    Inventors: Karl Schonafinger, Ursula Schindler, Eckhard Schraven
  • Patent number: 5668236
    Abstract: The present invention relates to a hydrophilic highly swellable hydrogel based on (co)polymerized hydrophilic monomers or based on graft (co)polymers, characterized in that it is post-crosslinked with a polyamidoamine in an aqueous medium.
    Type: Grant
    Filed: April 29, 1996
    Date of Patent: September 16, 1997
    Assignee: Cassella Aktiengesellschaft
    Inventors: Fritz Engelhardt, Ulrich Riegel, Uwe Stuven, Helmut Klotzsche, Gustav Remmel
  • Patent number: 5594083
    Abstract: Water-swellable hydrophilic polymers which contain polymers prepared by free radical (co)polymerization of one or more hydrophilic monomers of the formula I ##STR1## wherein R.sup.1 is hydrogen, methyl or ethyl,R.sup.2 is the group --COOR.sup.4, the sulphonyl group, the phosphonyl group, the phosphonyl group esterified by (C.sub.1 -C.sub.4)-alkanol or a group of the formula ##STR2## R.sup.3 is hydrogen, methyl, ethyl or the carboxyl group, R.sup.4 is hydrogen, amino or hydroxy-(C.sub.1 -C.sub.4)-alkyl andR.sup.5 is the sulphonyl group, the phosphonyl group or the carboxyl group, or grafting (co)polymerization of one or more hydrophilic monomers of the formula I onto a grafting base, using a free radical initiator which forms three or more free radical sites per molecule.
    Type: Grant
    Filed: March 22, 1995
    Date of Patent: January 14, 1997
    Assignee: Cassella Aktiengesellschaft
    Inventors: R udiger Funk, Fritz Engelhardt, Ulrich Riegel, Michael Wessling
  • Patent number: 5571764
    Abstract: The present invention relates to absorbents for water and aqueous solutions, in particular for blood, which contain a product from the tuber of a plant from the family of the Araceae.
    Type: Grant
    Filed: January 16, 1996
    Date of Patent: November 5, 1996
    Assignee: Cassella Aktiengesellschaft
    Inventors: Rainer Greve, Gerlinde Ebert, Ulrich Riegel, Fritz Engelhardt
  • Patent number: 5554611
    Abstract: The present invention consequently relates to the use of coumarins of the general formula I ##STR1## in which R.sup.1 and R.sup.6 are defined as indicated in the claims, for controlling and preventing disorders which arise as a result of an elevated NO level.
    Type: Grant
    Filed: November 8, 1994
    Date of Patent: September 10, 1996
    Assignee: Cassella Aktiengesellschaft
    Inventors: Karl Sch onafinger, Peter Klemm, J org Ostrowski, deceased
  • Patent number: 5530093
    Type: Grant
    Filed: January 30, 1995
    Date of Patent: June 25, 1996
    Assignee: Cassella Aktiengesellschaft
    Inventors: Fritz Engelhardt, Willi Steckelberg, Karl-Heinz Keil, Ralf Zerrer
  • Patent number: 5514806
    Abstract: The present invention relates to improved processes for the preparation of 1-amino-2,6-dimethylpiperidine whereby the yield is more than 90%. The processes involve the hydrogenation of 1-nitroso-2,6-dimethylpiperidine in the presence of a palladium catalyst partly poisoned with iron ions but in the substantial absence of water or other solubilizing agents added to the reaction vessel.
    Type: Grant
    Filed: May 17, 1994
    Date of Patent: May 7, 1996
    Assignee: Cassella Aktiengesellschaft
    Inventors: Wolfgang Rrbczynski, Manfred Schrod
  • Patent number: 5510489
    Abstract: The present invention relates to improved processes for the preparation of 1-amino-2,6-dimethylpiperidine whereby the yield is more than 90%. The processes involve the hydrogenation of 1-nitroso-2,6-dimethylpiperidine in the presence of a palladium catalyst which is partly poisoned with iron ions, in an aqueous solvent, and are characterized by the inclusion of at least one surfactant. The surfactant preferably is anionic or nonionic.
    Type: Grant
    Filed: May 17, 1994
    Date of Patent: April 23, 1996
    Assignee: Cassella Aktiengesellschaft
    Inventors: Wolfgang Rybczynski, Wolfgang Bauer, Eckard Kujath, Manfred Schrod
  • Patent number: 5508467
    Abstract: The present invention relates to a process for the preparation of compounds of the general formula I ##STR1## by reaction of compounds of the general formula II ##STR2## with compounds of the general formula III ##STR3## in inert aprotic solvents in the presence of a base and subsequent rearrangement of the resulting intermediate compound with an alkali metal hydroxide, characterized in that the intermediate compound is not isolated.
    Type: Grant
    Filed: August 22, 1994
    Date of Patent: April 16, 1996
    Assignee: Cassella Aktiengesellschaft
    Inventors: Wolfgang Bauer, Klaus Delpy, Andreas Bittner
  • Patent number: 5502231
    Abstract: The present invention relates to a process for the preparation of compounds of the general formula I ##STR1## in which R.sup.1 and R.sup.2 are defined as stated in claim 1, characterized in that a 1,1,1-tris(hydroxymethyl)-(C.sub.2 -C.sub.5)-alkane or 2,2-bis(hydroxymethyl)-1,3-propanediol is reacted with vinylphosphonic anhydride.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: March 26, 1996
    Assignee: Cassella Aktiengesellschaft
    Inventors: Fritz Engelhardt, Ulrich Riegel, Hans-Jerg Kleiner
  • Patent number: 5500436
    Abstract: The invention relates to the use of 2-(N-(2-aminoethyl)amino)acetic acid derivatives of the formula I ##STR1## in which R denotes, for example, phenyl or thienyl, and their pharmacologically acceptable acid addition salts as pharmacological active compounds.
    Type: Grant
    Filed: November 10, 1994
    Date of Patent: March 19, 1996
    Assignee: Cassella Aktiengesellschaft
    Inventors: Karl Schonafinger, Ursula Schindler, Eckhard Schraven
  • Patent number: 5489647
    Abstract: The present invention relates to hydrophilic, swellable graft polymers which comprise, in a random distribution, from 0.5 to 50% by weight of radicals of the general formula I ##STR1## and radicals of the general formula II ##STR2## from 49 to 99% by weight of radicals of the general formula III ##STR3## containing an acid group, and from 0.1 to 2% by weight of radicals of a crosslinking agent which are derived from monomers containing at least two olefinically unsaturated double bonds, where the radicals R.sup.1 to R.sup.4, X and Y and n and m are where X and Y, independently of one another are COCH.sub.3, CH.sub.2 COOR.sup.2, COCH.sub.2 CH.sub.2 COOH ##STR4## n and m, independently of one another, are 2 to 300, R.sup.1 is hydrogen or methyl, R.sup.2, independently of one another, are hydrogen, methyl or ethyl, R.sup.
    Type: Grant
    Filed: November 16, 1992
    Date of Patent: February 6, 1996
    Assignee: Cassella Aktiengesellschaft
    Inventors: Ulrich Kussmaul, Manfred Mayer, Uwe Stuven, Ulrich Riegel, Friedrich Engelhardt
  • Patent number: 5486531
    Abstract: The present invention relates to hydroxymethylfurazancarboxylic acid derivatives of the general formula I ##STR1## in which one of the radicals R.sup.1 and R.sup.2 represents hydroxymethyl and the other represents ##STR2## where X represents NR.sup.3 R.sup.4, OH or OR.sup.7, and R.sup.3, R.sup.4 and R.sup.7 are defined as indicated in claim 1, to processes for their preparation and to their use.
    Type: Grant
    Filed: March 7, 1994
    Date of Patent: January 23, 1996
    Assignee: Cassella Aktiengesellschaft
    Inventors: Karl Schonafinger, Helmut Bohn
  • Patent number: 5466791
    Abstract: The present invention relates to valuable monoazo dyes of the general formula I ##STR1## in which R is methyl or ethyl,R.sup.1 is methyl, ethyl, methoxyethyl or ethoxyethyl,R.sup.2 is methyl or ethyl, if n is equal to 0, and hydrogen, if n is equal to 1,R.sup.3 is methyl, ethyl, n-propyl or i-propyl andn is 0 or 1,to mixtures of dyes of the general formula I and to the preparation of these dyes and their mixtures and to their use for the dyeing of hydrophobic fiber materials.
    Type: Grant
    Filed: February 13, 1994
    Date of Patent: November 14, 1995
    Assignee: Cassella Aktiengesellschaft
    Inventors: Ulrich Buhler, Reinhard Kuhn, Margareta Boos
  • Patent number: 5424326
    Abstract: The present invention relates to phenyl-1,2,5-oxadiazolecarboxamide-2-oxides of the general formula I ##STR1## in which one of the radicals R.sup.1 and R.sup.2 represents ##STR2## and the other represents ##STR3## and R.sup.3 and R.sup.4 are defined as indicated in claim 1, to processes for their preparation and to their use for the treatment of disorders of the cardiovascular system, including angina pectoris and erectile dysfunctions.
    Type: Grant
    Filed: May 25, 1993
    Date of Patent: June 13, 1995
    Assignee: Cassella Aktiengesellschaft
    Inventors: Karl Schonafinger, Helmut Bohn
  • Patent number: 5399570
    Abstract: Aspartic acid derivatives of the formula ##STR1## in which X denotes, for example, ##STR2## and R denotes, for example, cyclohexylamino, have useful pharmacological properties.
    Type: Grant
    Filed: March 25, 1993
    Date of Patent: March 21, 1995
    Assignee: Cassella Aktiengesellschaft
    Inventors: Otmar Klingler, Gerhard Zoller, Melitta Just, Bernd Jablonka
  • Patent number: 5393894
    Abstract: The present invention relates to a process for the preparation of N-ethylcarbazole by reaction of carbazole or N-ethoxycarbonylcarbazole with diethyl carbonate.
    Type: Grant
    Filed: July 15, 1994
    Date of Patent: February 28, 1995
    Assignee: Cassella Aktiengesellschaft
    Inventors: Johannes Becherer, Peter Koch
  • Patent number: 5387716
    Abstract: The present invention relates to compounds of the general formula I ##STR1## wherein R.sup.1 denotes formyl or (C.sub.1 -C.sub.3)-alkylcarbonyl,R.sup.2 denotes the group CH.sub.2 --CH(A)--B, wherein A represents hydroxyl and B represents hydrogen or methyl, or A represents hydrogen and B represents hydroxymethyl, or the group COO--CH(X)--CH.sub.2 --D, wherein X represents hydrogen or methyl and D represents chlorine or bromine, or X represents hydrogen and D represents chloromethyl or bromomethyl, andR.sup.3 denotes (C.sub.1 -C.sub.4)-alkyl,processes for their preparation and their use.
    Type: Grant
    Filed: May 3, 1994
    Date of Patent: February 7, 1995
    Assignee: Cassella Aktiengesellschaft
    Inventors: Willi Steckelberg, Peter Koch