Patents Assigned to Cellomics, Inc.
  • Patent number: 10353130
    Abstract: An apparatus and method of delivering a precisely sized, homogeneous field of light within an optical system. The apparatus operates equally well over UV, visible, and NIR wavelengths, over a wide range of input beam divergence and regardless of heterogeneity. A tapered or contoured homogenizing rod that creates an evenly distributed illumination at a target area of specific size.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: July 16, 2019
    Assignee: Cellomics, Inc.
    Inventors: Dirk John Vandenberg, Monica Jo Tomaszewski, Keith Rao Heffley, Steven Roland Auger
  • Publication number: 20170276857
    Abstract: An apparatus and method of delivering a precisely sized, homogeneous field of light within an optical system. The apparatus operates equally well over UV, visible, and NIR wavelengths, over a wide range of input beam divergence and regardless of heterogeneity. A tapered or contoured homogenizing rod that creates an evenly distributed illumination at a target area of specific size.
    Type: Application
    Filed: December 8, 2015
    Publication date: September 28, 2017
    Applicant: Cellomics, Inc.
    Inventors: Dirk John VANDENBERG, Monica Jo TOMASZEWSKI, Keith Rao HEFFLEY, Steven Roland AUGER
  • Patent number: 9400365
    Abstract: A filter wheel assembly includes a filter wheel and an optical assembly. The filter wheel includes a plurality of viewing openings. The optical assembly includes an optical element secured within an aperture of a housing. The optical assembly is securable to the filter wheel at a viewing opening by a magnetic force. An optical apparatus includes an optical assembly receiver and first and second optical assemblies. The first optical assembly is securable to the optical assembly receiver and the second optical assembly is securable to the first optical assembly by a magnetic force to align the optical assembly receiver and the optical assemblies.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: July 26, 2016
    Assignee: Cellomics, Inc.
    Inventors: Dirk John Vandenberg, III, Keith R. Heffley
  • Patent number: 9201062
    Abstract: A method of predicting cell toxicity of a compound includes imaging cells positioned within a plurality of containers to obtain imaged cellular targets, each container being treated with a different concentration of the compound, the imaging being performed using a quantitative high-content cell imaging system; quantitatively measuring the imaged cellular targets to detect changes in multiple cellular targets associated with cytotoxicity of the compound; and analyzing measurements obtained from the measured imaged cellular targets over a range of compound concentrations to determine the toxicity of the compound.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: December 1, 2015
    Assignee: Cellomics, Inc.
    Inventors: Suk Jin Hong, Richik Niloy Ghosh
  • Patent number: 8860797
    Abstract: A stage assembly, an imaging system that uses the stage assembly, and methods for using the stage assembly in a high content screening system. The stage assembly includes a stage having a top surface and an opposing bottom surface and an opening extending between the top and bottom surfaces to receive a specimen plate. The stage assembly also includes a calibration sample bay formed in the stage. A calibration sample can also be secured within the calibration sample bay.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: October 14, 2014
    Assignee: Cellomics, Inc.
    Inventors: Richard C. Salisbury, Dirk John VandenBerg, III, Kim Anthony Ippolito
  • Patent number: 8818070
    Abstract: A method of predicting hepatotoxicity of a compound. The method includes imaging cells of hepatic origin positioned within a plurality of containers to obtain imaged cellular targets, each container being treated with a different concentration of the compound, the imaging being performed using a quantitative high-content cell imaging system; quantitatively measuring the imaged cellular targets to detect changes in multiple cellular targets associated with cytotoxicity of the compound; and analyzing measurements obtained from the measured imaged cellular targets over a range of compound concentrations to determine the hepatotoxicity of the compound.
    Type: Grant
    Filed: February 22, 2012
    Date of Patent: August 26, 2014
    Assignee: Cellomics, Inc.
    Inventors: Suk Jin Hong, Richik Niloy Ghosh
  • Patent number: 8649981
    Abstract: A method and system for setting image analysis parameters to control image analysis operations. The method and system include collecting set of digital training images including a set of states for the set of digital training images. An objective function is defined to determine a relative quality of plural different parameter sets used for digital image analysis. Values for the plural different parameter sets that maximize (or minimize) the objective function are determined. The method and system increases a usability of high content screening technologies by reducing a required level of expertise required to configure digital image processing.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: February 11, 2014
    Assignee: Cellomics, Inc.
    Inventors: Michael A. Sipe, R. Terry Dunlay
  • Patent number: 8259170
    Abstract: A stage assembly, an imaging system that uses the stage assembly, and methods for using the stage assembly in a high content screening system. The stage assembly includes a stage having a top surface and an opposing bottom surface and an opening extending between the top and bottom surfaces to receive a specimen plate. The stage assembly also includes a calibration sample bay formed in the stage. A calibration sample can also be secured within the calibration sample bay.
    Type: Grant
    Filed: August 24, 2009
    Date of Patent: September 4, 2012
    Assignee: Cellomics, Inc.
    Inventors: Richard C. Salisbury, Dirk John VandenBerg, III, Kim Anthony Ippolito
  • Patent number: 8121383
    Abstract: A method and system for setting image analysis parameters to control image analysis operations. The method and system include collecting set of digital training images including a set of states for the set of digital training images. An objective function is defined to determine a relative quality of plural different parameter sets used for digital image analysis. Values for the plural different parameter sets that maximize (or minimize) the objective function are determined. The method and system increases a usability of high content screening technologies by reducing a required level of expertise required to configure digital image processing.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: February 21, 2012
    Assignee: Cellomics, Inc.
    Inventors: Michael A. Sipe, R. Terry Dunlay
  • Patent number: 8103457
    Abstract: The present invention provides automated methods for cell body extension analysis, software for carrying out such methods, and detection devices comprising such software.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: January 24, 2012
    Assignee: Cellomics, Inc.
    Inventors: Everett Ramer, Oleg Lapets
  • Patent number: 8090748
    Abstract: Methods and system for efficient collection and storage of experimental data allow experimental data from high-throughput, feature-rich data collection systems, such as high-throughput cell data collection systems to be efficiently collected, stored, managed and displayed. The methods and system can be used, for example, for storing, managing, and displaying cell image data and cell feature data collected from microplates including multiple wells and a variety of bio-chips in which an experimental compound has been applied to a population of cells. The methods and system provide a flexible and scalable repository of experimental data including multiple databases at multiple locations including pass-through databases that can be easily managed and allows cell data to be analyzed, manipulated and archived. The methods and system may improve the identification, selection, validation and screening of new drug compounds that have been applied to populations of cells.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: January 3, 2012
    Assignee: Cellomics, Inc.
    Inventors: Keith S. Boyce, Brian K. McKenna, Phillip W. Glick, R. Terry Dunlay
  • Patent number: 8062856
    Abstract: The present invention provides systems, methods, screens, reagents and kits for optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for those that specifically affect neurite outgrowth.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: November 22, 2011
    Assignee: Cellomics, Inc.
    Inventors: Richik Ghosh, Robbin DeBiasio, Prem Janardhan
  • Patent number: 8050868
    Abstract: The present invention provides automated methods and associated software for determining the organization of a component of interest in individual cells by determining the amount or distribution of the cellular component of interest as a function of position relative to a reference component in the individual cells.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: November 1, 2011
    Assignee: Cellomics, Inc.
    Inventors: Gustavo Rosania, Paul Sammak, Richard Rubin
  • Patent number: 8024293
    Abstract: Methods and system for efficient collection and storage of experimental data allow experimental data from high-throughput, feature-rich data collection systems, such as high-throughput cell data collection systems to be efficiently collected, stored, managed and displayed. The methods and system can be used, for example, for storing, managing, and displaying cell image data and cell feature data collected from microplates including multiple wells and a variety of bio-chips in which an experimental compound has been applied to a population of cells. The methods and system provide a flexible and scalable repository of experimental data including multiple databases at multiple locations including pass-through databases that can be easily managed and allows cell data to be analyzed, manipulated and archived. The methods and system may improve the identification, selection, validation and screening of new drug compounds that have been applied to populations of cells.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: September 20, 2011
    Assignee: Cellomics, Inc.
    Inventors: Keith S. Boyce, Brian K. McKenna, Phillip W. Glick, R. Terry Dunlay
  • Patent number: 7853409
    Abstract: The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a fluorescent microscope, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropatterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: December 14, 2010
    Assignee: Cellomics, Inc.
    Inventors: R. Terry Dunlay, D. Lansing Taylor
  • Patent number: 7853411
    Abstract: The present invention provides systems, methods, and screens to measure receptor internalization in a single step with appropriate automation and throughput. This approach involves luminescent labeling of the receptor of interest and the automated measurement of receptor internalization to a perinuclear location.
    Type: Grant
    Filed: October 15, 2003
    Date of Patent: December 14, 2010
    Assignee: Cellomics, Inc.
    Inventors: Richard Rubin, Kenneth Giuliano, Albert Gough, R. Terry Dunlay, Bruce Ray Conway
  • Patent number: 7818130
    Abstract: A method and system for setting image analysis parameters to control image analysis operations. The method and system include collecting set of digital training images including a set of states for the set of digital training images. An objective function is defined to determine a relative quality of plural different parameter sets used for digital image analysis. Values for the plural different parameter sets that maximize (or minimize) the objective function are determined. The method and system increases a usability of high content screening technologies by reducing a required level of expertise required to configure digital image processing.
    Type: Grant
    Filed: December 9, 2005
    Date of Patent: October 19, 2010
    Assignee: Cellomics, Inc.
    Inventors: Michael A. Sipe, R. Terry Dunlay
  • Patent number: 7706591
    Abstract: The present invention provides automated methods for cell body extension analysis, software for carrying out such methods, and detection devices comprising such software.
    Type: Grant
    Filed: July 13, 2006
    Date of Patent: April 27, 2010
    Assignee: Cellomics, Inc.
    Inventors: Everett Ramer, Oleg P. Lapets
  • Patent number: 7565247
    Abstract: The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a fluorescent microscope, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropaterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: July 21, 2009
    Assignee: Cellomics, Inc.
    Inventors: R. Terry Dunlay, D. Lansing Taylor
  • Patent number: 7482167
    Abstract: The present invention provides a test plate and methods for adjusting fluorescence imaging systems involving using a plate with fluorescent microbeads bound to a surface.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: January 27, 2009
    Assignee: Cellomics, Inc.
    Inventors: Paul Sammak, Gustavo Rosania, Lawrence J. Zana, Kim Ippolito, Jason Bush, Alex Friedman, Sarah Burroughs Tencza, Ravi Kapur