Abstract: Methods of manufacture and use of phosphates of transition metals are described as positive electrodes for secondary lithium batteries, including a process for the production of LiMPO4 with controlled size and morphology, M being FexCoyNizMnw, where 0?x?1, 0?y?1, 0?w?1, and x+y+z+w=1. According to an exemplary embodiment, a process is described for the manufacture of LiFePO4 including the steps of providing an equimolar aqueous solution of Li1+, Fe3+ and PO43?, evaporating water from the solution to produce a solid mixture, decomposing the solid mixture at a temperature of below 500° C. to form a pure homogeneous Li and Fe phosphate precursor, and annealing the precursor at a temperature of less than 800° C. in a reducing atmosphere to produce the LiFePO4 powder. The obtained powders can have a particle size of less than 1 ?m, and can provide superior electrochemical performance when mixed for an appropriate time with an electrically conductive powder.
Type:
Grant
Filed:
April 11, 2007
Date of Patent:
March 2, 2010
Assignees:
Le Centre National de la Rocherche Scientifique, Umicore
Inventors:
Calin Wurm, Mathieu Morcrette, Sylvain Gwizdala, Christian Masquelier
Abstract: A device for controlling power transfer between two cores of a direct current network, in which the cores, which are source-charge interconnection nodes, include protective and contact members, placed in different areas of a power distribution system in which the direct current network is installed. The device includes an electronic power converter including two switching cells mutually interconnected by an inductance, wherein each switching cell includes two switches, and a module for controlling the converter, which ensures both a controllable direct current power transfer and stabilization of the direct current voltage.
Type:
Grant
Filed:
October 27, 2006
Date of Patent:
March 2, 2010
Assignees:
Airbus France, Centre National de la Recherche Scientifique
Abstract: A device (2) for evaluating the state of wetting of a surface (8) includes an emitter (4) emitting a beam (F, F1, F2) which is incident in the direction of the surface (8) and a single element (12) for receiving the beam reflected by the surface (8). The device includes: A polarisation (10, 13, 14) including a first polarisation zone (13) and a second polarisation zone (14) designed to polarise a first part (F1) and a second part (F2) of the beam in a first and a second polarisation direction; and a evaluation element (28) for calculating a polarisation ratio between the polarisations of the first part of the reflected beam and the second part of the reflected beam to evaluate the state of wetting of the surface (8). Also described is an evaluation process and an associated indicator device.
Type:
Application
Filed:
July 2, 2007
Publication date:
February 25, 2010
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N. R.S), UNIVERSITE DE POITIERS
Abstract: The present invention relates to an anti-gene oligonucleotide which hybridizes specifically with the gene encoding human tyrosinase by Hoogsteen pairing between the complementary bases, said oligonucleotide forming a triple helix structure with the human tyrosinase gene. The invention also relates to the use of said oligonucleotide as a skin-depigmenting or skin-bleaching agent in a cosmetic composition or in a dermatological composition.
Type:
Application
Filed:
September 1, 2006
Publication date:
February 25, 2010
Applicants:
L.V.M.H. RECHERCHE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), MUSEUM NATIONAL D'HISTOIRE NATURELLE
Inventors:
Robin Kurfürst, Mathilde Bonnet-Duquennoy, Kristell Lazou, Carine Giovannangeli
Abstract: The present invention relates to a catalyst system which is a mixture of at least two catalytic species, the first catalytic species being a dehydrogenation catalyst and the second catalytic species being an epoxidation catalyst and comprising silver. The present invention also relates to a process for the production of epoxides, in particular a process for the production of an epoxide from an alkane or a mixture comprising an alkane and an alkene, which process comprises contacting said alkane or mixture comprising said alkane and said alkene and a source of oxygen with such a catalyst system comprising a mixture of at least two catalytic species, the first catalytic species providing dehydrogenation activity and the second catalytic species providing epoxidation activity and comprising silver.
Type:
Application
Filed:
January 10, 2008
Publication date:
February 25, 2010
Applicant:
Centre National De La Recherche Scientifique ( C.N.R.S.)
Inventors:
Jean-Marie Basset, Jean-Richard Llinas, Mathias Mauvezin, Mostafa Taoufik, Jean Thivolle-Cazat
Abstract: The invention relates to novel hybrid compounds comprising at least one polyon entity (Po)—for example oligomer or polymer—in which at least one of the hydroxyl functions of Po is substituted by at least one entity A that can be of a variable nature, for example polymer (e.g. polyorganosiloxane-POS), hydrocarbonated or mineral. The bond Ro between the entity Po and the entity A is obtained by means of “click chemistry” and corresponds to formula (II.1) or (II.2), Z representing —CH— or —N—. A is an entity selected from the group comprising the various polyols of Po, polyorganosiloxanes (POS), polyalkylene glycols, polyamides, polyesters, polystyrenes, alkyls, alkenyls, alkynyls, aryls, and combinations thereof, in addition to mineral materials such as silica and the combinations thereof. Said hybrid components can be used as emulsifiers, especially for cosmetics.
Type:
Application
Filed:
May 15, 2007
Publication date:
February 25, 2010
Applicants:
RHODIA OPERATIONS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS
Inventors:
Etienne Fleury, Sami Halila, Hugues Driguez, Sylvain Cottaz, Thierry Hamaide, Sebastien Fort
Abstract: The present invention relates to a compound of general formula (I) below in which R1, R2 and R3 represent, independently of one another, a hydrogen atom or a C1-C6 alkyl group or a (C1-C6 alkyl)carbonyl group, R4, R5, R6 and R7 represent a hydrogen or a C1-C6 alkyl group, a C1-C6 alkoxy group or a (C1-C6 alkyl)carbonyloxy group, and n is an integer between 8 and 20, or its pharmaceutically acceptable addition salts, isomers, enantiomers and diastereoisomers, and also mixtures thereof. The invention also relates to a pharmaceutical composition comprising the compound and to the use thereof as a neurotrophic agent.
Type:
Application
Filed:
March 2, 2007
Publication date:
February 25, 2010
Applicants:
Centre National de la Recherche Scientifique(CNRS), Universite de Luxembourg
Inventors:
Bang Luu, Frédérique Hauss, Djalil Coowar, Jiawei Liu, Paul Heuschling, Eleonora Morga, Luc Grandbarbe, Alessandro Michelucci
Abstract: The present invention has for an object a cationic lipophilic compound of the following general formula (I): wherein: a) R1 and R?1 each represent, independently from one another, an alkyl chain, an alkenyl chain or a polyalkenyl chain with from 10 to 24 carbon atoms, with the polyalkenyl chain having from 2 to 4 double links; b) R2 is a hydrogen atom or an alkyl chain having from 1 to 4 carbon atoms; and R3 is a group with the following formula (IIa) —(CH2)n— or following formula (IIb) —C(?NH)—NH—(CH2)n— wherein: n is an integer equal to 0, 1, 2, 3 or 4; and d) A+ is an organic cation; e) X? is an anion.
Type:
Grant
Filed:
November 7, 2003
Date of Patent:
February 23, 2010
Assignees:
Centre National de la Recherche Scientifique (CNRS), Institut National de la Sante de de la Recherche Medicale (INSERM), Universite de Bretagne Occidentale, Centre Hospitalier Universitaire de Brest
Inventors:
Hervé Des Abbayes, Jean-Jacques Yaouanc, Jean-Claude Clement, Karine Le Ny, Claude Ferec, Tristan Montier, Pascal Delepine
Abstract: The invention relates to a medicament comprising at least one reducing alkyl-sugar monomer having a hydroxyl function which is substituted by an alkoxy radical at C2-C40, said medicament being preferably intended to regulate inflammatory mechanisms. The reducing sugar is preferably selected from the group containing rhamnose, fucose and glucose. The invention also relates to a cosmetic treatment method involving the topical application of a composition comprising at least one reducing alkyl-sugar monomer having a hydroxyl function which is substituted by an alkoxy radical at C2-C40.
Type:
Grant
Filed:
October 29, 2004
Date of Patent:
February 23, 2010
Assignees:
Pierre Fabre Dermo-Cosmetique, Centre National de la Recherche Scientifique (CNRS)
Abstract: Method and device for the detection of an essentially rectilinear contrast edge (E) in a direction, whereby a periodic sweep (?) of global visual angle (??) of the optical sensors, by translation (S) in another direction transverse to the first direction, is carried out. The translation provides a periodic sweep of non-uniform angular speed (?) during a part of the period of sweeping and a measurement of a time difference (t) from the signals provided by the sensors (D1, D2), depending on the angular position of the contrast edge (E) with relation to a reference direction (OY12) within the global visual angle (??) from the sweep law (?), the reference direction being connected to a specific value for the time difference (t). The above is of application to spatial stabilization of a sight line and the fine following and fixing of an object with at least one contrast edge.
Type:
Grant
Filed:
March 16, 2005
Date of Patent:
February 23, 2010
Assignee:
Centre National de la Recherche Scientifique (C.N.R.S.)
Inventors:
Nicolas Franceschini, Stephane Viollet, Marc Boyron
Abstract: The invention relates to a digalactolipidic antigen exposed on the surface of apicomplex parasites, in the form of a vegetable-type digalactoglycerolipid, and adapted for inducing the production of specific antibodies capable of inhibiting the proliferation and/or the invasive properties of said parasites; the invention also relates to a derived antibody or functional antibody fragment, and to their diagnostic, immunotherapeutic and vaccine applications in human beings or animals.
Type:
Application
Filed:
February 7, 2008
Publication date:
February 18, 2010
Applicants:
COMMISSARIAT A L'ENERGIE ATOMIQUE, CENTRE NATIONAL DE LA RECHERCHE SEIENTIFIQUE
Inventors:
Cyrille Botte, Nadia Saidani, Maryse Block, Jean-Francois Dubremetz, Henri Vial, Marie-France Cesbron-Delauw, Corinne Mercier, Eric Marechal
Abstract: The invention relates to the therapeutic use of a SMR1-peptide or a pharmaceutically active amount of said SMR1-peptide, for the preparation of a therapeutic composition for preventing or treating diseases wherein a modulation of the activity of a membrane metallopeptidase, notably a membrane-zinc metallopeptidase, is sought, in a mammal, specifically in a human.
Type:
Application
Filed:
October 16, 2009
Publication date:
February 18, 2010
Applicants:
INSTITUT PASTEUR, Centre National De La Recherche Scient.
Abstract: Disclosed is a method for manufacturing a diamond film of electronic quality at a high rate using a pulsed microwave plasma. The plasma that has a finite volume is formed near a substrate (in a vacuum chamber) by subjecting a gas containing at least hydrogen and carbon to a pulsed discharge. The pulsed discharge has a succession of low-power states and of high-power states and a peak absorbed power PC, in order to obtain carbon-containing radicals in the plasma. These carbon-containing radicals are deposited on the substrate in order to form a diamond film. Power is injected into the volume of the plasma with a peak power density of at least 100 W/cm3, while maintaining the substrate to a substrate temperature of between 700° C. and 1000 ° C.
Type:
Grant
Filed:
June 18, 2003
Date of Patent:
February 16, 2010
Assignees:
Centre National de la Recherche Scientifique - CNRS, Universite Paris Nord (Paris XII) Institut Galilee
Inventors:
Alix Hélène Gicquel, François Silva, Xavier Duten, Khaled Hassouni, Guillaume Vincent Lombardi, Antoine Rousseau
Abstract: 2? and 3?-Prodrugs of 1?, 2?, 3? or 4?-branched ?-D or ?-L nucleosides, or their pharmaceutically acceptable salts and derivatives are described, which are useful in the prevention and treatment of Flaviviridae infections and other related conditions. These modified nucleosides provide superior results against flaviviruses and pestiviruses, including hepatitis C virus and viruses generally that replicate through an RNA dependent RNA reverse transcriptase. Compounds, compositions, methods and uses are provided for the treatment of Flaviviridae infection, including HCV infection, that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.
Type:
Grant
Filed:
June 27, 2003
Date of Patent:
February 16, 2010
Assignees:
Idenix Pharmaceuticals, Inc., University of Cagliari, Centre National de la Recherche Scientifique, L'Universite Montpellier II
Abstract: The invention relates to an electrochemical method and reactor in which at least one electrochemical reaction compartment (5, 6) comprises a plurality of microchannels whose grooves have a cross section of at least partially curved contour with a radius of curvature greater than 30 ?m and an area of between 2500 ?m2 and 20000 ?m2. Application to the synthesis of diastereoisomers by continuous regeneration of NADH or NADPH.
Type:
Grant
Filed:
November 18, 2005
Date of Patent:
February 16, 2010
Assignees:
Universite Paul Sabatier Toulouse III, Centre National de la Recherche Scientifique (C.N.R.S.)
Inventors:
Theodore Tzedakis, Cheikhou Kane, Anne Launay
Abstract: The invention relates to a measuring tape (10) comprising a stack of at least two layers, characterized in that it also includes a first layer, called support layer, based on composite material (11) and a layer, called top layer, (12) based on a polymer having a high glass transition temperature so that, in conditions of use, said polymer is in a glassy state to maintain the element in the wound or folded position. The invention also relates to a deployable structure including said measuring tape intended notably for space applications.
Type:
Application
Filed:
July 10, 2009
Publication date:
February 11, 2010
Applicants:
Thales, Centre National De La Recherche Scientifique
Inventors:
Arnaud Allezy, Laurent Blanchard, Christian Hochard, François Guinot
Abstract: The present invention relates to a composition comprising a siRNA and a transfecting compound consisting of an aminoglycoside of the class of 4,5-disubstituted 2-deoxystreptamine ring linked via a spacer molecule to a lipid moiety of formula —(R1)R2 wherein R1 and R2 represent, independently of one another, a hydrogen atom or a fatty aliphatic chain or R1 or R2 is absent, with the proviso that at least one of R1 and R2 represents a fatty aliphatic chain; or —OR3 or —NR3 wherein R3 represents a steroidal derivative. The invention also concerns in vitro and in vivo applications of these compositions.
Type:
Application
Filed:
October 4, 2007
Publication date:
February 11, 2010
Applicants:
Centre National De La Recherche Scientifique (CNRS, Institut National De La Sante Et De La Recherche Medicale (INSERM)
Inventors:
Jean-Marie Lehn, Jean-Pierre Vigneron, Pierre Lehn, Bruno Pitard
Abstract: The invention relates to a lubricating metal coating and to a process for its preparation. The material constituting the coating in a composite material comprising a metal matrix within which talc particles are distributed as lamellae, the metal matrix being composed of a metal chosen from Fe, Co, Ni, Mn, Cr, Cu, W, Mo, Zn, Au, Ag, Pb or Sn or of an alloy of these metals or of a metal/semimetal alloy. The coating is obtained by a process consisting in carrying out an electrolytic deposition using a solution of precursors of the metal matrix of the coating which additionally comprises talc particles in suspension, which particles are modified at the surface by irreversible adsorption of a cellulose-derived compound by replacement of all or part of the hydroxyl groups.
Type:
Grant
Filed:
December 8, 2003
Date of Patent:
February 9, 2010
Assignee:
Centre National de la Recherche Scientifique
Inventors:
François Martin, Jean-Pierre Bonino, Patrice Bacchin, Stéphane Vaillant, Eric Ferrage, William Vautrin, Philippe Barthes
Abstract: A sighting device for an examination by in vivo tomography of an eye of a subject including a viewer controlled by a control system for displaying at least one moving target where the at least one moving target has at least one of a programmable shape and a programmable trajectory, and is visible by the eye of the subject during the examination period to allow the subject to fixate and follow the target with their eye.
Type:
Grant
Filed:
September 12, 2008
Date of Patent:
February 9, 2010
Assignees:
Centre National de la Recherche Scientifique, Observatoire de Paris, Mauna Kea Technologies
Inventors:
François Lacombe, David Lafaille, Marie Glanc, Eric Gendron, Douchane Stefanovitch
Abstract: A method of preparing cyclene having formula (I) from triethylenetetraamine having formula (VIII) or ethylenediamine having formula (VIII?) includes a series of steps. The first series of steps (I) includes a step A (one-pot preparation of the compound having formula (IIa) from the compound having formula (VIII)), followed by a step B (transforming the compound having formula (IIa) into cyclene having formula (I)). The second series of steps (II) includes a step C (preparing the compound having formula (IIb) from the compound having formula (VIII)), followed by a step D (transforming the compound having formula (IIb) into cylcene having formula (I)). The third series of steps (III) includes a step E involving the onepot preparation of the compound having formula (IIa) from the compound having formula (VIII), followed by a step B involving the transformation of the compound having formula (IIa) into cyclene having formula (I).
Type:
Grant
Filed:
June 4, 2004
Date of Patent:
February 9, 2010
Assignee:
Centre National de la Recherche Scientifique (C.N.R.S.)
Inventors:
Frederic Boschetti, Fanny Chaux, Franck Denat, Roger Guilard, Henry Ledon