Abstract: This invention relates to a method for users localization and guidance of the movements of the users through a building adapted in relation to an event, along paths leading to one or more given target places, with connected objects (T, T?) in communication link with a remote resource server which is a control server (S) accessible by a communication network, comprising the following steps: on the basis of a digital model of the building (BIM, CIM), nodes (N) and edges (A) are computed; a user waiting list is assigned to each passage node; a Directed Acyclic Graph (DAG) of movement toward the target places (“E”, “S”, “W”) is automatically computed with the nodes and the edges (A); the actual location of an event is detected; the actual position of each user located in the building is computed; as a function of the profile of the user, of the user's location in real time in the building causing the inaccessibility of certain nodes of the Directed Acyclic Graph (DAG), the so-called ‘updated’ Directed Acyclic Gra

Abstract: The invention is in the field of therapy of gut inflammatory diseases such as Inflammatory Bowel Diseases (IBD) or Irritable Bowel Syndrome (IBS) including Gluten hypersensitivity. The inventors showed that ELA2A secreted by epithelial cells in the extracellular space is over-expressed in IBD conditions degrading tight junction proteins and controlling cytokines expression. Overexpression of ELA2A conferred a pro-inflammatory phenotype both in cell expression systems and in vivo in animal model of IBD. The inventors also showed that ELA2 over-expressing intestinal epithelial cells increase the release of CXCL8 protein compared to control cells. The increased CXCL-8 protein release observed in cells overexpressing ELA2A is inhibited by ELAFIN addition to the culture, in a dose-dependent manner. In particular, the invention relates to inhibitors of Elastase ELA2A, for use in the treatment of Inflammatory Bowel Diseases, such as Crohn's Disease, Ulcerative Colitis, Celiac disease, and Pouchitis.

Abstract: Devices and methods for the stimulation of neural signaling of an apical splenic nerve, the device having a transducer for placement on or around the apical splenic nerve, and a signal generator to generate a signal that stimulates or inhibits the neural activity of the apical splenic nerve to produce a physiological response. The transducer has at least one electrode, and the signal generator is a voltage or current source. The stimulation electrical signal has a frequency of between 1 Hz and 50 Hz.

Abstract: Modulation of neural signaling of a pancreas-related sympathetic nerve is capable of improving glycaemic control by inhibiting T cell activation or migration to the pancreas, and hence providing a way of treating or preventing type 1 diabetes.

Abstract: The present invention relates to a new antibody anti-nectin-4. Nectin-4 is a tumor-associated antigen overexpressed in several cancers and notably in 30%, 49% and 86% of breast, ovarian and lung carcinomas, respectively, which are tumors of bad prognosis. Treatments remain still elusive. That's why the inventors developed a new targeted therapy based on an antibody having specificity to nectin-4 (called 14A5.2 mab). Indeed, the inventors selected this antibody for its intrinsic prophylactic anti-metastatic properties and also for the treatment of localized primary and metastatic cancer. More, the 14A5.2 mab could be indicated for the treatment of cancer resistant to ASG-22ME (from Astellas company). Thus, the invention relates to the 14A5.2 mab and its uses thereof.

Abstract: The invention is a method applicable to oil and gas exploration and exploitation for automatically detecting geological objects belonging to a given type of geological object in a seismic image, on a basis of a priori probabilities of belonging to a type of geological object assigned to each of samples of the image to be interpreted. The image is transformed into seismic attributes applied beforehand, followed by a classification method. For each of the classes, an a posteriori probability of belonging to a type of geological object is determined for each of the samples of the class according to the a priori probabilities, of the class, of belonging, and according to a parameter ? describing a confidence in the a priori probabilities of belonging. Based on the class of the sample, the determined a posteriori probability of belonging to a type of geological object is assigned for the samples of the class.

Abstract: Disclosed is an acoustic resonance spectrometry system for analysing a sample, which includes an optical pump-probe device adapted to generate a pump beam and a probe beam, the pump beam being consisted of a series of ultra-short pump light pulses having a repetition frequency in the spectral domain of the gigahertz, the pump beam being directed towards an optoacoustic transducer to generate a periodic grating of coherent acoustic phonons in the sample, the probe beam being directed towards the sample to form a scattering beam of the probe beam on the grating of phonons, a frequency variation device being adapted to vary the repetition frequency of the pump beam in a spectral range and a photo-detection system configured to measure a scattering signal as a function of the repetition frequency in the spectral range.

Abstract: Stimulation of neural signalling of an apical splenic nerve can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating inflammatory disorders.

Abstract: The device for electrochemically synthesizing intermediate species of a chemical entity which comprises an electrochemical oxidation cell including a first working electrode and a first counter electrode, capable, when these first electrodes are subject to an electric potential, of generating the intermediate species by oxidation of a solution introduced into the electrochemical oxidation cell and comprising the chemical entity, and an electrochemical stabilization cell including a second working electrode and a second counter electrode respectively distinct from the first working electrode and counter electrode, capable, when these second electrodes are subject to an electric potential, of achieving reduction of a solution. The stabilization cell is connected in series to the oxidation cell so as to allow continuous reduction of the intermediate species generated in the oxidation cell. Applications can be in the pharmaceutical, agri-food and environment fields.

Abstract: The invention provides an assay-ready frozen eukaryotic cell (stored frozen) in a composition that includes a cryopreservative and an inhibitor of xanthine oxidase, a kit containing a plurality of the assay-ready frozen eukaryotic cell, and a method of preparation thereof to minimize the variability in the performance of the cell, particularly in terms of undesirable intra- and inter-assay variability.

Abstract: The present invention provides a cell for use in a one-step cell-based assay for an extracellular ligand (e.g., IFN?) that initiates a ligand-specific signal at the nucleus of the cell and for neutralizing antibodies against the extracellular ligand. The cell-based one-step assay allows both the extracellular ligand concentration and the neutralizing antibody titer to be quantified in a single sample (e.g., serum) without the need for sample dilution and addition of exogenous extracellular ligand.

Abstract: A polymer film, polymer gel, and polymer foam each contain an electrically conductive polymer and an ionic liquid and are each useful as a component of an electronic device.

Abstract: According to one aspect, the invention relates to an angular optical filtering element (?i) optimised for angular filtering about a given operating angle of incidence (?i, 1) in a given spectral band. The angular filtering element (?i) comprises a first nanostructured, band-pass, spectral filter (11i, 301) and a second nanostructured, band-pass, spectral filter (12i, 302). Each of the first and second spectral filters comprises, respectively, in said spectral band, a first and a second central filtering wavelength that respectively has a first and second angular dispersion curve defined depending on the angle of incidence (?inc) on the optical filtering element (?i), the curves of angular dispersion being secant about the operating angle of incidence (?i, 1) of the optical filtering element. The invention applies to the production of a selective angular filtering device and to a multidirectional optical detection system.

Abstract: According to a first aspect, the invention relates to a generator of at least three coherent laser beams at least one beam of which is in the infrared domain and at least one beam of which is in the visible domain, comprising: an elementary source for emitting a first continuous-wave laser beam, at a first given infrared wavelength; a nonlinear crystal frequency doubler, allowing, from a first beam sampled from the first laser beam at the first wavelength, a second laser beam to be generated at a second wavelength; and a nonlinear crystal sum frequency generator, allowing, from a second beam sampled from the first laser beam at the first wavelength and from the second laser beam at the second wavelength, a third laser beam to be generated at a third wavelength.

Abstract: The device for electrochemically synthesizing intermediate species of a chemical entity which comprises an electrochemical oxidation cell including a first working electrode and a first counter electrode, capable, when these first electrodes are subject to an electric potential, of generating the intermediate species by oxidation of a solution introduced into the electrochemical oxidation cell and comprising the chemical entity, and an electrochemical stabilization cell including a second working electrode and a second counter electrode respectively distinct from the first working electrode and counter electrode, capable, when these second electrodes are subject to an electric potential, of achieving reduction of a solution. The stabilization cell is connected in series to the oxidation cell so as to allow continuous reduction of the intermediate species generated in the oxidation cell. Applications can be in the pharmaceutical, agri-food and environment fields.

Abstract: The present invention relates to a commercializable cell and to a gene reporter assay method and a kit which use this cell to determine the presence and/or the level of a molecule that activates signal transduction activity of a cell surface protein. This cell is treated in such a manner that it will have a sufficiently long shelf life for its intended purpose, whereupon at the end of its useful shelf life or at the end of its use, i.e., in an assay, the cell undergoes cellular death.

Abstract: The invention relates to a method of preparing a fluorinated copolymer, comprising a step of copolymerization of a fluorinated monomer (of the vinylidene fluoride type) with an ?-trifluoromethacrylic acid monomer or derivative of ?-trifluoromethacrylic acid, in the presence of a xanthate or trithiocarbonate compound. The invention also relates to copolymers obtained by this method as well as block copolymers comprising a copolymer block prepared according to this method.

Abstract: According to one aspect, the invention relates a spectral band-pass filter, which is optimized for the transmission of an incident wave at at least a first given central wavelength ?0, and which includes: a metal grating having a thickness (t) greater than approximately ?0/50 and including at least a first set of substantially identical, parallel slots having a width (W) less than around ?0/10, and being spaced apart periodically or quasi-periodically according to a first period that is less than said first central wavelength, a layer of dielectric material having a thickness (h) and a given refractive index (ng), which is coupled to the metal grating to form a waveguide for the waves diffracted by the grating, said first period of the grating being designed such that only orders 0 and ±1 of a wave having normal incidence and a wavelength ?0 are diffracted in the layer of dielectric material, the assembly of the dielectric layer and grating being suspended, during use, in a fluid having a refractive index of

Abstract: An intervertebral disc prosthesis comprises a structure having a rigid upper plate, a rigid lower plate, and a core inserted between said plates, the structure being made from thermoplastic material, the core further comprising a thermoplastic monomaterial having graduated elastic and damping properties. According to one alternative, the core is composed of an elastomeric central nucleus surrounded by one or more rings which are referred to as rings having ranks j relative to the core, and which are more rigid.

Abstract: Disclosed are methods and devices that can improve water usage by plants and grasses by, for example, inducing preferential root tropism and assisting in redistributing water within the soil.