Patents Assigned to Centre Nationale de la Recherche Scientifique
  • Publication number: 20160124286
    Abstract: According to a first aspect, the invention relates to a generator of at least three coherent laser beams at least one beam of which is in the infrared domain and at least one beam of which is in the visible domain, comprising: an elementary source for emitting a first continuous-wave laser beam, at a first given infrared wavelength; a nonlinear crystal frequency doubler, allowing, from a first beam sampled from the first laser beam at the first wavelength, a second laser beam to be generated at a second wavelength; and a nonlinear crystal sum frequency generator, allowing, from a second beam sampled from the first laser beam at the first wavelength and from the second laser beam at the second wavelength, a third laser beam to be generated at a third wavelength.
    Type: Application
    Filed: April 15, 2014
    Publication date: May 5, 2016
    Applicants: Observatoire De Paris, Centre Nationale de la Recherche Scientifique - CNRS
    Inventors: Mohand Ouali Acef, Frédéric Du Burck, Noël Dimarcq
  • Publication number: 20160053389
    Abstract: The device for electrochemically synthesizing intermediate species of a chemical entity which comprises an electrochemical oxidation cell including a first working electrode and a first counter electrode, capable, when these first electrodes are subject to an electric potential, of generating the intermediate species by oxidation of a solution introduced into the electrochemical oxidation cell and comprising the chemical entity, and an electrochemical stabilization cell including a second working electrode and a second counter electrode respectively distinct from the first working electrode and counter electrode, capable, when these second electrodes are subject to an electric potential, of achieving reduction of a solution. The stabilization cell is connected in series to the oxidation cell so as to allow continuous reduction of the intermediate species generated in the oxidation cell. Applications can be in the pharmaceutical, agri-food and environment fields.
    Type: Application
    Filed: January 6, 2014
    Publication date: February 25, 2016
    Applicants: CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITE DE NANTES
    Inventors: Mohammed BOUJTITA, Ugo BUSSY
  • Patent number: 9188580
    Abstract: The present invention relates to a commercializable cell and to a gene reporter assay method and a kit which use this cell to determine the presence and/or the level of a molecule that activates signal transduction activity of a cell surface protein. This cell is treated in such a manner that it will have a sufficiently long shelf life for its intended purpose, whereupon at the end of its useful shelf life or at the end of its use, i.e., in an assay, the cell undergoes cellular death.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: November 17, 2015
    Assignees: LE CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE, BIOMONITOR LIMITED
    Inventors: Michael G. Tovey, Christophe Lallemand
  • Patent number: 9184461
    Abstract: The invention relates to a method of preparing a fluorinated copolymer, comprising a step of copolymerization of a fluorinated monomer (of the vinylidene fluoride type) with an ?-trifluoromethacrylic acid monomer or derivative of ?-trifluoromethacrylic acid, in the presence of a xanthate or trithiocarbonate compound. The invention also relates to copolymers obtained by this method as well as block copolymers comprising a copolymer block prepared according to this method.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: November 10, 2015
    Assignees: Arkema France, Ecole Nationale Superieure de Chimie de Montpellier, Centre Nationale de la Recherche Scientifique
    Inventors: Bruno Ameduri, Yogesh Patil
  • Patent number: 9052454
    Abstract: According to one aspect, the invention relates a spectral band-pass filter, which is optimized for the transmission of an incident wave at at least a first given central wavelength ?0, and which includes: a metal grating having a thickness (t) greater than approximately ?0/50 and including at least a first set of substantially identical, parallel slots having a width (W) less than around ?0/10, and being spaced apart periodically or quasi-periodically according to a first period that is less than said first central wavelength, a layer of dielectric material having a thickness (h) and a given refractive index (ng), which is coupled to the metal grating to form a waveguide for the waves diffracted by the grating, said first period of the grating being designed such that only orders 0 and ±1 of a wave having normal incidence and a wavelength ?0 are diffracted in the layer of dielectric material, the assembly of the dielectric layer and grating being suspended, during use, in a fluid having a refractive index of
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: June 9, 2015
    Assignees: Centre Nationale de la Recherche Scientifique-CNRS, Office National d'Etudes et de Recherches Aérospatiales-ONERA
    Inventors: Grégory Vincent, Riad Haidar, Stéphane Collin, Jean-Luc Pelouard
  • Publication number: 20150045890
    Abstract: An intervertebral disc prosthesis comprises a structure having a rigid upper plate, a rigid lower plate, and a core inserted between said plates, the structure being made from thermoplastic material, the core further comprising a thermoplastic monomaterial having graduated elastic and damping properties. According to one alternative, the core is composed of an elastomeric central nucleus surrounded by one or more rings which are referred to as rings having ranks j relative to the core, and which are more rigid.
    Type: Application
    Filed: April 25, 2012
    Publication date: February 12, 2015
    Applicants: UNIVERSITE LILLE 1 SCIENCES ET TECHNOLOGIES, CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jean-Marc Lefebvre, Roland Seguela, Caroline Frederix, Richard Assaker
  • Publication number: 20140173980
    Abstract: Disclosed are methods and devices that can improve water usage by plants and grasses by, for example, inducing preferential root tropism and assisting in redistributing water within the soil.
    Type: Application
    Filed: December 20, 2013
    Publication date: June 26, 2014
    Applicants: CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE, RHODIA OPERATIONS
    Inventors: Cesare CEJAS, Remi DREYFUS, Lawrence HOUGH, Jean-Christophe CASTAING
  • Patent number: 8581310
    Abstract: The transistor comprises first and second source/drain electrodes formed in a semiconductor film by N-doped and P-doped areas, respectively. A polarization voltage is applied between the two source/drain electrodes in order to impose to the P-doped electrode a potential higher than that of the N-doped electrode. The transistor comprises first and second devices for generating a potential barrier in the semiconductor film. The two potential barriers are opposed to the passage of the charge carriers emitted by the first and second source/drain electrodes, respectively. The two potential barriers are shifted with respect to an axis connecting the two source/drain electrodes. The two devices for generating a potential barrier are configured to generate a potential barrier having a variable amplitude and it are electrically connected to the gate and to the counter electrode.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: November 12, 2013
    Assignees: Commissariat a l'Energie Atomique et aux Energies Alternatives, Centre Nationale de la Recherche Scientifique
    Inventors: Jing Wan, Sorin Cristoloveanu, Cyrille Le Royer, Alexander Zaslavsky
  • Patent number: 8512863
    Abstract: The present invention is directed to a process for the preparation of an aqueous dispersion of coacervates having a core-shell structure, the core (a) being an inorganic particle being anionic or cationic and the shell (b) being a copolymer wherein said copolymer comprises at least two parts, A and B, part A being cationic if particle (a) is anionic, and anionic if particle (a) is cationic, and part B being neutral in pH conditions of said dispersion. More particularly, the invention is directed to treating compositions comprising that aqueous dispersion of coacervates delivering antifouling, water sheeting, antisoiling, anti-adhesion, adhesion, anti-deposition, and/or anti-UV properties onto all kinds of surfaces.
    Type: Grant
    Filed: July 11, 2007
    Date of Patent: August 20, 2013
    Assignees: Rhodia Inc., Centre Nationale de la Recherche Scientifique
    Inventors: Jean-Paul Chapel, Mikel Morvan, Ling Qi
  • Patent number: 8450342
    Abstract: The invention relates to trisubstituted or tetrasubstituted imidazo[4,5b]pyridines, to their uses as well as to a process for manufacturing them. The compounds of the invention are imidazo[4,5b]pyridines. The first general synthesis of 3,5,7 imidazo[4,5b]pyridines is disclosed in the description. The invention founds application, in particular, in the pharmaceutical field.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: May 28, 2013
    Assignees: Centre Nationale de la Recherche Scientifique, Universite de Rennes 1, Universite Paris Descartes
    Inventors: Laurent Meijer, Karima Bettayeb, Herve Galons, Luc Demange, Nassima Oumata
  • Patent number: 8426123
    Abstract: A method for conducting a neutralization assay for the determination of the titer of antibodies in a sample is provided which is an improvement over existing neutralization assays because the sensitivity of the reporter gene assay to determine neutralization is increased by the use of a “one time use” cell line transformed with a reporter gene construct. The titer is determined for antibodies specific for a predetermined target molecule that activates the signal transduction activity of a cell surface protein or a pattern recognition receptor or are specific for an antagonist for the predetermined target molecule.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: April 23, 2013
    Assignees: Biomonitor Limited, Le Centre Nationale de la Recherche Scientifique
    Inventors: Michael G. Tovey, Christophe Lallemand
  • Patent number: 8160770
    Abstract: Disclosed is a method of detecting at least one oscillatory fault in at least one positional slaving chain for at least one airfoil of an aircraft. The method involves estimating a reference position of the airfoil in the absence of a fault, and calculating a residual value based on the difference between the estimated reference position and the actual position measured by at least one sensor. The calculated residual value is compared with at least one predetermined threshold value to determine the number of successive and alternating overshoots of the predetermined threshold value by the residual value, and oscillatory fault is determined based on the determined number.
    Type: Grant
    Filed: December 15, 2008
    Date of Patent: April 17, 2012
    Assignees: Airbus Operations SAS, Centre Nationale de la Recherche Scientifique, Universite de Bordeaux
    Inventors: Philippe Goupil, Ali Zolghadri, Loic Lavigne
  • Patent number: 8048525
    Abstract: An adsorption method includes the step of adsorbing hybrid particles from a colloidal dispersion of such particles at an interface between the dispersion and a second phase, said hybrid particles comprising: (a) a nanoscale inorganic core having an outer surface, and (b) an organic layer disposed on at least a portion of the surface of the inorganic core and comprising one or more phosphonates according to structure (I): wherein: R1 and R2 are each independently H, or a (C1-C20)hydrocarbon group, R3 is a divalent (C1-C20)hydrocarbon group, R4 and R5 are each independently H or (C1-C2)alkyl, provided that R4 differs from R5, R6 is H or a (C1-C30)hydrocarbon group, m and n are each independently integers of from 0 to about 200, provided that the sum of m+n is at least 1.
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: November 1, 2011
    Assignees: Rhodia, Inc., Centre Nationale de la Recherche Scientifique
    Inventors: Jean-Paul Chapel, Jean-Christophe Castaing, Jérôme Fresnais, Jean-Francois Berret, Ling Qi
  • Patent number: 8026354
    Abstract: Accordingly, the invention provides constructs in which the nucleic acids encoding Plasmodium falciparum MSP4 and MSP5, and the resulting polypeptides, have been modified. More particularly, this invention provides constructs encoding recombinant MSP4 and MSP5 polypeptides, which are expressed as soluble, secreted polypeptides in a baculovirus-insect cell expression system. It was surprisingly found that the recombinant polypeptides contain an EGF-like domain at the C-terminus that is properly folded in the polypeptide.
    Type: Grant
    Filed: November 22, 2006
    Date of Patent: September 27, 2011
    Assignees: Institut Pasteur, Centre Nationale de la Recherche Scientifique
    Inventors: Shirley Longacre, Hannah Polson, Ronald Perraut, Faridabano Nato
  • Publication number: 20110189658
    Abstract: The present invention provides a cell for use in a one-step cell-based assay for an extracellular ligand (e.g., I FN?) that initiates a ligand-specific signal at the nucleus of the cell and for neutralizing antibodies against the extracellular ligand. The cell-based one-step assay allows both the extracellular ligand concentration and the neutralizing antibody titer to be quantified in a single sample (e.g., serum) without the need for sample dilution and addition of exogenous extracellular ligand.
    Type: Application
    Filed: March 4, 2009
    Publication date: August 4, 2011
    Applicants: LE CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE, BIOMONITOR LIMITED
    Inventors: Michael Tovey, Christopher Lallemand
  • Publication number: 20110133857
    Abstract: The present invention relates to the field of acoustic wave devices, and particularly to that of transducers capable of operating at very high frequencies, from a few hundred MHz to several gigahertz, and its subject is more particularly an interface acoustic wave device including at least two substrates and a layer of ferroelectric material, the latter being contained between a first electrode and a second electrode and having first positive-polarization domains and second negative-polarization domains, the first and second domains being alternated, wherein the assembly constituted by the first electrode, the layer of ferroelectric material, and the second electrode is contained between a first substrate and a second substrate.
    Type: Application
    Filed: September 17, 2009
    Publication date: June 9, 2011
    Applicants: ETAT FRANCAIS REPRESENTE PAR LE DELEGUE GENERAL POUR L'ARMEMENT, CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE FRANCHE COMTE
    Inventors: Roger Petit, Sylvain Ballandras, Emilie Courjon, Dorian Gachon
  • Patent number: 7923015
    Abstract: A method for visualizing an active synapse wherein said method comprises: (a) exposing cells forming the active synapse to a biomarker comprising at least fragment C of tetanus toxin and a reporter protein; and (b) visualizing the biomarker; wherein the accumulation of the biomarker into dendritic spines of the cells allows visualization of an active synapse. Also, a method for screening molecules capable of modulating synapse activity is provided. A kit useful for the early diagnosis of neurodegenerative disease comprises a biomarker comprising at least fragment C of tetanus toxin and a reporter protein.
    Type: Grant
    Filed: April 6, 2004
    Date of Patent: April 12, 2011
    Assignees: Institut Pasteur, Centre Nationale de la Recherche Scientifique
    Inventors: Rafael Vazquez-Martinez, Philippe Brulet
  • Patent number: 7923216
    Abstract: A hybrid protein (GFP-TTC) comprising the non-toxic proteolytic C fragment of tetanus toxin fused to green fluorescent protein was used to analyze the functional synaptic organization of neural networks. When injected intramuscularly in vivo, the GFP-TTC hybrid protein binds to tetanus neurotoxin receptors and clusters very rapidly to the active neuromuscular junction. Membrane traffic by GFP-TTC at the pre-synaptic level of the neuromuscular junction is strongly and rapidly influenced by exogenously co-injecting neurotrophic factors, such as BDNF, NT-4, and GDNF, but not by NGF, NT-3, and CNTF. The membrane traffic, directly detected using GFP-TTC in vivo, permits methods of analyzing synaptic functioning as well as methods of modulating neuronal transport using neurotrophic factors and agonists or antagonists thereof.
    Type: Grant
    Filed: September 16, 2003
    Date of Patent: April 12, 2011
    Assignees: Institut Pasteur, Centre Nationale de la Recherche Scientifique
    Inventors: Sylvie Roux, Philippe Brulet, Cécile Saint Cloment, Julien Barbier, Jordi Molgo
  • Patent number: 7833765
    Abstract: The invention concerns multiparticulate galenic formulations for oral administration and designed for colon targeted delivery of active principles selected from the group comprising enzymes capable of inactivating macrolides and the like, enzymes capable of inactivating quinolones and ?-lactamases.
    Type: Grant
    Filed: December 29, 2008
    Date of Patent: November 16, 2010
    Assignees: Da Volterra, Centre Nationale de la Recherche Scientifique
    Inventors: Sandrine Bourgeois, Elias Fattal, Antoine Andremont, Patrick Couvreur
  • Publication number: 20100033902
    Abstract: A composite suitable as a charge-storing material for electrochemical capacitors contains carbon nanotubes and a carbonaceous materiel. The carbonaceous material is the carbonization residue of a biopolymer or seaweed rich in heteroatoms. Wherein the carbonization residue of the biopolymer or seaweed is electrically conductive and has a heteroatom content as detected by XPS of at least 6%.
    Type: Application
    Filed: August 17, 2009
    Publication date: February 11, 2010
    Applicants: SGL CARBON SE, CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE, L'UNIVERSITÉ D'ORLÉANS
    Inventors: Martin Cadek, Mario Wachtler, Encarnacion Raymundo-Pinero, Francois Beguin