Patents Assigned to Centre Nationale de la Recherche Scientifique
  • Publication number: 20090162889
    Abstract: The present invention relates to a commercializable cell and to a gene reporter assay method and a kit which use this cell to determine the presence and/or the level of a molecule that activates signal transduction activity of a cell surface protein. This cell is treated in such a manner that it will have a sufficiently long shelf life for its intended purpose, whereupon at the end of its useful shelf life or at the end of its use, i.e., in an assay, the cell undergoes cellular death.
    Type: Application
    Filed: December 16, 2008
    Publication date: June 25, 2009
    Applicants: Le Centre Nationale de la Recherche Scientifique, nEUtekBio Limited
    Inventors: Michael G. TOVEY, Christophe Lallemand
  • Publication number: 20090136947
    Abstract: A method for conducting a neutralization assay for the determination of the titer of antibodies in a sample is provided which is an improvement over existing neutralization assays because the sensitivity of the reporter gene assay to determine neutralization is increased by the use of a “one time use” cell line transformed with a reporter gene construct. The titer is determined for antibodies specific for a predetermined target molecule that activates the signal transduction activity of a cell surface protein or a pattern recognition receptor or are specific for an antagonist for the predetermined target molecule.
    Type: Application
    Filed: October 29, 2008
    Publication date: May 28, 2009
    Applicants: LE CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE, NEUTEKBIO LIMITED
    Inventors: MICHAEL G. TOVEY, CHRISTOPHE LALLEMAND
  • Publication number: 20090111178
    Abstract: The present invention relates to a commercializable cell and to a gene reporter assay method and a kit which use this cell to determine the presence and/or the level of a molecule that activates signal transduction activity of a cell surface protein. This cell is treated in such a manner that it will have a sufficiently long shelf life for its intended purpose, whereupon at the end of its useful shelf life or at the end of its use, i.e., in an assay, the cell undergoes cellular death.
    Type: Application
    Filed: June 19, 2007
    Publication date: April 30, 2009
    Applicant: Le Centre Nationale de la Recherche Scientifique
    Inventors: Michael G. Tovey, Christophe Lallemand
  • Patent number: 7470536
    Abstract: The present invention relates to a commercializable cell and to a gene reporter assay method and a kit which use this cell to determine the presence and/or the level of a molecule that activates signal transduction activity of a cell surface protein. This cell is treated in such a manner that it will have a sufficiently long shelf life for its intended purpose, whereupon at the end of its useful shelf life or at the end of its use, i.e., in an assay, the cell undergoes cellular death.
    Type: Grant
    Filed: October 3, 2003
    Date of Patent: December 30, 2008
    Assignees: Neutekbio Limited, Le Centre Nationale de la Recherche Scientifique
    Inventors: Michael G. Tovey, Christophe Lallemand
  • Publication number: 20080008592
    Abstract: A method and apparatus for reducing a selected tonal noise generated by an axial flow fan operating in a non-uniform flow by locating at least one obstruction in the non-uniform flow such that the at least one obstruction generates a noise that is out of phase with the selected tonal noise. The noise generated by the at least one obstruction interferes with the selected tonal noise, thus reducing the selected tonal noise. It is also contemplated to use additional obstructions to reduce other tonal noises generated by the axial flow fan.
    Type: Application
    Filed: June 27, 2007
    Publication date: January 10, 2008
    Applicants: SOCIETE DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUEE - SOCPRA-SC, CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE POITIERS
    Inventors: Anthony Gerard, Alain Berry, Patrice Masson, Yves Gervais
  • Patent number: 7270671
    Abstract: The present invention provides an implantable device for semiautomatic suturing using a surgical thread, the suturing enabling biological and/or artificial tissues to be united, the device comprising: blocking means enabling two strands of the thread of a suture to be connected together in a blocking zone; a bearing element having a bearing surface for bearing against the tissues to be sutured together; and controlled tensioning means for applying controlled tensioning to said thread, and suitable, after the two strands of said thread have been blocked together using said blocking means, for exerting a tension at a first predetermined tension value, with the junction between said bearing element and said blocking zone of the device being provided by said controlled tensioning means.
    Type: Grant
    Filed: August 5, 2003
    Date of Patent: September 18, 2007
    Assignees: Unversite de la Mediterranee (Aix-Marseille II), Centre Nationale de la Recherche Scientifique (CNRS)
    Inventors: Jean Fuseri, Yves Alimi, Frédéreic Mouret, Vincent Garitey, Régis Rieu
  • Patent number: 6566579
    Abstract: The invention relates to methods of introducing a heterologous DNA sequence into a mouse embryonic stem cell wherein the DNA sequence is inserted by homologous recombination into a villin gene/I-SceI hybrid by creating a double strand break with I-SceI meganuclease. Subsequently, the mouse embryonic stem cells can be used to generate a transgenic mouse comprising the heterologous DNA sequence. Additionally, the methods can be used for gene replacement in ovo where a mouse oocyte containing a villin gene/I-SceI hybrid within its genome exists or is first generated. More generally, the methods can be used for the targeted insertion of a heterologous DNA sequence into any cell containing a villin gene/I-SceI hybrid sequence within its genome.
    Type: Grant
    Filed: July 17, 1998
    Date of Patent: May 20, 2003
    Assignees: Institut Pasteur, Institut Curie, Centre Nationale de la Recherche Scientifique
    Inventors: Frederic Jaisser, Michel Cohen-Tannoudji, Sylvie Robine, Andre Choulika, Daniel Louvard, Charles Babinet
  • Patent number: 6248537
    Abstract: Eukaryotic genomes are duplicated by the activation of multiple bidirectional origins of replication. The replication programs of these cells depend on the temporal and spatial organization of replication origins throughout the genome. To investigate the replication program in a higher eukaryote, we employed a technique called molecular combing. This technique allows for a quantitative analysis of DNA replication on a genome wide basis. As a model system, Xenopus laevis sperm chromatin were differentially labeled at successive time points after the beginning of DNA synthesis. Genomic DNA was then extracted and combed on a glass surface. Direct measurements made on the labeled DNA provided a comprehensive analysis of the spatial and temporal organization of the X. laevis early embryo replication program and revealed that the number of replication origins activated per kilobase increases throughout the period of DNA synthesis.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: June 19, 2001
    Assignees: Institut Pasteur, Centre Nationale de la Recherche Scientifique
    Inventors: Aaron Bensimon, John Herrick, Olivier Hyrien
  • Patent number: 6121231
    Abstract: KAL protein is identified the active agent in a therapeutic composition for treatment of injury to nerve tissue, including spinal cord tissue, as well as support of treatment for renal grafts. Additionally, therapeutic treatment of renal injury, and kidney transplantation and renal surgery, is effected by administration of KAL protein. The therapeutic agent may be administered locally, or intravenously. Retinal disorders may be similarly treated.
    Type: Grant
    Filed: December 6, 1996
    Date of Patent: September 19, 2000
    Assignees: Institut Pasteur, Centre Nationale de la Recherche Scientifique
    Inventors: Christine Petit, Nadia Soussi-Yanticostas, Jean-Pierre Hardelin, Catherine Sarailh, Genevieve Rougon, Renaud Legouis, Olivier Ardouin, Jean-Claude Mazie
  • Patent number: 6056963
    Abstract: This invention is directed to a composition comprising one or more human immunodeficiency virus type 2 (HIV-2) envelope proteins and a pharmaceutically acceptable carrier. The proteins of the claimed invention are gp300, p200 and p90/80 of HIV-2. The composition is useful for the diagnostic assay of HIV-2 and as an antigen for the production of antibodies, for example.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 2, 2000
    Assignee: Institut Pasteur and Centre Nationale de la Recherche Scientifique (C.N.R.S.)
    Inventors: Luc Montagnier, Anne G. Laurent-Crawford, Bernard Krust, Ara G. Hovanessian, Marie-Anne Rey Cuille
  • Patent number: 5530066
    Abstract: The invention relates to monomers derived from perhalogenated sultones, to a process for their preparation, to the polymers obtained from the said monomers and to their use for the production of ion-conductive materials.The monomers are compounds corresponding to the formula A--CFX--SO.sub.2 Z in which A denotes one group R.sup.3 --O--CF.sub.2 -- or R.sup.3 -- or R.sup.1 R.sup.2 N--CO--; Z denotes F, Cl, --OSi(CH.sub.3).sub.3 or an ionic group, Z being other than F when A denotes R.sup.3 --O--CF.sub.2 -- or R.sup.3 --; X denotes F, Cl, H or R.sub.F, X being R.sub.F when A denotes R.sup.3 --; the radicals R.sup.1, R.sup.2 and R.sup.3 are chosen from polymerizable nonperfluorinated organic radicals; R.sub.F is chosen from perfluoroalkyl radicals and perfluoroaryl radicals.The polymers obtained from these monomers can be employed for the production of ion-conductive materials.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: June 25, 1996
    Assignees: Centre Nationale de la Recherche Scientifique, Hydro Quebec
    Inventors: Michel Armand, Jean-Yves Sanchez, Salime Sylla
  • Patent number: 5514807
    Abstract: The present invention relates to new noncentrosymmetric crystal structures consisting of an optionally substituted 2-amino-5-nitropyridinium halide.It also relates to a process for the preparation of these crystal structures. Finally, it relates to a device with an electro-optical effect comprising said crystal structure.
    Type: Grant
    Filed: April 6, 1994
    Date of Patent: May 7, 1996
    Assignees: France Telecom, Centre Nationale de la Recherche Scientifique (CNRS)
    Inventors: Jacques Pecaut, Jean-Pierre Levy, Rene Masses, Joseph Zyss, Rolland Hierle
  • Patent number: 4808488
    Abstract: A hybrid superconductive fiber or strand comprises at least two layers surrounding a core wherein the fiber or strand comprises two superconductive materials. One of the superconductive materials is a Chevrel phase, optionally doped, which constitutes one of the layers or the core. The other superconductive material, other than the Chevrel phase, constitutes another layer, optionally lacunar, or the core.
    Type: Grant
    Filed: May 22, 1987
    Date of Patent: February 28, 1989
    Assignee: Centre Nationale de la Recherche Scientifique (CNRS)
    Inventors: Roger A. Chevrel, Marcel M. Sergent, Maryvonne F. Hirrien
  • Patent number: 4647629
    Abstract: This invention relates to a process of cross-linking a halogenated polymer be nucleophilic substitution of the halogen atoms by means of a coupling agent constituted by an organo-metallic thiolate, wherein said coupling thiolate is an alkaline or alkaline-earth thiolate not comprising an amine function, of general formula: ##STR1## in which: Me designates an alkaline or alkaline-earth metal;R.sub.1 designates an aliphatic or aromatic radical and;R.sub.2 designates a group selected from the group constituted by: ##STR2## in which R.sub.3, R.sub.4 and R.sub.5 designate an alkyl or aryl group not comprising an amine function.
    Type: Grant
    Filed: June 17, 1985
    Date of Patent: March 3, 1987
    Assignee: Centre Nationale de la Recherche Scientifique
    Inventors: Alain Michel, Christian Gondard
  • Patent number: 4623263
    Abstract: An apparatus for the thermal measurement of the texture of a porous body, including a measuring head, a measuring assembly and a processing and control circuit. The measuring head is provided with two identical cylindrical cells, a measuring cell and a reference cell, arranged in a furnace. The measuring assembly measures the mean temperature of the measuring cell, and measures a calorific effect in the measuring cell, and includes a calorific effect detector, a calibration circuit, a temperature regulator including a furnace heater. The measuring circuit supplies a temperature signal and a calorific effect signal to the processing and control circuit, which in turn controls the heater.
    Type: Grant
    Filed: November 1, 1984
    Date of Patent: November 18, 1986
    Assignees: Commissariat a l'Energie Atomique, Centre Nationale de la Recherche Scientifique
    Inventors: Paul Barberi, Pierre Bergez, Maurice Brun, Michel Chevalier, Charles Eyraud, Jean-Francois Quinson
  • Patent number: 4348599
    Abstract: For generation of a light beam having a narrow linewidth, an energy extraction beam of narrow linewidth, typically from a pulsed laser, is directed into a Raman medium having a large stimulated line. A second source, typically a pulsed laser, delivers a beam coaxial to the first in the medium. The frequency of the first beam is within the stimulated emission line of the medium induced by the second frequency and energy transfer occurs from the second to the first beam without substantial increase in the spectral linewidth.
    Type: Grant
    Filed: May 15, 1981
    Date of Patent: September 7, 1982
    Assignee: Centre Nationale de la Recherche Scientifique
    Inventors: Francois Pradere, Robert Frey