Abstract: Identification and use of compounds which inhibit the expression or activity of micro-RNAs for preventing and/or attenuating ageing. An in vitro method for screening for candidate compounds for preventing and/or attenuating ageing of the skin including (a) bringing at least one test compound in contact with a sample of fibroblasts, (b) measuring the expression or the activity of at least one microRNA chosen from miR-134 and miR-152 in said fibroblasts, and (c) selecting the compounds for which an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the expression or an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the activity of at least one microRNA is measured in the fibroblasts treated in (a) compared with the untreated fibroblasts.

Abstract: Esters of O-substituted hydroxy carboxylic acids are provided having Formula 1, or 2, or both Formulas 1 and 2: wherein R and R1 are independently selected from the group consisting of substituted and unsubstituted, branched- and straight-chain, saturated, unsaturated, and polyunsaturated C1-C22 alkyl, substituted and unsubstituted C3-C8 cycloalkyl, substituted and unsubstituted C6-C20 carbocyclic aryl, and substituted and unsubstituted C4-C20 heterocyclic; wherein the heteroatoms are selected from sulfur, nitrogen, and oxygen; and wherein n is 1-6. Process of producing esters of O-substituted hydroxy carboxylic acids are also provided.

Abstract: The invention relates to an article which comprises a bottle of cosmetic product and a pack. The pack includes at least one wall having at least one region in relief suggesting, or even reproducing, a bottle shape so as to immobilize it with respect to the wall. The invention also relates to a pack for a bottle of cosmetic product and a method for removing a bottle of cosmetic product from a case.

Abstract: The applicator for applying a composition to the eyelashes includes a stem and a brush including at least two independent supports following one after the other along an axis of the stem, each support carrying projections that present respective bases. At least one group of at least four consecutive bases of each support form a regular succession about the axis, two of the bases of the group constituting two ends that terminate the succession.

Abstract: The invention relates to a display rack for shades of nail varnish, comprising a support and coloured tabs which are mounted on the support in a mobile manner, independently from each other.

Abstract: The dispenser member for dispensing fluid, the dispenser member includes a pump, a push-button configured to control dispensing of the fluid, a dispensing nozzle in the push-button, a shutter of the nozzle, and at least one magnet configured to move the shutter relative to the nozzle upon activation of the push-button. The fluid may include at least one of a care product, make-up, and toiletry.

Abstract: At least one microRNA selected from among hsa-miR-330, hsa-miR-7 and hsa-miR-137, the mature forms thereof, and the precursors thereof, for depigmenting the skin, and an in vitro method for identifying depigmenting compounds, which includes the steps of: a) placing at least one test compound in contact with a sample of melanocytes; b) measuring the expression or activity of at least one microRNA selected from among miR-330, miR-7 and miR-137, the mature forms thereof, and the precursors thereof, in the melanocytes; c) selecting the compounds for which at least 20% activation of the expression or of the activity of at least one of the microRNAs is measured in the melanocytes treated in a) by an element for comparing with the untreated melanocytes.

Abstract: Disclosed is an oil-in-water type emulsion composition containing a physiologically acceptable salt of a tranexamate ester and a method for producing the same. An oil-in-water type emulsion composition containing a physiologically acceptable salt of a tranexamate ester can be obtained by preparing an oil phase including: A) a physiologically acceptable salt of a tranexamate ester; B) an amphiphilic substance; C) an oily substance; and D) water, a water-soluble organic solvent or a mixture thereof wherein the weight ratio of the ingredients A:B is in the range of 1:0.5 to 1:2.5, the weight ratio of the ingredients A:C is in the range of 1:1 to 1:5.0, and the weight ratio of the ingredients A:D is 1:0.2 to 1:5.0, and adding the oil phase to a water phase including E) water, a water-soluble organic solvent or a mixture thereof.

Abstract: A method for screening an active agent intended for preventing or combating the cutaneous signs resulting from a non-pathological impairment of barrier function, which includes the selection of active agents that stimulate the expression of the ceramide transport protein CERT in cultured human keratinocytes.

Abstract: A cosmetic method for releasing an active principle in a controlled fashion to uninjured skin, as a function of the ion content in or on skin, by exchange with the ions, in order to provide at least one cosmetic benefit to the skin, the method includes applying onto skin a composition containing, in a cosmetically acceptable medium, at least one resinate including one organic ion-exchange resin and at least one ionizable cosmetic active principle bonded in noncovalent fashion to the resin.

Abstract: A cosmetic composition including diacetylresveratryl thioctate and a solvent. The solvent has a h value less than or equal to 8 and a d value greater than or equal to 16.9. Also, the use of the abovementioned composition to prevent and/or combat skin ageing.

Abstract: The present application provides a composite particle having a good feeling upon application and capable of effectively preventing make-up smudges by selectively adsorbing sebum, particularly, free fatty acid, and moreover, having a toning effect on the skin texture, and a cosmetic composition containing the composite particle. The composite particle of the present invention comprises a resin particle coated on its surface with amorphous calcium phosphate and calcium carbonate, which resin particle contains a polymer of a vinyl monomer and any one of a phosphorous acid diester component having a certain configuration and a partially esterified phosphoric acid component having a certain configuration.

Abstract: Method of identifying and using compounds which inhibit the expression or activity of micro-RNAs for preventing and/or attenuating ageing, and/or for hydrating skin. An in vitro method for screening for candidate compounds for preventing and/or attenuating ageing of the skin, and/or for hydrating the skin, includes the following steps: a. bringing at least one test compound in contact with a sample of keratinocytes; b. measuring the expression or the activity of at least one microRNA in the keratinocytes; c. selecting the compounds for which an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the expression or an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the activity of at least one microRNA is measured in the keratinocytes treated in a. compared with the untreated keratinocytes.

Abstract: A novel polypeptide isolated from the cornified envelope, similar polypeptides and fragments of the polypeptide, isolated nucleotide sequences encoding the polypeptides, as well as a cosmetic and/or pharmaceutical composition containing such polypeptides are described. The polypeptides have cosmetic and/or therapeutic use to reinforce the barrier function of the epidermis, prevent and/or treat the signs of skin dryness and prevent and/or treat disorders of the barrier function or the weakening of the epidermis.

Abstract: Cosmetic and therapeutic, in particular dermatological bioprecursors have the formula [A]n-PP-[B]m wherein PP is a polyphenol radical in which each hydroxyl function is protected by a group A or a group B, A is a saturated or unsaturated, substituted or unsubstituted alkyl radical having 1 to 20 carbon atoms which is bonded to the polyphenol, n is an integer not less than 1, and B is a precursor of a biologically active molecule, which is also bonded to the polyphenol, and m is an integer also not less than 1.

Abstract: The device for presenting a given fragrance comprises a presenting rod (10) in a confining enclosure (20), this confining enclosure comprising a collar (21) and this presenting rod comprising a porous portion (11) loaded with this fragrance and designed to fit through this collar, and another portion forming a head (12) suitable for grasping and designed to close this collar in a rest configuration such that the porous portion is, inside this confining enclosure, in a region where the fragrance exists in the gaseous state only, the constituent materials of the presenting rod underneath the head and those of the confining enclosure having no smell of their own.

Abstract: A dispenser for viscous products, including: a container for a product, a sealing cap designed to be screwed onto the container, a pipette, and a piston capable of causing a suction of the product into the pipette, the dispenser being arranged such that, when the cap is screwed onto the container, the unscrewing of the cap in the direction of opening of the dispenser causes, by itself, a movement of the piston producing the suction.

Abstract: A cosmetic composition in the form of a water-in-oil emulsion includes a fatty phase and an aqueous phase, the fatty phase of which includes at least one hydrocarbon oil, at least one first copolymer of ethylene and of propylene and at least one second copolymer of styrene and of at least one olefin other than styrene. A cosmetic method for caring for or making up skin or the lips, and the topical application to the lips of this composition are also disclosed.

Abstract: A container (1) for a stick of a cosmetic or hygienic product, comprising an applicator element (3) in which a stick (2) of said product can move axially relative to a base (32), as well as a tubular storage element (4) comprising a top (41) that contains a mobile sleeve (42) and is suitable for covering the applicator element (3) in a configuration wherein said applicator element is fully inserted into the sleeve and connected to said top by means of an elastically compressible device having two stable axial positions relative to a hilly inserted configuration, said device comprising a resilient element (43) pushing the sleeve (42) towards the outside of the top, and, distributed between the top and the sleeve, a heart-shaped guide track (44) arranged parallel to an axial direction of the top, and a follower (45) carried by a generally axially pivoting arm (46) such as to define stable top and bottom positions allowing the applicator element to be gripped or not.

Abstract: A decorated card having at least one leaf, and a cutout formed in the leaf and defined by a cutout outline. The card is characterized by the fact that it has at least two threads extending under tension across the cutout outline, and a plurality of spangles, the spangles being held suspended from each of the threads under tension so as to cover at least part of the area defined by the cutout outline. A manufacturing method is also provided.