Patents Assigned to Cheng Kung University
  • Patent number: 8753119
    Abstract: A mounting method of dental cast is disclosed. The mounting method includes the steps of providing an articulator and a label module having at least a label and at least a reference object, generating a label coordinate information in accordance with the reference object and the label, providing a midface and mandible image information and generating a landmark coordinate information in accordance with a plurality of landmarks of the midface and mandible image information, generating a structure coordinate information in accordance with a plurality of structures of the articulator and the label, disposing a first dental cast connected with the label module on the articulator, and providing a detecting device to detect the label and adjust the position of the first dental cast in accordance with the midface and mandible image information, the label coordinate information, and the structure coordinate information.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: June 17, 2014
    Assignee: National Cheng Kung University
    Inventors: Jing-Jing Fang, Tung-Yiu Wong, Chia-Chang Tsai, Tai-Hong Kuo
  • Patent number: 8755661
    Abstract: An electromagnetic wave propagating structure includes a main body having surfaces capable of blocking propagation of an electromagnetic wave, and including an incident side and an exit side opposite to the incident side in a wave-propagating direction. The main body is formed with two wave-propagating channels that are spaced apart from each other by a distance not greater than the wavelength of the electromagnetic wave. Each of the wave-propagating channels extends from the incident side to the exit side, and has an inner dimension not greater than half of the wavelength of the electromagnetic wave. The electromagnetic wave propagating structure is adapted to allow an electromagnetic wave to propagate therethrough via the wave-propagating channels for focusing into a light spot having a spot size that is smaller than half of the wavelength of the electromagnetic wave.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: June 17, 2014
    Assignee: National Cheng Kung University
    Inventor: Kuan-Ren Chen
  • Patent number: 8747110
    Abstract: An orthognathic planning system applied with at least a dental cast includes an articulator, a detecting device, at least a label module and a data processing device. The dental cast is mounted on the articulator. The detecting device is disposed with respect to the articulator. The label module has at least a label and is disposed on the dental cast. The data processing device is signally connected with the detecting device and stores midface and mandible image data. The detecting device traces the label and provides position data, and the data processing device provides orthognathic planning data in accordance with the position data and the midface and mandible image data. The present invention also discloses an orthognathic planning method.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: June 10, 2014
    Assignee: National Cheng Kung University
    Inventors: Jing-Jing Fang, Tung-Yiu Wong, Tung-Chin Wu, Tai-Hong Kuo
  • Patent number: 8743447
    Abstract: An electrochromic device is provided. The electrochromic device includes a first substrate, an electrochromic layer, an electrode, an electrolyte layer and a second substrate. The electrochromic layer is formed on the first substrate, the electrode is disposed on the electrochromic layer, and the electrolyte layer is disposed between the electrode and the second substrate.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: June 3, 2014
    Assignee: National Cheng Kung University
    Inventors: Jen-Sue Chen, Wei-Ting Wu, Jih-Jen Wu, Kun-Keng Chiang
  • Publication number: 20140147508
    Abstract: The present invention relates to a nano-carrier for an anticancer drug, which comprises: a metal nanoparticle; and a polynucleotide for connecting with an anticancer drug having a pyrimidine group or a purine group, wherein the polynucleotide is connected to a surface of the metal nanoparticle, and the anticancer drug is bound to the polynucleotide through the pyrimidine group or the purine group. In addition, the present invention also provides a complex of an anticancer drug and a nano-carrier, a pharmaceutical composition thereof, a method for manufacturing the complex, and a method for treating a cancer by using the pharmaceutical composition.
    Type: Application
    Filed: January 29, 2014
    Publication date: May 29, 2014
    Applicant: National Cheng Kung University
    Inventors: Dar-Bin SHIEH, Chen-Sheng YEH, Dong-Hwang CHEN, Ya-Na WU, Ping-Ching WU
  • Publication number: 20140144493
    Abstract: The present invention relates to a mesoporous titania bead and the preparation method thereof, wherein said mesoporous titania bead has a diameter of 200-1000 nm, specific surface area of 50-100 m2/g, porosity of 40-60%, pore radius of 5-20 nm, pore volume of 0.20-0.30 cm3/g, and the titania comprised in the bead is anatase titania.
    Type: Application
    Filed: February 3, 2014
    Publication date: May 29, 2014
    Applicant: National Cheng Kung University
    Inventors: Jyh-Ming TING, Chun-Ren KE
  • Publication number: 20140120094
    Abstract: Reducing liver fibrosis in a subject having or being suspected of having a liver disease using an IL-20 antagonist, which can be an antibody that blocks a signaling pathway mediated by IL-20. Such antibodies include anti-IL-20 antibodies and anti-IL-20R antibodies that specifically block the IL-20 signaling pathway.
    Type: Application
    Filed: October 30, 2013
    Publication date: May 1, 2014
    Applicant: National Cheng Kung University
    Inventor: Ming-Shi Chang
  • Publication number: 20140120528
    Abstract: The invention relates to methods and biomarker for evaluating cancer metastasis, pharmaceutical composition for inhibiting cancer metastasis, and method for analyzing secretome. By combining a hollow fiber cartridge (HFC) culture system with quantitative proteomics technology, cancer metastasis-related secrectomes can be found. Furthermore, this is the first time to use PARK7 as a biomarker for judging the process of non-small cell lung cancer.
    Type: Application
    Filed: September 17, 2013
    Publication date: May 1, 2014
    Applicant: National Cheng Kung University
    Inventors: Pao-Chi LIAO, Ying-Hwa CHANG, Shu-Hui LEE, Hua-Chien CHANG, Yau-Lin TSENG, Wu-Wei LAI
  • Patent number: 8711021
    Abstract: A digital-to-analog converter and a performing method thereof are disclosed. The digital-to-analog converter includes a random rotation unit, a plurality of conversion units, and a summing unit. The random rotation unit receives a plurality of binary-weighted inputs and generates a plurality of rotated digital outputs according to a random rotation number. The conversion units respectively receive one of the rotated digital outputs and generate a respective analog output. The summing unit sums the respective analog outputs of the conversion units for generating an analog output. The present invention implements the dynamic element matching technique by randomly rotating the binary-weighted inputs, so as to reduce the manufacturing cost of the digital-to-analog converter.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: April 29, 2014
    Assignee: National Cheng Kung University
    Inventors: Wei-te Lin, Tai-haur Kuo
  • Patent number: 8703410
    Abstract: The present invention relates to a CO2 laser-transparent material having a mark on the surface thereof and the method for making the same. The method includes the following steps: providing a first substrate, which has a top surface and a bottom surface; providing a second substrate which has a top surface; putting the bottom surface of the first substrate on the top surface of the second substrate; irradiating a CO2 laser beam to the top surface of the second substrate by passing through the top surface and the bottom surface of the first substrate; and forming a mark on the bottom surface of the first substrate. The material of the mark is oxide of the second substrate or the same as the material of the second substrate. Whereby the cheap CO2 laser is utilized to form the mark on the first substrate, and the mark can be erased easily by a proper chemical for recycling the first substrate.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: April 22, 2014
    Assignee: National Cheng Kung University
    Inventors: Chen-Kuei Chung, Meng-Yu Wu, En-Jou Hsiao, Shih-Lung Lin
  • Patent number: 8703495
    Abstract: A blood coagulation detection device includes a micro channel unit, an optical signal unit, an opto-electronic conversion circuit, an amplifier circuit, and a filter circuit. The micro channel unit has a sample detection area. The optical signal unit transmits a reference light to the micro channel unit so as to form a message light. The opto-electronic conversion circuit receives the message light and converts the message light into an electrical signal. The amplifier circuit is electrically connected to the opto-electronic conversion circuit for amplifying the electrical signal. The filter circuit is electrically connected to the amplifier circuit for filtering the amplified electrical signal.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: April 22, 2014
    Assignee: National Cheng Kung University
    Inventors: Kung-Chia Young, Song-Jeng Huang, Chin-Lung Yang
  • Publication number: 20140107535
    Abstract: The present disclosure is to destroy adipose tissue non-invasively by using focused ultrasound (FUS) and to increase the treatment efficiency by the synergy of the novel FUS and electrical stimulation. Lipid can be released from the destroyed adipocytes and stay in the interstitial fluid of undestroyed adipocytes. In the meanwhile or after the treatment of FUS, a passive exercise of muscle in thighs or other parts is performed by electrical stimulation to consume energy. Therefore, metabolism of the free lipid can be enhanced by supplying energy to the muscles. The ultrasound treatment of the present disclosure is able to increase the treatment area, and while in combination with electrical stimulation, it can efficiently remove lipids in the circulation.
    Type: Application
    Filed: October 11, 2013
    Publication date: April 17, 2014
    Applicants: National Cheng Kung University, National Health Research Institutes
    Inventors: Chou-Ching Lin, Gin-Shin Chen
  • Patent number: 8692235
    Abstract: An organic photoelectric semiconductor device including organic group VA salts in an organic salt-containing layer and a method for manufacturing the same are provided. The organic photoelectric semiconductor device includes: a first electrode; an organic active layer disposed over the first electrode; an organic salt-containing layer disposed over the organic active layer, where the organic salt-containing layer includes quaternary group VA salts of cations represented by the following formula (I) or derivatives thereof and anions; and a second electrode, disposed over the organic salt-containing layer, where, X, R1, R2, R3 and R4 are defined the same as the specification. Accordingly, the present invention can enhance the transmission of electrons and thus enhances the performance of devices.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: April 8, 2014
    Assignee: National Cheng Kung University
    Inventors: Ten-Chin Wen, Sung-Nien Hsieh, Tzung-Fang Guo, Wei-Chou Hsu, Chen-Yan Li
  • Patent number: 8690687
    Abstract: A magnetic coupling assembly has a supporting base, a first disk, a second disk and two piezoelectric actuators. The piezoelectric actuators are mounted between the supporting base and the first disk to drive the first disk to move along an axial direction of the supporting base and to adjust the air gap between the first and second disks. Each piezoelectric actuator has a housing, a pushing arm and at least one piezoelectric block. The pushing arm is mounted slidably in and extends out of the housing along a longitudinal direction parallel with the axial direction of the supporting base and has an end securely connected with the first disk. The at least one piezoelectric block is mounted in the housing and is attached to the pushing arm to push the pushing arm to move along the longitudinal direction.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: April 8, 2014
    Assignee: National Cheng Kung University
    Inventors: Mi-Ching Tsai, Hung-Shiang Chuang, Sheng-He Wang, Po-Jen Ko, Kwei-Yuan Chiou
  • Patent number: 8689800
    Abstract: A magnetic navigation control apparatus includes a sensing unit, a control unit and a magnetic field generating unit. The sensing unit generates a sensing signal according to the position of a magnetic element. The control unit is electrically connected with the sensing unit and generates a first control signal and a second control signal according to the sensing signal. The magnetic field generating unit is electrically connected with the control unit and has a housing, a plurality of interpoles, and a plurality of short poles. The interpoles are disposed in the housing. The short poles are disposed between the interpoles evenly. The magnetic field generating unit generates a navigation signal according to the first control signal, thereby controlling the magnetic element to move in at least one direction within a target region. The magnetic navigation control apparatus has greater magnetic navigation effects, and can thus reduce the cost.
    Type: Grant
    Filed: August 15, 2011
    Date of Patent: April 8, 2014
    Assignees: National Cheng Kung University, Delta Electronics, Inc.
    Inventors: Ray-Lee Lin, Sheng-Fu Hsiao
  • Patent number: 8688256
    Abstract: An advanced process control (APC) system, an APC method, and a computer program product, which, when executed, performs an APC method are provided for incorporating virtual metrology (VM) into APC. The present inventions uses a reliance index (RI) and a global similarity index (GSI) to adjust at least one controller gain of a run-to-run (R2R) controller when the VM value of a workpiece is adopted to replace the actual measurement value of the workpiece. The RI is used for gauging the reliability of the VM value, and the GSI is used for assessing the degree of similarity between the set of process data for generating the VM value and all the sets of historical process data used for building the conjecturing model.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: April 1, 2014
    Assignees: National Cheng Kung University, Foresight Technology Company, Ltd.
    Inventors: Fan-Tien Cheng, Chi-An Kao, Wei-Ming Wu
  • Patent number: 8679760
    Abstract: The present invention relates to a biomarker associated with a cancer and a method using the biomarker to evaluate a risk of proliferation, invasion, or metastasis of a cancer. The method of the present invention comprises the following steps: (A) providing a tissue sample to evaluate for risk of proliferation, invasion, or metastasis of a cancer, wherein the tissue sample comprises a non-cancer region, and a suspected cancer region; (B) detecting expression levels of a biomarker and a predetermined standard in the non-cancer region and the suspected cancer region respectively, wherein the biomarker is T-cell lymphoma invasion and metastasis 2 (TIAM2); (C) comparing the expression levels of the biomarker and the predetermined standard in the non-cancer region to the expression levels of the biomarker and the predetermined standard in the suspected cancer region.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: March 25, 2014
    Assignee: National Cheng Kung University
    Inventors: H. Sunny Sun, Jia-Shing Chen
  • Patent number: 8679542
    Abstract: A nucleic acid cleavage kit is used to cleave a target nucleic acid. The nucleic acid cleavage kit includes a carrier, an oligonucleotide, and a nucleic acid cleavage agent. The oligonucleotide recognizes at least partial sequence of the target nucleic acid. Then, the nucleic acid cleavage agent cleaves the target nucleic acid. A nucleic acid cleavage detection apparatus including the nucleic acid cleaving kit and a gene therapy by administering the nucleic acid cleavage kit are also disclosed.
    Type: Grant
    Filed: May 18, 2010
    Date of Patent: March 25, 2014
    Assignee: National Cheng Kung University
    Inventors: Dar-Bin Shieh, Tsung-Lin Tsai, Wu-Chou Su, Kao-Shu Chuang, Jih-Ru Hwu
  • Publication number: 20140080739
    Abstract: Provided is a capture nanobead with multiple oriented adapting peptides, comprising: a nanobead; and multiple adapting peptides, each adapting peptide specifically recognizing an IgG constant region or fragment thereof and being chemically conjugated with the nanobead, whereby the adapting peptides are orientedly arranged on the nanobead. The capture nanobeads is capable of binding or conjugating with capture molecules such capture antibodies, which is useful as the basis to bind to alternative antibodies or Fab fragments in sandwich immunoassays.
    Type: Application
    Filed: September 19, 2012
    Publication date: March 20, 2014
    Applicant: National Cheng Kung University
    Inventor: Lynn Ling-Huei Huang
  • Patent number: 8673358
    Abstract: The present invention relates to a nano-carrier for an anticancer drug, which comprises: a metal nanoparticle; and a polynucleotide for connecting with an anticancer drug having a pyrimidine group or a purine group, wherein the polynucleotide connects to a surface of the metal nanoparticle, and the anticancer drug binds to the polynucleotide through the pyrimidine group or the purine group. In addition, the present invention also provides a complex of an anticancer drug and a nano-carrier, a pharmaceutical composition thereof, a method for manufacturing the complex, and a method for treating a cancer by using the pharmaceutical composition.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: March 18, 2014
    Assignee: National Cheng Kung University
    Inventors: Dar-Bin Shieh, Chen-Sheng Yeh, Dong-Hwang Chen, Ya-Na Wu, Ping-Ching Wu