Abstract: The present invention relates to a new type of functionalized nanoparticles for drug delivery, comprising a type of polymer nanoparticles, a polymer stabilizer coating, and a drug, wherein said polymer stabilizer coating is coated on the surface of said type of polymer nanoparticles, and said drug is conjugated to said polymer stabilizer coating. The present invention also relates to a method for preparing the nanoparticles; and provides a method for treating an ischemic or degenerative disease, comprising administrating an effective amount of the type of functionalized nanoparticles to a subject.
Type:
Grant
Filed:
July 19, 2010
Date of Patent:
December 1, 2015
Assignee:
NATIONAL CHENG KUNG UNIVERSITY
Inventors:
Patrick C. H. Hsieh, Min-Feng Cheng, Chih Han Chang, Wei-Yin Liao
Abstract: A single-inductor multi-output (SIMO) conversion device for enlarging load range is disclosed. The SIMO conversion device comprises a power stage comprising a first switch and a second switch and receiving a direct-current (DC) current. A DC voltage source inputs the DC current to an inductor by timing of the first and second switches. Each control output circuit has a third switch connected with the inductor in series to receive an immediate current. The control output circuit sends out an output voltage selectively by the third switch. A control stage circuit receives a plurality of feedback voltage signals and selectively controls the order of adjusting energy of the output voltages by order control signals. The present invention uses a current sensing circuit to obtain the immediate current and switches control signals to establish the best order thereof according to different loads.
Type:
Grant
Filed:
December 31, 2013
Date of Patent:
December 1, 2015
Assignee:
NATIONAL CHUNG CHENG UNIVERSITY
Inventors:
Chung-Hsun Huang, Chao-Chun Chen, Zhen-Yu Sun
Abstract: A system integrating a tidal power generation device and a wind power generation device and a method thereof are provided. The system includes a wind power generation device, a tidal power generation device and an integration device. The wind power generation device generates a first voltage, the tidal power generation device generates a second voltage, and the integration device integrates the first and the second voltages for a further use.
Abstract: An electrical connector includes an insulating housing defining an inserting chamber and terminal grooves communicating with the inserting chamber, electrical terminals of which each has an elastic arm received in the terminal groove and a contact portion protruding towards the inserting chamber at a front end of the elastic arm, and a pressing member slidably sleeved round a front of the insulating housing. A plurality of pressing boards are protruded at inner sides of the pressing member and projects in the terminal grooves to resist against the elastic arms. The contact portions are located in the terminal grooves when the pressing member is at an initial position. After a mating connector is mated with the electrical connector, push the pressing member rearward to make the pressing blocks press the elastic arms so as to make the contact portions project into the inserting chamber and contact with the mating connector.
Abstract: The present invention relates to an urchin-like iron oxide and a method for producing the urchin-like iron oxide. The urchin-like iron oxide comprises a core and multiple needle-like elongations protruded from the core. The needle-like elongations could be wire, rod, tube, cone, and flake. The length/width ratio of the needle-like elongation is high enough to apply in an optoelectronic field. The method in accordance with the present invention is to stably heat an iron-contained powder under room temperature by a thermal oxidation. The surface of the iron-contained powder is slow oxidized to form an urchin-like iron oxide with multiple uniform distributed needle-like elongations protruded from the surface. The size of each needle-like elongation is easily adjusted and changed by controlling the heating temperature. The method has advantages of simplified operation and lowered expense.
Abstract: A composite electrode and a lithium-based battery are disclosed, wherein the composite electrode comprises: a substrate and a conductive layer formed on the substrate, wherein the conductive layer comprises graphite powders, Si-based powders, Ti-based powders, or a combination thereof embedded in a conductive matrix and coated with diamond films, and the diamond films are formed of diamond grains. The novel electrodes of the present invention when used in the Li-based battery can provide superior performance including excellent chemical inertness, physical integrity, and charge-discharge cycling life-time, and exhibit high electric conductivity and excellent lithium ion permeability.
Abstract: An antenna device includes a first dielectric substrate made of a high dielectric coefficient material, a plurality of first contact pads fastened on a periphery of a top surface of the first dielectric substrate, a plurality of second dielectric substrates made of the high dielectric coefficient material, and a plurality of Yagi-Uda antennae respectively disposed on top surfaces of the second dielectric substrates. The second dielectric substrates are fastened on the first dielectric substrate. Each of the Yagi-Uda antennae has a drive, and a plurality of directors disposed in an outside position of the drive and spaced from an outer side of the drive. The directors are shorter than the drive, and the directors are arranged along a direction of being gradually away from the drive and gradually become shorter. An inner side of the drive defines a signal feed point.
Abstract: A measurement method for environment depth and the image extraction device thereof is revealed. First, rotate an image extraction unit and extract a plurality of images using an image extraction device according to different viewing angles of a target object. Then, use disparity information of the plurality of images and an image parameter of the image extraction unit to give a plurality pieces of depth-of-field information, which are further used for giving environment depth information. The image extraction device has an image extraction unit and a rotating member. The rotating member is connected with the base; the rotating member is connected to the image extraction unit, which is located on one side of the rotating member. The plurality of images with different viewing angles are extracted to the image extraction unit as the rotating member rotates about a rotating center to different image extracting locations.
Abstract: The invention relates to methods and biomarker for evaluating cancer metastasis, pharmaceutical composition for inhibiting cancer metastasis, and method for analyzing secretome. By combining a hollow fiber cartridge (HFC) culture system with quantitative proteomics technology, cancer metastasis-related secrectomes can be found. Furthermore, this is the first time to use PARK7 as a biomarker for judging the process of non-small cell lung cancer.
Abstract: The invention relates to a method for manufacturing a solar cell with a nanostructural film, including steps of treating a glass substrate with UV ozone, uniformly coating a polystyrene nanospherical layer containing plural nanospheres on the surface of the glass substrate and curing the polystyrene nanospherical layer for adhesion onto the glass substrate, forming a first optical layer on the surface of the polystyrene nanospherical layer, curing and releasing the first optical layer from the polystyrene nanospherical layer to obtain a concave spherical nanostructured film, and finally affixing the concave spherical nanostructured film on the surface of a solar cell to manufacture a solar cell with nanostructure after curing by baking.
Abstract: A method for manufacturing a nanostructural film in a solar cell is revealed herein to include steps of forming an optical layer on a surface of a solar cell, heating a substrate of the solar cell at a temperature ranging from 100° C. to 200° C., imprinting a micro-pattern of a brightness enhanced film (BEF) on the optical layer in a vacuum environment, wherein the micro-pattern has a triangular pyramid shape and arranged periodically on the optical layer, finally removing the BEF after cooling so that the optical layer is formed into a nanostructured film corresponding to the micro-pattern of the BEF.
Abstract: A wearable electronic device includes an electronic assembly and at least one detachable power supply strap. The electronic assembly includes a first main body, a circuit module, a first buckling device and a first connector. The circuit module is disposed inside the first main body. The first buckling device and the first connector are disposed outside the first main body. The first connector is electrically connected with the circuit module. The power supply strap mounted to one end of the electronic assembly includes a second main body, a second battery module disposed inside the second main body, a second connector and a second buckling device matchable with the first buckling device. The second connector and the second buckling device are disposed to one end of the second main body. The second connector is electrically connected with the second battery module and is connected with the first connector.
Abstract: A ratchet driving mechanism for a hand tool includes: a drive unit, including a drive shaft, a position member and a plurality of latch members, wherein each of the latch members includes a latch plate and an elastic piece; an adjustment ring, sleeved on the drive shaft and formed with a plurality of cavities allowing the position member to be selectively latched and positioned and an accommodation slot allowing each of the latch plates to inwardly/outwardly move; and a ratchet unit, sleeved on the drive shaft and formed with a plurality of ratchet teeth allowing each of the latch plates to be engaged. Accordingly, during the drive shaft driving the ratchet unit for generating rotation, the position member is able to precisely position the ratchet unit on drive shaft.
Abstract: The present invention relates to a method of transferring a graphene film comprising the steps of (A) providing a carrier, wherein the carrier has a first surface, and a second surface, and a first graphene film is formed on the first surface; (B) disposing a patterned protection layer on the second surface of the carrier; (C) patternin carrier with the first graphene film on a target substrate; (E) removing the the carrier to expose the first graphene film; (D) disposing the patterned carrier to transfer the first graphene film on the substrate.
Abstract: The present disclosure is directed to a regulator, a pharmaceutical composition encompassing the regulator and the application thereof. The regulator modulates the expression integrins and/or EMP2, and is employed for treating integrins-associated and/or EMP2-associated diseases.
Abstract: A game joystick includes a lower half body, an upper half body covering on the lower half body, a battery cover covering on the upper half body and elastic elements mounted in the upper half body. The upper half body is concaved downward to form a plurality of buckling slots. An opening is opened in one sidewall of each buckling slot. The battery cover protrudes downward to form a plurality of buckling strips of which each defines a first pushing surface and a second pushing surface. The elastic element has a first elastic arm fastened in the upper half body, and a second elastic arm passing through the opening to elastically project in the buckling slot. The second elastic arms cooperate with the first pushing surfaces and the second pushing surfaces of the buckling strips inserted into the buckling slots to close or open the battery cover easily.
Abstract: An oxidative method for water is provided. The oxidative method includes providing a compound having properties of a p-type semiconductor and an n-type semiconductor; obtaining a mixture by adding the compound to the water; and illuminating the mixture using a light source to excite the compound.