Patents Assigned to Chiba University
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Patent number: 9427457Abstract: Provided is a novel soluble factor that modulates morphogenesis and cell proliferation, such as cardiac development and/or cardiomyocyte differentiation. Specifically provided are: an inhibitor of Wnt signalling, comprising an insulin-like growth-factor-binding protein (IGFBP), the protein being binding to a Wnt receptor, and/or a polynucleotide encoding the protein; a medicament for prevention and/or treatment of a disease due to enhanced Wnt signalling, comprising the inhibitor of Wnt signalling, and a medicament for induction of cardiomyocyte differentiation; and a method for prevention and/or treatment of a disease due to enhanced Wnt signalling and a method of inducing cardiomyocyte differentiation, the methods each comprising using the inhibitor of Wnt signalling, and a cardiomyocyte, which is obtained by the method of inducing cardiomyocyte differentiation, and a use thereof.Type: GrantFiled: February 27, 2015Date of Patent: August 30, 2016Assignee: National University Corporation Chiba UniversityInventors: Issei Komuro, Ichiro Shiojima, Weidong Zhu
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Patent number: 9404158Abstract: [PROBLEM TO BE SOLVED] An object of the present invention is to provide a novel tumor marker and use thereof. In more detail, the present invention provides a novel tumor marker, a method for measuring said tumor marker and a measurement kit, a method for detecting cancer using the same, a kit for detecting cancer, a method for screening a preventive and/or therapeutic agent for cancer, as well as a medicament such as cancer vaccine. [SOLUTION] According to the present invention, a method for measuring an alternative splicing variant of OATP1B3 mRNA in a sample to be examined is provided. Said measurement method comprises measuring mRNA comprising a nucleotide sequence represented by SEQ ID NO: 1 in the sequence listing table in a sample to be examined isolated from living organism with differentiation from a mRNA comprising a nucleotide sequence represented by SEQ ID NO: 2. Said measurement method is useful for detecting cancer or screening a preventive and/or therapeutic agent.Type: GrantFiled: February 18, 2011Date of Patent: August 2, 2016Assignee: National University Corporation Chiba UniversityInventors: Tomomi Furihata, Sayaka Matsumoto, Miki Nagai, Kan Chiba
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Patent number: 9366681Abstract: Disclosed are: a polypeptide marker for diagnosing arteriosclerosis; a gene marker for diagnosing arteriosclerosis; an antibody; a probe for detecting an arteriosclerosis marker gene; a DNA microarray or a DNA chip for detecting an arteriosclerosis marker gene; a method for detecting arteriosclerosis; and a kit for diagnosing arteriosclerosis; with which an arteriosclerotic lesion can be detected with much improved accuracy.Type: GrantFiled: March 4, 2013Date of Patent: June 14, 2016Assignees: Fujikura Kasei Co., Ltd., National University Corporation Chiba UniversityInventors: Rika Nakamura, Hideyuki Kuroda, Go Tomiyoshi, Takaki Hiwasa, Masaki Takiguchi, Naokatsu Saeki, Toshio Machida
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Patent number: 9355466Abstract: An image processing apparatus includes a skin information obtaining unit that extracts a skin area from an image and obtains skin information from the skin area; an independent component extracting unit that extracts independent components constituting the skin area from the skin information; and a bias calculation unit that calculates, based on the independent components, a bias representing color information of a light source used to illuminate the skin area when the image is captured.Type: GrantFiled: December 19, 2014Date of Patent: May 31, 2016Assignees: Ricoh Company, Ltd., Chiba UniversityInventors: Akihiro Kakinuma, Hiroshi Takahashi, Naohiro Kamijo, Norimichi Tsumura, Satomi Tanaka
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Patent number: 9315816Abstract: Provided are: a selection method for a gene switch and a gene circuit, including using, as a selector, an expression vector containing at least a gene sequence whose expression is controlled by a transcription regulatory factor to be expressed when a genetic switch and a genetic circuit including the genetic switch operate, and a promoter sequence operably linked to the gene sequence upstream thereof; and an expression vector to be used in the selection method. This enables an effective selection method for a genetic switch and a genetic circuit, the selection method being able to be conducted within a short time period and with high selection efficiency and less leakiness.Type: GrantFiled: November 2, 2011Date of Patent: April 19, 2016Assignee: National University Corporation Chiba UniversityInventors: Daisuke Umeno, Hiroki Fukutomi, Kyoichi Saito
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Patent number: 9249417Abstract: An object of the present invention is to achieve a method capable of increasing transfection efficiency of polyethyleneimine (PEI) and reducing toxicity thereof, to provide a PEI with high transfection efficiency, and to provide a method of introducing nucleic acids into cells comprising using the PEI. There are provided a method of introducing nucleic acids into cells comprising mixing acidified PEI with nucleic acids under acidic conditions and applying the resulting mixture to cells, a reagent for introducing nucleic acids into cells comprising an acidified PEI solution, and a reagent kit including the solution.Type: GrantFiled: July 8, 2013Date of Patent: February 2, 2016Assignee: National University Corporation Chiba UniversityInventors: Naoto Yamaguchi, Yasunori Fukumoto
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Patent number: 9244079Abstract: [Problem] The present invention provides a novel pathological marker of angiitis which serves as an alternative to MPO-ANCAs. [Means for Solution] According to one embodiment of the present invention, a method for testing angiitis which includes a step of detecting an antibody specifically recognizing a moesin in a biological sample is provided. In addition, according to another embodiment of the present invention, a reagent for testing angiitis which contains a substance that detects an antibody specifically recognizing a moesin in a biological sample is provided.Type: GrantFiled: May 12, 2011Date of Patent: January 26, 2016Assignees: National University Corporation Chiba University, Educational Foundation Jichi Medical UniversityInventors: Kazuo Suzuki, Toshinori Nakayama, Hiroshi Nakajima, Tomokazu Nagao, Wako Yumura
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Patent number: 9207232Abstract: A measure for selective fluorescent labeling of the Golgi apparatus, which has low cytotoxicity and excellent intracellular stability, is provided. According to the present invention, provided are a ceramide derivative represented by the following Chemical formula 1: in the formula, R1 is an alkyl group having 1 to 12 carbon atoms, R2 is an alkyl group having 1 to 20 carbon atoms, and n is an integer of 1 to 20, and a Golgi apparatus-labeling fluorescent probe using the same.Type: GrantFiled: August 13, 2012Date of Patent: December 8, 2015Assignee: National University Corporation Chiba UniversityInventors: Atsushi Nishida, Hiroyuki Nakamura, Tomohiko Makiyama, Toshihiko Murayama
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Patent number: 9115405Abstract: An object of the present invention is to provide a novel tumor marker and use thereof. In more detail, the present invention provides a novel tumor marker, a method for measuring said tumor marker and a measurement kit, a method for detecting cancer using the same, a kit for detecting cancer, a method for screening a preventive and/or therapeutic agent for cancer, as well as a medicament such as cancer vaccine. According to the present invention, a method for measuring an alternative splicing variant of OATPIB3 mRNA in a sample to be examined is provided. Said measurement method comprises measuring mRNA comprising a nucleotide sequence represented by SEQ ID NO: 1 in the sequence listing table in a sample to be examined isolated from living organism with differentiation from a mRNA comprising a nucleotide sequence represented by SEQ ID NO: 2. Said measurement method is useful for detecting cancer or screening a preventive and/or therapeutic agent.Type: GrantFiled: February 5, 2013Date of Patent: August 25, 2015Assignee: National University Corporation Chiba UniversityInventors: Tomomi Furihata, Sayaka Matsumoto, Miki Nagai, Kan Chiba
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Patent number: 9101558Abstract: To provide a method of efficiently delivering cells having an anti-tumor activity to tumor tissues to evoke a stronger anti-tumor reaction, and a method of providing a more effective tumor regression effect, both in a cellular immunotherapy for cancer utilizing cells having an anti-tumor activity or antigen presenting cells for activating cells capable of exhibiting an anti-tumor activity. Provided are: a method of treating head and neck cancer, comprising administering an anti-cancer cell composition containing NKT cells activated in vitro with an NKT cell ligand into the tumor-feeding artery, and administering an NKT cell-stimulating agent containing antigen presenting cells treated with an NKT cell ligand through the upper respiratory tract mucous membrane; a use, in anti-cancer treatment of head and neck region, of the anti-cancer cell composition and the NKT cell-stimulating agent; a kit comprising the anti-cancer cell composition and the NKT cell-stimulating agent; and the anti-cancer cell composition.Type: GrantFiled: September 26, 2008Date of Patent: August 11, 2015Assignee: National University Corporation Chiba UniversityInventors: Masaru Taniguchi, Shigetoshi Horiguchi, Yoshitaka Okamoto, Toshinori Nakayama
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Publication number: 20150178950Abstract: An image processing apparatus includes a skin information obtaining unit that extracts a skin area from an image and obtains skin information from the skin area; an independent component extracting unit that extracts independent components constituting the skin area from the skin information; and a bias calculation unit that calculates, based on the independent components, a bias representing color information of a light source used to illuminate the skin area when the image is captured.Type: ApplicationFiled: December 19, 2014Publication date: June 25, 2015Applicants: Chiba University, RICOH COMPANY, LTD.Inventors: Akihiro KAKINUMA, Hiroshi TAKAHASHI, Naohiro KAMIJO, Norimichi TSUMURA, Satomi TANAKA
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Publication number: 20150164987Abstract: Provided is a novel soluble factor that modulates morphogenesis and cell proliferation, such as cardiac development and/or cardiomyocyte differentiation. Specifically provided are: an inhibitor of Wnt signalling, comprising an insulin-like growth-factor-binding protein (IGFBP), the protein being binding to a Wnt receptor, and/or a polynucleotide encoding the protein; a medicament for prevention and/or treatment of a disease due to enhanced Wnt signalling, comprising the inhibitor of Wnt signalling, and a medicament for induction of cardiomyocyte differentiation; and a method for prevention and/or treatment of a disease due to enhanced Wnt signalling and a method of inducing cardiomyocyte differentiation, the methods each comprising using the inhibitor of Wnt signalling, and a cardiomyocyte, which is obtained by the method of inducing cardiomyocyte differentiation, and a use thereof.Type: ApplicationFiled: February 27, 2015Publication date: June 18, 2015Applicant: National University Corporation Chiba UniversityInventors: Issei Komuro, Ichiro Shiojima, Weidong Zhu
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Patent number: 8987253Abstract: [PROBLEMS] To provide a novel compound having NMDA receptor channel blocking activity, and also a pharmaceutical agent comprising the compound. [MEANS FOR SOLVING PROBLEMS] A pharmaceutical agent for the treatment or prevention of a disease caused by overexcitation of an NMDA receptor, which comprises a compound having NMDA receptor channel blocking activity and represented by the formula (1), a salt thereof, or a hydrate of the compound or the salt.Type: GrantFiled: May 31, 2013Date of Patent: March 24, 2015Assignee: National University Corporation Chiba UniversityInventors: Kazuei Igarashi, Hiromitsu Takayama
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Patent number: 8962705Abstract: A method for removing cauxin in cat urine and a material for removing cauxin are provided. The material for removing cauxin in cat urine comprises a polymer substrate on which surface a trifluoroketone derivative is immobilized via dithiol.Type: GrantFiled: February 17, 2011Date of Patent: February 24, 2015Assignees: National University Corporation Chiba University, Incorporated National University Iwate University, Nippon Zenyaku Kogyo Co., Ltd.Inventors: Shinya Matsuno, Kyoichi Saito, Tetsuro Yamashita, Ayako Ito, Yasuyuki Suzuta
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Patent number: 8921616Abstract: An object of the invention is to provide a production method that can produce glycol from polyhydric alcohol with high selectivity and in a satisfactory yield. The object is achieved by using a silver catalyst in a reaction for synthesizing hydroxyketone from polyhydric alcohol having adjacent hydroxyl groups, and a hydrogenation catalyst in a reaction for synthesizing glycol from hydroxyketone.Type: GrantFiled: January 12, 2012Date of Patent: December 30, 2014Assignees: Clariant Catalysts (Japan) K.K., National University Corporation Chiba UniversityInventors: Tetsuro Kizaki, Keizo Iwatani, Xin Chen, Satoshi Sato
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Patent number: 8886928Abstract: An information processing device, which is used by a user and includes a storage device, encodes target information required for a device authentication by a server by using device-specific information or information based on the device-specific information as an encryption key, and stores the encoded target information. The information processing device uses a decryption key that corresponds to the encryption key used in the generation of the stored encoded target information to decode the encoded target information, and sends the decoded target information to the server. The server receives the target information from the information processing device, and determines whether or not the received target information is correct.Type: GrantFiled: January 29, 2013Date of Patent: November 11, 2014Assignees: Chiba University, Safety Angle Inc.Inventors: Mitsuru Tada, Masayuki Itoi
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Publication number: 20140329266Abstract: A measure for selective fluorescent labeling of the Golgi apparatus, which has low cytotoxicity and excellent intracellular stability, is provided. According to the present invention, provided are a ceramide derivative represented by the following Chemical formula 1: in the formula, R1 is an alkyl group having 1 to 12 carbon atoms, R2 is an alkyl group having 1 to 20 carbon atoms, and n is an integer of 1 to 20, and a Golgi apparatus-labeling fluorescent probe using the same.Type: ApplicationFiled: August 13, 2012Publication date: November 6, 2014Applicant: National University Corporation Chiba UniversityInventors: Atsushi Nishida, Hiroyuki Nakamura, Tomohiko Makiyama, Toshihiko Murayama
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Publication number: 20140302473Abstract: Provided is a stethoscopy training system which is inexpensive and has a simple configuration, without using a device which measures a respiratory operation of a simulated patient. The stethoscopy training system for this objective is formed from: a simulated stethoscope (1) having a sound acquisition unit further comprising a location display means (1d), a tube, and ear pipes; a location sensing means (2) for sensing the location of the sound acquisition unit; biological sound database (3); a biological sound reproducing means (4); and a timing display means (5) for displaying a timing of a repetition of a reproduced respiratory sound. The database retains as information biological sounds which are prerecorded from actual patients in correspondence with chest locations.Type: ApplicationFiled: May 11, 2012Publication date: October 9, 2014Applicants: Kenzmedico Co., Ltd., National University Corporation Chiba UniversityInventors: Toshiya Nakaguchi, Masahiro Tanabe
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Publication number: 20140228199Abstract: An ammonia-producing catalyst includes a p-type semiconductor, an n-type semiconductor, and a metal fine particle having a function of adsorbing nitrogen. In the ammonia-producing catalyst including the metal fine particle, generation of ammonia is promoted, and the generated amount of ammonia is increased. An ammonia-producing catalyst includes a p-type semiconductor, an n-type semiconductor, and an ammonia-fixing compound for fixing ammonia. In the ammonia-producing catalyst including the ammonia-fixing compound, a fixed yield of ammonia is sufficiently increased.Type: ApplicationFiled: February 11, 2014Publication date: August 14, 2014Applicants: National University Corporation Chiba University, DENSO CORPORATIONInventors: Masaki Yoshinaga, Hiroaki Yotou, Takumi Okamoto, Miho Itoh, Katsuyoshi Hoshino
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Publication number: 20140218781Abstract: Provided are a light-adjusting element and a product containing the same. The light-adjusting element usable even with a transmission display device, and has a high-quality mirror state capable of a high contrast ratio. A light-adjusting element, according to one embodiment of the present invention, is characterized by including: a pair of substrates; a pair of electrodes formed on opposing surfaces of the pair of substrates, with one electrode being a transparent electrode that has nanometer-scale depressions and protrusions; and en electrolyte layer, interposed between the pair of electrodes, which has electrolyte as well as a mediator and an electrochromic material that has silver. Furthermore, a device according to one embodiment of the present invention at least partially includes the light-adjusting element.Type: ApplicationFiled: March 2, 2012Publication date: August 7, 2014Applicant: National University Corporation Chiba UniversityInventors: Norihisa Kobayashi, Kazuki Nakamura, Shingo Araki